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Shoji Hata et al.
Nature cell biology, 21(9), 1138-1151 (2019-09-05)
One of the first steps in mitotic spindle assembly is the dissolution of the centrosome linker followed by centrosome separation driven by EG5, a tetrameric plus-end-directed member of the kinesin-5 family. However, even in the absence of the centrosome linker
More than just optic disc swelling.
Roomasa Channa et al.
JAMA ophthalmology, 131(11), 1477-1478 (2013-11-16)
Apoorva Baluapuri et al.
Molecular cell, 74(4), 674-687 (2019-04-01)
The MYC oncoprotein binds to promoter-proximal regions of virtually all transcribed genes and enhances RNA polymerase II (Pol II) function, but its precise mode of action is poorly understood. Using mass spectrometry of both MYC and Pol II complexes, we
Catherine W M Ong et al.
PLoS pathogens, 11(5), e1004917-e1004917 (2015-05-23)
Pulmonary cavities, the hallmark of tuberculosis (TB), are characterized by high mycobacterial load and perpetuate the spread of M. tuberculosis. The mechanism of matrix destruction resulting in cavitation is not well defined. Neutrophils are emerging as key mediators of TB
Juliane Mooz et al.
Science signaling, 7(337), ra73-ra73 (2014-08-07)
The RAF family of kinases mediates RAS signaling, and RAF inhibitors can be effective for treating tumors with BRAF(V600E) mutant protein. However, RAF inhibitors paradoxically accelerate metastasis in RAS-mutant tumors and become ineffective in BRAF(V600E) tumors because of reactivation of
Stuart L Johnson et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(21), 8720-8725 (2013-05-08)
The development of neural circuits relies on spontaneous electrical activity that occurs during immature stages of development. In the developing mammalian auditory system, spontaneous calcium action potentials are generated by inner hair cells (IHCs), which form the primary sensory synapse.
Lyme disease.
Thomas F Castiglione
The New England journal of medicine, 371(7), 683-683 (2014-08-15)
Rebekah K Franklin et al.
Drug metabolism and disposition: the biological fate of chemicals, 43(8), 1236-1245 (2015-06-03)
Doxycycline (doxy) is used in treating intracellular and extracellular infections. Liposomal (LE) antibiotics allow low-frequency dosing and extended efficacy compared with standard (STD) formulations. We developed a novel sulfuric acid-loading method for doxycycline liposomes (LE-doxy). We hypothesized that a single
Mio Nakanishi et al.
Cell, 177(4), 910-924 (2019-04-16)
The assembly of organized colonies is the earliest manifestation in the derivation or induction of pluripotency in vitro. However, the necessity and origin of this assemblance is unknown. Here, we identify human pluripotent founder cells (hPFCs) that initiate, as well as
Job C Tharappel et al.
The Journal of surgical research, 190(2), 692-698 (2014-06-16)
Despite improvements in ventral hernia repair techniques, their recurrence rates are unacceptably high. Increased levels of matrix metalloproteinases (MMPs) and reduced collagen-1 to -3 ratios are implicated in incisional hernia formation. We have recently shown doxycycline treatment for 4 wk after
Jolien S de Groot et al.
The Journal of pathology, 245(4), 456-467 (2018-05-19)
Although mutational inactivation of E-cadherin (CDH1) is the main driver of invasive lobular breast cancer (ILC), approximately 10-15% of all ILCs retain membrane-localized E-cadherin despite the presence of an apparent non-cohesive and invasive lobular growth pattern. Given that ILC is
Jochen Stritzker et al.
Journal of virology, 88(19), 11556-11567 (2014-07-25)
Exogenous gene induction of therapeutic, diagnostic, and safety mechanisms could be a considerable improvement in oncolytic virotherapy. Here, we introduced a doxycycline-inducible promoter system (comprised of a tetracycline repressor, several promoter constructs, and a tet operator sequence) into oncolytic recombinant
Shan Wang et al.
Nature communications, 6, 6517-6517 (2015-03-17)
The MSI2 RNA-binding protein is a potent oncogene playing key roles in haematopoietic stem cell homeostasis and malignant haematopoiesis. Here we demonstrate that MSI2 is expressed in the intestinal stem cell compartment, that its expression is elevated in colorectal adenocarcinomas
Marc C Dolan et al.
The American journal of tropical medicine and hygiene, 85(6), 1114-1120 (2011-12-07)
A field trial was conducted in a Lyme disease-endemic area of New Jersey to determine the efficacy of a doxycyline hyclate rodent bait to prophylactically protect and cure small-mammal reservoirs and reduce infection rates in questing Ixodes scapularis ticks for
Kango Gopal Gopinath et al.
Tropical doctor, 44(2), 89-91 (2013-12-18)
Spotted fever (SF), a tick-borne rickettsial infection, is being increasingly reported from mainly northern Indian states. A lack of awareness and confirmatory laboratory tests underestimate the incidence of this infection which, in India, is predominantly seen during the rainy season.
Jixiu Shan et al.
Biochimica et biophysica acta, 1853(3), 539-548 (2014-12-20)
Amino acid (AA) deprivation in mammalian cells activates a collection of signaling cascades known as the AA response (AAR), which is characterized by transcriptional induction of stress-related genes, including FBJ murine osteosarcoma viral oncogene homolog (cFOS). The present study established
Sarah E W Grubb et al.
Infection and immunity, 77(9), 3872-3878 (2009-07-08)
Candida albicans is a commensal organism that under certain circumstances can become pathogenic. During systemic infection C. albicans is disseminated via the circulation to distant organs, where it causes multiple organ failure. Despite the severity of systemic C. albicans infection
M N Washington et al.
Cell death & disease, 6, e1836-e1836 (2015-08-08)
Autophagy can sustain or kill tumor cells depending upon the context. The mechanism of autophagy-associated cell death has not been well elucidated and autophagy has enhanced or inhibited sensitivity of cancer cells to cytotoxic chemotherapy in different models. ARHI (DIRAS3)
Gu-Choul Shin et al.
Nature communications, 10(1), 3185-3185 (2019-07-20)
Unfolded protein response (UPR) is an adaptive mechanism that aims at restoring ER homeostasis under severe environmental stress. Malignant cells are resistant to environmental stress, which is largely due to an activated UPR. However, the molecular mechanisms by which different
Swamy K Tripurani et al.
Molecular biology of the cell, 29(22), 2784-2799 (2018-09-07)
Mice that lack the epidermal growth factor receptor (EGFR) fail to develop a hair coat, but the mechanism responsible for this deficit is not completely understood. Here, we show that EGFR plays a critical role to attenuate wingless-type MMTV integration
Yangyang Ma et al.
Cell death discovery, 4, 21-21 (2018-03-14)
Derivation of bona fide porcine pluripotent stem cells is still a critical issue because porcine embryonic stem cells (ESCs) are not available yet, and most of the culture conditions to maintain porcine induced pluripotent stem cells (piPSCs) are based on
Lei Gao et al.
Nature communications, 10(1), 1665-1665 (2019-04-12)
Lung cancer is the leading cause of cancer-related deaths worldwide. Tumor suppressor genes remain to be systemically identified for lung cancer. Through the genome-wide screening of tumor-suppressive transcription factors, we demonstrate here that GATA4 functions as an essential tumor suppressor
Ryan M J Genga et al.
Cell reports, 27(3), 708-718 (2019-04-18)
Studies in vertebrates have outlined conserved molecular control of definitive endoderm (END) development. However, recent work also shows that key molecular aspects of human END regulation differ even from rodents. Differentiation of human embryonic stem cells (ESCs) to END offers
Regulation of glioma cell invasion by 3q26 gene products PIK 3 CA, SOX 2 and OPA 1
Schaefer T, et al.
Brain Pathology (2018)
Christine M Khosropour et al.
Sexually transmitted infections, 90(1), 3-7 (2013-10-10)
Doxycycline, one of two recommended therapies for non-gonococcal urethritis (NGU), consists of a 7-day course of therapy (100 mg BID). Since suboptimal adherence may contribute to poor treatment outcomes, we examined the association between self-reported imperfect adherence to doxycycline and
Celien Lismont et al.
Biochimica et biophysica acta. Biomembranes, 1861(10), 182991-182991 (2019-05-28)
Peroxisomes have the intrinsic ability to produce and scavenge hydrogen peroxide (H2O2), a diffusible second messenger that controls diverse cellular processes by modulating protein activity through cysteine oxidation. Current evidence indicates that H2O2, a molecule whose physicochemical properties are similar
Jia Wang et al.
Oncotarget, 6(9), 7325-7338 (2014-10-31)
microRNA-29b (miR-29b) is known to be associated with TGF-β-mediated fibrosis, but the mechanistic action of miR-29b in liver fibrosis remains unclear and is warranted for investigation. We found that miR-29b was significantly downregulated in human and mice fibrotic liver tissues
Arun M Unni et al.
eLife, 4, e06907-e06907 (2015-06-06)
Human lung adenocarcinomas (LUAD) contain mutations in EGFR in ∼15% of cases and in KRAS in ∼30%, yet no individual adenocarcinoma appears to carry activating mutations in both genes, a finding we have confirmed by re-analysis of data from over
Tomofumi Tadauchi et al.
Biotechnology progress, 35(2), e2772-e2772 (2018-12-29)
Chinese hamster ovary (CHO) cells are conventionally used to generate therapeutic cell lines via random integration (RI), where desired transgenes are stably integrated into the genome. Targeted integration (TI) approaches, which involve integration of a transgene into a specific locus
Alessio Giannelli et al.
Parasitology research, 113(6), 2391-2394 (2014-05-02)
Canine spirocercosis caused by Spirocerca lupi is a life-threatening helminthic disease featured by severe clinical signs and potential development of oesophageal neoplasia. This infection is considered fairly frequent in Europe but almost unknown in Italy, from where only few reports
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