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Angelo Pommella et al.
Scientific reports, 5, 13163-13163 (2015-08-26)
Vesicle and cell rupture caused by large viscous stresses in ultrasonication is central to biomedical and bioprocessing applications. The flow-induced opening of lipid membranes can be exploited to deliver drugs into cells, or to recover products from cells, provided that
Alice Verchère et al.
Nature communications, 6, 6890-6890 (2015-04-23)
Antibiotic resistance is a major public health issue and many bacteria responsible for human infections have now developed a variety of antibiotic resistance mechanisms. For instance, Pseudomonas aeruginosa, a disease-causing Gram-negative bacteria, is now resistant to almost every class of
Lenka Novakova et al.
Journal of the neurological sciences, 358(1-2), 201-206 (2015-09-08)
Natalizumab therapy reduces inflammation and degeneration of the CNS in relapsing-remitting multiple sclerosis (RRMS). In cerebrospinal fluid (CSF) the concentration of 24S-hydroxycholesterol (24OHC) reflect neurodegeneration, whereas 27-hydroxycholesterol (27OHC) is dependent on the integrity of the blood-brain barrier (BBB). To measure
Daniela M T Malina et al.
Journal of clinical lipidology, 9(4), 542-552 (2015-08-01)
Plant sterol (PS) supplementation has been widely used alone or combined with lipid-lowering therapies (LLTs) to reduce low-density lipoprotein (LDL) cholesterol. The effects of PS added to high-intensity LLT are less reported, especially regarding the effects on cholesterol synthesis and
Joanna E Kontaraki et al.
Journal of the American Society of Hypertension : JASH, 9(10), 802-810 (2015-09-12)
MicroRNAs regulate several aspects of physiological and pathologic cardiac hypertrophy, and they represent promising therapeutic targets in cardiovascular disease. We assessed the expression levels of the microRNAs miR-1, miR-133a, miR-26b, miR-208b, miR-499, and miR-21, in 102 patients with essential hypertension
Kensuke Toyama et al.
Journal of cardiology, 64(2), 91-97 (2014-01-25)
Statins and exercise therapy are clinically effective in preventing cardiovascular events in patients with coronary artery disease (CAD). The aim of this study was to determine the effects of statins combined with exercise on the renal function of CAD patients.
Masao Takahashi et al.
Heart and vessels, 30(5), 587-594 (2014-06-01)
A recent study showed eicosapentaenoic acid (EPA) is a promising treatment for prevention of coronary events in hypercholesterolemic patients. Meanwhile, a high red blood cell distribution width (RDW) is a known risk factor for cardiovascular events. However, few studies have
Belinda T Lee et al.
BMC nephrology, 16, 77-77 (2015-05-31)
We studied the association of inflammatory biomarkers including C-reactive protein (CRP), tumor necrosis factor-alpha (TNF-α), and interleukin-6 (IL-6) with chronic kidney disease (CKD). We conducted a case-control study among 201 CKD patients and 201 community-based controls in the greater New
Yung-Chih Kuo et al.
International journal of pharmaceutics, 473(1-2), 334-344 (2014-07-08)
CRM197-grafted liposomes containing cardiolipin (CL) (CRM197/CL-liposomes) were used to enhance the permeability of neuron growth factor (NGF) across the blood-brain barrier (BBB) for promoting the neuroprotective effect of NGF. CRM197/CL-liposoms were incubated with a monolayer of human astrocyte (HA)-regulated human
Jean-Marie Swiecicki et al.
Biopolymers, 104(5), 533-543 (2015-04-08)
The internalization of cell-penetrating peptides (CPPs) into liposomes (large unilamellar vesicles, LUVs) was studied with a rapid and robust procedure based on the quenching of a small fluorescent probe, 7-nitrobenz-2-oxa-1,3-diazole (NBD). Quenching can be achieved by reduction with dithionite or
Ashish V Kalra et al.
Cancer research, 74(23), 7003-7013 (2014-10-03)
A major challenge in the clinical use of cytotoxic chemotherapeutics is maximizing efficacy in tumors while sparing normal tissue. Irinotecan is used for colorectal cancer treatment but the extent of its use is limited by toxic side effects. Liposomal delivery
Eun Sil Koh et al.
Journal of translational medicine, 13, 203-203 (2015-06-28)
Anthocyanins are major constituents of food colours and have been reported to possess anti-diabetic activities for potential medicinal use. The precise role of anthocyanins in diabetic nephropathy is poorly understood. We investigated whether anthocyanin-rich Seoritae extract (SE) can potentially prevent
Daniela Quinteros et al.
PloS one, 9(10), e110344-e110344 (2014-10-21)
For the treatment of chronic ocular diseases such as glaucoma, continuous instillations of eye drops are needed. However, frequent administrations of hypotensive topical formulations can produce adverse ocular surface effects due to the active substance or other components of the
Sam Chen et al.
Journal of controlled release : official journal of the Controlled Release Society, 196, 106-112 (2014-10-07)
Recently developed lipid nanoparticle (LNP) formulations of siRNA have proven to be effective agents for hepatocyte gene silencing following intravenous administration with at least three LNP-siRNA formulations in clinical trials. The aim of this work was to develop LNP-siRNA systems
Noriyuki Doukyu et al.
Journal of bioscience and bioengineering, 120(1), 24-30 (2015-01-13)
An extracellular cholesterol oxidase producer, Pseudomonas aeruginosa strain PA157, was isolated by a screening method to detect 6β-hydroperoxycholest-4-en-3-one-forming cholesterol oxidase. On the basis of a putative cholesterol oxidase gene sequence in the genome sequence data of P. aeruginosa strain PAO1
Yanqing Zang et al.
Bioscience, biotechnology, and biochemistry, 79(1), 117-123 (2014-09-12)
We investigated the effects of a mixture of daidzin and glycitin, which are the glycoside-form isoflavones of daidzein and glycitein, respectively, on body weight, lipid levels, diabetic markers, and metabolism in a high-fat diet (HF) fed C57BL/6J mice for 92 days.
Corinne Caillaud et al.
The Journal of endocrinology, 225(2), 77-88 (2015-03-15)
Erythropoietin (EPO) ameliorates glucose metabolism through mechanisms not fully understood. In this study, we investigated the effect of EPO on glucose metabolism and insulin signaling in skeletal muscle. A 2-week EPO treatment of rats fed with a high-fat diet (HFD)
Richa Dubey et al.
Biochimica et biophysica acta, 1849(1), 32-43 (2014-12-03)
MiRNAs and transcription factors have emerged as important regulators for gene expression and are known to regulate various biological processes, including cell proliferation, differentiation and apoptosis. Previously, using genome-wide expression profiling studies, we have shown an inverse relationship of STAT6
Dylan S Mackay et al.
The American journal of clinical nutrition, 101(3), 432-439 (2015-03-04)
Benefits of plant sterols (PS) for cholesterol lowering are compromised by large variability in efficacy across individuals. High fractional cholesterol synthesis measured by deuterium incorporation has been associated with nonresponse to PS consumption; however, prospective studies that show this association
Marie Boegh et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 95(Pt A), 136-143 (2015-01-28)
The mucus lining of the gastrointestinal tract epithelium is recognized as a barrier to efficient oral drug delivery. Recently, a new in vitro model for assessment of drug permeation across intestinal mucosa was established by applying a biosimilar mucus matrix
Lei Yan et al.
Journal of peptide science : an official publication of the European Peptide Society, 21(7), 577-585 (2015-04-09)
Membrane curvature and lipid composition plays a critical role in interchanging of matter and energy in cells. Peptide curvature sensors are known to activate signaling pathways and promote molecular transport across cell membranes. Recently, the 25-mer MARCKS-ED peptide, which is
Dilip Shrestha et al.
Biochimica et biophysica acta, 1840(1), 667-680 (2014-02-01)
Cluster of differentiation 1 (CD1) represents a family of proteins which is involved in lipid-based antigen presentation. Primarily, antigen presenting cells, like B cells, express CD1 proteins. Here, we examined the cell-surface distribution of CD1d, a subtype of CD1 receptors
Tuija Jääskeläinen et al.
The British journal of nutrition, 113(9), 1418-1426 (2015-05-21)
Vitamin D has been suggested to protect against depression, but epidemiological evidence is scarce. The present study investigated the relationship of serum 25-hydroxyvitamin D (25(OH)D) with the prevalence of depressive and anxiety disorders. The study population consisted of a representative
Britt Hofmann et al.
Experimental gerontology, 59, 13-20 (2014-05-14)
Advanced glycation end product (AGE) accumulations as well as a high fat diet are associated with cardiovascular diseases. AGEs are recognized by several receptor molecules of which the receptor of AGEs (RAGE) is currently the most intensively studied. Activation of
Stephan Laggai et al.
World journal of hepatology, 5(10), 558-567 (2013-11-02)
To establish a simple method to quantify lipid classes in liver diseases and to decipher the lipid profile in p62/IMP2-2/IGF2BP2-2 transgenic mice. Liver-specific overexpression of the insulin-like growth factor 2 mRNA binding protein p62/IMP2-2/IGF2BP2-2 was used as a model for
Suryanarayan Somanathan et al.
Circulation research, 115(6), 591-599 (2014-07-16)
Familial hypercholesterolemia is a genetic disorder that arises because of loss-of-function mutations in the low-density lipoprotein receptor (LDLR) and homozygous familial hypercholesterolemia is a candidate for gene therapy using adeno-associated viral vectors. Proprotein convertase subtilisin/kexin type 9 (PCSK9) and inducible
Angela Jaszczak et al.
The journals of gerontology. Series B, Psychological sciences and social sciences, 69 Suppl 2, S4-14 (2014-06-19)
The second Wave (W2) of the National Social Life, Health, and Aging Project (NSHAP), a nationally representative, longitudinal survey of older adults now between the ages of 62 and 90, conducted approximately 3,400 interviews. Selected coresidential romantic partners as well
Rob S Burke et al.
Pharmaceutical research, 31(12), 3445-3460 (2014-07-02)
To develop a tool based on siRNA-mediated knockdown of hepatic P450 oxidoreductase (POR) to decrease the CYP-mediated metabolism of small molecule drugs that suffer from rapid metabolism in vivo, with the aim of improving plasma exposure of these drugs. siRNA
Annamaria Pratelli et al.
The Journal of general virology, 96(Pt 2), 331-337 (2014-11-09)
Coronaviruses are enveloped RNA viruses that have evolved complex relationships with their host cells, and modulate their lipid composition, lipid synthesis and signalling. Lipid rafts, enriched in sphingolipids, cholesterol and associated proteins, are special plasma membrane microdomains involved in several
Gemma Vilahur et al.
Revista espanola de cardiologia (English ed.), 68(3), 216-225 (2014-12-03)
The Mediterranean diet, rich in polyphenols, has shown to be cardioprotective. However the mechanisms involved remain unknown. We investigated whether supplementation with a pomegranate extract rich in polyphenols renders beneficial effects on coronary function in a clinically relevant experimental model
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