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Haolin Chen et al.
Experimental gerontology, 72, 8-15 (2015-09-04)
The capacity of Brown Norway rat Leydig cells to produce testosterone (T) decreases with aging. In a previous study, we reported that a new generation of Leydig cells can be restored in both young and old rat testes after a...
Shanna A Arnold et al.
Clinical & experimental metastasis, 33(1), 29-44 (2015-10-13)
The extracellular matrix protein fibronectin (FN) contributes to the structural integrity of tissues as well as the adhesive and migratory functions of cells. While FN is abundantly expressed in adult tissues, the expression of several alternatively spliced FN isoforms is...
Falk Saupe et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 31(3), 1204-1214 (2016-12-21)
With the aim to improve the efficacy of therapeutic vaccines that target self-antigens, we have developed a novel fusion protein vaccine on the basis of the C-terminal multimerizing end of the variable lymphocyte receptor B (VLRB), the Ig equivalent in...
Lei Yan et al.
Journal of peptide science : an official publication of the European Peptide Society, 21(7), 577-585 (2015-04-09)
Membrane curvature and lipid composition plays a critical role in interchanging of matter and energy in cells. Peptide curvature sensors are known to activate signaling pathways and promote molecular transport across cell membranes. Recently, the 25-mer MARCKS-ED peptide, which is...
Koray Soygun et al.
Microscopy research and technique, 83(1), 3-9 (2019-10-12)
This study aimed to use scanning electron microscopy with energy dispersive spectroscopy (SEM-EDS) to examine the elements that passed into the gastric acid solution after the application of a gastric acid erosive cycle to chitosan modified glass ionomer cement (GIC)....
Flavia Pinzari et al.
Fungal biology, 120(12), 1582-1599 (2016-11-29)
Fungi dissolve soil minerals by acidification and mechanical disruption. Dissolution may occur at the microscale (contact between fungus and mineral) and medium scale (entire mineral grains). Mineral weathering by fungi and other microorganisms is thought to be of significant global...
Steven Dreissig et al.
PloS one, 10(9), e0137677-e0137677 (2015-09-12)
The detection of meiotic crossovers in crop plants currently relies on scoring DNA markers in a segregating population or cytological visualization. We investigated the feasibility of using flow-sorted haploid nuclei, Phi29 DNA polymerase-based whole-genome-amplification (WGA) and multi-locus KASP-genotyping to measure...
Bum-Ho Bin et al.
EMBO molecular medicine, 6(8), 1028-1042 (2014-07-11)
The zinc transporter protein ZIP13 plays critical roles in bone, tooth, and connective tissue development, and its dysfunction is responsible for the spondylocheirodysplastic form of Ehlers-Danlos syndrome (SCD-EDS, OMIM 612350). Here, we report the molecular pathogenic mechanism of SCD-EDS caused...
Monica Mattarozzi et al.
Micron (Oxford, England : 1993), 75, 18-26 (2015-05-20)
Environmental scanning electron microscopy (ESEM) permits to analyze samples in their native-hydrated state, allowing a broad spectrum of biological applications. In this study, ESEM equipped with energy dispersive X-ray spectrometer (EDS) was used as a fast method to analyze tissue...
Yueyang Zhang et al.
International journal of clinical and experimental medicine, 8(5), 7599-7605 (2015-07-30)
Oxidative stress involved in the regulation of arterial erectile dysfunction (A-ED). Previously report have indicated that quercetin have an antioxidant effect. In the current study, we have established the rats' model for study the therapeutic effect of quercetin on A-ED...
F Xavier Donadeu et al.
Biology of reproduction, 91(5), 111-111 (2014-09-26)
Several aspects of equine ovarian physiology are unique among domestic species. Moreover, follicular growth patterns are very similar between horses and humans. This study aimed to characterize, for the first time, global gene expression profiles associated with growth and preovulatory...
Norsuhaila Abdul Wahab et al.
Journal of the science of food and agriculture, 95(13), 2704-2711 (2014-11-21)
Diverse plants species in the forest remain under-utilised and they are mainly consumed only by local people. However, increasing issues in food security prompted the present study, which explores the nutritional and antioxidant aspects of Malaysian under-utilised vegetables. The studied...
Teresa Massardo et al.
Journal of addiction medicine, 9(2), 139-146 (2015-02-24)
Cocaine is a known risk factor for several vascular ischemic events. The underlying mechanisms leading to the complications are not fully understood, although thrombus formation and accelerated atherosclerosis are prominent findings. Evidence of endothelial dysfunction (ED), a key phenomenon in...
Akio Takayanagi et al.
The journal of sexual medicine, 12(8), 1713-1721 (2015-07-28)
We evaluated the potential preventive effects and mechanisms of intravenously preloaded mesenchymal stem cells (MSCs) for erectile dysfunction (ED) in a cavernous nerve (CN) injury model. Male Sprague-Dawley (SD) rats were used for this study. Rats were randomized into two...
Michelle L Pershing et al.
Neuropharmacology, 90, 33-41 (2014-12-03)
The levels of kynurenic acid (KYNA), an endogenous negative modulator of alpha7 nicotinic acetylcholine receptors (α7nAChRs), are elevated in the brains of patients with schizophrenia (SZ). We reported that increases of brain KYNA in rats, through dietary exposure to its...
Yasushi Sawanobori et al.
PloS one, 9(10), e109995-e109995 (2014-10-22)
Thymic epithelial cells (TECs) are thought to play an essential role in T cell development and have been detected mainly in mice using lectin binding and antibodies to keratins. Our aim in the present study was to create a precise...
Heng Zhou et al.
Biochemical and biophysical research communications, 456(3), 815-820 (2014-12-17)
Epstein-Barr virus (EBV) infects various types of cells and mainly establishes latent infection in B lymphocytes. The viral latent membrane protein 1 (LMP1) plays important roles in transformation and proliferation of B lymphocytes infected with EBV. Triptolide is a compound...
J F Zhang et al.
Journal of animal science, 93(4), 1656-1665 (2015-05-29)
A total of 400 1-d-old Arbor Acres broiler chicks were raised at a recommended environmental temperature from d 1 to 20 (experimental day [ED] = ED1 to ED20). On ED21, the chicks were weighed and reallocated into 5 treatment groups...
Larissa Brazolotto Ferreira et al.
Experimental gerontology, 72, 157-161 (2015-10-13)
Alterations in the hypothalamic-pituitary-gonadal axis in females determine the transition from regular to irregular reproductive cycles, with loss of fertility. Stimulation of noradrenergic neurons of the anteroventral periventricular neurons (AVPV) is essential for regular reproductive cycles. Therefore, we examined the...
Han-Soo Kim et al.
Stem cell reviews, 10(6), 761-771 (2014-06-30)
Recently, cell-based therapy has been highlighted as an alternative to treating ischemic brain damage in stroke patients. The present study addresses the therapeutic potential of polysialic acid-neural cell adhesion molecule (PSA-NCAM)-positive neural precursor cells (NPC(PSA-NCAM+)) derived from human embryonic stem...
Falk Saupe et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 29(8), 3253-3262 (2015-04-15)
We recently showed that it is possible to compromise tumor vessel function and, as a consequence, suppress growth of aggressive preclinical tumors by immunizing against the tumor vascular markers extra domain-A (ED-A) or -B (ED-B) of fibronectin, using a fusion...
W N Addison et al.
Bone, 71, 244-256 (2014-12-03)
Bone cell culture systems are essential tools for the study of the molecular mechanisms regulating extracellular matrix mineralization. MC3T3-E1 osteoblast cell cultures are the most commonly used in vitro model of bone matrix mineralization. Despite the widespread use of this...
T Shintani et al.
In vitro cellular & developmental biology. Animal, 53(9), 810-817 (2017-07-16)
Heparin-binding protein 17 (HBp17)/fibroblast growth factor-binding protein-1 (FGFBP-1) was first purified from medium conditioned by A431 cells for its capacity to bind to fibroblast growth factors 1 and 2 (FGF-1 and -2). Among FGF family members, FGF-2 is a potent...
Puneet Gill et al.
Materials science & engineering. C, Materials for biological applications, 50, 37-44 (2015-03-10)
The constant demand for new implant materials and the multidisciplinary design approaches for stent applications have expanded vastly over the past decade. The biocompatibility of these implant materials is a function of their surface characteristics such as morphology, surface chemistry...
Agnes Simonyi et al.
Life sciences, 128, 30-38 (2015-03-07)
Elderberry (Sambucus spp.) is one of the oldest medicinal plants noted for its cardiovascular, anti-inflammatory, and immune-stimulatory properties. In this study, we investigated the anti-inflammatory and anti-oxidant effects of the American elderberry (Sambucus nigra subsp. canadensis) pomace as well as...
Lieza G Exalto et al.
Journal of the neurological sciences, 351(1-2), 18-23 (2015-03-10)
The metabolic syndrome (MetS) refers to a cluster of cardiovascular risk factors that is associated with an increased risk of cognitive impairment and dementia. It is unclear however, if the presence of the MetS is associated with a particular clinical...
Atsushi Tamura et al.
Macromolecular bioscience, 15(8), 1134-1145 (2015-04-30)
We have developed cationic polyrotaxanes composed of N,N-dimethylaminoethyl (DMAE) group-modified α-cyclodextrins (α-CDs) threaded along a poly(ethylene glycol) (PEG) chain capped with a terminal bulky stopper (DMAE-PRX) for the intracellular delivery of proteins through the polyelectrolyte complexation. Herein, to ascertain the...
Mesay Mulugeta Wolle et al.
Journal of chromatography. A, 1347, 96-103 (2014-05-14)
An ion chromatography-inductively coupled plasma mass spectrometry (IC-ICP-MS) method was developed for the redox speciation analysis of iron (Fe) based on in-column complexation of Fe(2+) and Fe(3+) by dipicolinic acid (DPA). The effects of column type, mobile phase composition and...
Sarah Louise Dombernowsky et al.
Nature communications, 6, 7518-7518 (2015-06-26)
The metalloproteinase ADAM17 activates ErbB signalling by releasing ligands from the cell surface, a key step underlying epithelial development, growth and tumour progression. However, mechanisms acutely controlling ADAM17 cell-surface availability to modulate the extent of ErbB ligand release are poorly...
Daniel Ansari et al.
Anticancer research, 34(8), 3905-3910 (2014-07-31)
Mucin 4 (MUC4) is a cell surface glycoprotein that is overexpressed in most pancreatic tumors. The aim of the present study was to characterize MUC4 expression in experimental pancreatic cancer in order to clarify the correlation between MUC4 and pancreatic...
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