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D9434

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Changik Lee et al.
Journal of neuroscience research, 93(9), 1405-1412 (2015-05-28)
In the visual cortex, synaptic plasticity is very high during the early developmental stage known as the critical period and declines with development after the critical period. Changes in the properties of N-methyl-D-aspartate receptor (NMDAR) and γ-aminobutyric acid type A...
Valeria Iansante et al.
Nature communications, 6, 7882-7882 (2015-08-11)
Most tumour cells use aerobic glycolysis (the Warburg effect) to support anabolic growth and evade apoptosis. Intriguingly, the molecular mechanisms that link the Warburg effect with the suppression of apoptosis are not well understood. In this study, using loss-of-function studies...
Robinson Junior Ndeddy Aka et al.
International journal of phytoremediation, 18(2), 200-209 (2015-10-28)
Bacterial inoculation may influence Brassica juncea growth and heavy metal (Ni, Cr, and Cd) accumulation. Three metal tolerant bacterial isolates (BCr3, BCd33, and BNi11) recovered from mine tailings, identified as Pseudomonas aeruginosa KP717554, Alcaligenes feacalis KP717561, and Bacillus subtilis KP717559...
Yumi Kohara et al.
Physiology & behavior, 140, 15-22 (2014-12-08)
Cognitive dysfunction due to higher blood glucose level has been reported previously. Genistein (GEN) is a phytoestrogen that we hypothesized might lead to improved memory, despite elevated blood glucose levels at the time of memory consolidation. To investigate this hypothesis...
Yi Shi et al.
Nature methods, 12(12), 1135-1138 (2015-10-06)
It remains particularly problematic to define the structures of native macromolecular assemblies, which are often of low abundance. Here we present a strategy for isolating complexes at endogenous levels from GFP-tagged transgenic cell lines. Using cross-linking mass spectrometry, we extracted...
S-H Wen et al.
Free radical research, 48(8), 907-918 (2014-05-23)
15-F2t-isoprostane is not only a specific marker of lipid peroxidation but also demonstrated to have potent bioactivities and can exert deleterious effects via activating thromboxane A2 receptor (TxA2r). We already demonstrated that lipid peroxidation represents a mechanism of intestinal ischemia/reperfusion...
M A Gales et al.
The Annals of pharmacotherapy, 29(5), 523-529 (1995-05-01)
To review the data examining the use of rapid infusion of amphotericin B in dextrose infusions. A MEDLINE search of the English-language literature and review of pertinent references' bibliographies was used to identify articles evaluating the effect of amphotericin B...
Chuyang Chen et al.
Small (Weinheim an der Bergstrasse, Germany), 11(29), 3557-3567 (2015-03-27)
This study demonstrates a facile but efficient hydrothermal method for the direct synthesis of both carbonaceous silver (Ag@C core-shell) nanocables and carbonaceous nanotubes under mild conditions (<180 °C). The carbonaceous tubes can be formed by removal of the silver cores...
Farah Hossain et al.
Food microbiology, 53(Pt B), 24-30 (2015-12-19)
The antifungal activities of eight essential oils (EOs) namely basil, cinnamon, eucalyptus, mandarin, oregano, peppermint, tea tree and thyme were evaluated for their ability to inhibit growth of Aspergillus niger, Aspergillus flavus, Aspergillus parasiticus and Penicillium chrysogenum. The antifungal activity...
Nayara Peixoto-Silva et al.
Life sciences, 95(1), 14-21 (2013-12-24)
Studies have demonstrated that early weaning can promote metabolic syndrome during adulthood and that obesity increases oxidative stress. Thus, we aimed to evaluate redox status in a pharmacological early weaning rodent model programmed for metabolic syndrome at adulthood. Lactating dams...
Jamila R Sanchez et al.
Mutation research, 779, 124-133 (2015-07-24)
Increased paternal age is associated with a greater risk of producing children with genetic disorders originating from de novo germline mutations. Mice mimic the human condition by displaying an age-associated increase in spontaneous mutant frequency in spermatogenic cells. The observed...
Anamika Singh et al.
Thrombosis and haemostasis, 113(4), 750-758 (2015-02-06)
Diabetes mellitus (DM) patients have an increased incidence of cardiovascular events. Blood tissue factor-procoagulant activity (TF-PCA), the initiating mechanism for blood coagulation, is elevated in DM. We have shown that hyperglycaemia (HG), hyperinsulinaemia (HI) and combined HG+HI (induced using 24-hour...
Laura C Tegtmeyer et al.
The New England journal of medicine, 370(6), 533-542 (2014-02-07)
Congenital disorders of glycosylation are genetic syndromes that result in impaired glycoprotein production. We evaluated patients who had a novel recessive disorder of glycosylation, with a range of clinical manifestations that included hepatopathy, bifid uvula, malignant hyperthermia, hypogonadotropic hypogonadism, growth...
Hany M El-Bassossy et al.
Journal of translational medicine, 13, 82-82 (2015-04-19)
We have previously shown that hyperuricemia plays an important role in the vascular complications of insulin resistance (IR). Here we investigated the effect of xanthine oxidase (XO) inhibition on the cardiac complications of IR. IR was induced in rats by...
L V Harmanchuk et al.
Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994), 59(2), 52-58 (2013-07-05)
The effect of mitokorrectine (complex native oligopeptides isolated from neonatal pig brain) on endothelial cells in culture was investigated. It was revealed that the drug concentration-dependently induces angiogenesis in vitro. Mitogen effect of Mitokorrectine was shown by MTT-test and routine...
Min-Kyung Kang et al.
Journal of molecular medicine (Berlin, Germany), 93(7), 759-772 (2015-06-13)
Renal fibrosis is a crucial event in the pathogenesis of diabetic nephropathy (DN). The process known as epithelial to mesenchymal transition (EMT) contributes to the accumulation of matrix proteins in kidneys, in which renal tubular epithelial cells play an important...
Karen V Ambrose et al.
Scientific reports, 5, 10939-10939 (2015-06-10)
Epichloë spp. are symbiotic fungal endophytes of many cool season grasses. The presence of the fungal endophytes often confers insect, drought, and disease tolerance to the host grasses. The presence of the fungal endophytes within the host plants does not...
Taha Haffar et al.
Biochemical and biophysical research communications, 459(1), 54-59 (2015-02-26)
Here we sought to evaluate the effect of palmitate on cytokine and PPAR activity/expression. We investigated the effect of BSA conjugated palmitate and oleate on PPAR activity, PPAR-α and δ expression, as well as the expression of cytokines and key...
Houda Banani et al.
International journal of food microbiology, 182-183, 1-8 (2014-05-24)
The yeast-like fungus Aureobasidium pullulans PL5 is a microbial antagonist against postharvest pathogens of fruits. The strain is able to produce hydrolases, including glucanases, chitinases and proteases. The alkaline serine protease gene ALP5 from A. pullulans was cloned, inserted into...
Emily Archer Slone et al.
Journal of leukocyte biology, 98(5), 791-804 (2015-07-29)
Multiple pathologic conditions, including hemorrhage, tumor angiogenesis, and ischemia-reperfusion events, will result in hypoxia and subsequent reperfusion. Previous studies have analyzed the lipid changes within whole tissues and indicated that ischemia-reperfusion altered tissue and cellular phospholipids. Using an in vitro...
Yuanyuan Wu et al.
Clinica chimica acta; international journal of clinical chemistry, 448, 133-138 (2015-06-24)
Rapidly increasing healthcare costs in economically advantaged countries are currently unsustainable, while in many developing nations, even 50-year-old technologies are too expensive to implement. New and unconventional technologies are being explored as solutions to this problem. In this study, we...
O Carolina Rojas et al.
Mycoses, 58(5), 267-272 (2015-03-03)
Chromoblastomycosis is a chronic granulomatous disease caused frequently by fungi of the Fonsecaea genus. The objective of this study was the phenotypic and molecular identification of F. pedrosoi strains isolated from chromoblastomycosis patients in Mexico and Venezuela. Ten strains were included...
Junlan Zhou et al.
The Journal of endocrinology, 225(3), 181-189 (2015-05-03)
Obesity is associated with insulin resistance and type 2 diabetes; molecular mechanisms that promote energy expenditure can be utilized for effective therapy. Src-associated in mitosis of 68 kDa (Sam68) is potentially significant, because knockout (KO) of Sam68 leads to markedly reduced...
Mitchell B Sally et al.
The journal of trauma and acute care surgery, 76(1), 62-68 (2013-12-26)
The appropriate level of glucose control in organ donors after neurologic determination of death (DNDD) remains uncertain. We hypothesized that a glucose target of 180 mg/dL would be appropriate for optimizing organ transplantation rates and outcomes. Demographic, critical care, organ...
Jun Huang et al.
International journal of biological macromolecules, 78, 165-172 (2015-04-15)
Starches were isolated from rhizomes of Curcuma longa, Canna edulis and Canna indica and bulbs of Lilium lancifolium, and showed a B-type X-ray diffraction pattern. Their physicochemical properties were investigated and compared. These starches showed significantly different granule morphologies and...
Tuomas Komulainen et al.
Toxicology, 331, 47-56 (2015-03-10)
Sodium valproate (VPA) is a potentially hepatotoxic antiepileptic drug. Risk of VPA-induced hepatotoxicity is increased in patients with mitochondrial diseases and especially in patients with POLG1 gene mutations. We used a HepG2 cell in vitro model to investigate the effect...
Jocelyn Campbell et al.
Ecology, 94(5), 1186-1195 (2013-07-19)
Foliose lichens with cyanobacterial bionts (bipartite and tripartite) form a distinct assemblage of epiphytes strongly associated with humid microclimatic conditions in inland British Columbia. Previous research showed that these cyano- and cephalolichen communities are disproportionately abundant and species-rich on conifer...
Hasbullah Daud et al.
New biotechnology, 33(1), 179-186 (2015-05-28)
An understanding of the metabolic profile of cell proliferation and differentiation should support the optimization of culture conditions for hematopoietic stem and progenitor cell (HSPC) proliferation, differentiation, and maturation into red blood cells. We have evaluated the key metabolic parameters...
Metabolic quirks yield tumour hope.
Heidi Ledford
Nature, 508(7495), 158-159 (2014-04-11)
Arnaud Béduneau et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 87(2), 290-298 (2014-04-08)
Standard monoculture models utilizing Caco-2 monolayers were extensively used to mimic the permeability of the human intestinal barrier. However, they exhibit numerous limitations such as the lack of mucus layer, an overestimation of the P-gp-mediated efflux and a low paracellular...
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