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Keyword:'d2438'
Showing 1-30 of 7671 results for "

d2438

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Szczepan Mogilski et al.
Pharmacology, biochemistry, and behavior, 133, 99-110 (2015-04-08)
The aim of this study was to evaluate the analgesic as well as anti-inflammatory activities of the new pyrrolo[3,4-d]pyridazinone derivatives. Moreover, the present study attempted to assess some of the mechanisms involved in the pharmacological activity of these compounds. In
Cristina Pavan et al.
Particle and fibre toxicology, 11, 76-76 (2014-12-20)
The hemolytic activity of inhaled particles such as silica has been widely investigated in the past and represents a usual toxicological endpoint to characterize particle reactivity despite the fact that red blood cells (RBCs) are not involved in the pathogenesis
Junqiang Li et al.
Advanced materials (Deerfield Beach, Fla.), 27(35), 5196-5202 (2015-08-08)
Organometal halide perovskite and poly(ethylene oxide) composite thin films are studied. Single-layer light-emitting diodes using the composite thin film sandwiched between indium tin oxide and indium-gallium eutectic alloy exhibit a low turn-on voltage and high brightness because of the ionic
Anne Scheffler et al.
Toxicology letters, 234(2), 81-91 (2015-02-24)
After consumption of red clover-based dietary supplements, plasma concentrations of the isoflavone irilone (IRI) equal that of the well-investigated daidzein. Since some isoflavones are genotoxic, the potential of IRI to induce mutations was investigated. Gene mutations were determined by hypoxanthine-guanine
Zhaoqiang Ding et al.
Materials science & engineering. C, Materials for biological applications, 48, 469-479 (2015-01-13)
A novel molecularly imprinted optosensing material based on multi-walled carbon nanotube-quantum dots (MWCNT-QDs) has been designed and synthesized for its high selectivity, sensitivity and specificity in the recognition of a target protein bovine serum albumin (BSA). Molecularly imprinted polymer coated
Katharina Mahal et al.
Experimental cell research, 336(2), 263-275 (2015-06-24)
Histone deacetylases (HDAC) which play a crucial role in cancer cell proliferation are promising drug targets. However, HDAC inhibitors (HDACi) modelled on natural hydroxamic acids such as trichostatin A frequently lead to resistance or even an increased agressiveness of tumours.
Ramon Weishaupt et al.
Biomacromolecules, 16(11), 3640-3650 (2015-09-29)
Controlled and efficient immobilization of specific biomolecules is a key technology to introduce new, favorable functions to materials suitable for biomedical applications. Here, we describe an innovative and efficient, two-step methodology for the stable immobilization of various biomolecules, including small
Mónica Boj et al.
Biology of reproduction, 93(2), 40-40 (2015-07-03)
In marine teleosts, such as the gilthead seabream, several aquaporin paralogs are known to be expressed during the hyperosmotic induction of spermatozoon motility in seawater. Here, we used immunological inhibition of channel function to investigate the physiological roles of Aqp1aa
Hwa Jun Cha et al.
Molecular medicine reports, 10(4), 1663-1670 (2014-07-30)
Ultraviolet (UV) radiation impairs intracellular functions by directly damaging DNA and by indirectly generating reactive oxygen species (ROS), which induce cell cycle arrest and apoptosis. UV radiation can also alter gene expression profiles, including those of mRNA and microRNA (miRNA).
Ji-Hye Yun et al.
Biochimica et biophysica acta, 1848(6), 1294-1302 (2015-03-11)
The melanocortin receptors (MCRs) are members of the G protein-coupled receptor (GPCR) 1 superfamily with seven transmembrane (TM) domains. Among them, the melanocortin-4 receptor (MC4R) subtype has been highlighted recently by genetic studies in obese humans. In particular, in a
Alexandra T K Lee et al.
Alcoholism, clinical and experimental research, 39(11), 2123-2133 (2015-10-16)
Chronic pancreatitis, a known complication of alcohol abuse, is characterized histopathologically by prominent fibrosis. Pancreatic stellate cells (PSCs) are responsible for producing this fibrous tissue in chronic pancreatitis and are activated by alcohol. Progression of alcoholic chronic pancreatitis (as assessed
Muyi Yang et al.
The Prostate, 75(13), 1363-1375 (2015-05-28)
The sex determing region Y-box 4 (SOX4) gene is a critical developmental transcriptional factor that is overexpressed in prostate cancer (PCa). While we and others have investigated the role of SOX4 overexpression in PCa, the molecular mechanism underlying its aberrant
Zhiqiang Chen et al.
Electromagnetic biology and medicine, 34(4), 309-316 (2014-05-27)
Magnetic nano-Fe3O4 particles (MNPs), static magnetic field (SMF) and extremely low-frequency altering electric magnetic field (ELFF) were utilized to treat nude mice loading hepatoma Bel-7402 cell lines to investigate the therapeutic values of MNPs combined with ELFF in vivo. Magnetic
Jaime Pei Pei Foong et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(18), 7106-7115 (2015-05-08)
Acetylcholine-activating pentameric nicotinic receptors (nAChRs) are an essential mode of neurotransmission in the enteric nervous system (ENS). In this study, we examined the functional development of specific nAChR subtypes in myenteric neurons using Wnt1-Cre;R26R-GCaMP3 mice, where all enteric neurons and
Jan Zitko et al.
Bioorganic & medicinal chemistry, 23(1), 174-183 (2014-12-03)
Substitution of chlorine in 5-chloro-N-phenylpyrazine-2-carboxamide (1) with simple n-alkylamines yielded a series of 5-alkylamino-N-phenylpyrazine-2-carboxamides (propylamino to octylamino derivatives), which possessed similar or increased activity against Mycobacterium tuberculosis H37Rv compared to parent 5-chloro derivative (1), with MIC ranging from 2.5 to
Lianghua Ding et al.
Apoptosis : an international journal on programmed cell death, 19(8), 1269-1280 (2014-05-23)
Baicalein is a new drug that has shown promising anti-cancer effects against a broad spectrum of tumors. However, the potential effect on osteosarcoma cells and the mechanisms involved are still largely unknown. Resistance to chemotherapy remains a major obstacle in
Chunhua Wan et al.
Toxicology and applied pharmacology, 281(3), 294-302 (2014-12-03)
Chronic exposure to excessive manganese (Mn) has been known to lead to neuronal loss and a clinical syndrome resembling idiopathic Parkinson's disease (IPD). p53 plays an integral role in the development of various human diseases, including neurodegenerative disorders. However, the
Kiyotada Naitou et al.
Scientific reports, 5, 12623-12623 (2015-07-29)
Chronic abdominal pain in irritable bowel syndrome (IBS) usually appears in combination with disturbed bowel habits, but the etiological relationship between these symptoms remains unclear. Noradrenaline is a major neurotransmitter controlling pain sensation in the spinal cord. To test the
Christabelle J Darcy et al.
Critical care (London, England), 18(4), R163-R163 (2014-08-03)
Impaired T cell function in sepsis is associated with poor outcome, but the mechanisms are unclear. In cancer, arginase-expressing myeloid derived suppressor cells (MDSCs) deplete arginine, impair T cell receptor CD3 zeta-chain expression and T cell function and are linked
Lucas Daniel Trucco et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 28(12), 5262-5276 (2014-09-13)
KLF6 is a member of the Krüppel-like factor family of transcription factors, with diverse roles in the regulation of cell physiology, including proliferation, signal transduction, and apoptosis. Mutations or down-regulation of KLF6 have been described in several human cancers. In
Gabriela Martínez-Revollar et al.
Experimental cell research, 339(1), 67-80 (2015-10-11)
The lack of a successful treatment for triple-negative breast cancer demands the study of the heterogeneity of cells that constitute these tumors. With this aim, two clones from triple negative breast MDA-MB-231 cancer cells were isolated: One with fibroblast-like appearance
Yoshihiro Okita et al.
Oncology reports, 34(2), 639-647 (2015-06-18)
Studies of tumor-infiltrating immune cells have revealed that immune escape plays an important role in tumor growth. The aim of the present study was to investigate the impact of metastasis affecting CD4+ T cell subsets in human clinical samples. Single-cell
Emmanuel Ampofo et al.
Marine drugs, 13(11), 6774-6791 (2015-11-17)
The marine-derived kinase inhibitor fascaplysin down-regulates the PI3K pathway in cancer cells. Since this pathway also plays an essential role in platelet signaling, we herein investigated the effect of fascaplysin on thrombosis. Fascaplysin effects on platelet activation, platelet aggregation and
Ying Gao et al.
Journal of ethnopharmacology, 169, 24-33 (2015-04-12)
Paeonia suffruticosa Andrews (PSE) is a well-known Chinese medicine that has been widely used as an anti-tumor, anti-oxidative and anti-inflammatory agent. cis- and trans-gnetin H are two resveratrol oligomers isolated from the seeds of PSE. Although resveratrol is widely considered
T Sato et al.
Oncogene, 33(42), 5028-5038 (2014-04-22)
Relapse of chronic myeloid leukemia (CML) is triggered by stem cells with a reconstituting capacity similar to that of hematopoietic stem cells (HSCs) and CML stem cells are a source of resistance in drug therapy with tyrosine kinase inhibitors (TKIs).
Andrew W Lee et al.
Journal of virology, 82(7), 3702-3712 (2008-01-25)
Despite extensive evidence of cell signaling alterations induced by human immunodeficiency virus type 1 (HIV-1) in vitro, the relevance of these changes to the clinical and/or immunologic status of HIV-1-infected individuals is often unclear. As such, mapping the details of
John P Alao et al.
BMC cancer, 14, 853-853 (2014-11-21)
The RET tyrosine kinase receptor has emerged as a target in thyroid and endocrine resistant breast cancer. We previously reported the synthesis of kinase inhibitors with potent activity against RET. Herein, we have further investigated the effect of the lead
Ming Chen et al.
Medical mycology, 53(2), 194-198 (2015-01-22)
In this study, we investigate the susceptibility of Candida albicans, Candida glabrata, Candida krusei, Candida parapsilosis, Candida tropicalis, and Aspergillus fumigatus using the EUCAST microdilution minimum inhibitory concentration (MIC) method (final tea supernatant concentration range 5.0-0.005 mg/ml) to 23 different
Wufu Zhu et al.
Bioorganic & medicinal chemistry, 22(24), 6746-6754 (2014-12-04)
A series of 7,8-dihydro-5H-thiopyrano[4,3-d]pyrimidine derivatives (7a-q, 10a-q) were designed, synthesized and their chemical structures were confirmed by 1H NMR, 13C NMR, MS and HRMS spectrum.All the compounds were evaluated for the inhibitory activity against mTOR kinase at 10 μM level.
Wenjuan Wu et al.
International journal of molecular medicine, 36(4), 1104-1110 (2015-08-12)
Human immediate early response 2 (IER2) has been characterized as a putative nuclear protein that functions as a transcription factor or transcriptional co‑activator in the regulation of cellular responses, and may be involved in the regulation of tumor progression and metastasis.
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