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Lampson M Fan et al.
The Journal of clinical investigation, 129(8), 3374-3386 (2019-07-23)
Oxidative stress plays an important role in aging-related neurodegeneration. This study used littermates of WT and Nox2-knockout (Nox2KO) mice plus endothelial cell-specific human Nox2 overexpression-transgenic (HuNox2Tg) mice to investigate Nox2-derived ROS in brain aging. Compared with young WT mice (3-4
Minna Niittykoski et al.
Translational oncology, 10(5), 772-779 (2017-08-12)
Oncolytic adenoviruses show promise in targeting gliomas because they do not replicate in normal brain cells. However, clinical responses occur only in a subset of patients. One explanation could be the heterogenic expression level of virus receptors. Another contributing factor
Gesa Volkers et al.
ACS chemical biology, 13(8), 2320-2328 (2018-07-18)
Polysialyltransferases synthesize polysialic acid on cell surface-expressed glycoconjugates, which is crucial for developing processes and signaling pathways in eukaryotes. Recent advances in cancer research have rendered polysialyltransferases important drug targets because polysialic acid contributes to cancer cell progression, metastasis, and
Nick J I Hamilton et al.
Tissue engineering. Part C, Methods, 25(2), 93-102 (2019-01-17)
This article describes a method for engrafting epithelial progenitor cells to a revascularized scaffold in a protective and supportive collagen-rich environment. This method has the potential to overcome two key limitations of existing grafting techniques as epithelial cells are protected
Bhakti R Pathak et al.
Molecular and cellular biochemistry, 411(1-2), 11-21 (2015-09-16)
Cysteine-rich secretory protein 3 (CRISP-3) is upregulated in prostate cancer as compared to the normal prostate tissue. Higher expression of CRISP-3 has been linked to poor prognosis and hence it has been thought to act as a prognostic marker for
H55N polymorphism is associated with low citrate synthase activity which regulates lipid metabolism in mouse muscle cells
Gabriel BM, et al.
PLoS ONE, 12(11), e0185789-e0185789 (2017)
Muscle Cell and Tissue: Current Status of Research Field (2018)
Hynda K Kleinman et al.
Seminars in cancer biology, 15(5), 378-386 (2005-06-25)
The basement membrane extracellular matrix contacts epithelial, endothelial, fat and smooth muscle cells. Because this extracellular matrix is so thin, it had been hard to study its composition, structure, and function. An extract of a tumor was found to contain
Chang Liu et al.
Frontiers in oncology, 9, 1475-1475 (2020-02-18)
Patients with advanced thyroid carcinoma have poor prognosis with low overall survival. Unfortunately, the underlying mechanisms of thyroid carcinoma progression remain unclear. The elevated expression of thymidine kinase 1 (TK1) has been implicated in the progression of thyroid carcinoma, while
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Immunohistochemical Characterization and Sensitivity to Human Adenovirus Serotypes 3, 5, and 11p of New Cell Lines Derived from Human Diffuse Grade II to IV Gliomas
Niittykoski M, et al.
Translational Oncology, 10(5), 772-779 (2017)
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