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Shoudong Guo et al.
Biochimica et biophysica acta, 1841(6), 836-846 (2014-03-08)
Both sphingosine 1-phosphate (S1P) and estrogen have been documented to play endothelial protective roles. However, it remains unclear whether estrogen could regulate the anabolism of the bioactive molecule S1P and the underlying mechanisms. In this study, 108 healthy participants were
New insights into metabolic regulation via bifurcated function of estrogen receptor α.
Tsutomu Wada et al.
Diabetes, 62(12), 3996-3998 (2013-11-23)
Anwesha Chatterjee et al.
Journal of biochemical and molecular toxicology, 28(12), 529-538 (2014-08-19)
The objective of the present study was to characterize the role of resveratrol (Res) and vitamin C (VC) in prevention of estrogen-induced breast cancer through regulation of cap "n"collar (CNC) b-zip transcription factors. Human breast epithelial cell line MCF-10A was
Lisa Stefanie Hönikl et al.
Journal of neuro-oncology, 147(3), 567-575 (2020-04-03)
Glioblastoma multiforme (GBM) is a highly malignant glial tumor, affecting men more often than women. The reason for this gender-specific predominance remains unclear, raising the question whether these effects are subject to hormonal control. The purpose of this study was
Rujuan Dai et al.
Journal of immunology (Baltimore, Md. : 1950), 183(11), 6998-7005 (2009-11-06)
Estrogen regulation of inflammatory responses has broad physiological and pathological consequences. However, the molecular mechanism of estrogen regulation of inflammation is still poorly understood. In this study, we report that activation of both STAT-1 and NF-kappaB signaling is essential for
Martin J Kelly et al.
Frontiers in neuroendocrinology, 33(4), 376-387 (2012-08-09)
It is well known that many of the actions of estrogens in the central nervous system are mediated via intracellular receptor/transcription factors that interact with steroid response elements on target genes. However, there now exists compelling evidence for membrane estrogen
Daniel W Bayless et al.
Cell, 176(5), 1190-1205 (2019-02-05)
Sexually naive animals have to distinguish between the sexes because they show species-typical interactions with males and females without meaningful prior experience. However, central neural pathways in naive mammals that recognize sex of other individuals remain poorly characterized. We examined
Rui Zhou et al.
Oncotarget, 6(42), 44609-44622 (2015-11-21)
Small-cell lung cancer (SCLC) is a highly aggressive neuroendocrine tumor that has an extremely poor clinical prognosis. Metastasis is the key event in SCLC progression, but its mechanism has not been fully elucidated. MicroRNAs (miRNAs) have been proven to participate
Susan H Corbett et al.
Southern medical journal, 107(7), 433-436 (2014-07-11)
To identify trends in compounding pharmacies with a focus on women's health and, more specifically, the types and combinations of medications used in the treatment of vulvodynia. This survey study was conducted with 653 nonchain pharmacies that compound medications. Each
Lourdes Santana et al.
Journal of medicinal chemistry, 51(21), 6740-6751 (2008-10-07)
The work provides a new model for the prediction of the MAO-A and -B inhibitor activity by the use of combined complex networks and QSAR methodologies. On the basis of the obtained model, we prepared and assayed 33 coumarin derivatives
Van T M Nguyen et al.
Nature communications, 6, 10044-10044 (2015-11-28)
Endocrine therapies target the activation of the oestrogen receptor alpha (ERα) via distinct mechanisms, but it is not clear whether breast cancer cells can adapt to treatment using drug-specific mechanisms. Here we demonstrate that resistance emerges via drug-specific epigenetic reprogramming.
Simone Bertini et al.
European journal of medicinal chemistry, 46(6), 2453-2462 (2011-04-13)
In a continuing effort to improve the subtype selectivity and agonist potency of estrogen receptor β (ERβ) ligands, we have designed and developed a thus far unexplored structural series obtained by molecular refinements of monoaryl-substituted salicylaldoximes (Salaldox B). The most
Jun Li et al.
PloS one, 9(7), e102847-e102847 (2014-07-23)
The extranuclear estrogen receptor pathway opens up novel perspectives in many physiological and pathological processes, especially in breast carcinogenesis. However, its function and mechanisms are not fully understood. Herein we present data identifying Shp2, a SH2-containing tyrosine phosphatase, as a
Rachana Maniyar et al.
Journal of Cancer, 9(21), 3874-3885 (2018-11-10)
Angiogenesis, a highly regulated process, is exploited by tumors like breast cancer to ensure a constant supply of oxygen and nutrients and is key for tumor survival and progression. Estrogen and alcohol independently have been observed to contribute to angiogenesis
Robert W Yucha et al.
Tissue engineering. Part A, 20(1-2), 189-196 (2013-08-10)
An estimated 12% of women in the United States suffer from some form of infertility. In vitro fertilization (IVF) is the most common treatment for infertility encompassing over 99% of all assisted reproductive technologies. However, IVF has a low success
K Murakami et al.
Maturitas, 33(1), 71-80 (1999-12-10)
Age-related changes of steroid levels in the central nervous system (CNS) are not well understood. To investigate whether steroidal conditions in the CNS of women change with aging and menopause, steroid levels have been measured in serum and cerebrospinal fluid
Joel S Finkelstein et al.
The New England journal of medicine, 369(11), 1011-1022 (2013-09-13)
Current approaches to diagnosing testosterone deficiency do not consider the physiological consequences of various testosterone levels or whether deficiencies of testosterone, estradiol, or both account for clinical manifestations. We provided 198 healthy men 20 to 50 years of age with
Jiani Chen et al.
The New phytologist, 229(6), 3303-3317 (2020-11-21)
DNA methylation plays crucial roles in cellular development and stress responses through gene regulation and genome stability control. Precise regulation of DOMAINS REARRANGED METHYLTRANSFERASE 2 (DRM2), the de novo Arabidopsis DNA methyltransferase, is crucial to maintain DNA methylation homeostasis to
Xiaohan Yuan et al.
Journal of cellular physiology (2019-02-03)
Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 (NUCKS1) is a highly phosphorylated nuclear protein ubiquitously expressed in vertebrates. NUCKS1 has been reported to be a key chromatin modifier and transcriptional regulator of a number of signaling pathways, but the
Rukmani Pandey et al.
The Journal of endocrinology, 244(1), 53-70 (2019-10-28)
Estrogen deficiency reduces estrogen receptor-alpha (ERα) and promotes apoptosis in the hippocampus, inducing learning-memory deficits; however, underlying mechanisms remain less understood. Here, we explored the molecular mechanism in an ovariectomized (OVX) rat model, hypothesizing participation of autophagy and growth factor
Kathryn Wilsterman et al.
Biology of reproduction, 101(5), 906-915 (2019-07-31)
Successful implantation requires complex signaling between the uterine endometrium and the blastocyst. Prior to the blastocyst reaching the uterus, the endometrium is remodeled by sex steroids and other signals to render the endometrium receptive. In vitro models have facilitated major
Gonadal steroids and body composition, strength, and sexual function in men.
Vita Birzniece
The New England journal of medicine, 369(25), 2455-2455 (2013-12-20)
Andrew L LaFrate et al.
Bioorganic & medicinal chemistry, 17(10), 3528-3535 (2009-04-28)
Steroidal bivalent ligands for the estrogen receptor (ER) were designed using crystal structures of ERalpha dimers as a template. The syntheses of several 17alpha-ethynylestradiol-based bivalent ligands with varying linker compositions and lengths are described. The binding affinities of these bivalent
Aldehyde oxidase: an enzyme of emerging importance in drug discovery.
David C Pryde et al.
Journal of medicinal chemistry, 53(24), 8441-8460 (2010-09-22)
Ping Wang et al.
Autophagy, 16(1), 123-139 (2019-03-27)
Autophagy is a conserved catabolic process in eukaryotes that contributes to cell survival in response to multiple stresses and is important for organism fitness. In Arabidopsis thaliana, the core machinery of autophagy is well defined, but its transcriptional regulation is
Tiefeng Cao et al.
Oncogene, 38(27), 5356-5366 (2019-05-16)
Uterine leiomyomas or fibroids (UFs) are benign tumors characterized by hyperplastic smooth muscle cells and excessive deposition of extracellular matrix (ECM). Afflicting ~80% of women, and symptomatic in 25%, UFs bring tremendous suffering and are an economic burden worldwide; they
Jennifer R Wardell et al.
Biology of reproduction, 89(5), 116-116 (2013-09-27)
Estrogen signaling in the ovary is a fundamental component of normal ovarian function, and evidence also indicates that excessive estrogen is a risk factor for ovarian cancer. We have previously demonstrated that the gonadally enriched TFIID subunit TAF4B, a paralog
Dulce Mesa-Siverio et al.
Bioorganic & medicinal chemistry, 16(6), 3387-3394 (2008-02-05)
Five new dibenzylbutane type lignans (1-5) were isolated from the stem bark of Iryanthera lancifolia. Their structures were determined by extensive 1D and 2D NMR spectroscopic studies and chemical evidence. Seventeen of the isolated compounds were tested for their estrogenic
Fortune Kohen et al.
Journal of medicinal chemistry, 50(25), 6405-6410 (2007-11-10)
The isoflavones biochanin A ( 1a), genistein ( 1b), and daidzein ( 4) at concentrations >20 microM inhibit cell growth of various cancer cell lines. To enhance the antiproliferative activities of these compounds, we synthesized three analogs, 2-[3-carboxy-(6-tert-butoxycarbonylamino)-hexylamino-propyl]-7,5-dihydroxy-4'-methoxyisoflavone ( 3a)
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