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Minjun Chen et al.
Drug discovery today, 16(15-16), 697-703 (2011-06-01)
Drug-induced liver injury (DILI) is a leading cause of drugs failing during clinical trials and being withdrawn from the market. Comparative analysis of drugs based on their DILI potential is an effective approach to discover key DILI mechanisms and risk
Massimiliano de Zambotti et al.
The Journal of clinical endocrinology and metabolism, 100(8), 2918-2926 (2015-06-17)
Most studies show sleep homeostasis and continuity remain stable across the menstrual cycle in young women. The influence of the menstrual cycle on physiological sleep in midlife women is unknown. The objective of the study was to assess the impact
Laura A Schaap et al.
Clinical endocrinology, 63(2), 152-160 (2005-08-03)
The objective of this study was to examine whether low levels of oestradiol and testosterone are associated with impaired mobility, low muscle strength and the incidence of falls in a population-based sample of older men and women. Cross-sectional population-based study
J Stebbing et al.
Oncogene, 34(16), 2103-2114 (2014-06-10)
Kinase suppressor of Ras-1 (KSR1) facilitates signal transduction in Ras-dependent cancers, including pancreatic and lung carcinomas but its role in breast cancer has not been well studied. Here, we demonstrate for the first time it functions as a tumor suppressor
Yuji Narukawa et al.
Journal of natural medicines, 69(1), 130-134 (2014-09-17)
Two new diterpenoids, 14α-hydroxy-9α,13α-epoxylabd-5(6)-en-7-on-16,15-olide (1) and 13ξ-hydroxylabd-5(6),8(9)-dien-7-on-16,15-olide (2) along with six known diterpenoids were isolated from the aerial parts of Leonotis leonurus R. Br. These structures were determined on the basis of spectroscopic analyses. Some of the isolated compounds showed
Julie M Fox et al.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, 35(7), 554-562 (2015-03-11)
Influenza infection causes an increase in indoleamine 2, 3-dioxygenase (IDO) activity in the lung parenchyma. IDO catabolizes tryptophan into kynurenine, leading to immune dampening. Multiple cell types express IDO, and while IFN-γ upregulates IDO in dendritic cells and macrophages, it
Shama Nasim et al.
Bioorganic & medicinal chemistry letters, 20(24), 7450-7453 (2010-11-09)
A series of 3-O-phosphorylated analogs (4-10) of a novel bone-targeting estradiol analog (3) were synthesized after a thorough study of the reaction of 3 with a selection of phosphoryl chlorides under a variety of reaction conditions. Evaluation of these novel
Neil A O'Brien et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 20(13), 3507-3520 (2014-06-01)
Altered PI3K/mTOR signaling is implicated in the pathogenesis of a number of breast cancers, including those resistant to hormonal and HER2-targeted therapies. The activity of four classes of PI3K/mTOR inhibitory molecules, including a pan-PI3K inhibitor (NVP-BKM120), a p110α isoform-specific PI3K
Diana S M Ottoz et al.
Nucleic acids research, 42(17), e130-e130 (2014-07-19)
The precise control of gene expression is essential in basic biological research as well as in biotechnological applications. Most regulated systems available in yeast enable only the overexpression of the target gene, excluding the possibility of intermediate or weak expression.
Lydia M M Vermeer et al.
Experimental neurology, 263, 8-16 (2014-09-30)
Migraine is one of the most common neurological disorders, leading to more than 1% of total disability reported and over 68 million visits to emergency rooms or physician's offices each year in the United States. Three times as many women
Hongwei Kan et al.
Molecular medicine reports, 12(3), 4546-4553 (2015-06-11)
Women undergoing the natural menopause can experience progressive cognitive dysfunction, particularly in the form of memory impairment. However, the mechanisms underlying memory impairments in the menopause remain to be elucidated. There is increasing evidence that oxidative damage caused by excessive
James S Wright et al.
Journal of medicinal chemistry, 54(2), 433-448 (2010-12-31)
Long-term use of estrogen supplements by women leads to an increased risk of breast and uterine cancers. Possible mechanisms include metabolism of estradiol and compounds related to tumor-initiating quinones, and ligand-induced activation of the estrogen receptors ERα and ERβ which
Esra D P Çakır et al.
Journal of pediatric endocrinology & metabolism : JPEM, 28(11-12), 1219-1226 (2015-05-15)
The objective of the study was to evaluate the pubertal development and linear growth of Turner Syndrome (TS) girls regularly monitored in our department. The data of 13 patients with TS were evaluated retrospectively. Left hand radiograms were evaluated by
Monireh Mahmoodi et al.
Reproduction (Cambridge, England), 147(5), 733-741 (2014-02-05)
Ovarian tissue transplantation is performed to preserve fertility in patients undergoing chemotherapy and radiotherapy. However, ischemia/reperfusion (IR) injury and free radical production occurring during the revascularization of the transplanted tissue are the major limitations of this procedure. The aim of
Li-Han Hsu et al.
Cancer science, 106(1), 51-59 (2014-10-24)
Estrogen has been postulated to contribute to the development and progression of lung cancer. We examined the epidemiologic evidence, explored the characteristics of estrogen receptors (ER) in lung adenocarcinoma, and investigated the effect of estrogen on lung cancer cell migration
Shanfei Ge et al.
Journal of cellular biochemistry, 116(11), 2455-2464 (2015-02-05)
Estradiol (E2) is a major determinant of gender-based differences in the development of hepatic fibrosis. MicroRNAs (miRNAs) are endogenous 19-25 nucleotide, noncoding, single-stranded RNAs that regulate gene expression by blocking the translation or decreasing the stability of mRNAs and play
Susann Busch et al.
Cancer research, 75(7), 1457-1469 (2015-04-04)
One third of the patients with estrogen receptor α (ERα)-positive breast cancer who are treated with the antiestrogen tamoxifen will either not respond to initial therapy or will develop drug resistance. Endocrine response involves crosstalk between ERα and TGFβ signaling
Mohamed-Elamir F Hegazy et al.
Journal of natural products, 74(5), 937-942 (2011-04-23)
In a continued investigation of medicinal plants from the genus Tephrosia, phytochemical analysis of a methylene chloride-methanol (1:1) extract of the air-dried aerial parts of Tephrosia candida afforded two new 8-prenylated flavonoids, namely, tephrocandidins A (1) and B (2), a
T T Lahdes-Vasama et al.
BJU international, 92(9), 972-976 (2003-11-25)
To test the hypothesis that men with a history of undescended testicle have voiding problems similar to those in rodents exposed to excessive amounts of oestrogens during development, although the role of oestrogen in the failure of the human testicle
S W Bai et al.
Neurourology and urodynamics, 22(3), 198-205 (2003-04-23)
The aims of this study were to investigate whether endogenous steroid hormones are (1) related to pathogenesis of stress urinary incontinence after menopause, (2) are related to severity of stress urinary incontinence, and (3) are related to prognostic parameters of
Wen-Chin Tsai et al.
International journal of cardiology, 176(1), 110-118 (2014-07-20)
Aging and testosterone deficiency contribute to the pathogenesis of atrial fibrillation (AF). We determine the effects of testosterone replacement on the electrophysiology and arrhythmogenesis of pulmonary vein (PV) and left atrium (LA) in aged rabbits. Electrocardiography, heart rate variability, echocardiography
Thomas R Gawriluk et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(40), E4194-E4203 (2014-09-24)
Autophagy is an important cellular process that serves as a companion pathway to the ubiquitin-proteasome system to degrade long-lived proteins and organelles to maintain cell homeostasis. Although initially characterized in yeast, autophagy is being realized as an important regulator of
Jia-Yih Feng et al.
PloS one, 9(6), e97967-e97967 (2014-06-07)
Sex hormones have diverse immunomodulatory effects that may be involved in the pathogenesis of sepsis. However, the roles of serum sex hormones in predicting outcomes and the severity of organ dysfunction, especially acute kidney injury (AKI), in septic shock patients
Pascal Pigeon et al.
Journal of medicinal chemistry, 48(8), 2814-2821 (2005-04-15)
A series of ruthenocene derivatives, 1-[4-(O(CH(2))(n)()N(CH(3))(2))phenyl]-1-(4-hydroxyphenyl)-2-ruthenocenylbut-1-ene, with n = 2-5, based on the structure of the breast cancer drug tamoxifen has been prepared. These compounds were obtained, via a McMurry cross-coupling reaction, as a mixture of Z and E isomers
Quan Jiang et al.
Journal of medicinal chemistry, 53(16), 6153-6163 (2010-07-31)
Daidzein (1) is a natural estrogenic isoflavone. We report here that 1 can be transformed into anti-estrogenic ligands by simple alkyl substitutions of the 7-hydroxyl hydrogen. To test the effect of such structural modifications on the hormonal activities of the
Sandra L Olmsted et al.
Bioorganic & medicinal chemistry letters, 22(2), 977-979 (2011-12-20)
A series of 17α-(heteroaryl)vinyl estradiols was prepared to evaluate the influence of heteroatom on the affinity and efficacy of estrogenic ligands for the estrogen receptor-alpha ligand binding domain (ERα-LBD). The products demonstrated reduced binding affinity compared to the parent 17α-E-phenyl
Timothy A Blizzard et al.
Bioorganic & medicinal chemistry letters, 16(4), 834-838 (2005-11-29)
A series of 19-substituted androstenediol derivatives was prepared. Some of the novel analogs were surprisingly potent and selective ligands for ER-beta.
Hideyuki Iwahata et al.
Journal of assisted reproduction and genetics, 32(4), 521-526 (2015-01-27)
Closed vitrification poses a risk of adversely affecting embryo development, while it may minimize the risk of contamination. We assessed the effects of closed-system human embryo vitrification on fetal development after implantation, neonatal outcome, and clinical safety. This was a
María Castelló-Ruiz et al.
Neuroscience letters, 575, 53-57 (2014-05-28)
While the estrogen treatment of stroke is under debate, selective estrogen receptor modulators (SERMs) arise as a promising alternative. We hypothesize that bazedoxifene (acetate, BZA), a third generation SERM approved for the treatment of postmenopausal osteoporosis, reduces ischemic brain damage
Isabel R V Hartwig et al.
Journal of molecular medicine (Berlin, Germany), 92(10), 1093-1104 (2014-06-04)
Observational as well as experimental studies support that prenatal challenges seemed to be associated with an increased risk for allergic airway diseases in the offspring. However, insights into biomarkers involved in mediating this risk are largely elusive. We here aimed
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