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Helena Johansson et al.
PloS one, 5(10), e13678-e13678 (2010-11-05)
Reprogramming of somatic cells for derivation of either embryonic stem (ES) cells, by somatic cell nuclear transfer (SCNT), or ES-like cells, by induced pluripotent stem (iPS) cell procedure, provides potential routes toward non-immunogenic cell replacement therapies. Nucleolar proteins serve as
Jenan Al-Matouq et al.
Cancer letters, 410, 41-49 (2017-09-28)
Despite its documented role in cell cycle regulation, over-expression of the cyclin-dependent kinase activator CDC25A does not consistently correlate with worse cancer patient outcomes or predict successful clinical response to CDC25A inhibition. The current study was undertaken to investigate CDC25A
Benjamin Causton et al.
Journal of immunology (Baltimore, Md. : 1950), 195(2), 683-694 (2015-06-05)
Innate immune responses to allergens by airway epithelial cells (AECs) help initiate and propagate the adaptive immune response associated with allergic airway inflammation in asthma. Activation of the transcription factor NF-κB in AECs by allergens or secondary mediators via G
Mary E Klein et al.
Oncogene, 37(37), 5066-5078 (2018-05-24)
CDK4/6 inhibitors are being used to treat a variety of human malignancies. In well-differentiated and dedifferentiated liposarcoma their clinical promise is associated with their ability to downregulate the MDM2 protein. The downregulation of MDM2 following treatment with CDK4/6 inhibitors also
Agata Zieba et al.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 31(2), 253-263 (2017-09-25)
Antibodies are important tools in anatomical pathology and research, but the quality of in situ protein detection by immunohistochemistry greatly depends on the choice of antibodies and the abundance of the targeted proteins. Many antibodies used in scientific research do
Conor J O'Leary et al.
Cell reports, 20(2), 370-383 (2017-07-13)
Denudation of the ependyma due to loss of cell adhesion mediated by cadherin-based adherens junctions is a common feature of perinatal hydrocephalus. Junctional stability depends on the interaction between cadherins and the actin cytoskeleton. However, the molecular mechanism responsible for
Liselotte Vesterlund et al.
The International journal of developmental biology, 55(3), 313-319 (2011-06-29)
During development there is a multitude of signaling events governing the assembly of the developing organism. Receptors for signaling molecules such as fibroblast growth factor receptor 2 (FGFR2) enable the embryo to communicate with the surrounding environment and activate downstream
Eun-Kyung Kwon et al.
Biochimica et biophysica acta. Molecular cell research, 1864(1), 1-11 (2016-10-19)
Members of the herpesviral family use multiple strategies to hijack infected host cells and exploit cellular signaling for their pathogenesis and latent infection. Among the most intriguing weapons in the arsenal of pathogenic herpesviruses are the constitutively active virally-encoded G
Anna Woroniuk et al.
Nature communications, 9(1), 2124-2124 (2018-05-31)
The perinuclear actin cap is an important cytoskeletal structure that regulates nuclear morphology and re-orientation during front-rear polarisation. The mechanisms regulating the actin cap are currently poorly understood. Here, we demonstrate that STEF/TIAM2, a Rac1 selective guanine nucleotide exchange factor
Taro Matsumoto et al.
Arteriosclerosis, thrombosis, and vascular biology, 28(12), 2123-2130 (2008-09-06)
Angiogenesis is an integral part of many physiological processes but may also aggravate pathological conditions such as cancer. Development of effective angiogenesis inhibitors requires a thorough understanding of the molecular mechanisms regulating vessel formation. The aim of this project was
Karin Bauer et al.
Carcinogenesis, 32(6), 935-943 (2011-04-05)
Slits are a group of secreted glycoproteins that act as molecular guidance cues in cellular migration. Recently, several studies demonstrated that Slit-2 can operate as candidate tumour suppressor protein in various tissues. In this study, we show Slit-2 expression in
Ruimin Wang et al.
Molecular neurobiology (2018-06-29)
Hypothermia is currently the only approved therapy for global cerebral ischemia (GCI) after cardiac arrest; however, it unfortunately has multiple adverse effects. As a noninvasive procedure, photobiomodulation (PBM) therapy has emerged as a potential novel treatment for brain injury. PBM
Hui Yao et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 107, 1712-1719 (2018-09-28)
The hyper-activation of PI3K/AKT signaling is common in many kinds of malignant tumors and promotes cell growth. Moreover, FBXL5 is reported to play an important role in the progression of gastric cancer and cervical cancer. In this view, this study
Rafael B Junqueira et al.
Journal of prosthodontics : official journal of the American College of Prosthodontists (2018-10-16)
To evaluate the radiopacity of luting cements submitted to different aging procedures. Twenty discs (1 × 4 mm) of each of the following cements were prepared: zinc phosphate, RelyX Luting 2, Variolink 2, AllCem, RelyX U200, Multilink, Panavia F2.0, and
Gene T Yocum et al.
American journal of physiology. Lung cellular and molecular physiology, 312(6), L812-L821 (2017-03-25)
Asthma is a common disorder characterized, in part, by airway smooth muscle (ASM) hyperresponsiveness. Transient receptor potential vanilloid 1 (TRPV1) is a nonselective cation channel expressed on airway nerve fibers that modulates afferent signals, resulting in cough, and potentially bronchoconstriction.
Zijian Tang et al.
Methods in molecular biology (Clifton, N.J.), 1487, 195-201 (2016-12-08)
RAS/MAPK signaling responds to diverse extracellular cues and regulates a wide array of cellular processes. Given its biological importance, abnormalities in RAS/MAPK signaling cascade have been intimately implicated in numerous human diseases, including cancer. Herein, we describe a novel methodology
Y Zhang et al.
Cell death & disease, 3, e308-e308 (2012-05-11)
Biomaterials that can drive stem cells to an appropriate differentiation level and decrease apoptosis of transplanted cells are needed in regenerative medicine. Nanomaterials are promising novel materials for such applications. Here we reported that carboxylated multiwalled carbon nanotube (MWCNT 1)
Yongxin Yu et al.
Molecular cell, 46(1), 7-17 (2012-03-06)
Histone modifications play important roles in regulating DNA-based biological processes. Of the modified sites, histone H3 lysine 56 (H3K56) is unique in that it lies within the globular core domain near the entry-exit sites of the nucleosomal DNA superhelix and
Aleksandra R Dukic et al.
Cellular signalling, 32, 1-11 (2017-01-13)
Communication between adjacent cells can occur via gap junctions (GJ) composed of connexin (Cx) hexamers that allow passage of small molecules. One of the most widely and highly expressed Cxs in human tissues is Cx43, shown to be regulated through
Mahmoud Bahari et al.
Journal of dentistry (Tehran, Iran), 11(3), 248-255 (2015-01-30)
To evaluate the effect of different light intensities on the degree of conversion (DC) of dual-cured resin cement at different depths of translucent fiber posts. Thirty translucent fiber posts were randomly assigned into three (n=10) groups. They were cemented in
Aria Vaishnavi et al.
Cancer research, 77(13), 3551-3563 (2017-04-22)
Oncogenic kinase fusions of ALK, ROS1, RET, and NTRK1 act as drivers in human lung and other cancers. Residual tumor burden following treatment of ALK or ROS1+ lung cancer patients with oncogene-targeted therapy ultimately enables the emergence of drug-resistant clones
Ransom H Poythress et al.
American journal of physiology. Cell physiology, 305(2), C215-C227 (2013-05-25)
Turnover of focal adhesions (FAs) is known to be critical for cell migration and adhesion of proliferative vascular smooth muscle (VSM) cells. However, it is often assumed that FAs in nonmigratory, differentiated VSM (dVSM) cells embedded in the wall of
Veronica Ceccarelli et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, fj201800245R-fj201800245R (2018-05-15)
In cancer cells, global genomic hypomethylation is found together with localized hypermethylation of CpG islands within the promoters and regulatory regions of silenced tumor suppressor genes. Demethylating agents may reverse hypermethylation, thus promoting gene re-expression. Unfortunately, demethylating strategies are not
Patricia Santofimia-Castaño et al.
Biochimica et biophysica acta. General subjects, 1862(6), 1283-1295 (2018-03-14)
NUPR1 is a multifunctional intrinsically disordered protein (IDP) involved, among other functions, in chromatin remodelling, and development of pancreatic ductal adenocarcinoma (PDAC). It interacts with several biomolecules through hydrophobic patches around residues Ala33 and Thr68. The drug trifluoperazine (TFP), which
Franziska Wetzel et al.
Cellular and molecular life sciences : CMLS, 74(2), 373-392 (2016-09-09)
The zonula occludens (ZO)-2 protein links tight junctional transmembrane proteins to the actin cytoskeleton and associates with splicing and transcription factors in the nucleus. Multiple posttranslational modifications control the intracellular distribution of ZO-2. Here, we report that ZO-2 is a
Ahmed M Hashad et al.
Scientific reports, 8(1), 3445-3445 (2018-02-24)
Vascular T-type Ca2+ channels (CaV3.1 and CaV3.2) play a key role in arterial tone development. This study investigated whether this conductance is a regulatory target of angiotensin II (Ang II), a vasoactive peptide that circulates and which is locally produced
Sara Przetocka et al.
Molecular cell, 72(3), 568-582 (2018-10-23)
Protecting stalled DNA replication forks from degradation by promiscuous nucleases is essential to prevent genomic instability, a major driving force of tumorigenesis. Several proteins commonly associated with the repair of DNA double-strand breaks (DSBs) by homologous recombination (HR) have been
Youg R Thaker et al.
The Journal of biological chemistry, 292(15), 6281-6290 (2017-02-12)
The adaptor protein Src homology 2 domain-containing leukocyte phosphoprotein of 76 kDa (SLP-76) plays a crucial role in T cell activation by linking antigen receptor (T cell receptor, TCR) signals to downstream pathways. At its N terminus, SLP-76 has three
Vincent Muczynski et al.
Blood, 129(17), 2443-2454 (2017-02-19)
Recently, we have identified scavenger receptor class A member I (SR-AI) as a receptor for coagulation factor X (FX), mediating the formation of an FX reservoir at the macrophage surface. Here, we demonstrate that the FX/SR-AI-complex comprises a third protein
Jolien Steyaert et al.
Human molecular genetics, 27(23), 4103-4116 (2018-11-01)
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are neurodegenerative diseases characterized by the progressive loss of specific groups of neurons. Due to clinical, genetic and pathological overlap, both diseases are considered as the extremes of one disease spectrum and
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