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Showing 1-30 of 115 results
Antibody Drug Conjugate Mimic Enables LC-MS Method Development Without Risk
Here we show how LC and MS methods may be optimized using a non-toxic surrogate of the ADC, an “ADC-mimic”, that behaves very similarly to the Cys-linked ADC Adcetris (Seattle Genetics).
Extraction and Analysis of Neonicotinoid Pesticides from Flower Blossoms Using Supel™ QuE and Ascentis® Express
Extraction and Analysis of Neonicotinoid Pesticides from Flower Blossoms Using Supel™ QuE and Ascentis® Express
Chiral LC-MS Analysis of Methamphetamine in Urine on Astec® CHIROBIOTIC® V2
Efficient LC-MS separation of methamphetamine enantiomers in urine allows sensitive differentiation of illicit D-methamphetamine from over-the-counter L-methamphetamine.
Measurement of acetic acid vapor in the workplace using passive sampling SPME and on-fiber derivatization with 1-pyrenyldiazomethane: Comparison with active sampling
Measurement of acetic acid vapor in the workplace using passive sampling SPME and on-fiber derivatization with 1-pyrenyldiazomethane: Comparison with active sampling.
Chiral LC-MS/MS of D- and L-2-Hydroxyglutaric Acid Biomarkers
We describe here a rapid and sensitive method to separate and measure D-2-OHG and L-2-OHG enantiomers using high-resolution mass spectrometry (HRMS) detection.
Fast and Accurate LC-MS Analysis of Vitamin D Metabolites Using Ascentis® Express F5 HPLC Columns
Fast and Accurate LC-MS Analysis of Vitamin D Metabolites, Using Ascentis® Express F5 HPLC Columns from Supelco®
Analysis of a Bispecific Monoclonal Antibody Using Size Exclusion Chromatography and Mass Spectrometry
Bispecific antibodies are a new class of biotherapeutics where one therapeutic agent can target two different antigens. This application note demonstrates a new size exclusion chromatographic method for characterizing these new biotherapeutics by mass spectrometry.
Analysis of Human Plasma Lipids Using sub-2 μM C18 UHPLC Column with MS Detection
A comprehensive platform for lipidomics studies by LC/MS, applied without any modification in conditions and suitable to both ESI and APCI interfaces.
Mass Spectral Column Bleed in Nitrogen-Containing Polar-Embedded HPLC Stationary Phases
Mass Spectral Column Bleed in Nitrogen-Containing Polar-Embedded HPLC Stationary Phases
UHPLC/MS Analysis of Cannabinoids Extracted from Raw Cannabis Sativa (Marijuana) on Ascentis® Express RP-Amide
THC solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material; Cannabidiolic acid solution, 1.0 mg/mL in acetonitrile, ampule of 1 mL, certified reference material; Cannabichromene solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material;
HPLC Analysis of Carotene Compounds on Ascentis® RP-Amide
HPLC Analysis of Carotene Compounds on Ascentis® RP-Amide
Banned and Other Neonicotinoids from Plant Material
On Friday, April 27, 2018, the European Union decided to ban the use of three neonicotinoid insecticides from use on field crops, having deemed them dangerous to bees. This application demonstrates the analysis of these banned compounds and others from
LC MS Analysis of Nucleotides Effect of pH
ZIC-cHILIC is a densely bonded zwitterionic stationary phase with phosphorylcholine functional groups covalently attached to silica.
HPLC Analysis of Heroin, Cocaine, Amphetamine and MDMA on Ascentis® Express HILIC
Separation of Heroin, analytical standard, ≥98% (HPLC); Cocaine hydrochloride, analytical standard; D-Amphetamine hemisulfate salt solution, 1.0 mg/mL in methanol, analytical standard, for drug analysis; (±)-3,4-Methylenedioxymethamphetamine hydrochloride solution, analytical standard, for drug analysis, 1.0 mg/mL in methanol
Empowering biochemists to analyze glycoproteins with exceptional reproducibility
Fast, high-resolution separations of procainamide labeled glycans - dextran ladder, human IgG and cetuximab
Quantifying Picogram Concentrations of Aflatoxin M1 in Liquid Milk Using SPE Cleanup and LC/MS Analysis
Fast method for the cleanup, analysis, and quantification of aflatoxin M1 in milk samples to EU regulatory standards (0.025 μg/kg).
Fast Extraction and Low Level Detection of Chloramphenicol in Shrimp
A highly selective and sensitive analytical method was developed for chloramphenicol using a QuEChERS type sample preparation approach and LC-MS/MS detection.
Development of a Method for Analysis of Phthalate Esters in Vegetable Oils
Rapid, easy, sensitive method for the anaysis of PAEs, using LLE and direct immersion SPME, demonstrated good accuracy, repeatability, linearity and LOQ.
Reduce Matrix Background and Improve Overall Analyte Recovery for the Analysis of Pesticides in Beef Kidney
Supel QuE Z-Sep+ was successfully demonstrated for cleanup of beef kidney matrix, providing reduced background and less interference in the GC-MS analysis of the target pesticides
Mass Spectrometry Metabolite Library Protocol
MSMLS™ (Mass Spectrometry Metabolite Library of Standards) is a collection of high quality small biochemical molecules that span a broad range of primary metabolism. These are high purity (>95%) compounds supplied in an economical, ready-to-use format.
GC Analysis of Volatiles in Milk on Supel-Q™ PLOT after SPME using a 75 µm PDMS/Carboxen Fiber
Separation of 4-Methyl-2-pentanone; Dimethyl disulfide; Hexanal; 3-Methylpentane; Acetone
GC Analysis of Agricultural Pesticides (Standard) on SLB®-5ms
GC Analysis of Agricultural Pesticides (Standard) on SLB®-5ms
Flow-Modulation Comprehensive 2D GC/MS for the Determination of Allergens in Fragrances
The proposed method appears to be reliable and sensitive for the determination of allergens in perfumes, following the SCCNFP Opinion.
GC Analysis of Polynuclear Aromatic Hydrocarbons (PAHs) in Salmon on SPB®-608 after QuEChERS Cleanup using Supel™ QuE Z-Sep, Fast GC Analysis
GC Analysis of Polynuclear Aromatic Hydrocarbons (PAHs) in Salmon on SPB®-608 (20 m x 0.18 mm I.D., 0.18 µm) after QuEChERS Cleanup using Supel™ QuE Z-Sep, Fast GC Analysis
Extraction and Analysis of PAHs in Olive Oil using Molecularly Imprinted Polymer SPE and GC-MS
Extraction and Analysis of PAHs in Olive Oil using Molecularly Imprinted Polymer SPE and GC-MS
LC/MS Analysis of Aflatoxin M1 in Milk on Ascentis® Express HILIC after SPE using Supel™ Tox AflaZea, Quantifying Picogram Concentrations
Protocol for LC/MS Analysis of Aflatoxin M1 in Milk on Ascentis® Express HILIC after SPE using Supel™ Tox AflaZea, Quantifying Picogram Concentrations
Analysis of Fipronil and Fipronil Sulfone in Eggs, Chicken Meat and Mayonnaise
A short abstract on a method using QuEChERS and GC/MS/MS for determination of fipronil & fipronil sulfone.
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