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Haolin Chen et al.
Experimental gerontology, 72, 8-15 (2015-09-04)
The capacity of Brown Norway rat Leydig cells to produce testosterone (T) decreases with aging. In a previous study, we reported that a new generation of Leydig cells can be restored in both young and old rat testes after a
Shanna A Arnold et al.
Clinical & experimental metastasis, 33(1), 29-44 (2015-10-13)
The extracellular matrix protein fibronectin (FN) contributes to the structural integrity of tissues as well as the adhesive and migratory functions of cells. While FN is abundantly expressed in adult tissues, the expression of several alternatively spliced FN isoforms is
Falk Saupe et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 31(3), 1204-1214 (2016-12-21)
With the aim to improve the efficacy of therapeutic vaccines that target self-antigens, we have developed a novel fusion protein vaccine on the basis of the C-terminal multimerizing end of the variable lymphocyte receptor B (VLRB), the Ig equivalent in
Lei Yan et al.
Journal of peptide science : an official publication of the European Peptide Society, 21(7), 577-585 (2015-04-09)
Membrane curvature and lipid composition plays a critical role in interchanging of matter and energy in cells. Peptide curvature sensors are known to activate signaling pathways and promote molecular transport across cell membranes. Recently, the 25-mer MARCKS-ED peptide, which is
Koray Soygun et al.
Microscopy research and technique, 83(1), 3-9 (2019-10-12)
This study aimed to use scanning electron microscopy with energy dispersive spectroscopy (SEM-EDS) to examine the elements that passed into the gastric acid solution after the application of a gastric acid erosive cycle to chitosan modified glass ionomer cement (GIC).
Flavia Pinzari et al.
Fungal biology, 120(12), 1582-1599 (2016-11-29)
Fungi dissolve soil minerals by acidification and mechanical disruption. Dissolution may occur at the microscale (contact between fungus and mineral) and medium scale (entire mineral grains). Mineral weathering by fungi and other microorganisms is thought to be of significant global
Steven Dreissig et al.
PloS one, 10(9), e0137677-e0137677 (2015-09-12)
The detection of meiotic crossovers in crop plants currently relies on scoring DNA markers in a segregating population or cytological visualization. We investigated the feasibility of using flow-sorted haploid nuclei, Phi29 DNA polymerase-based whole-genome-amplification (WGA) and multi-locus KASP-genotyping to measure
Bum-Ho Bin et al.
EMBO molecular medicine, 6(8), 1028-1042 (2014-07-11)
The zinc transporter protein ZIP13 plays critical roles in bone, tooth, and connective tissue development, and its dysfunction is responsible for the spondylocheirodysplastic form of Ehlers-Danlos syndrome (SCD-EDS, OMIM 612350). Here, we report the molecular pathogenic mechanism of SCD-EDS caused
Monica Mattarozzi et al.
Micron (Oxford, England : 1993), 75, 18-26 (2015-05-20)
Environmental scanning electron microscopy (ESEM) permits to analyze samples in their native-hydrated state, allowing a broad spectrum of biological applications. In this study, ESEM equipped with energy dispersive X-ray spectrometer (EDS) was used as a fast method to analyze tissue
Heng Zhou et al.
Biochemical and biophysical research communications, 456(3), 815-820 (2014-12-17)
Epstein-Barr virus (EBV) infects various types of cells and mainly establishes latent infection in B lymphocytes. The viral latent membrane protein 1 (LMP1) plays important roles in transformation and proliferation of B lymphocytes infected with EBV. Triptolide is a compound
Yueyang Zhang et al.
International journal of clinical and experimental medicine, 8(5), 7599-7605 (2015-07-30)
Oxidative stress involved in the regulation of arterial erectile dysfunction (A-ED). Previously report have indicated that quercetin have an antioxidant effect. In the current study, we have established the rats' model for study the therapeutic effect of quercetin on A-ED
F Xavier Donadeu et al.
Biology of reproduction, 91(5), 111-111 (2014-09-26)
Several aspects of equine ovarian physiology are unique among domestic species. Moreover, follicular growth patterns are very similar between horses and humans. This study aimed to characterize, for the first time, global gene expression profiles associated with growth and preovulatory
T Shintani et al.
In vitro cellular & developmental biology. Animal, 53(9), 810-817 (2017-07-16)
Heparin-binding protein 17 (HBp17)/fibroblast growth factor-binding protein-1 (FGFBP-1) was first purified from medium conditioned by A431 cells for its capacity to bind to fibroblast growth factors 1 and 2 (FGF-1 and -2). Among FGF family members, FGF-2 is a potent
Norsuhaila Abdul Wahab et al.
Journal of the science of food and agriculture, 95(13), 2704-2711 (2014-11-21)
Diverse plants species in the forest remain under-utilised and they are mainly consumed only by local people. However, increasing issues in food security prompted the present study, which explores the nutritional and antioxidant aspects of Malaysian under-utilised vegetables. The studied
Teresa Massardo et al.
Journal of addiction medicine, 9(2), 139-146 (2015-02-24)
Cocaine is a known risk factor for several vascular ischemic events. The underlying mechanisms leading to the complications are not fully understood, although thrombus formation and accelerated atherosclerosis are prominent findings. Evidence of endothelial dysfunction (ED), a key phenomenon in
Akio Takayanagi et al.
The journal of sexual medicine, 12(8), 1713-1721 (2015-07-28)
We evaluated the potential preventive effects and mechanisms of intravenously preloaded mesenchymal stem cells (MSCs) for erectile dysfunction (ED) in a cavernous nerve (CN) injury model. Male Sprague-Dawley (SD) rats were used for this study. Rats were randomized into two
Michelle L Pershing et al.
Neuropharmacology, 90, 33-41 (2014-12-03)
The levels of kynurenic acid (KYNA), an endogenous negative modulator of alpha7 nicotinic acetylcholine receptors (α7nAChRs), are elevated in the brains of patients with schizophrenia (SZ). We reported that increases of brain KYNA in rats, through dietary exposure to its
Yasushi Sawanobori et al.
PloS one, 9(10), e109995-e109995 (2014-10-22)
Thymic epithelial cells (TECs) are thought to play an essential role in T cell development and have been detected mainly in mice using lectin binding and antibodies to keratins. Our aim in the present study was to create a precise
Larissa Brazolotto Ferreira et al.
Experimental gerontology, 72, 157-161 (2015-10-13)
Alterations in the hypothalamic-pituitary-gonadal axis in females determine the transition from regular to irregular reproductive cycles, with loss of fertility. Stimulation of noradrenergic neurons of the anteroventral periventricular neurons (AVPV) is essential for regular reproductive cycles. Therefore, we examined the
J F Zhang et al.
Journal of animal science, 93(4), 1656-1665 (2015-05-29)
A total of 400 1-d-old Arbor Acres broiler chicks were raised at a recommended environmental temperature from d 1 to 20 (experimental day [ED] = ED1 to ED20). On ED21, the chicks were weighed and reallocated into 5 treatment groups
M Higaki et al.
In vitro cellular & developmental biology. Animal, 56(3), 222-233 (2020-03-19)
Heparin-binding protein 17/fibroblast growth factor-binding protein-1 (HBp17/FGFBP-1) was purified from A431 cell-conditioned media based on its capacity to bind to fibroblast growth factor 1 and 2 (FGF-1 and FGF-2). HBp17/FGFBP-1 has been observed to induce the tumorigenic potential of epithelial
Han-Soo Kim et al.
Stem cell reviews, 10(6), 761-771 (2014-06-30)
Recently, cell-based therapy has been highlighted as an alternative to treating ischemic brain damage in stroke patients. The present study addresses the therapeutic potential of polysialic acid-neural cell adhesion molecule (PSA-NCAM)-positive neural precursor cells (NPC(PSA-NCAM+)) derived from human embryonic stem
W N Addison et al.
Bone, 71, 244-256 (2014-12-03)
Bone cell culture systems are essential tools for the study of the molecular mechanisms regulating extracellular matrix mineralization. MC3T3-E1 osteoblast cell cultures are the most commonly used in vitro model of bone matrix mineralization. Despite the widespread use of this
Falk Saupe et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 29(8), 3253-3262 (2015-04-15)
We recently showed that it is possible to compromise tumor vessel function and, as a consequence, suppress growth of aggressive preclinical tumors by immunizing against the tumor vascular markers extra domain-A (ED-A) or -B (ED-B) of fibronectin, using a fusion
Puneet Gill et al.
Materials science & engineering. C, Materials for biological applications, 50, 37-44 (2015-03-10)
The constant demand for new implant materials and the multidisciplinary design approaches for stent applications have expanded vastly over the past decade. The biocompatibility of these implant materials is a function of their surface characteristics such as morphology, surface chemistry
Shiyu Zhao et al.
The Journal of surgical research, 191(2), 290-301 (2014-05-02)
Superparamagnetic iron oxide magnetic nanomaterials (SPIO) are tracers used for treatment of central nervous and cardiovascular system complications in animal models. The present study investigated survival and proliferation of SPIO-labeled bone marrow mesenchymal stem cells (BMSCs) to determine their potential
Luis Rodriguez-Rodriguez et al.
Clinical and experimental rheumatology, 33(1 Suppl 88), S33-S40 (2015-03-19)
Fibromyalgia (FM) has been associated with affective spectrum disorders and other chronic pain disorders, which tend to co-occur in individuals and co-aggregate among families. The objective of our study was to investigate the genetic risk factors associated with the presence
Mònica Rosa et al.
Journal of proteome research, 14(8), 3162-3173 (2015-06-20)
Human μ-opioid receptor (hMOR) is a class-A G-protein-coupled receptor (GPCR), a prime therapeutic target for the management of moderate and severe pain. A chimeric form of the receptor has been cocrystallized with an opioid antagonist and resolved by X-ray diffraction;
Friedrich Finkenwirth et al.
The Journal of biological chemistry, 290(27), 16929-16942 (2015-05-21)
Energy-coupling factor (ECF) transporters for vitamins and metal ions in prokaryotes consist of two ATP-binding cassette-type ATPases, a substrate-specific transmembrane protein (S component) and a transmembrane protein (T component) that physically interacts with the ATPases and the S component. The
Francesco Cambuli et al.
Nature communications, 5, 5538-5538 (2014-11-27)
Embryonic (ES) and trophoblast (TS) stem cells reflect the first, irrevocable cell fate decision in development that is reinforced by distinct epigenetic lineage barriers. Nonetheless, ES cells can seemingly acquire TS-like characteristics upon manipulation of lineage-determining transcription factors or activation
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