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Durgesh V Wagle et al.
The journal of physical chemistry letters, 6(15), 2924-2928 (2015-08-13)
From macroscopic measurements of deep eutectic solvents such as glyceline (1:2 molar ratio of choline chloride to glycerol), the long-range translational diffusion of the larger cation (choline) is known to be slower compared to that of the smaller hydrogen bond
William M Howe et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(20), 8742-8752 (2013-05-17)
We previously reported involvement of right prefrontal cholinergic activity in veridical signal detection. Here, we first recorded real-time acetylcholine release in prefrontal cortex (PFC) during specific trial sequences in rats performing a task requiring signal detection as well as rejection
Alexandra Petruş et al.
Canadian journal of physiology and pharmacology, 93(9), 811-818 (2015-09-02)
A substantial body of evidence indicates that pharmacological activation of mitochondrial ATP-sensitive potassium channels (mKATP) in the heart is protective in conditions associated with ischemia/reperfusion injury. Several mechanisms have been postulated to be responsible for cardioprotection, including the modulation of
Alexandra Deviers et al.
International journal of radiation oncology, biology, physics, 90(2), 385-393 (2014-08-12)
Because lactate accumulation is considered a surrogate for hypoxia and tumor radiation resistance, we studied the spatial distribution of the lactate-to-N-acetyl-aspartate ratio (LNR) before radiation therapy (RT) with 3D proton magnetic resonance spectroscopic imaging (3D-(1)H-MRSI) and assessed its impact on
Dale A Fortin et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(50), 16698-16712 (2014-12-17)
Stoichiometric labeling of endogenous synaptic proteins for high-contrast live-cell imaging in brain tissue remains challenging. Here, we describe a conditional mouse genetic strategy termed endogenous labeling via exon duplication (ENABLED), which can be used to fluorescently label endogenous proteins with
Kristin Zscharnack et al.
Analytica chimica acta, 854, 145-152 (2014-12-07)
H2O2 is a widely occurring molecule which is also a byproduct of a number of enzymatic reactions. It can therefore be used to quantify the corresponding enzymatic substrates. In this study, the time-resolved fluorescence emission of a previously described complex
J Li et al.
Clinical radiology, 70(1), 37-41 (2014-12-03)
To assess the role of proton MR spectroscopy (MRS) in the detection of changes in metabolite levels of the cerebellum after heat stroke (HS). The study group consisted of eight patients after HS, with a Glasgow Coma Scale (GCS) score
Jacob C Nordman et al.
Journal of neurochemistry, 129(4), 649-662 (2013-12-20)
Cholinergic signaling plays an important role in regulating the growth and regeneration of axons in the nervous system. The α7 nicotinic receptor (α7) can drive synaptic development and plasticity in the hippocampus. Here, we show that activation of α7 significantly
Marina Orevi et al.
Clinical nuclear medicine, 39(12), 1033-1038 (2014-10-08)
This prospective pilot study was aimed to evaluate ¹¹C-choline PET/CT (choline) as a tool for localization of parathyroid adenoma (PTA). Forty patients with biochemical hyperparathyroidism underwent choline and ⁹⁹mTc-MIBI imaging within a median interval of 56 days. Choline and MIBI
L Van den Bergh et al.
Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al], 189(9), 789-795 (2013-06-26)
The aim of this work was to determine whether 11C-choline positron emission tomography (PET)-computed tomography (CT) makes a positive contribution to multiparametric magnetic resonance imaging (MRI) for localisation of intraprostatic tumour nodules. A total of 73 patients with biopsy-proven intermediate-
Tom Vander Hoogerstraete et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 21(33), 11757-11766 (2015-07-17)
In a conventional solvent extraction system, metal ions are distributed between two immiscible phases, typically an aqueous and an organic phase. In this paper, the proof-of-principle is given for the distribution of metal ions between three immiscible phases, two ionic
Artor Niccoli-Asabella et al.
Recenti progressi in medicina, 104(2), 73-75 (2013-03-29)
In a patient with cerebral gliomatosis type II MRI revealed a large area of altered signal in the temporal region, parietal and occipital lobes associated with a single nodule with perilesional contrast enhancement, which showed increased uptake on PET/CT with
Vignesh Thiagarajan et al.
Journal of colloid and interface science, 462, 334-340 (2015-10-18)
Choline, a type of Vitamin B, is an important nutrient in the human body and is involved in key metabolic pathways. Abnormal levels of choline leads to diseased conditions. The levels of choline and its associated compounds are found to
Andreas Hecker et al.
Journal of immunology (Baltimore, Md. : 1950), 195(5), 2325-2334 (2015-07-24)
IL-1β is a potent proinflammatory cytokine of the innate immune system that is involved in host defense against infection. However, increased production of IL-1β plays a pathogenic role in various inflammatory diseases, such as rheumatoid arthritis, gout, sepsis, stroke, and
Benjamin Kolisnyk et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(37), 14908-14920 (2013-09-13)
One of the key brain regions in cognitive processing and executive function is the prefrontal cortex (PFC), which receives cholinergic input from basal forebrain cholinergic neurons. We evaluated the contribution of synaptically released acetylcholine (ACh) to executive function by genetically
Noorul Adawiyah Mustahil et al.
Chemosphere, 229, 349-357 (2019-05-13)
Ionic liquids (ILs) based surfactants have been emerged as attractive alternatives to the conventional surfactants owing to their tailor-made and eco-friendly properties. Therefore, present study described the synthesis of nine new fatty amino acids based IL surfactants utilizing lauroyl sarcosinate
Werner J Geldenhuys et al.
Bioorganic & medicinal chemistry letters, 20(16), 4870-4877 (2010-07-20)
The high affinity neuronal choline transporter (CHT1) is responsible for the uptake of choline into the pre-synaptic terminal of cholinergic neurons. Considering our past experience with modeling the blood-brain barrier choline transporter (BBBCHT) as drug delivery vector to the CNS
Akiko Mizuno-Yasuhira et al.
Drug metabolism and disposition: the biological fate of chemicals, 42(9), 1456-1465 (2014-07-10)
A strategy for assessing potential drug-drug interactions (DDIs) based on a simulated intestinal concentration is described. The proposed prediction method was applied to the DDI assessment of luseogliflozin, a novel antidiabetic drug, against miglitol absorbed via the intestinal sodium-glucose cotransporter
Kim M Yonemori et al.
The Journal of nutrition, 143(6), 894-899 (2013-04-26)
Choline and betaine are important nutrients for human health, but reference food composition databases for these nutrients became available only recently. We tested the feasibility of using these databases to estimate dietary choline and betaine intakes among ethnically diverse adults
N Andres Parra et al.
International journal of radiation oncology, biology, physics, 90(2), 376-384 (2014-07-30)
Magnetic resonance (MR) imaging and computed tomography (CT) are used almost exclusively in radiation therapy planning of glioblastoma multiforme (GBM), despite their well-recognized limitations. MR spectroscopic imaging (MRSI) can identify biochemical patterns associated with normal brain and tumor, predominantly by
Femke S den Boon et al.
Pflugers Archiv : European journal of physiology, 467(7), 1551-1564 (2014-08-02)
Activation of the endocannabinoid (eCB) system by exogenous cannabinoids (drug abuse) can alter the physiology of the brain circuits involved in higher-order cognitive functions such as the medial prefrontal cortex (mPFC). A proper balance between excitation and inhibition (E/I balance)
Amal Al-Tamimi et al.
Natural product research, 33(9), 1322-1328 (2018-05-22)
Capparis spinosa L. is a perennial plant typical of the Mediterranean flora and a multipurpose plant used for curing various human ailments. Quaternary ammonium compounds (QACs), as constituents of Capparaceae, play important roles in protecting against abiotic stress. Aim of
David J Lin et al.
Journal of neurophysiology, 112(4), 942-950 (2014-05-23)
Recent studies have demonstrated that vision influences the functional remodeling of the mouse retinogeniculate synapse, the connection between retinal ganglion cells and thalamic relay neurons in the dorsal lateral geniculate nucleus (LGN). Initially, each relay neuron receives a large number
Eugen Brailoiu et al.
Cell reports, 26(2), 330-337 (2019-01-10)
Sigma-1 receptors (Sig-1Rs) are integral ER membrane proteins. They bind diverse ligands, including psychoactive drugs, and regulate many signaling proteins, including the inositol 1,4,5-trisphosphate receptors (IP3Rs) that release Ca2+ from the ER. The endogenous ligands of Sig-1Rs are unknown. Phospholipase
Nik Nurhanan Nik Mansor et al.
Sensors (Basel, Switzerland), 18(3) (2018-03-03)
A tri-enzyme system consisting of choline kinase/choline oxidase/horseradish peroxidase was used in the rapid and specific determination of the biomarker for bacterial sepsis infection, secretory phospholipase Group 2-IIA (sPLA2-IIA). These enzymes were individually immobilized onto the acrylic microspheres via succinimide
Martine R Groen et al.
Journal of neurophysiology, 112(2), 287-299 (2014-04-25)
Synaptic plasticity rules change during development: while hippocampal synapses can be potentiated by a single action potential pairing protocol in young neurons, mature neurons require burst firing to induce synaptic potentiation. An essential component for spike timing-dependent plasticity is the
Veronika Fischer et al.
Journal of colloid and interface science, 453, 186-193 (2015-05-20)
It was recently demonstrated that a nano-clustering was present in the monophasic "pre-Ouzo" region of ternary liquid mixtures without surfactants. The goal of this work is to check if this nano-clustering is also present in the surfactant-free and water-free "green"
Zienab Alrefaie et al.
Behavioural brain research, 287, 156-162 (2015-04-04)
Complications of diabetes mellitus include cognitive impairments and functional changes in the brain. The present study aimed to investigate the possible beneficial effect of vitamin D3 on episodic memory and cholinergic transmission in the prefrontal cortex of streptozotocin-induced diabetic rats.
L Martin et al.
Oncogene, 34(32), 4211-4218 (2014-11-18)
SLC7A11 encodes a subunit of the xCT cystine/glutamate amino-acid transport system and has a critical role in the generation of glutathione and the protection of cells from oxidative stress. Expression of SLC7A11 promotes tumorigenesis and chemotherapy resistance, but while SLC7A11
Ayano Takeuchi-Yorimoto et al.
Toxicology and applied pharmacology, 268(3), 264-277 (2013-03-14)
Nonalcoholic steatohepatitis (NASH) is characterized by combined pathology of steatosis, lobular inflammation, fibrosis, and hepatocellular degeneration, with systemic symptoms of diabetes or hyperlipidemia, all in the absence of alcohol abuse. Given the therapeutic importance and conflicting findings regarding the potential
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