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Helena Johansson et al.
PloS one, 5(10), e13678-e13678 (2010-11-05)
Reprogramming of somatic cells for derivation of either embryonic stem (ES) cells, by somatic cell nuclear transfer (SCNT), or ES-like cells, by induced pluripotent stem (iPS) cell procedure, provides potential routes toward non-immunogenic cell replacement therapies. Nucleolar proteins serve as
Conor J O'Leary et al.
Cell reports, 20(2), 370-383 (2017-07-13)
Denudation of the ependyma due to loss of cell adhesion mediated by cadherin-based adherens junctions is a common feature of perinatal hydrocephalus. Junctional stability depends on the interaction between cadherins and the actin cytoskeleton. However, the molecular mechanism responsible for
Rafael B Junqueira et al.
Journal of prosthodontics : official journal of the American College of Prosthodontists (2018-10-16)
To evaluate the radiopacity of luting cements submitted to different aging procedures. Twenty discs (1 × 4 mm) of each of the following cements were prepared: zinc phosphate, RelyX Luting 2, Variolink 2, AllCem, RelyX U200, Multilink, Panavia F2.0, and
Aria Vaishnavi et al.
Cancer research, 77(13), 3551-3563 (2017-04-22)
Oncogenic kinase fusions of ALK, ROS1, RET, and NTRK1 act as drivers in human lung and other cancers. Residual tumor burden following treatment of ALK or ROS1+ lung cancer patients with oncogene-targeted therapy ultimately enables the emergence of drug-resistant clones
Liselotte Vesterlund et al.
The International journal of developmental biology, 55(3), 313-319 (2011-06-29)
During development there is a multitude of signaling events governing the assembly of the developing organism. Receptors for signaling molecules such as fibroblast growth factor receptor 2 (FGFR2) enable the embryo to communicate with the surrounding environment and activate downstream
Eun-Kyung Kwon et al.
Biochimica et biophysica acta. Molecular cell research, 1864(1), 1-11 (2016-10-19)
Members of the herpesviral family use multiple strategies to hijack infected host cells and exploit cellular signaling for their pathogenesis and latent infection. Among the most intriguing weapons in the arsenal of pathogenic herpesviruses are the constitutively active virally-encoded G
Benjamin Causton et al.
Journal of immunology (Baltimore, Md. : 1950), 195(2), 683-694 (2015-06-05)
Innate immune responses to allergens by airway epithelial cells (AECs) help initiate and propagate the adaptive immune response associated with allergic airway inflammation in asthma. Activation of the transcription factor NF-κB in AECs by allergens or secondary mediators via G
Mary E Klein et al.
Oncogene, 37(37), 5066-5078 (2018-05-24)
CDK4/6 inhibitors are being used to treat a variety of human malignancies. In well-differentiated and dedifferentiated liposarcoma their clinical promise is associated with their ability to downregulate the MDM2 protein. The downregulation of MDM2 following treatment with CDK4/6 inhibitors also
Agata Zieba et al.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 31(2), 253-263 (2017-09-25)
Antibodies are important tools in anatomical pathology and research, but the quality of in situ protein detection by immunohistochemistry greatly depends on the choice of antibodies and the abundance of the targeted proteins. Many antibodies used in scientific research do
Jenan Al-Matouq et al.
Cancer letters, 410, 41-49 (2017-09-28)
Despite its documented role in cell cycle regulation, over-expression of the cyclin-dependent kinase activator CDC25A does not consistently correlate with worse cancer patient outcomes or predict successful clinical response to CDC25A inhibition. The current study was undertaken to investigate CDC25A
Ransom H Poythress et al.
American journal of physiology. Cell physiology, 305(2), C215-C227 (2013-05-25)
Turnover of focal adhesions (FAs) is known to be critical for cell migration and adhesion of proliferative vascular smooth muscle (VSM) cells. However, it is often assumed that FAs in nonmigratory, differentiated VSM (dVSM) cells embedded in the wall of
Yongxin Yu et al.
Molecular cell, 46(1), 7-17 (2012-03-06)
Histone modifications play important roles in regulating DNA-based biological processes. Of the modified sites, histone H3 lysine 56 (H3K56) is unique in that it lies within the globular core domain near the entry-exit sites of the nucleosomal DNA superhelix and
Aleksandra R Dukic et al.
Cellular signalling, 32, 1-11 (2017-01-13)
Communication between adjacent cells can occur via gap junctions (GJ) composed of connexin (Cx) hexamers that allow passage of small molecules. One of the most widely and highly expressed Cxs in human tissues is Cx43, shown to be regulated through
Karin Bauer et al.
Carcinogenesis, 32(6), 935-943 (2011-04-05)
Slits are a group of secreted glycoproteins that act as molecular guidance cues in cellular migration. Recently, several studies demonstrated that Slit-2 can operate as candidate tumour suppressor protein in various tissues. In this study, we show Slit-2 expression in
Ruimin Wang et al.
Molecular neurobiology (2018-06-29)
Hypothermia is currently the only approved therapy for global cerebral ischemia (GCI) after cardiac arrest; however, it unfortunately has multiple adverse effects. As a noninvasive procedure, photobiomodulation (PBM) therapy has emerged as a potential novel treatment for brain injury. PBM
Hui Yao et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 107, 1712-1719 (2018-09-28)
The hyper-activation of PI3K/AKT signaling is common in many kinds of malignant tumors and promotes cell growth. Moreover, FBXL5 is reported to play an important role in the progression of gastric cancer and cervical cancer. In this view, this study
Mahmoud Bahari et al.
Journal of dentistry (Tehran, Iran), 11(3), 248-255 (2015-01-30)
To evaluate the effect of different light intensities on the degree of conversion (DC) of dual-cured resin cement at different depths of translucent fiber posts. Thirty translucent fiber posts were randomly assigned into three (n=10) groups. They were cemented in
Bojun Zhang et al.
American journal of physiology. Heart and circulatory physiology, 314(2), H359-H369 (2017-11-05)
Endothelial dysfunction in chronic hypoxia (CH)-induced pulmonary hypertension is characterized by reduced store-operated Ca2+ entry (SOCE) and diminished Ca2+-dependent production of endothelium-derived vasodilators. We recently reported that SOCE in pulmonary arterial endothelial cells (PAECs) is tightly regulated by membrane cholesterol
Y Zhang et al.
Cell death & disease, 3, e308-e308 (2012-05-11)
Biomaterials that can drive stem cells to an appropriate differentiation level and decrease apoptosis of transplanted cells are needed in regenerative medicine. Nanomaterials are promising novel materials for such applications. Here we reported that carboxylated multiwalled carbon nanotube (MWCNT 1)
Veronica Ceccarelli et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, fj201800245R-fj201800245R (2018-05-15)
In cancer cells, global genomic hypomethylation is found together with localized hypermethylation of CpG islands within the promoters and regulatory regions of silenced tumor suppressor genes. Demethylating agents may reverse hypermethylation, thus promoting gene re-expression. Unfortunately, demethylating strategies are not
Patricia Santofimia-Castaño et al.
Biochimica et biophysica acta. General subjects, 1862(6), 1283-1295 (2018-03-14)
NUPR1 is a multifunctional intrinsically disordered protein (IDP) involved, among other functions, in chromatin remodelling, and development of pancreatic ductal adenocarcinoma (PDAC). It interacts with several biomolecules through hydrophobic patches around residues Ala33 and Thr68. The drug trifluoperazine (TFP), which
Franziska Wetzel et al.
Cellular and molecular life sciences : CMLS, 74(2), 373-392 (2016-09-09)
The zonula occludens (ZO)-2 protein links tight junctional transmembrane proteins to the actin cytoskeleton and associates with splicing and transcription factors in the nucleus. Multiple posttranslational modifications control the intracellular distribution of ZO-2. Here, we report that ZO-2 is a
Ahmed M Hashad et al.
Scientific reports, 8(1), 3445-3445 (2018-02-24)
Vascular T-type Ca2+ channels (CaV3.1 and CaV3.2) play a key role in arterial tone development. This study investigated whether this conductance is a regulatory target of angiotensin II (Ang II), a vasoactive peptide that circulates and which is locally produced
Sara Przetocka et al.
Molecular cell, 72(3), 568-582 (2018-10-23)
Protecting stalled DNA replication forks from degradation by promiscuous nucleases is essential to prevent genomic instability, a major driving force of tumorigenesis. Several proteins commonly associated with the repair of DNA double-strand breaks (DSBs) by homologous recombination (HR) have been
Youg R Thaker et al.
The Journal of biological chemistry, 292(15), 6281-6290 (2017-02-12)
The adaptor protein Src homology 2 domain-containing leukocyte phosphoprotein of 76 kDa (SLP-76) plays a crucial role in T cell activation by linking antigen receptor (T cell receptor, TCR) signals to downstream pathways. At its N terminus, SLP-76 has three
Vincent Muczynski et al.
Blood, 129(17), 2443-2454 (2017-02-19)
Recently, we have identified scavenger receptor class A member I (SR-AI) as a receptor for coagulation factor X (FX), mediating the formation of an FX reservoir at the macrophage surface. Here, we demonstrate that the FX/SR-AI-complex comprises a third protein
Jolien Steyaert et al.
Human molecular genetics, 27(23), 4103-4116 (2018-11-01)
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are neurodegenerative diseases characterized by the progressive loss of specific groups of neurons. Due to clinical, genetic and pathological overlap, both diseases are considered as the extremes of one disease spectrum and
Graziela Avila Galhano et al.
Brazilian oral research, 22(3), 264-269 (2008-10-25)
This study evaluated the effect of mechanical cycling on the bond strength of zirconia posts to root dentin. Thirty single-rooted human teeth were transversally sectioned to a length of 16 mm. The canal preparation was performed with zirconia post system
Alexis Bretteville et al.
Methods in molecular biology (Clifton, N.J.), 1523, 297-305 (2016-12-16)
Tau is a microtubule associated protein (MAP) that is expressed in neurons of the central nervous system. Tau proteins are deregulated in a group of pathologies, including Alzheimer's disease, commonly called tauopathies. Therefore intensive research has been conducted to understand
Kaisa Auvinen et al.
Scientific reports, 9(1), 15698-15698 (2019-11-02)
Endothelial cells contain several nanoscale domains such as caveolae, fenestrations and transendothelial channels, which regulate signaling and transendothelial permeability. These structures can be covered by filter-like diaphragms. A transmembrane PLVAP (plasmalemma vesicle associated protein) protein has been shown to be
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