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Shoudong Guo et al.
Biochimica et biophysica acta, 1841(6), 836-846 (2014-03-08)
Both sphingosine 1-phosphate (S1P) and estrogen have been documented to play endothelial protective roles. However, it remains unclear whether estrogen could regulate the anabolism of the bioactive molecule S1P and the underlying mechanisms. In this study, 108 healthy participants were
New insights into metabolic regulation via bifurcated function of estrogen receptor α.
Tsutomu Wada et al.
Diabetes, 62(12), 3996-3998 (2013-11-23)
Susan H Corbett et al.
Southern medical journal, 107(7), 433-436 (2014-07-11)
To identify trends in compounding pharmacies with a focus on women's health and, more specifically, the types and combinations of medications used in the treatment of vulvodynia. This survey study was conducted with 653 nonchain pharmacies that compound medications. Each
Joel S Finkelstein et al.
The New England journal of medicine, 369(11), 1011-1022 (2013-09-13)
Current approaches to diagnosing testosterone deficiency do not consider the physiological consequences of various testosterone levels or whether deficiencies of testosterone, estradiol, or both account for clinical manifestations. We provided 198 healthy men 20 to 50 years of age with
Gonadal steroids and body composition, strength, and sexual function in men.
Vita Birzniece
The New England journal of medicine, 369(25), 2455-2455 (2013-12-20)
Wenbo Li et al.
Nature, 498(7455), 516-520 (2013-06-04)
The functional importance of gene enhancers in regulated gene expression is well established. In addition to widespread transcription of long non-coding RNAs (lncRNAs) in mammalian cells, bidirectional ncRNAs are transcribed on enhancers, and are thus referred to as enhancer RNAs
Aniruddha Das et al.
Archives of sexual behavior, 43(7), 1403-1415 (2014-03-07)
Using nationally representative data from the 2005-2006 U.S. National Social Life, Health, and Aging Project, this study queried relationship, sexual, and sex hormone patterns among married evangelical women and men aged 57-85, relative to those in other religions. Results suggested
Seiro Satohisa et al.
Endocrinology, 155(8), 3005-3016 (2014-06-01)
Adduction of a nitric oxide (NO) moiety (NO(•)) to cysteines termed as S-nitrosylation (SNO) has emerged as a crucial mechanism for NO signaling crucial for mediating the vascular effects of estrogens. Mitochondrion is a known vascular risk factor; however, the
Coadministrating luteolin minimizes the side effects of the aromatase inhibitor letrozole.
Li F, Wong TY, Lin SM, et al.
Journal of Pharmacology and Experimental Therapeutics, 351(2), 270-277 (2014)
Kathryn J Grive et al.
Developmental biology, 392(1), 42-51 (2014-05-20)
Primary ovarian insufficiency (POI) affects 1% of women under the age of 40 and is associated with premature ovarian follicle depletion. TAF4b deficiency in adult female mouse models results in hallmarks of POI including stereotyped gonadotropin alterations indicative of early
Bu B Yeap et al.
The Journal of clinical endocrinology and metabolism, 99(1), E9-18 (2013-11-22)
Testosterone (T) levels decline with age and lower T has been associated with increased mortality in aging men. However, the associations of its metabolites, dihydrotestosterone (DHT) and estradiol (E2), with mortality are poorly defined. We assessed associations of T, DHT
Juan M Fregeneda-Grandes et al.
Journal of water and health, 11(4), 720-728 (2013-12-18)
Serum steroid profiles were investigated in order to evaluate the potential use of circulating sex steroid levels as a tool for sex identification in brown trout. Changes in the serum concentrations of testosterone (T), progesterone (P), 17-β-estradiol (E2), and cortisol
Gonadal steroids and body composition, strength, and sexual function in men.
Paul F Schellhammer
The New England journal of medicine, 369(25), 2456-2456 (2013-12-20)
Characterization of the zebrafish Ugt repertoire reveals a new class of drug-metabolizing UDP glucuronosyltransferases.
Wang Y, Huang H, and Wu Q
Molecular Pharmacology, 86(1), 62-75 (2014)
Zhonghua Shi et al.
Endocrinology, 155(5), 1982-1990 (2014-03-08)
Omental adipose tissue plays a central role in insulin resistance in gestational diabetes mellitus (GDM), and the molecular mechanisms leading to GDM remains vague. Evidence demonstrates that maternal hormones, such as estradiol, contribute to insulin resistance in GDM. In this
Mariana Nigro et al.
Endocrinology, 155(8), 2881-2891 (2014-06-11)
Menopause is associated with increased visceral adiposity and disrupted glucose homeostasis, but the underlying molecular mechanisms related to these metabolic changes are still elusive. Brown adipose tissue (BAT) plays a key role in energy expenditure that may be regulated by
Estrogens and myocardial chymase: new insights into pathological hypertrophy and remodeling.
Jorge E Jalil et al.
Hypertension (Dallas, Tex. : 1979), 65(2), 271-272 (2014-11-19)
Jeremy K Larson et al.
Nanotoxicology, 8(8), 856-866 (2013-09-03)
Gold nanoparticles (GNPs) have gained considerable attention for application in science and industry. However, the untoward effects of such particles on female fertility remain unclear. The objectives of this study were to (1) examine the effects of 10-nm GNPs on
Lianguo Chen et al.
Aquatic toxicology (Amsterdam, Netherlands), 149, 116-125 (2014-03-04)
This study evaluated the potential adverse effects of butenolide, a promising antifouling compound, using the marine medaka (Oryzias melastigma), a model fish for marine ecotoxicology. The active ingredient used in the commercial antifoulant SeaNine 211, 4,5-dichloro-2-n-octyl-4-isothiazolin-3-one (DCOIT) was employed as
Xuefang Liang et al.
Environmental pollution (Barking, Essex : 1987), 189, 184-193 (2014-04-01)
Assessing protein responses to endocrine disrupting chemicals is critical for understanding the mechanisms of chemical action and for the assessment of hazards. In this study, the response of the liver proteome of male rare minnows (Gobiocypris rarus) treated with 17β-estradiol
On estrogen, cholesterol metabolism, and breast cancer.
Margaret Warner et al.
The New England journal of medicine, 370(6), 572-573 (2014-02-07)
Laura Ballester et al.
Fertility and sterility, 102(6), 1762-1768 (2014-09-23)
To determine optimal conditions for the inclusion of oviductal fluid (OF) in IVF protocols. Experimental prospective study. Mammalian reproduction research laboratory. Oviducts and ovaries from porcine females were collected at a slaughterhouse. A total of 30 oviducts and 1,285 oocytes
Kara J Connelly et al.
Endocrinology, 156(1), 193-202 (2014-10-21)
Peak bone mass, one of the most important predictors for fracture risk later in life, is attained during puberty and adolescence and influenced by neonatal and pubertal sex-specific gonadal hormones and GH-IGF-I secretion patterns. This study examined the effects of
Zhiping Li et al.
Cancer research, 74(14), 3959-3970 (2014-05-17)
The cyclin D1 gene encodes the regulatory subunit of a holoenyzme that phosphorylates the retinoblastoma protein (pRb) and nuclear respiratory factor (NRF1) proteins. The abundance of cyclin D1 determines estrogen-dependent gene expression in the mammary gland of mice. Using estradiol
Irene Kwan et al.
The Cochrane database of systematic reviews, 8(8), CD005289-CD005289 (2014-08-26)
Traditional monitoring of ovarian hyperstimulation during in vitro fertilisation (IVF) and intra-cytoplasmic sperm injection (ICSI) treatment has included transvaginal ultrasonography (TVUS) plus serum estradiol levels to ensure safe practice by reducing the incidence and severity of ovarian hyperstimulation syndrome (OHSS)
Brian P Kenealy et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(49), 19051-19059 (2013-12-07)
Release of gonadotropin releasing hormone (GnRH) from the medial basal hypothalamus (MBH)/median eminence region (S-ME) is essential for normal reproductive function. GnRH release is profoundly regulated by the negative and positive feedback effects of ovarian estradiol (E2). Here we report
Iu O Kovaleva et al.
Eksperimental'naia i klinicheskaia farmakologiia, 76(5), 7-9 (2013-08-02)
We have studied the role of female sex hormone estradiol in the development of hypoxic pulmonary arterial hypertension. Previously, it was shown that the development of pulmonary hypertension in Wistar female rats is accompanied by a twofold increase in the
Lydia M M Vermeer et al.
Experimental neurology, 263, 8-16 (2014-09-30)
Migraine is one of the most common neurological disorders, leading to more than 1% of total disability reported and over 68 million visits to emergency rooms or physician's offices each year in the United States. Three times as many women
Venkataraman Sriraman et al.
Biochemical pharmacology, 89(2), 266-275 (2014-03-19)
FSH signalling through its cognate receptor is critical for follicular development and ovulation. An earlier study had documented thiazolidinone derivatives to activate FSH receptor expressed in CHO cells and rat granulosa cells; however development of this compound for clinical use
Richard Piet et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(26), 10828-10839 (2013-06-28)
Circulating gonadal steroid hormones are thought to modulate a wide range of brain functions. However, the effects of steroid fluctuations through the ovarian cycle on the intrinsic properties of neurons are not well understood. We examined here whether gonadal steroids
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