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Sujan Badal et al.
The Journal of biological chemistry, 290(36), 22287-22297 (2015-07-25)
Fluoroquinolones (FQ) are powerful broad-spectrum antibiotics whose side effects include renal damage and, strangely, tendinopathies. The pathological mechanisms underlying these toxicities are poorly understood. Here, we show that the FQ drugs norfloxacin, ciprofloxacin, and enrofloxacin are powerful iron chelators comparable
Adám Solti et al.
Plant physiology and biochemistry : PPB, 52, 91-97 (2012-02-07)
Chloroplasts contain 80-90% of iron taken up by plant cells. Though some iron transport-related envelope proteins were identified recently, the mechanism of iron uptake into chloroplasts remained unresolved. To shed more light on the process of chloroplast iron uptake, trials
Isabelle J Schalk
Chembiochem : a European journal of chemical biology, 14(3), 293-294 (2013-01-15)
Pumping iron: Raymond's group has identified and described the molecular details of an ABC transporter. Together with a binding protein at the cell surface, it is able to extract an unstable form of ferricitrate.
Li Yuan et al.
International journal of pharmaceutics, 454(1), 82-89 (2013-07-16)
Supplementation with iron-fortified foods is an effective method for treating iron deficiency diseases. However, traditional iron agents used to treat anemia of inflammation (AI) have little effect. In this study, two types of iron liposomes, heme liposomes (HEME-LIP) and ferric
Guus A M Kortman et al.
PloS one, 7(1), e29968-e29968 (2012-01-25)
Recent trials have questioned the safety of untargeted oral iron supplementation in developing regions. Excess of luminal iron could select for enteric pathogens at the expense of beneficial commensals in the human gut microflora, thereby increasing the incidence of infectious
Lu Zhao et al.
The Journal of nutritional biochemistry, 26(11), 1174-1182 (2015-08-05)
Estrogen deficiency has been considered to be a major cause of osteoporosis, but recent epidemiological evidence and mechanistic studies have indicated that aging and the associated increase in reactive oxygen species (ROS) are the proximal pathogenic factors. Through ROS-mediated reactions
Xiaoya He et al.
Stem cell research & therapy, 6, 207-207 (2015-11-01)
Despite the strong appeal of ferritin as a magnetic resonance imaging (MRI) reporter for stem cell research, no attempts have been made to apply this genetic imaging reporter in stem cells in an inducible manner, which is important for minimizing
Keiji Nishida et al.
PLoS biology, 10(2), e1001269-e1001269 (2012-03-06)
Most organisms are simply diamagnetic, while magnetotactic bacteria and migratory animals are among organisms that exploit magnetism. Biogenic magnetization not only is of fundamental interest, but also has industrial potential. However, the key factor(s) that enable biogenic magnetization in coordination
Virendra Kumar et al.
Ultrastructural pathology, 39(1), 38-48 (2014-09-06)
The aim of this study was to investigate the morphologic and ultrastructural features of biofilms of slow and fast-growing mycobacteria in different stress conditions, presence and absence of oleic acid albumin dextrose catalase (OADC) enrichment and at different temperatures: 30
Keitaro Yokoyama et al.
American journal of nephrology, 36(5), 478-487 (2012-11-14)
JTT-751 (ferric citrate hydrate) is a novel oral, iron-based phosphate binder being developed for the treatment of hyperphosphatemia among chronic kidney disease patients who are on dialysis. This study investigated the dose-response and safety of JTT-751 among Japanese hemodialysis patients.
Mohamad F Aslam et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 28(8), 3671-3678 (2014-04-30)
The ferritin core is composed of fine nanoparticulate Fe(3+) oxohydroxide, and we have developed a synthetic mimetic, nanoparticulate Fe(3+) polyoxohydroxide (nanoFe(3+)). The aim of this study was to determine how dietary iron derived in this fashion is absorbed in the
Izumi Yanatori et al.
Cell biology international, 39(4), 427-434 (2014-12-11)
Ferristatin II, discovered as an iron transport inhibitor, promotes the internalization and degradation of transferrin receptor 1 (TfR1). DMT1, which mediates iron transport across cell membranes, is located at the plasma membrane of enterocytes and imports dietary iron into the
Jamie P Dwyer et al.
American journal of kidney diseases : the official journal of the National Kidney Foundation, 61(5), 759-766 (2013-02-02)
Most dialysis patients require phosphate binders to control hyperphosphatemia. Ferric citrate has been tested in phase 2 trials as a phosphate binder. This trial was designed as a dose-response and efficacy trial. Prospective, phase 3, multicenter, open-label, randomized clinical trial.
F Baldi et al.
Journal of applied microbiology, 107(4), 1241-1250 (2009-06-11)
To investigate Klebsiella oxytoca strain BAS-10 growth on ferric citrate under anaerobic conditions for exopolysaccharide (EPS) production and localization on cell followed by the purification and the EPS determination of the iron-binding stability constant to EPS or biotechnological applications. Klebsiella
Míriam R García et al.
International journal of food microbiology, 208, 65-74 (2015-06-10)
Fish quality has a direct impact on market price and its accurate assessment and prediction are of main importance to set prices, increase competitiveness, resolve conflicts of interest and prevent food wastage due to conservative product shelf-life estimations. In this
Andrew J Ghio et al.
Journal of inorganic biochemistry, 147, 126-133 (2015-04-07)
Mechanistic pathways underlying inflammatory injury following exposures to vanadium-containing compounds are not defined. We tested the postulate that the in vitro biological effect of vanadium results from its impact on iron homeostasis. Human bronchial epithelial (HBE) cells exposed to vanadyl
Juan Du et al.
Archives of microbiology, 197(7), 883-888 (2015-05-27)
A yellow-colored, Gram-negative, strictly aerobic, non-motile, rod-shaped bacterium, designated THG-MM5(T), was isolated from road soil in Yongin-si, Gyeonggi-do, Republic of Korea. Based on 16S rRNA gene sequence, strain THG-MM5(T) was moderately related to Sphingomonas sediminicola KACC 15039(T) (96.1%), Sphingomonas ginsengisoli
Nadia M Bastide et al.
Cancer research, 75(5), 870-879 (2015-01-17)
Epidemiology shows that red and processed meat intake is associated with an increased risk of colorectal cancer. Heme iron, heterocyclic amines, and endogenous N-nitroso compounds (NOC) are proposed to explain this effect, but their relative contribution is unknown. Our study
Jimena Carrillo-Tripp et al.
The Journal of general virology, 95(Pt 10), 2285-2296 (2014-07-06)
The cell line IPLB-LD-652Y, derived from the gypsy moth (Lymantria dispar L.), is routinely used to study interactions between viruses and insect hosts. Here we report the full genome sequence and biological characteristics of a small RNA virus, designated Lymantria
Kyung Hwa Won et al.
Antonie van Leeuwenhoek, 107(2), 565-573 (2014-12-19)
An ivory white, rod-shaped, non-motile, non-spore forming, Gram-staining-negative, and aerobic bacterium designated THG-G118T, was isolated from a soil sample collected in a bamboo plantation in Seoul, Republic of Korea. The 16S rRNA gene sequence analysis revealed a clear affiliation of
Lucie Y Guo et al.
Experimental eye research, 129, 31-37 (2014-12-03)
Age-related macular degeneration (AMD) is the most common cause of blindness among older adults in developed countries, and retinal iron accumulation may exacerbate the disease. Iron can upregulate the production of amyloid precursor protein (APP). Since amyloid-β (Aβ), a byproduct
David Lloyd et al.
Microbiology (Reading, England), 161(Pt 1), 213-218 (2014-11-20)
Investigation of a series of nutrient-supplemented thixotropic gels at successive dilutions that impede the trajectories of a highly vigorous motile flagellated protist, Spironucleus vortens, provides insights into both its swimming characteristics and a means for its immobilization. The progress of
Jun Wang et al.
Scientific reports, 5, 10729-10729 (2015-06-04)
Lactoferrin (Lf) can bind to lactoferrin receptor (LfR), leading to iron transport through the plasma membrane. Besides iron transportation, Lf also has antioxidant and anti-inflammatory properties. In the brain, Lf is only synthesized by activated microglia. LfR is present in
Ajay A Vashisht et al.
The Journal of biological chemistry, 290(22), 14218-14225 (2015-04-22)
Xeroderma pigmentosum group D (XPD) helicase is a component of the transcription factor IIH (TFIIH) transcription complex and plays essential roles in transcription and nucleotide excision repair. Although iron-sulfur (Fe-S) cluster binding by XPD is required for activity, the process
Solange Le Blanc et al.
American journal of physiology. Cell physiology, 302(12), C1780-C1785 (2012-04-13)
Heme-Fe is an important source of dietary iron in humans; however, the mechanism for heme-Fe uptake by enterocytes is poorly understood. Heme carrier protein 1 (HCP1) was originally identified as mediating heme-Fe transport although it later emerged that it was
Junmo Hwang et al.
Biochemical and biophysical research communications, 464(1), 168-175 (2015-06-28)
Iron chelation is a promising therapeutic strategy for cancer that works, in part, by inducing overexpression of N-myc downstream-regulated gene 1 protein (NDRG1), a known growth inhibitor and metastasis suppressor. However, details of the signaling cascades that convert physical stress
Hiroshi Kawabata et al.
Experimental hematology, 43(5), 404-413 (2015-01-31)
Hepcidin is the central regulator of systemic iron homeostasis; dysregulation of hepcidin expression causes various iron metabolic disorders, including hereditary hemochromatosis and anemia of inflammation. To identify molecules that modulate hepcidin expression, we developed a bioassay system for hepcidin gene
Marcus J Edwards et al.
Structure (London, England : 1993), 20(7), 1275-1284 (2012-06-12)
Members of the genus Shewanella translocate deca- or undeca-heme cytochromes to the external cell surface thus enabling respiration using extracellular minerals and polynuclear Fe(III) chelates. The high resolution structure of the first undeca-heme outer membrane cytochrome, UndA, reveals a crossed
Miriam A Rosenbaum et al.
PloS one, 7(2), e30827-e30827 (2012-02-10)
Shewanella oneidensis is a target of extensive research in the fields of bioelectrochemical systems and bioremediation because of its versatile metabolic capabilities, especially with regard to respiration with extracellular electron acceptors. The physiological activity of S. oneidensis to respire at
Yuping Yuan et al.
International journal of molecular medicine, 36(2), 363-368 (2015-06-18)
Helicobacter pylori (H. pylori) is a life-threatening pathogen which causes chronic gastritis, gastric ulcers and even stomach cancer. Treatment normally involves bacterial eradication; however, this type of treatment only has a rate of effectiveness of <80%. Thus, it is a
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