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Haolin Chen et al.
Experimental gerontology, 72, 8-15 (2015-09-04)
The capacity of Brown Norway rat Leydig cells to produce testosterone (T) decreases with aging. In a previous study, we reported that a new generation of Leydig cells can be restored in both young and old rat testes after a...
Koray Soygun et al.
Microscopy research and technique, 83(1), 3-9 (2019-10-12)
This study aimed to use scanning electron microscopy with energy dispersive spectroscopy (SEM-EDS) to examine the elements that passed into the gastric acid solution after the application of a gastric acid erosive cycle to chitosan modified glass ionomer cement (GIC)....
Shanna A Arnold et al.
Clinical & experimental metastasis, 33(1), 29-44 (2015-10-13)
The extracellular matrix protein fibronectin (FN) contributes to the structural integrity of tissues as well as the adhesive and migratory functions of cells. While FN is abundantly expressed in adult tissues, the expression of several alternatively spliced FN isoforms is...
Monica Mattarozzi et al.
Micron (Oxford, England : 1993), 75, 18-26 (2015-05-20)
Environmental scanning electron microscopy (ESEM) permits to analyze samples in their native-hydrated state, allowing a broad spectrum of biological applications. In this study, ESEM equipped with energy dispersive X-ray spectrometer (EDS) was used as a fast method to analyze tissue...
Maria Carmen Catapano et al.
Molecules (Basel, Switzerland), 24(17) (2019-08-28)
Hydroxyl radicals (•OH) can be generated via Fenton chemistry catalyzed by transition metals. An in vitro Fenton system was developed to test both the inhibition and stimulation of •OH formation, by monitoring salicylate aromatic hydroxylation derivatives as markers of •OH...
Flavia Pinzari et al.
Fungal biology, 120(12), 1582-1599 (2016-11-29)
Fungi dissolve soil minerals by acidification and mechanical disruption. Dissolution may occur at the microscale (contact between fungus and mineral) and medium scale (entire mineral grains). Mineral weathering by fungi and other microorganisms is thought to be of significant global...
Bum-Ho Bin et al.
EMBO molecular medicine, 6(8), 1028-1042 (2014-07-11)
The zinc transporter protein ZIP13 plays critical roles in bone, tooth, and connective tissue development, and its dysfunction is responsible for the spondylocheirodysplastic form of Ehlers-Danlos syndrome (SCD-EDS, OMIM 612350). Here, we report the molecular pathogenic mechanism of SCD-EDS caused...
Falk Saupe et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 31(3), 1204-1214 (2016-12-21)
With the aim to improve the efficacy of therapeutic vaccines that target self-antigens, we have developed a novel fusion protein vaccine on the basis of the C-terminal multimerizing end of the variable lymphocyte receptor B (VLRB), the Ig equivalent in...
Lei Yan et al.
Journal of peptide science : an official publication of the European Peptide Society, 21(7), 577-585 (2015-04-09)
Membrane curvature and lipid composition plays a critical role in interchanging of matter and energy in cells. Peptide curvature sensors are known to activate signaling pathways and promote molecular transport across cell membranes. Recently, the 25-mer MARCKS-ED peptide, which is...
Puneet Gill et al.
Materials science & engineering. C, Materials for biological applications, 50, 37-44 (2015-03-10)
The constant demand for new implant materials and the multidisciplinary design approaches for stent applications have expanded vastly over the past decade. The biocompatibility of these implant materials is a function of their surface characteristics such as morphology, surface chemistry...
Dirk Dobritzsch et al.
Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS), 31, 92-97 (2015-05-26)
Freshwater fungi which can survive under metal exposure receive increasing scientific attention. Enhanced synthesis of sulphide and glutathione but no phytochelatin synthesis in response to cadmium (up to 80 μM Cd(2+) in the medium) was measured in the aquatic hyphomycete...
Hao Yu et al.
Journal of prosthodontic research, 63(3), 340-346 (2019-02-23)
This study aimed to evaluate the effects of chemical conditioning and self-adhesive resins (SARs) on the bonding of mechanically conditioned high-strength composite resin block (HSCRB). Eighteen sections of HSCRB (KZR-CAD HR 3 Gammatheta, Yamakin) were treated with alumina air abrasion...
Zehra Edis et al.
Pathogens (Basel, Switzerland), 8(4) (2019-10-30)
Antimicrobial agents containing symmetrical triiodides complexes with halogen bonding may release free iodine molecules in a controlled manner. This happens due to interactions with the plasma membrane of microorganisms which lead to changes in the structure of the triiodide anion....
Keiichi Moriguchi et al.
Microscopy (Oxford, England), 68(2), 111-121 (2018-11-01)
A 3, 3'-diaminobenzidine (DAB)-based method was used to detect the localization of endogenous peroxidase activity in Indian rhinoceros (Rhinoceros unicornis) parotid gland acinar cells. The tissue had previously been resin-embedded in gelatin capsules for routine electron microscopic observations and thus...
Daisy Rymen et al.
Genes, 10(11) (2019-11-17)
The Ehlers-Danlos syndromes (EDS) constitute a clinically and genetically heterogeneous group of connective tissue disorders. Tenascin X (TNX) deficiency is a rare type of EDS, defined as classical-like EDS (clEDS), since it phenotypically resembles the classical form of EDS, though...
Stéphane Faucher et al.
Analytica chimica acta, 1028, 104-112 (2018-06-10)
A careful separation, identification and characterization of polymer-coated quantum dots (P-QDs) in complex media such as soil solution is the key point to understand their behaviour and to accurately predict their fate in the environment. In the present study, a...
Andrea Porto Carreiro Campos et al.
Micron (Oxford, England : 1993), 120, 17-24 (2019-02-14)
The study of fossil feathers has been revitalized in the last few decades and has contributed significantly to paleontological studies of dinosaurs and birds. Specific morphological and physicochemical characteristics of the microscale structures of feathers and the protein keratin are...
Ilker Kara et al.
Journal of forensic sciences, 60(4), 1030-1033 (2015-04-14)
In this study, chemical composition and morphology of gunshot residue (GSR) of 9 × 19 mm Parabellum-type MKE (Turkey)-brand ammunition were analyzed by scanning electron microscope and energy dispersive X-ray spectrometer. GSR samples were collected by "swab" technique from the shooter's right hand...
How can novel microscopic approaches shed light on the function of nucleic acid-based drugs?
Daniel Vocelle et al.
Future medicinal chemistry, 7(13), 1623-1625 (2015-09-19)
Luciana Abreu da Rosa et al.
Molecular and cellular endocrinology, 511, 110850-110850 (2020-05-11)
Testosterone (T) and its 17-α epimer, epitestosterone (EpiT), are described as having non-classical effects in addition to their classical androgen actions via the intracellular androgen receptor (iAR). The actions of these androgens play an essential role in triggering factors that...
Tuomas Mansikkala et al.
Molecules (Basel, Switzerland), 25(13) (2020-07-08)
Lignans are bioactive compounds that are especially abundant in the Norway spruce (Picea abies L. Karst.) knotwood. By combining a variety of chromatographic, spectroscopic and imaging techniques, we were able to quantify, qualify and localise the easily extractable lignans in...
Pei Jin Lim et al.
Genes, 10(7) (2019-07-11)
Kyphoscoliotic Ehlers-Danlos Syndrome (kEDS) is a rare genetic heterogeneous disease clinically characterized by congenital muscle hypotonia, kyphoscoliosis, and joint hypermobility. kEDS is caused by biallelic pathogenic variants in either PLOD1 or FKBP14. PLOD1 encodes the lysyl hydroxylase 1 enzyme responsible...
Steven Dreissig et al.
PloS one, 10(9), e0137677-e0137677 (2015-09-12)
The detection of meiotic crossovers in crop plants currently relies on scoring DNA markers in a segregating population or cytological visualization. We investigated the feasibility of using flow-sorted haploid nuclei, Phi29 DNA polymerase-based whole-genome-amplification (WGA) and multi-locus KASP-genotyping to measure...
Yueyang Zhang et al.
International journal of clinical and experimental medicine, 8(5), 7599-7605 (2015-07-30)
Oxidative stress involved in the regulation of arterial erectile dysfunction (A-ED). Previously report have indicated that quercetin have an antioxidant effect. In the current study, we have established the rats' model for study the therapeutic effect of quercetin on A-ED...
Heng Zhou et al.
Biochemical and biophysical research communications, 456(3), 815-820 (2014-12-17)
Epstein-Barr virus (EBV) infects various types of cells and mainly establishes latent infection in B lymphocytes. The viral latent membrane protein 1 (LMP1) plays important roles in transformation and proliferation of B lymphocytes infected with EBV. Triptolide is a compound...
Norsuhaila Abdul Wahab et al.
Journal of the science of food and agriculture, 95(13), 2704-2711 (2014-11-21)
Diverse plants species in the forest remain under-utilised and they are mainly consumed only by local people. However, increasing issues in food security prompted the present study, which explores the nutritional and antioxidant aspects of Malaysian under-utilised vegetables. The studied...
F Xavier Donadeu et al.
Biology of reproduction, 91(5), 111-111 (2014-09-26)
Several aspects of equine ovarian physiology are unique among domestic species. Moreover, follicular growth patterns are very similar between horses and humans. This study aimed to characterize, for the first time, global gene expression profiles associated with growth and preovulatory...
Teresa Massardo et al.
Journal of addiction medicine, 9(2), 139-146 (2015-02-24)
Cocaine is a known risk factor for several vascular ischemic events. The underlying mechanisms leading to the complications are not fully understood, although thrombus formation and accelerated atherosclerosis are prominent findings. Evidence of endothelial dysfunction (ED), a key phenomenon in...
T Shintani et al.
In vitro cellular & developmental biology. Animal, 53(9), 810-817 (2017-07-16)
Heparin-binding protein 17 (HBp17)/fibroblast growth factor-binding protein-1 (FGFBP-1) was first purified from medium conditioned by A431 cells for its capacity to bind to fibroblast growth factors 1 and 2 (FGF-1 and -2). Among FGF family members, FGF-2 is a potent...
Akio Takayanagi et al.
The journal of sexual medicine, 12(8), 1713-1721 (2015-07-28)
We evaluated the potential preventive effects and mechanisms of intravenously preloaded mesenchymal stem cells (MSCs) for erectile dysfunction (ED) in a cavernous nerve (CN) injury model. Male Sprague-Dawley (SD) rats were used for this study. Rats were randomized into two...
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