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Christopher J Brooks et al.
Aviation, space, and environmental medicine, 85(4), 440-444 (2014-04-24)
According to 40 yr of data, the fatality rate for a helicopter crash into water is approximately 25%. Does warning time and the final position of the helicopter in the water influence the survival rate? The National Transportation Safety Board
Hidetada Ogata et al.
The Journal of endocrinology, 222(2), 191-200 (2014-06-04)
Glucose-dependent insulinotropic polypeptide (GIP), a gut hormone secreted from intestinal K-cells, potentiates insulin secretion. Both K-cells and pancreatic β-cells are glucose-responsive and equipped with a similar glucose-sensing apparatus that includes glucokinase and an ATP-sensitive K(+) (KATP) channel comprising KIR6.2 and
Anna A DePaoli-Roach et al.
The Journal of biological chemistry, 290(2), 841-850 (2014-11-25)
Glycogen is a branched polymer of glucose that acts as an energy reserve in many cell types. Glycogen contains trace amounts of covalent phosphate, in the range of 1 phosphate per 500-2000 glucose residues depending on the source. The function
C L Marvig et al.
International journal of food microbiology, 192, 51-57 (2014-10-13)
The most notorious spoilage organism of sweet intermediate moisture foods (IMFs) is Zygosaccharomyces rouxii, which can grow at low water activity, low pH and in the presence of organic acids. Together with an increased consumer demand for preservative free and
Nami Kang et al.
Bulletin of environmental contamination and toxicology, 93(5), 555-560 (2014-09-28)
This study was performed to determine the ecosystem health of an urban stream using DNA damage biomarkers of sentinel fish species along with chemical analyses of water and sediments in the impacted and reference zones. The results based on single-cell
Shigeo Hayashi et al.
Journal of enzyme inhibition and medicinal chemistry, 29(6), 846-867 (2014-02-13)
Because of the pivotal role of cyclooxygenase (COX) in the inflammatory processes, non-steroidal anti-inflammatory drugs (NSAIDs) that suppress COX activities have been used clinically for the treatment of inflammatory diseases/syndromes; however, traditional NSAIDs exhibit serious side-effects such as gastrointestinal damage
Satinder K Shrama et al.
Nanoscale research letters, 9(1), 122-122 (2014-03-19)
One-dimensional (1-D) ultrathin (15 nm) and thin (100 nm) aligned 1-D (0001) and (0001¯) oriented zinc oxide (ZnO) nanowire (NW) arrays were fabricated on copper substrates by one-step electrochemical deposition inside the pores of polycarbonate membranes. The aspect ratio dependence of the
Bárbara S F Rodrigues et al.
Chemistry & biodiversity, 12(3), 432-442 (2015-03-15)
The cytotoxic activities of extracts (50 μg/ml) from 48 fungal strains, recovered from sediments of Pecém's offshore port terminal (Northeast coast of Brazil), against HCT-116 colon cancer cell lines were investigated. The most promising extract was obtained from strain BRF082, identified
Kei Higashikawa et al.
PloS one, 9(11), e109866-e109866 (2014-11-05)
Cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) targeted therapy by anti-CTLA-4 monoclonal antibody (mAb) is highly effective in cancer patients. However, it is extremely expensive and potentially produces autoimmune-related adverse effects. Therefore, the development of a method to evaluate CTLA-4 expression prior
N Deschuyffeleer et al.
International journal of food microbiology, 192, 77-85 (2014-10-16)
High sugar products (sugar content > 50%) are generally considered to be stable against all forms of microbial spoilage during a prolonged shelf life of several months. However, one specific subgroup of micro-organisms, the xerophilic moulds, can develop quite fast
Orsolya Kinga Gondor et al.
Ecotoxicology and environmental safety, 108, 129-134 (2014-07-26)
UV-B radiation may have either a positive or negative impact under the same conditions in wheat, depending on the type of secondary abiotic stressor: Cd or drought. Supplemental UV-B prevented the wilting and leaf rolling induced by PEG treatment. In
Delfo D'Alessandro et al.
Biomedical materials (Bristol, England), 9(4), 045007-045007 (2014-07-17)
In this study, we performed a complete histologic analysis of constructs based on large diameter ( >100 μm) poly-L-lactic acid (PLLA) microfibers obtained via dry-wet spinning and rat Mesenchymal Stromal Cells (rMSCs) differentiated towards the osteogenic lineage, using acrylic resin embedding.
Xi Chen et al.
BioMed research international, 2015, 540731-540731 (2015-03-05)
Osteoporosis can be associated with the disordered balance between osteogenesis and adipogenesis of bone marrow-derived mesenchymal stem cells (BM-MSCs). Although low-frequency mechanical vibration has been demonstrated to promote osteogenesis, little is known about the influence of acoustic-frequency vibratory stimulation (AFVS).
Mehdi Razavi et al.
Journal of biomedical materials research. Part A, 103(5), 1798-1808 (2014-09-10)
The major issue for biodegradable magnesium alloys is the fast degradation and release of hydrogen gas. In this article, we aim to overcome these disadvantages by using a surface modified magnesium implant. We have recently coated AZ91 magnesium implants by
James Foster et al.
PloS one, 9(9), e106556-e106556 (2014-09-24)
Keratoconus (KC) is a complex thinning disease of the cornea that often requires transplantation. The underlying pathogenic molecular changes in this disease are poorly understood. Earlier studies reported oxidative stress, metabolic dysfunctions and accelerated death of stromal keratocytes in keratoconus
Jin Zhang et al.
Applied and environmental microbiology, 81(3), 1071-1084 (2014-12-03)
4-Hydroxybutyryl-coenzyme A (CoA) dehydratase (4HBD) from Clostridium aminobutyricum catalyzes the reversible dehydration of 4-hydroxybutyryl-CoA to crotonyl-CoA and the irreversible isomerization of vinylacetyl-CoA to crotonyl-CoA. 4HBD is an oxygen-sensitive homotetrameric enzyme with one [4Fe-4S](2+) cluster and one flavin adenine dinucleotide (FAD)
Jeffrey G Szabo et al.
Chemosphere, 113, 171-174 (2014-07-30)
Disinfecting water generated from a bioterrorism contamination event will require large amounts of disinfectant since the volume of water flushed from a drinking water distribution system or wash water collected from a contaminated outdoor area can accumulate quickly. Commonly used
Fubo Wang et al.
Oncotarget, 5(22), 11091-11102 (2014-12-20)
The current strategy for diagnosing prostate cancer (PCa) is mainly based on the serum prostate-specific antigen (PSA) test. However, PSA has low specificity and has led to numerous unnecessary biopsies. We evaluated the effectiveness of urinary metastasis-associated lung adenocarcinoma transcript
Audrey Gratia et al.
Analytica chimica acta, 853, 477-485 (2014-12-04)
A nuclear magnetic resonance (NMR) methodology was assessed regarding the identification and quantification of additives in three types of polylactide (PLA) intended as food contact materials. Additives were identified using the LNE/NMR database which clusters NMR datasets on more than
Femke S den Boon et al.
Pflugers Archiv : European journal of physiology, 466(12), 2257-2268 (2014-03-29)
The functional presence of type-2 cannabinoid receptors (CB2Rs) in layer II/III pyramidal neurons of the rat medial prefrontal cortex (mPFC) was recently demonstrated. In the present study, we show that the application of the endocannabinoids (eCBs) 2-arachidonoylglycerol (2-AG) and methanandamide
Jeffrey Brent
Clinical toxicology (Philadelphia, Pa.), 51(8), 731-736 (2013-09-06)
The intention is to assess whether the fundamental principle ("the solution to pollution is dilution") should be the guide for the initial medical management of corrosive dermal exposures. The US National Library of Medicine Pubmed database was searched utilizing all
Katleen J R Vallons et al.
Critical reviews in food science and nutrition, 54(3), 399-409 (2013-11-06)
High pressure processing is a promising non-thermal technology for the development of fresh-like, shelf-stable foods. The effect of high pressure on starch has been explored by many researchers using a wide range of techniques. In general, heat and pressure have
Letal I Salzberg et al.
Journal of bacteriology, 197(8), 1492-1506 (2015-02-11)
The PhoPR two-component signal transduction system controls one of three responses activated by Bacillus subtilis to adapt to phosphate-limiting conditions (PHO response). The response involves the production of enzymes and transporters that scavenge for phosphate in the environment and assimilate
Fernando Campos de Assis Fonseca et al.
PloS one, 10(2), e0118231-e0118231 (2015-02-24)
Sugarcane is a widely cultivated plant that serves primarily as a source of sugar and ethanol. Its annual yield can be significantly reduced by the action of several insect pests including the sugarcane giant borer (Telchin licus licus), a lepidopteran
Ye Yang et al.
Infection and immunity, 83(1), 247-258 (2014-10-29)
Animals develop in the presence of complex microbial communities, and early host responses to these microbes can influence key aspects of development, such as maturation of the immune system, in ways that impact adult physiology. We previously showed that the
Martin J J Ronis et al.
Experimental biology and medicine (Maywood, N.J.), 240(1), 58-66 (2014-09-03)
Differences in trace element composition and bioavailability between breast milk and infant formulas may affect metal homeostasis in neonates. However, there is a paucity of controlled studies in this area. Here, piglets were fed soy infant formula (soy), cow's milk
Barbara Montanini et al.
Genome biology, 15(7), 411-411 (2014-08-06)
We investigated how an extremely transposon element (TE)-rich organism such as the plant-symbiotic ascomycete truffle Tuber melanosporum exploits DNA methylation to cope with the more than 45,000 repeated elements that populate its genome. Whole-genome bisulfite sequencing performed on different developmental
Huihui Ti et al.
Food chemistry, 178, 186-194 (2015-02-24)
The phytochemical profile and antioxidant activities of unprocessed and extruded milled fractions of black rice were investigated. Extrusion increased the free phenolics, anthocyanins and oxygen radical absorbance capacity (ORAC) and decreased the bound forms. The total phenolics, anthocyanins and ORAC
Sabina Lip et al.
Postepy biochemii, 59(3), 295-304 (2013-12-25)
Transcription factors are proteins that are able to regulate the expression of target genes by specifically binding with DNA sequences and regulating the activity initiation complex of transcription. These proteins are key elements in the adaptation of plants to environmental
Moo Yong Park et al.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 30(3), 480-490 (2014-11-02)
MicroRNAs (miRs) are small non-coding RNAs that are important regulators of gene expression and have been implicated in atherosclerosis. Kidney injury distal to atherosclerotic renal artery stenosis (ARAS) is aggravated by atherosclerosis. Therefore, this study tested the hypothesis that renal
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