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Rebecca Gentek et al.
Immunity, 48(6), 1160-1171 (2018-06-03)
Hematopoiesis occurs in distinct waves. "Definitive" hematopoietic stem cells (HSCs) with the potential for all blood lineages emerge in the aorta-gonado-mesonephros, while "primitive" progenitors, whose potential is thought to be limited to erythrocytes, megakaryocytes, and macrophages, arise earlier in the
Marina Avetisyan et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(33), 11543-11558 (2015-08-21)
Factors providing trophic support to diverse enteric neuron subtypes remain poorly understood. We tested the hypothesis that hepatocyte growth factor (HGF) and the HGF receptor MET might support some types of enteric neurons. HGF and MET are expressed in fetal
Patrick W Heiser et al.
Development (Cambridge, England), 133(10), 2023-2032 (2006-04-14)
A recent study has shown that deletion of beta-catenin within the pancreatic epithelium results in a loss of pancreas mass. Here, we show that ectopic stabilization of beta-catenin within mouse pancreatic epithelium can have divergent effects on both organ formation
Luis F Menezes et al.
EBioMedicine, 5, 183-192 (2016-04-15)
The major gene mutated in autosomal dominant polycystic kidney disease was first identified over 20 years ago, yet its function remains poorly understood. We have used a systems-based approach to examine the effects of acquired loss of Pkd1 in adult
Lixiao Che et al.
Cell death and differentiation, 27(8), 2402-2416 (2020-03-07)
BRUCE is a DNA damage response protein that promotes the activation of ATM and ATR for homologous recombination (HR) repair in somatic cells, making BRUCE a key protector of genomic stability. Preservation of genomic stability in the germline is essential
Michal Hensler et al.
Lipids in health and disease, 10, 128-128 (2011-08-04)
Long-chain n-3 polyunsaturated fatty acids (LC n-3 PUFA) of marine origin exert multiple beneficial effects on health. Our previous study in mice showed that reduction of adiposity by LC n-3 PUFA was associated with both, a shift in adipose tissue
Jingyuan Li et al.
Developmental cell, 33(2), 125-135 (2015-04-14)
During embryogenesis, ectodermal stem cells adopt different fates and form diverse ectodermal organs, such as teeth, hair follicles, mammary glands, and salivary glands. Interestingly, these ectodermal organs differ in their tissue homeostasis, which leads to differential abilities for continuous growth
Keisuke Yanagida et al.
Developmental cell, 52(6), 779-793 (2020-02-16)
Transcriptional mechanisms that drive angiogenesis and organotypic vascular endothelial cell specialization are poorly understood. Here, we show that retinal endothelial sphingosine 1-phosphate receptors (S1PRs), which restrain vascular endothelial growth factor (VEGF)-induced angiogenesis, spatially restrict expression of JunB, a member of
Fei Chen et al.
Cell death & disease, 11(7), 501-501 (2020-07-08)
During radiologic or nuclear accidents, high-dose ionizing radiation (IR) can cause gastrointestinal syndrome (GIS), a deadly disorder that urgently needs effective therapy. Unfortunately, current treatments based on natural products and antioxidants have shown very limited effects in alleviating deadly GIS.
Alexander Gow
Methods in enzymology, 491, 143-161 (2011-02-19)
In recent years, recognition of the importance of protein aggregation in human diseases has increasingly come to the fore and it is clear that many degenerative disorders involve activation of a metabolic signaling cascade known as the unfolded protein response
H Carlijne Hassing et al.
Hepatology (Baltimore, Md.), 55(6), 1746-1753 (2012-01-12)
Type 2 diabetes mellitus (T2DM) impairs hepatic clearance of atherogenic postprandial triglyceride-rich lipoproteins (TRLs). We recently reported that livers from T2DM db/db mice markedly overexpress the heparan sulfate glucosamine-6-O-endosulfatase-2 (SULF2), an enzyme that removes 6-O sulfate groups from heparan sulfate
Bàrbara Laviña et al.
Development (Cambridge, England), 145(13) (2018-06-02)
Formation and homeostasis of the vascular system requires several coordinated cellular functions, but their precise interplay during development and their relative importance for vascular pathologies remain poorly understood. Here, we investigated the endothelial functions regulated by Cdc42 and their in
Effects of Repeated Intraperitoneal Injection of Pharmaceutical-grade and Nonpharmaceutical-grade Corn Oil in Female C57BL/6J Mice
Hubbard JS, et al.
Journal of the American Association For Laboratory Animal Science, 56(6), 779-785 (2017)
Qays Kharouf et al.
British journal of pharmacology, 177(16), 3712-3729 (2020-05-05)
Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are encoded by four genes (HCN1-4) with distinct biophysical properties and functions within the brain. HCN4 channels activate slowly at robust hyperpolarizing potentials, making them more likely to be engaged during hyperexcitable neuronal network activity
Sungho Jin et al.
Journal of neuroinflammation, 17(1), 195-195 (2020-06-21)
A growing body of evidence shows that hypothalamic inflammation is an important factor in the initiation of obesity. In particular, reactive gliosis accompanied by inflammatory responses in the hypothalamus are pivotal cellular events that elicit metabolic abnormalities. In this study
Corentine Marie et al.
Proceedings of the National Academy of Sciences of the United States of America, 115(35), E8246-E8255 (2018-08-16)
Oligodendrocyte precursor cells (OPCs) constitute the main proliferative cells in the adult brain, and deregulation of OPC proliferation-differentiation balance results in either glioma formation or defective adaptive (re)myelination. OPC differentiation requires significant genetic reprogramming, implicating chromatin remodeling. Mounting evidence indicates
Aase Ertesvag et al.
Immunology, 126(4), 514-522 (2008-09-10)
Interleukin-2 (IL-2) is an essential cytokine for T-lymphocyte homeostasis. We have previously reported that all-trans retinoic acid (atRA) enhances the secretion of IL-2 from human peripheral blood T cells in vitro, followed by increased proliferation and inhibition of spontaneous cell
Yingyi Mao et al.
Journal of food science, 77(5), E144-E152 (2012-11-21)
This study describes how the rheological properties of colloidal dispersions formed by heteroaggregation of oppositely charged protein-coated lipid droplets depend on total particle concentration. Mixed-particle emulsions were formed by mixing single-particle emulsions containing either β-lactoglobulin-coated lipid droplets (ζ≈-42 mV, d(43)≈
Svenja Koslowski et al.
International journal of environmental research and public health, 17(5) (2020-03-04)
Fipronil is an insecticide widely used for veterinary and agricultural purposes. While its insecticidal properties mostly rely on its high affinity antagonistic activity on insect γ aminobutyric acid (GABA) receptors, fipronil and its main metabolite fipronil sulfone nevertheless display non-negligible
J I Belle et al.
Cell death and differentiation, 23(5), 759-775 (2016-01-16)
p53 is a central mediator of cellular stress responses, and its precise regulation is essential for the normal progression of hematopoiesis. MYSM1 is an epigenetic regulator essential for the maintenance of hematopoietic stem cell (HSC) function, hematopoietic progenitor survival, and
Chun-Ling Dai et al.
Neurobiology of aging, 70, 40-50 (2018-06-27)
The ogt gene encodes O-linked N-acetylglucosamine transferase (O-GlcNAc transferase [OGT]) that catalyzes the transfer of β-N-acetylglucosamine (GlcNAc) from the uridine-diphosphate-GlcNAc to the hydroxyl group of serine or threonine residues of nucleocytoplasmic proteins. This process is a common protein posttranslational modification
Liang-Yin Chou et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 34(4), 5767-5781 (2020-03-05)
Chondrocytes in growth plates are responsible for longitudinal growth in long bones during endochondral ossification. Discoidin domain receptor 1 (Ddr1) is expressed in chondrocytes, but the molecular mechanisms by which DDR1 regulates chondrocyte behaviors during the endochondral ossification process remain
Tadeja Rezen et al.
BMC genomics, 10, 384-384 (2009-08-21)
Detoxification in the liver involves activation of nuclear receptors, such as the constitutive androstane receptor (CAR), which regulate downstream genes of xenobiotic metabolism. Frequently, the metabolism of endobiotics is also modulated, resulting in potentially harmful effects. We therefore used 1,4-Bis
Zhentian Wang et al.
Cancer cell, 37(6), 834-849 (2020-05-23)
Molecular mechanisms underlying adaptive targeted therapy resistance in pancreatic ductal adenocarcinoma (PDAC) are poorly understood. Here, we identify SETD5 as a major driver of PDAC resistance to MEK1/2 inhibition (MEKi). SETD5 is induced by MEKi resistance and its deletion restores
Oliver H Bell et al.
Frontiers in immunology, 10, 3033-3033 (2020-01-30)
Background: Whether retinal microglia can maintain or restore immune homeostasis during and after inflammation is unclear. We performed single-eye mRNA-sequencing on microglia at different timepoints following a single inflammatory stimulus to characterise their transcriptome during and after resolution of endotoxin-induced
Sichen Du et al.
Human gene therapy, 30(2), 155-167 (2018-08-21)
Gaucher disease (GD) is an autosomal recessive lysosomal storage disorder caused by mutations in the GBA gene. Enzyme replacement treatment is the most effective therapy available for type 1 GD patients, but it is very expensive and does not improve
Kaiyue Zhang et al.
The Journal of biological chemistry, 295(34), 12203-12213 (2020-07-10)
Mesenchymal stem cell (MSC)-derived extracellular vesicles (EVs) have been shown to stimulate regeneration in the treatment of kidney injury. Renal regeneration is also thought to be stimulated by the activation of Sox9+ cells. However, whether and how the activation mechanisms
Giulia Nato et al.
Development (Cambridge, England), 142(5), 840-845 (2015-02-07)
In the adult brain, subsets of astrocytic cells residing in well-defined neurogenic niches constitutively generate neurons throughout life. Brain lesions can stimulate neurogenesis in otherwise non-neurogenic regions, but whether local astrocytic cells generate neurons in these conditions is unresolved. Here
Adrian Fischer et al.
Nature communications, 11(1), 3068-3068 (2020-06-20)
Surgical adhesions are bands of scar tissues that abnormally conjoin organ surfaces. Adhesions are a major cause of post-operative and dialysis-related complications, yet their patho-mechanism remains elusive, and prevention agents in clinical trials have thus far failed to achieve efficacy.
Matthew R McFarlane et al.
Journal of lipid research, 56(8), 1560-1571 (2015-04-22)
SREBP cleavage-activating protein (Scap) is an endoplasmic reticulum membrane protein required for cleavage and activation of sterol regulatory element-binding proteins (SREBPs), which activate the transcription of genes in sterol and fatty acid biosynthesis. Liver-specific loss of Scap is well tolerated;
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