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P S Singh et al.
The Journal of the Association of Physicians of India, 60, 57-58 (2013-02-15)
Plasmodium falciparum is a malarial infection with high morbidity and wide spectrum of atypical presentation. Here we report an unusual presentation of malaria as tetany with alteration in calcium,phosphate and magnesium metabolism Hypocalcaemia in malaria can cause prolonged Q-Tc interval
Zaidoon Al-Jaderi et al.
Toxins, 7(11), 4730-4744 (2015-11-19)
Experimental autoimmune encephalomyelitis (EAE) is a CD4⁺ T cell mediated inflammatory demyelinating disease that is induced in mice by administration of peptides derived from myelin proteins. We developed EAE in SJL mice by administration of PLP139-151 peptide. The effect of
Dae-Jung Kang et al.
Biotechnology letters, 37(9), 1895-1904 (2015-05-23)
Resting cells of Pseudonocardia sp. KCTC 1029BP were used for the bioconversion of vitamin D3 to calcifediol which is widely used to treat osteomalacia and is industrially produced by chemical synthesis. To obtain the maximum bioconversion yield of calcifediol by
Mei Ding et al.
Experimental and therapeutic medicine, 8(6), 1737-1744 (2014-11-06)
Xuezhikang (XZK), an extract of red yeast rice, has been widely used for the management of hyperlipidemia and coronary heart disease (CHD); however, the effects of XZK treatment on kidney injury have not yet been fully identified. The aim of
Larissa DeDea
JAAPA : official journal of the American Academy of Physician Assistants, 26(10), 10-10 (2013-11-10)
Treating patients who are vitamin D deficient can be challenging. This article describes various formulations of vitamin D and their indications.
Valerie Hemmings
The practising midwife, 16(7), 16-17 (2013-08-06)
The National Diet and Nutrition Survey (Bates et al 2011) show adult females have low levels of vitamin D. Many women in midwives' care may be vitamin D deficient. The aim of this article is to update midwives' knowledge of
Jianfeng Zhang et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 35(3), 1219-1229 (2015-03-15)
Transplantation of bone-marrow derived stem/progenitor cells has an established therapeutic effect on cardiac muscle repair after injury. However, the exact mechanism that underlies this phenomenon is not completely understood. Here we transplanted mesenchymal stem cells (MSCs), a major population from
Fuyuko Koibuchi et al.
Biological & pharmaceutical bulletin, 37(7), 1241-1247 (2014-07-06)
Emerging evidence indicates that stress hormone glucocorticoids (GC) are an important modulator of brain development and function. To investigate whether GCs modulate neurosteroid biosynthesis in neural cells, we studied the effects of GCs on steroidogenic gene expression in human glioma
Michal Stuss et al.
The Journal of clinical endocrinology and metabolism, 98(5), E1007-E1011 (2013-04-02)
Recent research results have confirmed the high significance of the OPG/RANK/RANKL system in the development of bone diseases. The aim of the reported study was to assess gene expression levels of the OPG/RANK/RANKL system in peripheral blood mononuclear cells (PBMCs)
Umon Agata et al.
Journal of nutritional science and vitaminology, 59(1), 29-36 (2013-03-29)
Low calcium (Ca) intake is the one of risk factors for both bone loss and medial elastocalcinosis in an estrogen deficiency state. To examine the effect of different amounts of Ca intake on the relationship between bone mass alteration and
Melissa Jensen et al.
Journal of pediatric gastroenterology and nutrition, 61(2), 187-189 (2015-02-05)
Oral high-dose repletion vitamin D therapy, also known as stoss therapy, can be effective in the treatment of nutritional vitamin D deficiency rickets in infants and young children without liver disease and in patients with cystic fibrosis. There is no
Bao-Xin Liu et al.
Medicine, 94(25), e991-e991 (2015-06-25)
Osteoporosis and related fragility fractures represent a serious and global public health problem. To evaluate whether the modified eighth section of Eight-section Brocade (MESE) exercise could improve the symptom and indexes associated with osteoporosis in postmenopausal women. Guangzhou and Liuzhou
The hormone-like action of 1,25-(OH)2-cholecalciferol (a metabolite of the fat-soluble vitamin D) in the intestine.
A W Norman
Vitamins and hormones, 32, 325-384 (1974-01-01)
A G Fuchs et al.
Journal of helminthology, 88(4), 459-467 (2013-06-08)
Bisphosphonates have been proposed as pharmacological agents against parasite and cancer cell growth. The effect of these compounds on helminthic cell viability and acellular compartment morphology, however, has not yet been studied. The effects of different types of bisphosphonates, namely
Karin Amrein et al.
JAMA, 312(15), 1520-1530 (2014-10-01)
Low vitamin D status is linked to increased mortality and morbidity in patients who are critically ill. It is unknown if this association is causal. To investigate whether a vitamin D3 treatment regimen intended to restore and maintain normal vitamin
K L Little et al.
Journal of animal science, 93(3), 1284-1297 (2015-05-29)
The objectives of this experiment were to determine growth performance, visceral mass differences, carcass characteristics, fresh meat quality, and carcass cutability of growing-finishing pigs fed diets containing high-protein canola meal (CM-HP) or conventional canola meal (CM-CV). Seven dietary treatments were
Cristhian R L Francisco et al.
Food chemistry, 245, 845-853 (2017-12-31)
Mushroom extracts contain bioactive compounds potentially useful to functionalize foodstuffs. Herein, alcoholic extracts of Agaricus bisporus were studied for their bioactivity and viability as functional ingredients in a food product with high water content (yogurt). Extracts were microencapsulated (to improve
Umon Agata et al.
Journal of nutritional science and vitaminology, 61(5), 391-399 (2015-12-08)
Reduced estrogen secretion and low calcium (Ca) intake are risk factors for bone loss and arterial calcification in female rodents. To evaluate the effects of Ca intake at different amounts on bone mass changes and arterial calcification, 8-wk-old female Wistar
Ahmed Alsaqr et al.
AAPS PharmSciTech, 16(4), 963-972 (2015-01-23)
Transdermal delivery of therapeutic amounts of vitamin D3 is proposed to overcome its variable oral bioavailability, especially for people who suffer from fat malabsorption. The main challenge for this delivery route is to overcome the barrier properties of skin, especially
G B Ferreira et al.
The Journal of steroid biochemistry and molecular biology, 144 Pt A, 96-101 (2013-11-02)
1α,25-Dihydroxyvitamin D3 (1α,25(OH)2D3), and its analogs (i.e. 14,20-bis-epi-19-nor-23-yne-1α,25(OH)2D3 - TX527) have been shown to prevent autoimmunity and prolong islet graft survival in the non-obese diabetic (NOD) mouse. Their effects are mediated by their action on various immune cell types, such
Wei Hu et al.
Autophagy, 15(4), 707-725 (2019-01-08)
Helicobacter pylori (H. pylori) is a common human pathogenic bacterium. Once infected, it is difficult for the host to clear this organism using the innate immune system. Increased antibiotic resistance further makes it challenging for effective eradication. However, the mechanisms
Zhichao Liu et al.
PLoS computational biology, 7(12), e1002310-e1002310 (2011-12-24)
Drug-induced liver injury (DILI) is a significant concern in drug development due to the poor concordance between preclinical and clinical findings of liver toxicity. We hypothesized that the DILI types (hepatotoxic side effects) seen in the clinic can be translated
Masahiko Suzuki et al.
The American journal of clinical nutrition, 97(5), 1004-1013 (2013-03-15)
In our previous study, higher serum 25-hydroxyvitamin D [25(OH)D] concentrations and the vitamin D receptor (VDR) FokI CC genotype were associated with milder Parkinson disease (PD). We evaluated whether vitamin D3 supplementation inhibits the progression of PD on the basis
Sara S Oberhelman et al.
Mayo Clinic proceedings, 88(12), 1378-1387 (2013-12-03)
To determine whether a single monthly supplement is as effective as a daily maternal supplement in increasing breast milk vitamin D to achieve vitamin D sufficiency in their infants. Forty mothers with exclusively breast-fed infants were randomized to receive oral
Jing Zhang et al.
Calcified tissue international, 96(1), 80-87 (2014-11-25)
Thyroid hormones (THs) including thyroxine (T4) and triiodothyronine (T3) play critical roles in bone remodeling. However, the role and mechanism of THs in vascular calcification (VC) have been unclear. To explore the pathophysiological roles of T3 on VC, we investigated
Sarah Nicolai et al.
Science immunology, 5(43) (2020-01-05)
During industrialization, humans have been exposed to increasing numbers of foreign chemicals. Failure of the immune system to tolerate drugs, cosmetics, and other skin products causes allergic contact dermatitis, a T cell-mediated disease with rising prevalence. Models of αβ T
C Jackson et al.
QJM : monthly journal of the Association of Physicians, 100(4), 185-192 (2007-02-20)
We evaluated the effect of supplementation with vitamin D(3) (excluding the potential effect of calcium supplementation) on the risk of fall and fracture, primarily in postmenopausal women, using a systematic literature review of MEDLINE, EMBASE, BIOSIS and the Cochrane Database
David Feldman et al.
Nature reviews. Cancer, 14(5), 342-357 (2014-04-08)
Vitamin D is not really a vitamin but the precursor to the potent steroid hormone calcitriol, which has widespread actions throughout the body. Calcitriol regulates numerous cellular pathways that could have a role in determining cancer risk and prognosis. Although
P De Groote et al.
Cell death and differentiation, 22(6), 1012-1024 (2014-11-29)
Receptor-interacting protein kinase 4 (RIPK4)-deficient mice have epidermal defects and fusion of all external orifices. These are similar to Bartsocas-Papas syndrome and popliteal pterygium syndrome (PPS) in humans, for which causative mutations have been documented in the RIPK4 and IRF6
Isa Gabriela de Medeiros Cavalcante et al.
Experimental gerontology, 66, 10-16 (2015-04-02)
This study aimed to evaluate the effect of vitamin D3 megadose supplementation and influence of BsmI polymorphism in the VDR gene on the inflammatory profile and oxidative stress in elderly women with vitamin D deficiency. A double blind, randomized, placebo-controlled
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