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Shane Deegan et al.
Biochemical and biophysical research communications, 451(3), 367-373 (2014-08-03)
Cells respond to endoplasmic reticulum (ER) stress through the unfolded protein response (UPR), autophagy and cell death. In this study we utilized casp9(+/+) and casp9(-/-) MEFs to determine the effect of inhibition of mitochondrial apoptosis pathway on ER stress-induced-cell death
Moira C Vyner et al.
Acta biomaterialia, 31, 89-98 (2015-11-27)
Tissue cells are known to respond to the stiffness of the polymer substrate on which they are grown. It has been suggested that material stiffness influences the composition of the protein layer that adsorbs to the material surface, which affects
Astrid L Basse et al.
Scientific reports, 7(1), 4052-4052 (2017-06-24)
Brown adipose tissue takes up large amounts of glucose during cold exposure in mice and humans. Here we report an induction of glucose transporter 1 expression and increased expression of several glycolytic enzymes in brown adipose tissue from cold-exposed mice.
Xinxing Wang et al.
Journal of molecular and cellular cardiology, 129, 39-48 (2018-10-09)
TOMM40 is the channel-forming subunit of a translocase of the mitochondrial outer membrane (TOM) that is essential for protein transport into mitochondria. TOMM40 plays an important role in maintaining normal mitochondrial function. The correlation between occupational thermal exposure and mitochondria
Marta Toczek et al.
Nucleosides, nucleotides & nucleic acids, 37(11), 630-638 (2018-12-28)
Huntington's disease (HD) is a neurodegenerative disorder that is caused by expanded CAG repeats within the exon-1 of the huntingtin (HTT) gene. It has been shown that HTT interacts with the proteins involved in the gene transcription, endocytosis and metabolism
Yuki Nagata et al.
PloS one, 12(12), e0188821-e0188821 (2017-12-02)
Duchenne muscular dystrophy (DMD) is a severe X-linked recessive muscle disorder caused by mutations in the dystrophin gene. Nonetheless, secondary processes involving perturbation of muscle regeneration probably exacerbate disease progression, resulting in the fatal loss of muscle in DMD patients.
Dennie T Frederick et al.
PloS one, 9(7), e101286-e101286 (2014-07-02)
While response rates to BRAF inhibitiors (BRAFi) are high, disease progression emerges quickly. One strategy to delay the onset of resistance is to target anti-apoptotic proteins such as BCL-2, known to be associated with a poor prognosis. We analyzed BCL-2
Yipu Lin et al.
Influenza and other respiratory viruses, 11(3), 263-274 (2017-02-07)
Two new subclades of influenza A(H3N2) viruses became prominent during the 2014-2015 Northern Hemisphere influenza season. The HA glycoproteins of these viruses showed sequence changes previously associated with alterations in receptor-binding properties. To address how these changes influence virus propagation
Nicholas R Meyerson et al.
Cell host & microbe, 22(5), 627-638 (2017-11-07)
TRIM25 is an E3 ubiquitin ligase that activates RIG-I to promote the antiviral interferon response. The NS1 protein from all strains of influenza A virus binds TRIM25, although not all virus strains block the interferon response, suggesting alternative mechanisms for
Kazuhiro Ikeda et al.
Scientific reports, 7(1), 2850-2850 (2017-06-08)
Human pluripotent stem cells are a potentially powerful cellular resource for application in regenerative medicine. Because such applications require large numbers of human pluripotent stem cell-derived cells, a scalable culture system of human pluripotent stem cell needs to be developed.
Katheryn E Rothenberg et al.
Biophysical journal, 114(7), 1680-1694 (2018-04-12)
Cell migration is a complex process, requiring coordination of many subcellular processes including membrane protrusion, adhesion, and contractility. For efficient cell migration, cells must concurrently control both transmission of large forces through adhesion structures and translocation of the cell body
Takeshi Tsusaka et al.
Epigenetics & chromatin, 11(1), 56-56 (2018-10-06)
G9a and the related enzyme GLP were originally identified as histone lysine methyltransferases and then shown to also methylate several other non-histone proteins. Here, we performed a comprehensive screen to identify their substrates in mouse embryonic stem cells (mESCs). We
Hermanus Johannes Ruigrok et al.
Biophysical journal, 112(1), 87-98 (2017-01-12)
Multiplexed bioluminescence resonance energy transfer (BRET) assays were developed to monitor the activation of several functional transient receptor potential (TRP) channels in live cells and in real time. We probed both TRPV1 intramolecular rearrangements and its interaction with Calmodulin (CaM)
Daniel Martin et al.
Nature communications, 9(1), 2372-2372 (2018-07-10)
Dysregulation of the Hippo signaling pathway and the consequent YAP1 activation is a frequent event in human malignancies, yet the underlying molecular mechanisms are still poorly understood. A pancancer analysis of core Hippo kinases and their candidate regulating molecules revealed
Gabriel Scheubeck et al.
Viruses, 11(7) (2019-07-10)
Starvation sensitizes tumor cells to chemotherapy while protecting normal cells at the same time, a phenomenon defined as differential stress resistance. In this study, we analyzed if starvation would also increase the oncolytic potential of an oncolytic measles vaccine virus
Takayuki Sassa et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 32(6), 2966-2978 (2018-02-07)
Lipids secreted from the meibomian gland (meibum) form the superficial layer of the tear film and prevent water evaporation from the ocular surface and infection. Here, we identified the fatty acid (FA) elongases responsible for the synthesis of very long-chain
Alejandro Carnicer-Lombarte et al.
Journal of neural engineering, 14(3), 036012-036012 (2017-03-09)
High-density electrode arrays are a powerful tool in both clinical neuroscience and basic research. However, current manufacturing techniques require the use of specialised techniques and equipment, which are available to few labs. We have developed a high-density electrode array with
Daisuke Muramatsu et al.
Cell structure and function, 41(2), 145-152 (2016-10-14)
Pericentric regions form epigenetically organized, silent heterochromatin structures that accumulate histone H3 lysine 9 tri-methylation (H3K9me3) and heterochromatin protein 1 (HP1), a methylated H3K9-binding protein. At pericentric regions, Suv39h is the major enzyme that generates H3K9me3. Suv39h also interacts directly
Grace G Bushnell et al.
Cancer research, 79(8), 2042-2053 (2019-02-28)
For most cancers, metastasis is the point at which clinical treatment shifts from curative intent to extending survival. Biomaterial implants acting as a synthetic premetastatic niche recruit metastatic cancer cells and provide a survival advantage, and their use as a
Joao Fonseca et al.
Oncology letters, 17(1), 697-705 (2019-01-19)
Resveratrol (RES) is a polyphenol produced by certain plant species that has been well studied due to its ability to slow the growth of cancer cells. In numerous cell types and tissues, RES has been demonstrated to promote mitochondrial biogenesis
Toshimichi Tanaka et al.
Annals of surgical oncology, 26(5), 1401-1411 (2019-02-02)
Treatment-resistance genes limiting anticancer therapy have not been well clarified in colorectal cancer (CRC). We explored gene expression profiles to identify biomarkers for predicting treatment resistance to an anticancer drug in CRC. Six CRC cell lines were treated with phenylbutyrate
Frank Bunge et al.
Biomedical microdevices, 20(4), 98-98 (2018-11-11)
Microfluidic cell cultures are often used in academic research but only rarely in pharmaceutical research because of unsuitable designs, inappropriate choice of materials or incompatibility with standard equipment. In particular, microfluidic cell cultures to control the gaseous microenvironment rely on
Anna Pepe et al.
Scientific reports, 7(1), 3731-3731 (2017-06-18)
Shadoo (Sho), a member of prion protein family, has been shown to prevent embryonic lethality in Prnp
Jacqueline D Peda et al.
Disease models & mechanisms, 9(9), 1051-1061 (2016-08-05)
Polycystic kidney disease (PKD) is characterized by slow expansion of fluid-filled cysts derived from tubules within the kidney. Cystic expansion results in injury to surrounding parenchyma and leads to inflammation, scarring and ultimately loss of renal function. Macrophages are a
Jessica E Miller et al.
Scientific reports, 7(1), 17903-17903 (2017-12-22)
Endometriosis is a debilitating condition that is categorized by the abnormal growth of endometrial tissue outside the uterus. Although the pathogenesis of this disease remains unknown, it is well established that endometriosis patients exhibit immune dysfunction. Interleukin (IL)-33 is a
Susan Wagner et al.
Nucleic acids research, 44(22), 10772-10788 (2016-12-08)
The 12-subunit mammalian eIF3 is the largest and most complex translation initiation factor and has been implicated in numerous steps of translation initiation, termination and ribosomal recycling. Imbalanced eIF3 expression levels are observed in various types of cancer and developmental
Waldemar Schrimpf et al.
Methods (San Diego, Calif.), 140-141, 97-111 (2018-02-07)
Raster image cross-correlation spectroscopy (ccRICS) can be used to quantify the interaction affinities between diffusing molecules by analyzing the fluctuations between two-color confocal images. Spectral crosstalk compromises the quantitative analysis of ccRICS experiments, limiting multicolor implementations to dyes with well-separated
Suman Mukhopadhyay et al.
Cell cycle (Georgetown, Tex.), 14(20), 3331-3339 (2015-09-01)
mTOR - the mammalian/mechanistic target of rapamycin - has been implicated as a key signaling node for promoting survival of cancer cells. However, clinical trials that have targeted mTOR with rapamycin or rapamycin analogs have had minimal impact. In spite
Balamurugan Packialakshmi et al.
PloS one, 13(4), e0196277-e0196277 (2018-04-25)
Increases of the activity of mitochondrial electron transport chain generally lead to increases of production of ATP and reactive oxygen species (ROS) as by-products. MnSOD is the first line of defense against the stress induced by mitochondrial ROS. Our previous
Teodor E Yordanov et al.
Traffic (Copenhagen, Denmark), 20(9), 674-696 (2019-07-18)
Mechanisms that control lysosomal function are essential for cellular homeostasis. Lysosomes adapt in size and number to cellular needs but little is known about the underlying molecular mechanism. We demonstrate that the late endosomal/lysosomal multimeric BLOC-1-related complex (BORC) regulates the
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