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Martijn W H J Demmers et al.
Transplantation, 97(11), 1110-1118 (2014-04-08)
Although CD8+ T cell-mediated and natural killer (NK) cell-mediated cytotoxicity against renal tubular epithelial cells (TECs) plays a crucial role during rejection, the degree of inhibition of these lytic immune responses by immunosuppressive drugs is unknown. We investigated the CD8
Magdalena Bodnar-Broniarczyk et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 1104, 220-227 (2018-12-12)
The aim of this work was to develop and to validate LC-MS/MS method for tacrolimus (TAC) determination in whole blood samples using two different types of internal standards (IS): an isotope-labeled TAC13C,D2 and a structural analog ascomycin (ASC). Matrix effects
Radim Vrzal et al.
Toxicology in vitro : an international journal published in association with BIBRA, 29(5), 1088-1099 (2015-05-02)
In this paper we investigated the effects of several drugs used in transplant medicine, i.e. cyclosporine A, tacrolimus, rapamycin, everolimus, mycophenolate mofetil, fluvastatin and rosuvastatin, on the expression of major drug-metabolizing enzymes in human hepatocytes. Moreover, we tested the ability
César Díaz-García et al.
Fertility and sterility, 102(6), 1545-1552 (2014-12-03)
To investigate whether allogeneic uterine grafts in a rat model, with tacrolimus immunosuppression, can harbor pregnancies that result in offspring with normal postnatal growth. Experimental animal study. University hospital. Lewis rats as uterus donors and Piebald-Virol-Glaxo rats as recipients. Animals
Flavia D Toledo et al.
Archives of toxicology, 88(9), 1695-1709 (2014-03-13)
Oxidative stress (OS) is a common event in most hepatopathies, leading to mitochondrial permeability transition pore (MPTP) formation and further exacerbation of both OS from mitochondrial origin and cell death. Intracellular Ca²⁺ increase plays a permissive role in these events
Johann K Hitzler et al.
Pediatric blood & cancer, 61(6), 1126-1128 (2014-01-07)
We report on 27 patients with Down syndrome (DS) and acute lymphoblastic leukemia (ALL) who received allogeneic hematopoietic cell transplantation (HCT) between 2000 and 2009. Seventy-eight percent of patients received myeloablative conditioning and 52% underwent transplantation in second remission. Disease-free
Niall F Davis et al.
Pancreas, 43(5), 750-754 (2014-04-11)
This study aimed to identify the preoperative, perioperative, and postoperative factors affecting 10-year pancreas allograft survival after simultaneous pancreas and kidney (SPK) transplantation. Analysis was performed on a prospectively maintained database of 56 SPK transplants consecutively performed between January 1992
Sayako Yuda et al.
[Rinsho ketsueki] The Japanese journal of clinical hematology, 54(12), 2187-2191 (2014-01-24)
A 39-year-old woman (Case 1) and a 57-year-old woman (Case 2) underwent allogeneic bone marrow transplantation for acute lymphoblastic leukemia and follicular lymphoma, respectively. Both patients had received tacrolimus orally for treatment of or prophylaxis against graft-versus-host disease. Seventeen months
Arteriosclerosis in zero-time biopsy is a risk factor for tacrolimus-induced chronic nephrotoxicity.
Takafumi Yagisawa et al.
Nephrology (Carlton, Vic.), 20 Suppl 2, 51-57 (2015-06-03)
Calcineurin inhibitors reduce the acute rejection rate and greatly improve renal allograft survival. However, they are associated with some adverse events, including nephrotoxicity, a risk factor for allograft failure. Chronic calcineurin inhibitor-induced nephrotoxicity causes irreversible damage to renal components, such
Xun-feng Zou et al.
Transplant immunology, 33(2), 103-109 (2015-08-26)
Acute rejection is a major obstacle in patients with prolonged ischemia in deceased-donor renal transplantation. Chemokines and their receptors play a critical role in leukocyte trafficking, resulting in allograft rejection; therefore, the role of chemokine receptor CXCR3 in acute rejection
Yasuo Morishima et al.
Blood, 125(7), 1189-1197 (2014-12-19)
We hypothesized that the compatibility of each HLA loci between donor and patient induced divergent transplant-related immunologic responses, which attributed to the individualized manifestation of clinical outcomes. Here, we analyzed 7898 Japanese pairs transplanted with T-cell-replete marrow from an unrelated
Bin-wu Lin et al.
Investigative ophthalmology & visual science, 56(1), 45-53 (2014-12-11)
To investigate the effect of FK-506 eye drops on Botulinum toxin B (BTX-B)-induced mouse dry eye. Forty-five CBA/J mice were followed up for 4 weeks after treatment with 0.025% FK-506, vehicle or 0.9% saline eye drops 3 days after intralacrimal
Maria Rendina et al.
Transplant international : official journal of the European Society for Organ Transplantation, 27(7), 696-704 (2014-03-29)
Response to interferon-based therapies in HCV recurrence after liver transplantation (LT) is unsatisfactory, and major safety issues aroused in preliminary experience with boceprevir and telaprevir. As transplant community identified HCV viral clearance as a critical matter, efficacious and safe anti-HCV
Ahryon Cho et al.
Neuron, 82(1), 109-124 (2014-04-05)
Development of the nervous system begins with neural induction, which is controlled by complex signaling networks functioning in concert with one another. Fine-tuning of the bone morphogenetic protein (BMP) pathway is essential for neural induction in the developing embryo. However
Hye One Kim et al.
Annals of dermatology, 27(5), 523-530 (2015-10-30)
Topical calcineurin inhibitors (TCIs) have been successfully used to treat seborrheic dermatitis (SD) patients. Meanwhile, treatment of atopic dermatitis (AD) with low-dose, intermittent TCI has been proved to reduce disease flare-ups. This regimen is known as a maintenance treatment. The
Irene Görzer et al.
PloS one, 10(3), e0122975-e0122975 (2015-04-22)
The human Torque Teno virus (TTV) causes persistent viremia in most immunocompetent individuals. Elevated TTV levels are observed after solid organ transplantation and are related to the extent of immunosuppression especially during the phase of maintenance immunosuppression. However, the extent
Ryo Nasu et al.
Annals of hematology, 93(7), 1215-1223 (2014-03-05)
Although calcineurin inhibitors (CNIs) with short-term methotrexate (stMTX) constitute standard prophylaxis for graft-versus-host diseases (GVHD) in hematopoietic stem cell transplantations (HSCT), comparative efficacy of cyclosporine A (CsA) and tacrolimus (Tac) still remains unclear. We have altered GVHD prophylaxis for standard-risk
Baolian Wang et al.
Journal of ethnopharmacology, 155(3), 1473-1482 (2014-08-06)
Schisandra chinensis (SC), officially listed as a sedative and tonic in the Chinese Pharmacopoeia, has been used as a common component in various prescriptions in Traditional Chinese Medicine (TCM) and more recently in western medicine for its antihepatotoxic effect. To
Michael R Rickels et al.
The Journal of clinical endocrinology and metabolism, 98(11), E1780-E1785 (2013-10-03)
Islet transplantation can improve metabolic control for type 1 diabetes (T1D), an effect anticipated to improve insulin sensitivity. However, current immunosuppression regimens containing tacrolimus and sirolimus have been shown to induce insulin resistance in rodents. The objective of the study
Robert Caiazzo et al.
Transplantation, 99(5), 979-984 (2014-11-14)
Pancreatic islet transplantation offers a promising biotherapy for the treatment of type 1 diabetes, but this procedure has met significant challenges over the years. One such challenge is to address why primary graft function still remains inconsistent after islet transplantation.
Run-Zhang Shi et al.
Clinica chimica acta; international journal of clinical chemistry, 441, 99-104 (2014-12-30)
Liquid chromatography-tandem mass spectrometry (LC-MS/MS) provides sensitivity and specificity for monitoring tacrolimus drug level in blood, but it requires an LC system and sample preparation, which is not amenable to random access testing typical of immunoassays. Paper spray (PS) ionization
Babul Moni Ram et al.
Biochimica et biophysica acta, 1843(11), 2497-2512 (2014-07-09)
Cyclosporine A (CsA), a widely used immunosuppressant shows cytotoxic effects by either inducing apoptosis or redirecting the cell towards non-apoptotic cell death. However, there still remains a lacuna in understanding the mechanism of CsA induced non-apoptotic cell death. In the
Daizo Fukushima et al.
Transplantation, 99(1), 114-119 (2014-05-23)
Posttransplantation lymphoproliferative disorder (PTLD) in infants after liver transplantation is strongly associated with tacrolimus (Tac) administration and primary Epstein-Barr virus (EBV) transmission. From 1991 to 2012, 32 survivors younger than 2 years who had undergone living-donor liver transplantation using Tac
Alex Ganetsky et al.
The Journal of antimicrobial chemotherapy, 70(7), 2078-2083 (2015-04-18)
Emerging data suggest that the combination of tacrolimus and the CCR5 antagonist maraviroc, both cytochrome P450-3A4 substrates, may be effective in preventing graft-versus-host disease in patients undergoing allogeneic HSCT. This study evaluated whether a pharmacokinetic interaction exists between these agents.
Patrick Yerly et al.
Transplantation, 99(3), 586-593 (2014-07-02)
In heart transplantation, antibody-mediated rejection (AMR) is diagnosed and graded on the basis of immunopathologic (C4d-CD68) and histopathologic criteria found on endomyocardial biopsies (EMB). Because some pathologic AMR (pAMR) grades may be associated with clinical AMR, and because humoral responses
L E Becker et al.
Transplantation proceedings, 47(8), 2504-2512 (2015-11-01)
In simultaneous pancreas-kidney transplantation (SPKT), monitoring of the pancreas allograft is more complex than the kidney allograft due to difficulties in obtaining pancreas histology and weak clinical evidence supporting the role of donor-specific antibodies (DSA). We performed a single-center retrospective
Jamil R Azzi et al.
Journal of immunology (Baltimore, Md. : 1950), 191(12), 5785-5791 (2013-12-10)
Calcineurin inhibitors (CNIs) revolutionized the field of organ transplantation and remain the standard of care 40 years after the discovery of cyclosporine. The early impressive results of cyclosporine in kidney transplant recipients led to its subsequent use in other organ
Nikola Z Stefanović et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 70, 132-139 (2015-02-07)
The main goal of this study was to evaluate the influence of tacrolimus daily dose (TDD) as well as cytochrome P450 (CYP) 3A5 6986A>G and ABCB1 3435C>T polymorphisms on the erythrocytes' oxidative stress parameters in long-term period after renal transplantation
Nauras Shuker et al.
Therapeutic drug monitoring, 37(2), 262-269 (2014-09-30)
Intrapatient variability (IPV) in tacrolimus exposure is associated with renal allograft failure. The aim of this study was to investigate whether conversion from the twice-daily tacrolimus formulation (Tac-TD) to a once-daily formulation (Tac-OD) leads to a lower IPV in tacrolimus
T Nakamura et al.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 15(9), 2364-2377 (2015-05-07)
Mammalian target of rapamycin (mTOR) inhibitors are the main immunosuppressive drugs for organ transplant recipients. Nevertheless, the mechanisms by which mTOR inhibitors induce immunosuppression is not fully understood. Myeloid-derived suppressor cells (MDSCs) maintain host immunity; however, the relationship between mTOR
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