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Eva Ruusuvuori et al.
Sub-cellular biochemistry, 75, 271-290 (2013-10-23)
H(+) ions are remarkably efficient modulators of neuronal excitability. This renders brain functions highly sensitive to small changes in pH which are generated "extrinsically" via mechanisms that regulate the acid-base status of the whole organism; and "intrinsically", by activity-induced transmembrane
Sean R Williamson et al.
The American journal of surgical pathology, 37(8), 1131-1139 (2013-05-08)
Clear cell papillary renal cell carcinoma (CCPRCC) shares morphologic overlap with clear cell renal cell carcinoma, although it lacks chromosome 3p and VHL gene abnormalities. Rare cases have been reported in von Hippel-Lindau (VHL) patients (germline mutation of the VHL
Hao Liu et al.
Neurology India, 62(1), 53-56 (2014-03-13)
Craniopharyngioma is a benign tumor, but recurrences are common and prognosis is poor. The pathologic mechanism underlying the high recurrence is still unknown. We hypothesized that there are hypoxic microenvironments within craniopharyngiomas and hypoxia inducible factor-1 alpha (HIF-1α) and its
A C Klimowicz et al.
British journal of cancer, 109(7), 1859-1866 (2013-09-07)
Tumour hypoxia is associated with impaired apoptosis, resistance to therapy and poor prognosis. We previously reported that high stromal expression of the endogenous marker of hypoxia, carbonic anhydrase IX (CAIX), is associated with significantly reduced survival in oral squamous cell
Fabrizio Carta et al.
Journal of medicinal chemistry, 56(11), 4691-4700 (2013-05-08)
Dithiocarbamates (DTCs) were recently discovered as carbonic anhydrase (CA, EC 4.2.1.1) inhibitors. A series of xanthates and a trithiocarbonate, structurally related to the DTCs, were prepared by reaction of alcohols/thiols with carbon disulfide in the presence of bases. These compounds
L Capkova et al.
Neoplasma, 61(2), 161-169 (2014-01-30)
Malignant mesothelioma is an aggressive tumor with a poor prognosis. Carbonic anhydrase IX (CAIX) is a membranously located metalloenzyme involved in pH homeostasis with influence on regulation of cell proliferation, oncogenesis and tumor progression. Much attention has been paid recently
Romualdo Talento et al.
Ultrastructural pathology, 37(1), 70-76 (2013-02-07)
Despite progress in the classification of renal cell carcinomas (RCC), a subset of these carcinomas remains unclassified (RCC-U). Patients with RCC-U usually present at a late stage and have a poor prognosis. Several studies have attempted to extract new classifications
Paul C McDonald et al.
Sub-cellular biochemistry, 75, 255-269 (2013-10-23)
The development of hypoxic microenvironments within many types of solid tumors imposes a significant stress on cancer cells to which they must respond appropriately in order to survive and grow. Tumor-specific, hypoxia-induced upregulation of Carbonic Anhydrase IX (CAIX) is a
Cawas B Engineer et al.
Nature, 513(7517), 246-250 (2014-07-22)
Environmental stimuli, including elevated carbon dioxide levels, regulate stomatal development; however, the key mechanisms mediating the perception and relay of the CO2 signal to the stomatal development machinery remain elusive. To adapt CO2 intake to water loss, plants regulate the
Jeana L Drake et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(10), 3788-3793 (2013-02-23)
It has long been recognized that a suite of proteins exists in coral skeletons that is critical for the oriented precipitation of calcium carbonate crystals, yet these proteins remain poorly characterized. Using liquid chromatography-tandem mass spectrometry analysis of proteins extracted
Zenggang Pan et al.
American journal of clinical pathology, 140(3), 410-418 (2013-08-21)
To compare the immunohistochemical expression of diagnostic markers in primary clear cell renal cell carcinomas (RCCs) and their matched metastases. Tissue microarrays were constructed from 15 pairs of primary and metastatic clear cell RCCs and then evaluated for the immunohistochemical
Anne Sinning et al.
FEBS letters, 587(13), 1923-1928 (2013-05-15)
As a general rule a rise in pH increases neuronal activity, whereas it is dampened by a fall of pH. Neuronal activity per se also challenges pH homeostasis by the increase of metabolic acid equivalents. Moreover, the negative membrane potential
Gul N Shah et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(18), 7423-7428 (2013-04-17)
Prior studies with carbonic anhydrase (CA) inhibitors implicated mitochondrial CA in ureagenesis and gluconeogenesis. Subsequent studies identified two mitochondrial CAs. To distinguish the contribution of each enzyme, we studied the effects of targeted disruption of the murine CA genes, called
Wolfgang Maret
Advances in nutrition (Bethesda, Md.), 4(1), 82-91 (2013-01-16)
The nutritional essentiality of zinc for the growth of living organisms had been recognized long before zinc biochemistry began with the discovery of zinc in carbonic anhydrase in 1939. Painstaking analytical work then demonstrated the presence of zinc as a
Michael Klier et al.
The Journal of biological chemistry, 289(5), 2765-2775 (2013-12-18)
Proton-coupled monocarboxylate transporters (MCTs) are carriers of high-energy metabolites such as lactate, pyruvate, and ketone bodies and are expressed in most tissues. It has previously been shown that transport activity of MCT1 and MCT4 is enhanced by the cytosolic carbonic
Laurie C Hofmann et al.
Journal of experimental botany, 64(4), 899-908 (2013-01-15)
The concentration of CO(2) in global surface ocean waters is increasing due to rising atmospheric CO(2) emissions, resulting in lower pH and a lower saturation state of carbonate ions. Such changes in seawater chemistry are expected to impact calcification in
Julien Herrou et al.
Biochemistry, 52(50), 9020-9028 (2013-11-21)
The Gram-negative intracellular pathogen Brucella abortus is the causative agent of brucellosis, which is among the most common zoonoses globally. The B. abortus RicA protein binds the host-expressed guanosine nucleotide-binding protein, Rab2, and modulates B. abortus infection biology. We have
Xiuhong Shan et al.
Journal of computer assisted tomography, 37(1), 22-28 (2013-01-17)
The objective of this study was to investigate the correlation between the degree of necrosis displayed in computed tomography (CT) image and the expression of hypoxic and angiogenesis biomarkers of breast cancer. Forty-four breast cancer cases were examined with CT
Two-dimensional gel isoelectric focusing.
Stastna M and Slais K
Electrophoresis, 26, 3586-3591 (2005)
Bernardo V Alvarez et al.
BMC cardiovascular disorders, 13, 2-2 (2013-01-10)
Carbonic anhydrase enzymes (CA) catalyze the reversible hydration of carbon dioxide to bicarbonate in mammalian cells. Trans-membrane transport of CA-produced bicarbonate contributes significantly to cellular pH regulation. A body of evidence implicates pH-regulatory processes in the hypertrophic growth pathway characteristic
Peter Burghout et al.
Journal of bacteriology, 195(7), 1573-1582 (2013-01-29)
Although carbon dioxide (CO2) is known to be essential for Streptococcus pneumoniae growth, it is poorly understood how this respiratory tract pathogen adapts to the large changes in environmental CO2 levels it encounters during transmission, host colonization, and disease. To
Jaqueline Moisés Tobal et al.
Journal of medical microbiology, 63(Pt 1), 15-27 (2013-10-24)
Aspergillus fumigatus is a ubiquitous saprophytic fungus responsible for organic material decomposition, and plays an important role in recycling environmental carbon and nitrogen. Besides its important role in the environment, this fungus has been reported as one of the most
C Ostheimer et al.
Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al], 190(3), 276-282 (2013-12-11)
Hypoxic radioresistance plays a critical role in the radiotherapy of cancer and adversely impacts prognosis and treatment response. This prospective study investigated the interrelationship and the prognostic significance of several hypoxia-related proteins in non-small cell lung cancer (NSCLC) patients treated
Forskolin and camptothecin induce a 30 kDa protein associated with melatonin production in Y79 human retinoblastoma cells.
Janavs JL, et al.
The Journal of Neuroscience, 15, 298-309 (1995)
Dina Schütze et al.
Journal of cancer research and clinical oncology, 139(5), 747-754 (2013-01-30)
Carbonic anhydrase IX (CAIX) is involved in pH homeostasis, growth and survival of tumor cells. Besides the membranous form of CAIX, a soluble form is detectable in serum (s-CAIX). Overexpression of CAIX in tumors offers the opportunity for therapeutic strategies
Ronny Lehneck et al.
The FEBS journal, 281(7), 1759-1772 (2014-02-11)
Carbonic anhydrases (CAs) are metalloenzymes catalyzing the reversible hydration of carbon dioxide to bicarbonate (hydrogen carbonate) and protons. CAs have been identified in archaea, bacteria and eukaryotes and can be classified into five groups (α, β, γ, δ, ζ) that
F E Lock et al.
Oncogene, 32(44), 5210-5219 (2012-12-05)
The sub-population of tumor cells termed 'cancer stem cells' (CSCs) possess the capability to generate tumors, undergo epithelial-mesenchymal transition (EMT) and are implicated in metastasis, making treatments to specifically target CSCs an attractive therapeutic strategy. Tumor hypoxia plays a key
Leo Syrjänen et al.
Journal of medicinal chemistry, 56(18), 7372-7381 (2013-08-28)
Leishmaniasis is an infection provoked by protozoans belonging to the genus Leishmania. Among the many species and subsepecies of such protozoa, Leishmania donovani chagasi causes visceral leishmaniasis. A β-carbonic anhydrase (CA, EC 4.2.1.1) was cloned and characterized from this organism
Jan E Wachters et al.
The Laryngoscope, 123(9), 2154-2160 (2013-10-30)
To examine the prognostic value of hypoxia inducible factor HIF-1a, CA-IX, and OPN on clinical outcome in patients with T1-T2 supraglottic laryngeal squamous cell carcinoma (LSCC) treated with primarily radiotherapy (RT). Retrospective cohort study. Tumor tissue sections of 60 patients
Wolfgang Maret et al.
Metal ions in life sciences, 11, 1-29 (2013-02-23)
Cadmium is known for its toxicity in animals and man as it is not used in these species. Its only role in biology is as a zinc replacement at the catalytic site of a particular class of carbonic anhydrases in
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