Search Within
Applied Filters:
Showing 1-30 of 561 results for "


" within Papers
Wei-Feng Zheng et al.
Journal of cellular biochemistry, 120(6), 10748-10755 (2019-02-06)
The clinical use of doxorubicin (DOX) is limited by its toxic effect. However, there is no specific drug that can prevent DOX-related cardiac injury. C1qTNF-related protein-6 (CTRP6) is a newly identified adiponectin paralog with many protective functions on metabolism and
Yeyan Qiu et al.
Journal of nanoscience and nanotechnology, 13(8), 5935-5941 (2013-07-26)
Self-assembled nanoparticles were synthesized from water-soluble fructose-chitosan, substituted by succinyl linkages with phytosterols as hydrophobic moieties for self-assembly. The physicochemical properties of the prepared self-assembled nanoparticles were characterized by Fourier transform infrared spectroscopy, fluorescence spectroscopy, and transmission electron microscopy. Doxorubicin
J P Bilello et al.
Antimicrobial agents and chemotherapy, 58(8), 4431-4442 (2014-05-29)
The hepatitis C virus (HCV) nonstructural 5A (NS5A) protein is a clinically validated target for drugs designed to treat chronic HCV infection. This study evaluated the in vitro activity, selectivity, and resistance profile of a novel anti-HCV compound, samatasvir (IDX719)
Yusuke Minami et al.
Cancer science, 105(9), 1152-1159 (2014-07-06)
MicroRNA (miRNA) can function as tumor suppressors or oncogenes, and also as potential specific cancer biomarkers; however, there are few published studies on miRNA in synovial sarcomas, and their function remains unclear. We transfected the OncomiR miRNA Precursor Virus Library
Varsha Sharma et al.
Materials science & engineering. C, Materials for biological applications, 56, 393-400 (2015-08-08)
In this study, we have examined the encapsulation and release of hydrophilic and hydrophobic drugs in self-degrading niosomes as a unique method for anticancer therapy. Niosomes were prepared by amphiphilic self-assembly of Tween 80 and cholesterol through film hydration method.
Mopei Wang et al.
Thoracic cancer, 10(4), 918-929 (2019-03-19)
Delanzomib, a novel proteasome inhibitor, has demonstrated promising efficacy and antitumor ability in human multiple myeloma cell lines and patient-derived cells. However, the potential therapeutic effects of delanzomib on breast cancer remain unknown. In this study, we show that delanzomib
Nehal A Hamdy et al.
Acta poloniae pharmaceutica, 70(6), 987-1001 (2014-01-05)
2-Acetyl-5,6,7,8-tetrahydronaphthalene (1) was allowed to react with different aromatic aldehydes to produce the cyanopyridones 2a and 2b, which were treated with phosphorous pentasulfide to afford the corresponding thioxopyridine derivatives 3a and 3b, respectively. The reaction of 3a and 3b with
Somkamol Manchun et al.
Carbohydrate polymers, 126, 222-230 (2015-05-03)
Efficacy of doxorubicin (DOX) in colorectal cancer treatment is limited by undesirable side-effects, which are partially due to nonspecific delivery DOX to the tumor target site. This study aimed to develop pH-responsive dextrin nanogels (DNGs) as anticancer drug carriers with
Akshaya Kumar Swain et al.
ACS applied materials & interfaces, 7(15), 8013-8022 (2015-03-31)
In light of the growing interest in the search for cheap and effective solutions for cancer treatment, we report a simple one pot synthesis of polymer stabilized iron oxide-graphene (PIG) that could be realized on a large scale. The structural
Jing Zhao et al.
Oncotarget, 6(3), 1769-1778 (2015-01-17)
This study explored combinational anticancer therapy using α-helical peptides HPRP-A1/HPRP-A2 with the chemical drugs doxorubicin (DOX) and epirubicin (EPI). The in vitro activity of these drugs against different cancer cell lines was synergistically increased, as was their activity in a
Giulia Ruozi et al.
Nature communications, 6, 7388-7388 (2015-06-13)
Functional screening of expression libraries in vivo would offer the possibility of identifying novel biotherapeutics without a priori knowledge of their biochemical function. Here we describe a procedure for the functional selection of tissue-protective factors based on the in vivo
Yao-Fu Zeng et al.
Bioorganic & medicinal chemistry letters, 22(5), 1922-1925 (2012-02-10)
A series of tetracyclic diterpenoids bearing the α-methylenelactone group have been synthesized and screened for their in vitro anti-tumor activities against six human cancer cell lines. The results showed that compounds 1c, 2a and 2b exhibited significant cytotoxicity superior to
Jeremy Kress et al.
Biomedical optics express, 6(9), 3546-3555 (2015-09-30)
The efficacy of chemotherapy is related, in large part, to the concentration of drug that reaches tumor sites. Doxorubicin (DOX) is a common anti-cancer drug that is also approved for use in liposomal form for the treatment of ovarian cancer.
Maharajan Sivasubramanian et al.
Journal of nanoscience and nanotechnology, 13(11), 7271-7278 (2013-11-20)
The carboxymethyl dextran-y-cyclodextrin (CMD-yCD) conjugate was prepared as the carrier for the delivery of the poorly water-soluble anticancer drug, doxorubicin (DOX). The conjugate could form self-assembled nanoparticles (315 nm in diameter) in an aqueous solution, which might be due to
Silvia Damian et al.
Oncology, 84(6), 371-377 (2013-05-29)
The effectiveness of palonosetron without delayed dexamethasone dosing against emesis was investigated in patients scheduled to receive the corticosteroid-containing combination of doxorubicin and paclitaxel (AT) for 3 cycles. Chemo-naïve women with breast cancer receiving doxorubicin (60 mg/m(2)) and paclitaxel (200
Arthur H Cheng et al.
Cell reports, 26(12), 3191-3202 (2019-03-21)
Clock neurons within the mammalian suprachiasmatic nuclei (SCN) encode circadian time using interlocked transcription-translation feedback loops (TTFLs) that drive rhythmic gene expression. However, the contributions of other transcription factors outside of the circadian TTFLs to the functionality of the SCN
Fabrice Jardin et al.
Blood, 121(22), 4433-4434 (2013-06-01)
In this issue of Blood, Li et al report mutations in the 3′ untranslated region (3′UTR) of TP53 that modify the expression of p53 and thus its effect on response to therapy in diffuse large B-cell lymphoma (DLBCL) patients.
Noha M Saeed et al.
Biochemical pharmacology, 95(3), 145-155 (2015-02-24)
Doxorubicin (DOX) is a widely used chemotherapeutic agent however its clinical use is limited by cumulative cardiotoxicity. Epigallocatechin-3-gallate (EGCG), a main catechin in green tea, possesses a potent antioxidant, anti-apoptotic and anticancer properties. The current study aimed to investigate the
Lei Zhang et al.
PloS one, 9(10), e109814-e109814 (2014-10-07)
Unlike Western medicine that generally uses purified compounds and aims to target a single molecule or pathway, traditional Chinese medicine (TCM) compositions usually comprise multiple herbs and components that are necessary for efficacy. Despite the very long-time and wide-spread use
Golam Kibria et al.
Biological & pharmaceutical bulletin, 37(12), 1926-1935 (2014-12-03)
Multi-drug resistance (MDR) of cancers to chemotherapy including doxorubicin (DOX) is mediated by several factors. To design an effective therapy for the treatment of chemotherapy-resistant cancers, it is essential to explore the elements responsible for mediating MDR. However, exploring these
In vitro study of anticancer drug doxorubicin in PLGA-based microparticles
Lin R, et al.
Biomaterials, 26(21), 4476-4485 (2005)
Rui-Rui Zheng et al.
Oncology reports, 32(6), 2719-2725 (2014-10-02)
Breast cancer is the most frequently diagnosed cancer and the leading cause of cancer-related mortality in females worldwide. The efficacy of chemotherapeutic drugs on breast cancer is hindered by many factors, including that cancer stem-like side population (SP) cells may
Ashwani Koul et al.
Indian journal of experimental biology, 52(4), 323-331 (2014-04-30)
Doxorubicin (DOX) treatment (12 microg/g body weight, once a week for 2 weeks) resulted in a significant decrease in the heart rate along with an increase in QRS, ST, and QT intervals. Histopathological studies showed cardiomyocyte degeneration, cytoplasmic vacuolation and
Arjun Basnet et al.
Bioorganic & medicinal chemistry letters, 20(1), 42-47 (2009-12-04)
For the development of novel antitumor agents, 2,6-dithienyl-4-furyl pyridine derivatives were prepared and evaluated for their topoisomerase I and II inhibitory activity as well as cytotoxicity against several human cancer cell lines. Among the 21 prepared compounds, compound 24 exhibited
Kui Shin Voo et al.
International journal of cancer, 135(12), 2834-2846 (2014-04-29)
Immunotherapeutic strategies are promising approaches for the treatment of follicular lymphoma (FL). However, their efficacy may be limited by immunosuppressive elements in the immune system and tumor microenvironment. Therefore, strategies to reverse the effects of the immunosuppressive elements are needed.
Iman S Ahmed et al.
Drug development and industrial pharmacy, 41(3), 375-381 (2013-12-07)
The administration of grapefruit juice (GFJ) has been postulated to inhibit the activity of P-glycoprotein (P-gp) transport system and thus can enhance the uptake of substrate drugs. However, for various reasons, the results obtained have been always swaying between confirmation
Ahmed Kamal et al.
Bioorganic & medicinal chemistry letters, 21(1), 350-353 (2010-12-15)
An efficient one-pot iodination methodology for the synthesis of benzothiazolo-4β-anilino-podophyllotoxin (5a-h) and benzothiazolo-4β-anilino-4-O-demethylepipodophyllotoxin (6a-h) congeners has been successfully developed by using zirconium tetrachloride/sodium iodide. Interestingly, this protocol demonstrates enhancement of stereoselectivity apart from the improvement in the yields in comparison
Satyanarayana R Pondugula et al.
Biochemical and biophysical research communications, 460(4), 1002-1007 (2015-04-08)
Lymphoma is the most common hematopoietic tumor in dogs and humans, with similar pathogenesis and therapeutic responses. Anticancer drugs like vincristine (VCR) and doxorubicin (DOX) are often used in treating lymphoma. However, the cure rate is generally poor due to
Ahmed Kamal et al.
European journal of medicinal chemistry, 45(9), 3870-3884 (2010-06-18)
A series of new cinnamido-pyrrolo[2,1-c][1,4]benzodiazepine conjugates (4a-d and 5a-d) and their dimers (6a-d) have been designed, synthesized and evaluated for their biological activity. The anticancer screening of compound 4a by the NCI exhibited significant GI50 values ranging from 68 to
Imam Bakhsh Baloch et al.
European journal of medicinal chemistry, 43(2), 274-281 (2007-05-22)
Nine (1-8 and 10) new and two (9 and 11) known compounds have been isolated from roots of Euphorbia cornigera Boiss. Their structure and relative stereochemistry were acquired through NMR ((1)H, (13)C, COSY-45, HOHAHA, HMQC, HMBC, NOE and HMBC) spectroscopic
Page 1 of 19
Page 1 of 19