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edegly

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Beatriz Escudero-Pérez et al.
PLoS pathogens, 10(11), e1004509-e1004509 (2014-11-21)
During Ebola virus (EBOV) infection a significant amount of surface glycoprotein GP is shed from infected cells in a soluble form due to cleavage by cellular metalloprotease TACE. Shed GP and non-structural secreted glycoprotein sGP, both expressed from the same
Amelia Burch et al.
PloS one, 12(3), e0174895-e0174895 (2017-04-01)
Identification of synaptic cleft components has been hampered by the lack of a suitable preparation enriched in synaptic junctions devoid of adjoining peripheral membranes. Prior strategies for the isolation of synaptic junctions, relying on detergents for the removal of peripheral
Guillain-Barre syndrome: First description of a snake envenomation aetiology
Neil J, et al.
Journal of Neuroimmunology, 242(1-2), 72-77 (2012)
Angela Mika et al.
PLoS neglected tropical diseases, 5(9), e1331-e1331 (2011-10-08)
Pruritic scabies lesions caused by Sarcoptes scabiei burrowing in the stratum corneum of human skin facilitate opportunistic bacterial infections. Emerging resistance to current therapeutics emphasizes the need to identify novel targets for protective intervention. We have characterized several protein families
Axel T Lehrer et al.
Vaccine, 36(22), 3090-3100 (2017-02-22)
Infections with filoviruses in humans are highly virulent, causing hemorrhagic fevers which result in up to 90% mortality. In addition to natural infections, the ability to use these viruses as bioterrorist weapons is of significant concern. Currently, there are no
Identification of histoplasma-specific peptides in human urine
Crockett DK, et al.
International Journal of Peptides, 2012 (2012)
Cécile Sigoillot-Claude et al.
Vaccine, 33(32), 3843-3849 (2015-07-07)
Regulatory potency test for rabies vaccines requires mice vaccination followed by challenge with a live virus via intracerebral route. An alternative in vitro test, consistent with the "3R's" (Reduce, Replace, Refine) was designed to quantify active glycoprotein G using seroneutralizing
Vijaya L Simhadri et al.
Journal of medical genetics, 54(5), 338-345 (2016-12-23)
Haemophilia B is caused by genetic aberrations in the We analyse the molecular mechanisms underlying the FIX deficiency through in silico analysis and reproducing the c.459G>A (Val107Val) mutation in stable cell lines. Conformation and non-conformation sensitive antibodies, limited trypsin digestion
Primavera Alvarado et al.
Journal of microbiological methods, 175, 105981-105981 (2020-06-15)
The diagnosis of histoplasmosis depends on various approaches: direct clinical examination, fungus isolation from cultures of clinical samples, histopathological evaluation, and serological testing. In serodiagnostic assays, the Histoplasma capsulatum H and M antigenic glycoproteins have been extensively used. However, both
Scabies mite peritrophins are potential targets of human host innate immunity
Mika A, et al.
PLoS Neglected Tropical Diseases, 5(9), e1331-e1331 (2011)
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