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I V Golubev et al.
Acta naturae, 6(3), 76-88 (2014-10-29)
Hydrophobization of alpha-helices is one of the general approaches used for improving the thermal stability of enzymes. A total of 11 serine residues located in alpha-helices have been found based on multiple alignments of the amino acid sequences of D-amino
Evelien A W Smits et al.
Journal of liposome research, 25(1), 46-57 (2014-07-02)
Besides the development of sample preparation methods for the determination of separate liposomal-encapsulated prednisolone phosphate and non-encapsulated prednisolone concentrations in murine plasma and blood, this article also presents the first description of an accurate sample preparation method for the determination
Masanori Honsho et al.
The Journal of biological chemistry, 290(48), 28822-28833 (2015-10-16)
Plasmalogen biosynthesis is regulated by modulating fatty acyl-CoA reductase 1 stability in a manner dependent on cellular plasmalogen level. However, physiological significance of the regulation of plasmalogen biosynthesis remains unknown. Here we show that elevation of the cellular plasmalogen level
Fuiyee Lee et al.
PloS one, 9(7), e103254-e103254 (2014-07-23)
Graft versus host disease (GvHD) is one of the main complications after hematological stem cell transplantation (HSCT). CAMPATH-1H is used in the pre-transplant conditioning regimen to effectively reduce GvHD by targeting CD52 antigens on T cells resulting in their depletion.
Christian S Müller et al.
Biochemistry, 54(3), 711-721 (2014-12-30)
Cytochrome P450 3A4 (CYP3A4) is the major human P450 responsible for the metabolism of carbamazepine (CBZ). To explore the mechanisms of interactions of CYP3A4 with this anticonvulsive drug, we carried out multiple molecular dynamics (MD) simulations, starting with the complex
Tze-Bin Song et al.
ACS applied materials & interfaces, 7(44), 24601-24607 (2015-10-22)
Solution-processed silver nanowire networks are one of the promising candidates to replace a traditional indium tin oxide as next-generation transparent and flexible electrodes due to their ease of processing, moderate flexibility, high transparency, and low sheet resistance. To date, however
Eszter E Najbauer et al.
The journal of physical chemistry. B, 119(33), 10496-10510 (2015-07-23)
The conformers of α-serine were investigated by matrix-isolation IR spectroscopy combined with NIR laser irradiation. This method, aided by 2D correlation analysis, enabled unambiguously grouping the spectral lines to individual conformers. On the basis of comparison of at least nine
Sanja Ramljak et al.
Clinical laboratory, 61(11), 1687-1693 (2016-01-07)
Modern biomarkers for the assessment of liver cell damage are indicative for distinct hepato-cellular deteriorations. We investigated the prevalence of these markers in healthy subjects and patients with early stage type 2 diabetes mellitus (T2DM) on metformin monotherapy. The study
Nele Goeyvaerts et al.
Statistics in medicine, 34(20), 2858-2871 (2015-04-25)
Biomedical studies often generate repeated measures of multiple outcomes on a set of subjects. It may be of interest to develop a biologically intuitive model for the joint evolution of these outcomes while assessing inter-subject heterogeneity. Even though it is
Chaitali N Mahajan et al.
Pediatric research, 77(3), 455-462 (2014-12-19)
Persistent pulmonary hypertension of the newborn (PPHN) is associated with decreased lung angiogenesis and impaired pulmonary vasodilatation at birth. Prostanoids are important modulators of vascular tone and angiogenesis. We hypothesized that altered levels of prostacyclin (PGI₂), a potent vasodilator, and
Wei-Tsung Chen et al.
Biomaterials, 53, 699-708 (2015-04-22)
In this study, we aimed to validate the feasibility of receptor-targeted tumor theranostics with folate-conjugated (FA) and camptothecin-loaded (CPT) acoustic nanodroplets (NDs) (collectively termed FA-CPT-NDs). The ND formulation was based on lipid-stabilized low-boiling perfluorocarbon that can undergo acoustic droplet vaporization
Miki Igarashi et al.
Biochimica et biophysica acta, 1851(9), 1218-1226 (2015-05-31)
The gastrointestinal tract plays a critical role in the regulation of energy homeostasis by initiating neural and hormonal responses to the ingestion of nutrients. In addition to peptide hormones, such as cholecystokinin (CKK) and peptide YY (PYY), the lipid-derived mediator
Yuhong Liu et al.
Journal of chromatography. A, 1364, 64-73 (2014-09-04)
Methicillin resistant Staphylococcus aureus (MRSA) is a bacterium that is resistant to many antibiotics. Resistance to methicillin is related to production of penicillin binding protein 2a (PBP2a). The currently presented research involves the development of antibody-linked immunoaffinity solid phase microextraction
Yu Zhang et al.
Nanoscale, 7(32), 13775-13783 (2015-07-30)
Highly stable monodispersed nano Cu hydrosols were facilely prepared by an aqueous chemical reduction method through selecting copper hydroxide (Cu(OH)2) as the copper precursor, poly(acrylic acid) (PAA) and ethanol amine (EA) as the complexing agents, and hydrazine hydrate as the
Kenneth S Brandenburg et al.
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society, 23(6), 842-854 (2015-09-06)
Chronic nonhealing skin wounds often contain bacterial biofilms that prevent normal wound healing and closure and present challenges to the use of conventional wound dressings. We investigated inhibition of Pseudomonas aeruginosa biofilm formation, a common pathogen of chronic skin wounds
María L Salum et al.
Journal of photochemistry and photobiology. B, Biology, 148, 128-135 (2015-04-29)
Cinnamic acids are present in all kinds of plant tissues and hence in herbs and derived medicines, cosmetics and foods. The interest in their role in plants and their therapeutic applications has grown exponentially. Because of their molecular structure they
Lulu Dai et al.
International journal of molecular sciences, 16(6), 12014-12034 (2015-05-29)
Leptographium qinlingensis is a fungal associate of the Chinese white pine beetle (Dendroctonus armandi) and a pathogen of the Chinese white pine (Pinus armandi) that must overcome the terpenoid oleoresin defenses of host trees. L. qinlingensis responds to monoterpene flow
Chiao-Lin Chuang et al.
Journal of gastroenterology and hepatology, 30(1), 199-207 (2014-07-06)
Hypo-perfusion resulting from intense renal vasoconstriction is traditionally contributed to renal dysfunction in advanced liver disease, although cumulative studies demonstrated renal vasodilatation with impaired vascular contractility to endogenous vasoconstrictors in portal hypertension and compensated liver cirrhosis. The pathophysiology of altered
Ilaria Pelassa et al.
Human molecular genetics, 23(13), 3402-3420 (2014-02-06)
The expansion of homopolymeric glutamine (polyQ) or alanine (polyA) repeats in certain proteins owing to genetic mutations induces protein aggregation and toxicity, causing at least 18 human diseases. PolyQ and polyA repeats can also associate in the same proteins, but
Fátima Husein Abdalla et al.
Molecular and cellular biochemistry, 396(1-2), 201-211 (2014-07-30)
The ex vivo and in vitro effects of quercetin on NTPDase, adenosine deaminase (ADA), and acetycholinesterase (AChE) activities in lymphocytes, as well as the effects of quercetin on butyrylcholinesterase (BChE) activity in serum and myeloperoxidase (MPO) activity in plasma were
I Ojeda et al.
Analytical and bioanalytical chemistry, 406(25), 6363-6371 (2014-08-02)
A novel magnetoimmunosensor design for interleukin-6 (IL-6) which involved the covalent immobilization of anti-IL-6 antibodies onto carboxyl-functionalized magnetic microparticles and a sandwich-type immunoassay with signal amplification using poly-HRP-streptavidin conjugates is reported. All the variables concerning the preparation and the electroanalytical
Hussein N Yassine et al.
PloS one, 10(1), e0115320-e0115320 (2015-01-22)
Using mass spectrometric immunoassay, the abundance of SAA truncations relative to the native variants was examined in plasma of 91 participants with type 2 diabetes and chronic kidney disease and 69 participants without diabetes. The ratio of SAA 1.1 (missing
Úrsula A Rossi et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 72, 44-51 (2015-06-10)
A local gene therapy scheme for the delivery of type I interferons could be an alternative for the treatment of melanoma. We evaluated the cytotoxic effects of interferon-β (IFNβ) gene lipofection on tumor cell lines derived from three human cutaneous
Sejin Ahn et al.
ChemSusChem, 5(9), 1773-1777 (2012-08-15)
A simple direct solution coating process for forming CuInSe₂ (CIS) thin films was described, employing a low-cost and environmentally friendly precursor solution. The precursor solution was prepared by mixing metal acetates, ethanol, and ethanolamine. The facile formation of a precursor
Philippe Pierrat et al.
Langmuir : the ACS journal of surfaces and colloids, 31(45), 12362-12371 (2015-10-29)
Understanding the ionization behavior of lipid membranes is a key parameter for successful development of lipid-based drug delivery systems. Accurate determination of the ionization state of a titratable species incorporated in a lipid bilayer however requires special care. Herein we
Candice I Pelligra et al.
Small (Weinheim an der Bergstrasse, Germany), 10(21), 4304-4309 (2014-07-26)
Controlled density semiconducting oxide arrays are highly desirable for matching nanometer length scales specific to emerging applications. This work demonstrates a facile one-step method for templating hydrothermal growth which provides arrays with high-fidelity tuning of nanorod spacing and diameter. This
Shannon N Acker et al.
Pediatric research, 77(4), 511-519 (2015-01-13)
Pulmonary hypertension (PH) secondary to vascular remodeling contributes to poor outcomes in congenital diaphragmatic hernia (CDH), however mechanisms responsible are unknown. We hypothesized that pulmonary artery endothelial cell (PAEC) dysfunction contributes to smooth muscle cell (SMC) hyperplasia in experimental CDH.
Shoken Lee et al.
The EMBO journal, 34(5), 669-688 (2015-01-18)
P4-ATPases translocate aminophospholipids, such as phosphatidylserine (PS), to the cytosolic leaflet of membranes. PS is highly enriched in recycling endosomes (REs) and is essential for endosomal membrane traffic. Here, we show that PS flipping by an RE-localized P4-ATPase is required
S Dolatabadi et al.
Mycoses, 57 Suppl 3, 67-72 (2014-09-05)
Mucormycosis has emerged as a relatively common severe mycosis in patients with haematological and allogeneic stem cell transplantation. Source of transmission is from unidentified sources in the environment. Early diagnosis of infection and its source of contamination are paramount for
A F Alkaim et al.
Environmental technology, 36(17), 2190-2197 (2015-03-03)
The photocatalytic production of molecular hydrogen (H2) from aqueous solutions of alkyl-alkanolamines (triethanolamine (tri-EOA), diethanolamine (di-EOA), ethanolamine (EOA), ethylamine (EA) and ethanol over Pt-loaded commercial (Sachtleben Hombikat UV100) nanoparticle titanium dioxide photocatalysts was studied. These photocatalysts were characterized using X-ray
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