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D García-Párraga et al.
Diseases of aquatic organisms, 111(3), 191-205 (2014-10-17)
Decompression sickness (DCS), as clinically diagnosed by reversal of symptoms with recompression, has never been reported in aquatic breath-hold diving vertebrates despite the occurrence of tissue gas tensions sufficient for bubble formation and injury in terrestrial animals. Similarly to diving
Nikolaos Tsotakos et al.
American journal of physiology. Lung cellular and molecular physiology, 308(1), L58-L75 (2014-10-19)
Surfactant protein A (SP-A), a molecule with roles in lung innate immunity and surfactant-related functions, is encoded by two genes in humans: SFTPA1 (SP-A1) and SFTPA2 (SP-A2). The mRNAs from these genes differ in their 5'-untranslated regions (5'-UTR) due to
Iben B Pedersen et al.
Acta ophthalmologica, 93(2), 172-177 (2014-08-19)
To compare the frequency of rejection and graft failure after Descemet's stripping automated endothelial keratoplasty (DSAEK) and penetrating keratoplasty (PK) for secondary endothelial failure. Seventy-eight eyes undergoing DSAEK from 2006 to 2013 and 80 eyes undergoing PK from 1998 to
Yoko Watanabe et al.
Toxicology and applied pharmacology, 282(2), 119-128 (2014-12-22)
Benzophenone-3 (2-hydroxy-4-methoxybenzophenone; BP-3) is widely used as sunscreen for protection of human skin and hair from damage by ultraviolet (UV) radiation. In this study, we examined the metabolism of BP-3 by rat and human liver microsomes, and the estrogenic and
Zhitao Wang et al.
Cancer immunology, immunotherapy : CII, 64(3), 389-399 (2014-12-31)
Myeloid-derived suppressor cells (MDSCs) are heterogeneous, immature, myeloid progenitor cells, which suppress immune responses against tumors. CD14(+)HLA-DR(-/low) monocytic MDSCs (M-MDSC) are increased in patients suffering from multiple myeloma (MM). However, the frequency and function of M-MDSCs with the relationship between
Kannika Adthapanyawanich et al.
Archives of oral biology, 60(2), 320-332 (2014-12-02)
In the submandibular gland (SMG) of mice, the granular convoluted tubule (GCT) develops preferentially in males dependent on androgens. To clarify the molecular mechanism of androgen action in SMG, we examined the SMG of mice deficient for the androgen receptor
Tae Wook Nam et al.
Acta orthopaedica Belgica, 79(2), 211-215 (2013-07-05)
The authors compared the effect of postoperative administration of corticosteroids (dexamethasone) on prevertebral soft tissue swelling with that of placebo in patients with anterior cervical discectomy and fusion (ACDF). Sixty-two consecutive patients with degenerative disc disease of the cervical spine
[New and old medications for croup and seizures in children. Oral dexamethasone and buccal midazolam may provide better treatment].
Axelsson Inge et al.
Lakartidningen, 110(48), 2163-2163 (2014-01-18)
Tomoyuki Kawase et al.
Journal of biomedical materials research. Part B, Applied biomaterials, 102(6), 1289-1296 (2014-01-23)
An atmospheric-pressure plasma (APP) treatment was recently reported to render titanium (Ti) surfaces more suitable for osteoblastic cell proliferation and osteogenesis. However, the mechanism of action remains to be clearly demonstrated. In this study, we focused on cell adhesion and
Wanderley Marques Bernardo et al.
Revista da Associacao Medica Brasileira (1992), 59(4), 387-391 (2013-07-23)
To verify the efficacy of dexamethasone in the prophylaxis of nausea and vomiting in patients submitted to laparoscopic cholecystectomy. This was a systematic review of the literature through the MEDLINE, Embase, and LILACS databases. Only controlled and randomized clinical trials
Katherina Katsirntaki et al.
Tissue engineering. Part A, 21(3-4), 669-682 (2014-10-16)
Respiratory progenitors can be efficiently generated from pluripotent stem cells (PSCs). However, further targeted differentiation into bronchoalveolar sublineages is still in its infancy, and distinct specifying effects of key differentiation factors are not well explored. Focusing on airway epithelial Clara
Md Mesbah Uddin Ansary et al.
Inflammatory bowel diseases, 20(12), 2308-2320 (2014-10-31)
Apoptosis is a programmed physiological death of unwanted cells, and handling of apoptotic cells (ACs) is thought to have profound effects on immune-mediated disorders. However, there is scant information regarding the role of ACs in intestinal inflammation, in which immune
Silin Pang et al.
PloS one, 9(5), e98283-e98283 (2014-05-24)
Chronic stress can affect skin function, and some skin diseases might be triggered or aggravated by stress. Stress can activate the central hypothalamic-pituitary-adrenocortical (HPA) axis, which causes glucocorticoid levels to increase. The skin has HPA axis elements that react to
Bjoern Wagner et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 68, 68-77 (2014-12-17)
Here we present a miniaturized assay, referred to as Carrier-Mediated Distribution System (CAMDIS) for fast and reliable measurement of octanol/water distribution coefficients, log D(oct). By introducing a filter support for octanol, phase separation from water is facilitated and the tendency
M Carme Coll Ferrer et al.
PloS one, 9(7), e102329-e102329 (2014-07-16)
Lysozyme dextran nanogels (NG) have great potential in vitro as a drug delivery platform, combining simple chemistry with rapid uptake and cargo release in target cells with "stealth" properties and low toxicity. In this work, we study for the first
Jun Jin et al.
Journal of bioscience and bioengineering, 118(5), 593-598 (2014-06-05)
The main requirements for successful tissue engineering of the bone are non-immunogenic cells with osteogenic potential and a porous biodegradable scaffold. The purpose of this study is to evaluate the potential of a silk fibroin/hydroxyapatite (SF/HA) porous material as a
Fernando P Conte et al.
Molecules (Basel, Switzerland), 20(2), 2636-2657 (2015-02-06)
Gedunin, a natural limonoid from Meliaceae species, has been previously described as an antiinflammatory compound in experimental models of allergic inflammation. Here, we report the antiinflammatory and antinociceptive effects of gedunin in an acute model of articular inflammation induced by
Jung-Chun Lin et al.
PloS one, 10(3), e0121365-e0121365 (2015-03-24)
Carbon tetrachloride (CCl4) is widely used as an animal model of hepatotoxicity and the mechanisms have been arduously studied, however, the contribution of the sympathetic nervous system (SNS) in CCl4-induced acute hepatotoxicity remains controversial. It is also known that either
Linda M Kock et al.
Journal of biomechanics, 47(9), 2122-2129 (2013-12-03)
Flow-perfusion is being promoted as a way to grow tissue-engineered cartilage in vitro. Yet, there is a concern that flow-perfusion may induce unwanted mechanical effects on chondrogenesis and terminal differentiation. Therefore, the aim of this study is to evaluate the
P Svenningsen et al.
Acta physiologica (Oxford, England), 212(2), 166-174 (2014-06-11)
In the renal collecting ducts, ATP stimulates a Ca(2+) -activated chloride current. The identity of the channel responsible for the current under physiological conditions is not known and it was hypothesized that TMEM16a is a relevant candidate in the renal
Shaji K Kumar et al.
The Lancet. Oncology, 15(13), 1503-1512 (2014-12-03)
The combination of bortezomib, lenalidomide, and dexamethasone is a highly effective therapy for newly diagnosed multiple myeloma. Ixazomib is an investigational, oral, proteasome inhibitor with promising anti-myeloma effects and low rates of peripheral neuropathy. In a phase 1/2 trial we
Y Shetzer et al.
Cell death and differentiation, 21(9), 1419-1431 (2014-05-17)
p53 loss of heterozygosity (p53LOH) is frequently observed in Li-Fraumeni syndrome (LFS) patients who carry a mutant (Mut) p53 germ-line mutation. Here, we focused on elucidating the link between p53LOH and tumor development in stem cells (SCs). Although adult mesenchymal
Brian A Williams et al.
Pain medicine (Malden, Mass.), 16(1), 186-198 (2014-10-24)
The use of adjuvants in regional anesthesia has increased. However, there are knowledge gaps pertaining to 1) in vivo local tissue effects of these adjuvants; and 2) chemical compatibility and solubility of these drugs in solution with each other and
Jianfeng Zhang et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 35(3), 1219-1229 (2015-03-15)
Transplantation of bone-marrow derived stem/progenitor cells has an established therapeutic effect on cardiac muscle repair after injury. However, the exact mechanism that underlies this phenomenon is not completely understood. Here we transplanted mesenchymal stem cells (MSCs), a major population from
Natalie A Twine et al.
Bone, 67, 23-32 (2014-07-02)
The phenotype of osteoblastic (OB) cells in culture is currently defined using a limited number of markers of low sensitivity and specificity. For the clinical use of human skeletal (stromal, mesenchymal) stem cells (hMSC) in therapy, there is also a
Sanjay Mahant et al.
Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 150(5), 872-879 (2014-02-05)
To determine whether dexamethasone use in children undergoing tonsillectomy is associated with increased risk of postoperative bleeding. Retrospective cohort study using a multihospital administrative database. Thirty-six US children's hospitals. Children undergoing same-day tonsillectomy between the years 2004 and 2010. We
Alice Pievani et al.
Cytotherapy, 16(7), 893-905 (2014-05-06)
Cord blood (CB) and amniotic fluid (AF) could represent new and attractive mesenchymal stromal cell (MSC) sources, but their potential therapeutic applications are still limited by lack of standardized protocols for isolation and differentiation. In particular, chondrogenic differentiation has never
Fuyuko Koibuchi et al.
Biological & pharmaceutical bulletin, 37(7), 1241-1247 (2014-07-06)
Emerging evidence indicates that stress hormone glucocorticoids (GC) are an important modulator of brain development and function. To investigate whether GCs modulate neurosteroid biosynthesis in neural cells, we studied the effects of GCs on steroidogenic gene expression in human glioma
Peng Deng et al.
Biochemical and biophysical research communications, 458(1), 123-127 (2015-02-01)
Mammalian cysteine dioxygenase type 1 (CDO1) is an essential enzyme for taurine biosynthesis and the biodegradation of toxic cysteine. As previously suggested, Cdo1 may be a marker of liposarcoma progression and adipogenic differentiation, but the role of Cdo1 in adipogenesis
B Kempisty et al.
Journal of biological regulators and homeostatic agents, 28(3), 419-431 (2014-10-16)
The process of granulosa cell luteinization is part of the main process determining growth, differentiation and proliferation of these cells. Although the mechanisms underlying the regulation of luteinizing hormone receptor (LHR), follicle stimulating hormone receptor (FSHR) and cytochrome P450 aromatase
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