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Sevil Köse et al.
Experimental hematology, 57, 30-41 (2017-10-17)
Granulocyte colony-stimulating factor (G-CSF) is a well-known hematopoietic stem cell (HSC)-mobilizing agent used in both allogeneic and autologous transplantation. However, a proportion of patients or healthy donors fail to mobilize a sufficient number of cells. New mobilization agents are therefore
Anne Heller et al.
Ecotoxicology and environmental safety, 173, 469-481 (2019-02-26)
Exposure to lanthanides (Ln) poses a serious health risk to animals and humans. Since Ln are mainly excreted with urine, we investigated the effect of La, Ce, Eu, and Yb exposure on renal rat NRK-52E and human HEK-293 cells for
Nathalie Meyer-Schaller et al.
Developmental cell, 48(4), 539-553 (2019-02-05)
Epithelial-mesenchymal transition (EMT) enables cells to gain migratory and invasive features underlined by major transcriptional and epigenetic reprogramming. However, most studies have focused on the endpoints of the EMT process, and the epistatic hierarchy of the transcriptional networks underlying EMT
Biswa Nath Sharma et al.
Antimicrobial agents and chemotherapy, 58(11), 6724-6734 (2014-08-27)
The human JC polyomavirus (JCPyV) causes the fatal demyelinating disease progressive multifocal leukoencephalopathy (PML). A growing number of patients with induced or acquired immunosuppression are at risk for infection, and no effective antiviral therapy is presently available. The widely used
Elisa Bacelo et al.
Nanomaterials (Basel, Switzerland), 9(4) (2019-04-11)
Rheumatoid arthritis (RA) is an autoimmune disease that affects the synovial cavity of joints, and its pathogenesis is associated with an increased expression of pro-inflammatory cytokines, namely tumour necrosis factor-alpha (TNF-α). It has been clinically shown to have an adequate
Xin Xie et al.
Journal of cellular physiology, 233(11), 8884-8895 (2018-06-01)
Signaling by the transforming growth factor-β (TGF-β) is an essential pathway regulating a variety of cellular events. TGF-β is produced as a latent protein complex and is required to be activated before activating the receptor. The mechanical force at the cell
Zlata Vershinin et al.
The Journal of biological chemistry, 291(13), 6786-6795 (2016-02-05)
Lysine methylation of non-histone proteins has emerged as a key regulator of many cellular functions. Although less studied than other post-translational modifications such as phosphorylation and acetylation, the number of known methylated non-histone proteins is rapidly expanding. We have identified
Camille Leonetti et al.
Molecular neurodegeneration, 12(1), 20-20 (2017-02-25)
The ability of oligodendrocyte progenitor cells (OPCs) to give raise to myelin forming cells during developmental myelination, normal adult physiology and post-lesion remyelination in white matter depends on factors which govern their proliferation, migration and differentiation. Tissue plasminogen activator (tPA)
Pablo García-Valtanen et al.
Autophagy, 10(9), 1666-1680 (2014-07-22)
It has not been elucidated whether or not autophagy is induced by rhabdoviral G glycoproteins (G) in vertebrate organisms for which rhabdovirus infection is lethal. Our work provides the first evidence that both mammalian (vesicular stomatitis virus, VSV) and fish
Chinthasagar Bastian et al.
Neurobiology of disease, 126, 47-61 (2018-06-27)
White matter (WM) is injured in most strokes, which contributes to functional deficits during recovery. Casein kinase 2 (CK2) is a protein kinase that is expressed in brain, including WM. To assess the impact of CK2 inhibition on axon recovery
Van Bac Dang et al.
Electrophoresis, 38(7), 977-982 (2016-12-18)
Microfluidic systems with modular components are attractive alternatives to monolithically integrated microfluidic systems because of their flexibility. In this study, we apply the modular concept on a water-head-pressure-driven microfluidic oscillator and obtain a widely tunable flow rate and fluidic switching
Debora Lia et al.
Journal of cell science, 131(12) (2018-06-01)
Accumulation of 8-oxoguanine (8-oxoG) in mitochondrial DNA and mitochondrial dysfunction have been observed in cells deficient for the DNA glycosylase OGG1 when exposed to oxidative stress. In human cells, up to eight mRNAs for OGG1 can be generated by alternative
Zhe A Cheng et al.
Advanced science (Weinheim, Baden-Wurttemberg, Germany), 6(2), 1800361-1800361 (2019-01-30)
While new biomaterials for regenerative therapies are being reported in the literature, clinical translation is slow. Some existing regenerative approaches rely on high doses of growth factors, such as bone morphogenetic protein-2 (BMP-2) in bone regeneration, which can cause serious
Victoria Gillan et al.
Frontiers in cellular and infection microbiology, 7, 452-452 (2017-12-07)
Resistance to anthelmintic drugs is a major problem in the global fight against parasitic nematodes infecting humans and animals. While previous studies have identified mutations in drug target genes in resistant parasites, changes in the expression levels of both targets
Stian Henriksen et al.
Journal of virology, 90(22), 10398-10413 (2016-10-30)
The minor capsid protein of human BK polyomavirus (BKPyV), VP2, and its N-terminally truncated form, VP3, are both important for viral entry. The closely related simian virus 40 (SV40) reportedly produces an additional truncated form of VP2/3, denoted VP4, apparently
Alan J Ryan et al.
Journal of anatomy, 227(6), 732-745 (2014-11-21)
Scaffolds which aim to provide an optimised environment to regenerate bone tissue require a balance between mechanical properties and architecture known to be conducive to enable tissue regeneration, such as a high porosity and a suitable pore size. Using freeze-dried
Marwa El Soury et al.
Frontiers in molecular neuroscience, 11, 157-157 (2018-06-06)
Peripheral nerves are characterised by the ability to regenerate after injury. Schwann cell activity is fundamental for all steps of peripheral nerve regeneration: immediately after injury they de-differentiate, remove myelin debris, proliferate and repopulate the injured nerve. Soluble Neuregulin1 (NRG1)
Jiayue Ling et al.
Bio-protocol, 10(8), e3585-e3585 (2021-03-05)
Fibrinolysis is an integral part of the matrix remodeling process that contributes to tissue repair. Fibrin clots are broken down during fibrinolysis in a controlled process. Fibrin degradation products (FDPs) have also been shown to have a role in the
Mohsen Rokni et al.
International immunopharmacology, 59, 295-300 (2018-04-21)
Murine hybridoma cells can produce monoclonal antibody (MAb) and the production of these antibodies in culture and peritoneum can be affected by different factors, including stimulants, inhibitors and supplements. Among these factors, the impact of micronutrients on the production of
Kazuki Suda et al.
Biochemical and biophysical research communications, 511(2), 434-439 (2019-02-25)
Misfolded and aggregated proteins are eliminated to maintain protein homeostasis. Autophagy contributes to the removal of protein aggregates. However, if and how proteotoxic stress induces autophagy is poorly understood. Here we show that proteotoxic stress after treatment with azetidine-2-carboxylic acid
Vito Rt Zanotelli et al.
Molecular systems biology, 16(12), e9798-e9798 (2020-12-29)
Cells react to their microenvironment by integrating external stimuli into phenotypic decisions via an intracellular signaling network. To analyze the interplay of environment, local neighborhood, and internal cell state effects on phenotypic variability, we developed an experimental approach that enables
Michelle H Teplensky et al.
Journal of the American Chemical Society, 139(22), 7522-7532 (2017-05-17)
Utilizing metal-organic frameworks (MOFs) as a biological carrier can lower the amount of the active pharmaceutical ingredient (API) required in cancer treatments to provide a more efficacious therapy. In this work, we have developed a temperature treatment process for delaying
M L Alves da Silva et al.
Journal of tissue engineering and regenerative medicine, 9(6), 714-723 (2013-10-25)
Paracrine signalling from chondrocytes has been reported to increase the synthesis and expression of cartilage extracellular matrix (ECM) by stem cells. The use of conditioned medium obtained from chondrocytes for stimulating stem cells chondrogenic differentiation may be a very interesting
Rossella Borghi et al.
Journal of clinical medicine, 10(13) (2021-07-03)
PCDH19-related epilepsy is a rare genetic disease caused by defective function of PCDH19, a calcium-dependent cell-cell adhesion protein of the cadherin superfamily. This disorder is characterized by a heterogeneous phenotypic spectrum, with partial and generalized febrile convulsions that are gradually
George R R Bell et al.
Nature communications, 12(1), 6148-6148 (2021-11-18)
During chemotaxis, neutrophils use cell surface G Protein Coupled Receptors to detect chemoattractant gradients. The downstream signaling system is wired with multiple feedback loops that amplify weak inputs and promote spatial separation of cell front and rear activities. Positive feedback could
c-Src kinase inhibits osteogenic differentiation via enhancing STAT1 stability.
Alvandi, et al.
PLoS ONE, 15, e0241646-e0241646 (2020)
Zay Yar Oo et al.
Molecular oncology, 13(7), 1503-1518 (2019-05-03)
Drugs such as gemcitabine that increase replication stress are effective chemotherapeutics in a range of cancer settings. These drugs effectively block replication and promote DNA damage, triggering a cell cycle checkpoint response through the ATR-CHK1 pathway. Inhibiting this signalling pathway
Charles J d'Adhemar et al.
PloS one, 9(6), e100816-e100816 (2014-07-01)
The prognosis of epithelial ovarian cancer is poor in part due to the high frequency of chemoresistance. Recent evidence points to the Toll-like receptor-4 (TLR4), and particularly its adaptor protein MyD88, as one potential mediator of this resistance. This study
Lynda Vuong et al.
Cancer research, 79(7), 1480-1492 (2019-01-25)
A combination therapy approach is required to improve tumor immune infiltration and patient response to immune checkpoint inhibitors that target negative regulatory receptors. Galectin-3 is a β-galactoside-binding lectin that is highly expressed within the tumor microenvironment of aggressive cancers and
Anthony Laugeray et al.
Neurotoxicity research, 33(1), 87-112 (2017-09-08)
We recently demonstrated that perinatal exposure to the glutamate-related herbicide, glufosinate ammonium, has deleterious effects on neural stem cell (NSC) homeostasis within the sub-ventricular zone (SVZ), probably leading to ASD-like symptoms in offspring later in life. In the present study
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