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J Erik Johnson et al.
Vaccine, 27(22), 2930-2939 (2009-05-12)
Recombinant vesicular stomatitis viruses (rVSVs) are being developed as potential HIV-1 vaccine candidates. To characterize the in vivo replication and dissemination of rVSV vectors in mice, high doses of a highly attenuated vector expressing HIV-1 Gag, rVSV(IN)-N4CT9-Gag1, and a prototypic
Gozde Uzunalli et al.
Acta biomaterialia, 22, 8-18 (2015-05-02)
Pancreatic islet transplantation is a promising treatment for type 1 diabetes. However, viability and functionality of the islets after transplantation are limited due to loss of integrity and destruction of blood vessel networks. Thus, it is important to provide a
Manuel Ingo Günther et al.
Acta biomaterialia, 27, 140-150 (2015-09-09)
Despite recent progress in enhancing axonal growth in the injured spinal cord, the guidance of regenerating axons across an extended lesion site remains a major challenge. To determine whether regenerating axons can be guided in rostrocaudal direction, we implanted 2mm
Minsook Ye et al.
BMC complementary and alternative medicine, 15, 227-227 (2015-07-15)
Many studies have demonstrated that repeated injections of nicotine can produce progressive increases in locomotor activity and enhanced expression of c-fos and tyrosine hydroxylase (TH) in brain dopaminergic areas. Paecilomyces japonica (PJ) is a herbal medicine that is commonly used
Yanqiu Geng et al.
Stem cell research & therapy, 5(3), 80-80 (2014-06-26)
The mortality of rhabdomyolysis-induced acute kidney injury (AKI) is still high, as there is no effective therapy. It has been shown that bone marrow-derived mesenchymal stem cells (MSCs) can induce M2 macrophages, which mediate MSC protection in other experimental inflammation-related
Pippa Kern et al.
Comparative biochemistry and physiology. Part A, Molecular & integrative physiology, 190, 75-82 (2015-09-27)
Temperature and ultraviolet radiation (UVR) are key environmental drivers that are linked in their effects on cellular damage. Exposure to both high temperatures and UVR can cause cellular damage that result in the up-regulation of common protective mechanisms, such as
Kyoung-Woon Kim et al.
Arthritis research & therapy, 17, 41-41 (2015-04-19)
C-reactive protein (CRP) is one of the biomarkers for the diagnosis and assessment of disease activity in rheumatoid arthritis (RA). CRP is not only the by-product of inflammatory response, but also plays proinflammatory and prothrombotic roles. The aim of this
Bong-Kyu Kim et al.
BMB reports, 48(6), 360-366 (2015-03-17)
Colorectal cancer (CRC), the third most common cancer worldwide, also has the highest rate of cancer-related morbidity and mortality. WNT signaling is initiated by binding of WNT to various receptors, including frizzleds (FZDs), and plays a critical role in CRC
Cristian E Poblete et al.
International journal of oncology, 44(3), 647-654 (2014-01-16)
Prostate cancer (PC) is a leading male oncologic malignancy wideworld. During malignant transformation, normal epithelial cells undergo genetic and morphological changes known as epithelial-mesenchymal transition (EMT). Several regulatory genes and specific marker proteins are involved in PC EMT. Recently, syndecans
Gi-Bang Koo et al.
Cell research, 25(6), 707-725 (2015-05-09)
Receptor-interacting protein kinase-3 (RIP3 or RIPK3) is an essential part of the cellular machinery that executes "programmed" or "regulated" necrosis. Here we show that programmed necrosis is activated in response to many chemotherapeutic agents and contributes to chemotherapy-induced cell death.
Henrieta Scholtzova et al.
Journal of neuroscience research, 86(12), 2784-2791 (2008-07-11)
Memantine, an N-methyl-D-aspartate (NMDA) receptor antagonist, has been shown to improve learning and memory in several preclinical models of Alzheimer's disease (AD). Memantine has also been shown to reduce the levels of amyloid beta (A beta) peptides in human neuroblastoma
S T Ward et al.
European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology, 40(6), 731-738 (2013-11-20)
Lysyl oxidase (LOX) expression is elevated in colorectal cancer (CRC) tissue and associated with disease progression. A blood test may form a more acceptable diagnostic test for CRC although LOX has not previously been measured in the serum. We therefore
Birgitte Grum-Schwensen et al.
BMC cancer, 15, 44-44 (2015-04-18)
The tumor microenvironment plays a determinative role in stimulating tumor progression and metastasis. Notably, tumor-stroma signals affect the pattern of infiltrated immune cells and the profile of tumor-released cytokines. Among the known molecules that are engaged in stimulating the metastatic
Abhijit A Patil et al.
Oncotarget, 5(15), 6414-6424 (2014-07-30)
Brain tumours kill more children and adults under 40 than any other cancer. Around half of primary brain tumours are glioblastoma multiforme (GBMs) where treatment remains a significant challenge, where survival rates have improved little over the last 40 years
Joan Antoni Fernández-Blanco et al.
Journal of Crohn's & colitis, 9(6), 463-476 (2015-03-31)
Mast cells [MCs] are implicated in epithelial barrier alterations that characterize inflammatory and functional bowel disorders. In this study, we describe mast cell proteinases [chymases and tryptases] and tight junction [TJ] proteins kinetics in a rat model of postinfectious gut
G P Burrai et al.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 36(11), 9083-9091 (2015-06-20)
Canine mammary tumors (CMTs) share many features with human breast cancer (HBC), specifically concerning cancer-related pathways. Although the human epidermal growth factor receptor 2 (HER2) plays a significant role as a therapeutic and prognostic biomarker in HBC, its relevance in
Sandra F Martins et al.
Cancer genomics & proteomics, 10(2), 55-67 (2013-04-23)
Colorectal cancer (CRC) is the third most common type of cancer and the fourth most frequent cause of cancer death. Literature indicates that vascular endothelial growth factor is a predominant angiogenic factor and that angiogenesis plays an important role in
Qian Zhang et al.
Oncotarget, 6(17), 15095-15110 (2015-05-07)
Colorectal cancer (CRC) is the third and second most common cancer in males and females worldwide, respectively. Spondin-2 is a conserved secreted extracellular matrix protein and a candidate cancer biomarker. Here we found that Spondin-2 mRNA was upregulated in CRC
M Rodríguez-Piñón et al.
Theriogenology, 84(5), 818-826 (2015-06-28)
The cervical collagen remodeling during the estrous cycle of the ewe was examined. The collagen concentration determined by a hydroxyproline assay and the area occupied by collagen fibers (%C), determined by van Gieson staining, were assessed in the cranial and
Luciana Armada et al.
Journal of endodontics, 41(8), 1281-1287 (2015-05-10)
The receptor activator of nuclear factor kappa B (RANK)-RANK ligand (RANKL)-osteoprotegerin (OPG) system is important in osteoclastogenesis and may play a role in the development of apical periodontitis. This immunohistochemical study evaluated the distribution of the expression of these regulators
He-Qin Zhan et al.
Human pathology, 46(3), 476-481 (2015-01-15)
Xp11.2 translocation renal cell carcinoma (Xp11.2 RCC) with PSF-TFE3 gene fusion is a rare neoplasm. Only 22 cases of Xp11.2 RCCs with PSF-TFE3 have been reported to date. We describe an additional case of Xp11.2 RCC with PSF-TFE3 showing melanotic
Shin Akakura et al.
Biochemical and biophysical research communications, 448(4), 461-466 (2014-05-08)
Instead of relying on mitochondrial oxidative phosphorylation, most cancer cells rely heavily on aerobic glycolysis, a phenomenon termed as "the Warburg effect". We considered that this effect is a direct consequence of damage which persists in cancer cells that recover
N Ouyang et al.
British journal of cancer, 102(12), 1753-1761 (2010-06-10)
Pregnane X receptor (PXR) is a nuclear receptor that regulates the metabolism and disposition of various xenobiotics and endobioitics. We investigated a novel PXR function in regulating colon tumourigenesis in this study. Histochemistry, transfection, cell proliferation assay, anchorage-alpha-dependent assay, xenograft
Baljit Singh et al.
Breast cancer research : BCR, 16(6), 463-463 (2014-11-12)
Estrogen inhibition is effective in preventing breast cancer in only up to 50% of women with precancerous lesions and many experience side effects that are poorly tolerated. As insulin-like growth factor I (IGF-I) underlies both estrogen and progesterone actions and
José Fernando Bastos Moura et al.
International journal of radiation biology, 91(6), 500-509 (2015-03-12)
To design a novel model to study Cobalt-60 (Co-60)-induced radiation mucositis and to describe the pathways involved in its development. Hamsters' cheeks were treated with Co-60 radiation (10, 20, 30 or 35 Gy). Three days later, oral mucosa scarification was
Stéphane Epelbaum et al.
Neurobiology of aging, 36(6), 2043-2052 (2015-04-12)
Amyloid-β (Aβ) oligomers are the suspected culprit as initiators of Alzheimer's disease (AD). However, their diffusion in the brain remains unknown. Here, we studied Aβ oligomers' dissemination and evaluated their in vivo toxicity. Wild-type mice were injected with 50 pmol
David C Montrose et al.
Prostaglandins & other lipid mediators, 116-117, 26-36 (2014-12-03)
Release of the free fatty acid arachidonic acid (AA) by cytoplasmic phospholipase A2 (cPLA2) and its subsequent metabolism by the cyclooxygenase and lipoxygenase enzymes produces a broad panel of eicosanoids including prostaglandins (PGs). This study sought to investigate the roles
YuTing Feeling Chen et al.
The American journal of pathology, 184(6), 1695-1705 (2014-04-17)
Development of novel strategies to treat noninfectious posterior uveitis is an ongoing challenge, in part because of limited availability of animal models that mimic the naturally occurring disease in humans. Mice deficient in the autoimmune regulatory gene Aire develop a
Andrés P Varani et al.
Neuropharmacology, 90, 90-101 (2014-12-06)
The nicotine (NIC) withdrawal syndrome is considered to be a major cause of the high relapse rate among individuals undergoing smoking cessation. The aim of the present study was to evaluate a possible role of GABAB receptors in NIC withdrawal
Carl Jorns et al.
Cell transplantation, 23(8), 1009-1018 (2014-09-10)
Hepatocyte transplantation is an upcoming treatment for patients with metabolic liver diseases. Repeated cell infusions over 1-2 days improve clinical outcome. Isolated hepatocytes are usually cold stored in preservation solutions between repeated infusions. However, during cold storage isolated hepatocytes undergo
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