Ming Ma et al.
Journal of the American Society of Nephrology : JASN, 30(11), 2103-2111 (2019-08-28)
PKD1 or PKD2, the two main causal genes for autosomal dominant polycystic kidney disease (ADPKD), encode the multipass transmembrane proteins polycystin-1 (PC1) and polycystin-2 (PC2), respectively. Polycystins localize to the primary cilium, an organelle essential for cell signaling, including signal