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Takashi Sakurai et al.
Experimental cell research, 319(14), 2152-2165 (2013-06-08)
Cardiac remodeling resulting from impairment of myocardial integrity leads to heart failure, through still incompletely understood mechanisms. The fibroblast growth factor (FGF) system has been implicated in tissue maintenance, but its role in the adult heart is not well defined.
Daniel Adesse et al.
Microbes and infection, 10(1), 21-28 (2007-12-11)
Gap junction proteins (connexins) are required for myocardial function, since they allow intercellular transmission of current carrying ions and signaling molecules. Previous studies demonstrated that rat cardiac myocytes infected with Trypanosoma cruzi lost gap junctional communication and decreased automaticity. We
Iván Barría et al.
The American journal of tropical medicine and hygiene, 98(1), 105-112 (2017-11-17)
Trypanosoma cruzi, the etiological agent of Chagas diseases, invades the cardiac tissue causing acute myocarditis and heart electrical disturbances. In T. cruzi invasion, the parasite induces [Ca2+]i transients in the host cells, an essential phenomenon for invasion. To date, knowledge
Lukas J Motloch et al.
Journal of the American Heart Association, 7(18), e009598-e009598 (2018-10-30)
Background SERCA 2a gene transfer ( GT ) improves mechano-electrical function in animal models of nonischemic heart failure Whether SERCA 2a GT reverses pre-established remodeling at an advanced stage of ischemic heart failure is unclear. We sought to uncover the
A Tittarelli et al.
British journal of cancer, 113(2), 259-267 (2015-07-03)
Alterations in connexin 43 (Cx43) expression and/or gap junction (GJ)-mediated intercellular communication are implicated in cancer pathogenesis. Herein, we have investigated the role of Cx43 in melanoma cell proliferation and apoptosis sensitivity in vitro, as well as metastatic capability and
Gap Junctions: Basic Structure and Function
Gulistan M, et al.
The Journal of Investigative Dermatology, 127(11), 2516-2524 (2007)
Satoko Ishikawa et al.
American journal of physiology. Heart and circulatory physiology, 302(12), H2536-H2544 (2012-04-17)
Sarcolemmal connexin-43 (Cx43) and mitochondrial Cx43 play distinct roles: formation of gap junctions and production of reactive oxygen species (ROS) for redox signaling. In this study, we examined the hypothesis that Cx43 contributes to activation of a major cytoprotective signal
Connections with connexins: the molecular basis of direct intercellular signaling.
Bruzzone R, et al.
European Journal of Biochemistry, 238(1), 1-27 (1996)
Alice E Zemljic-Harpf et al.
The American journal of pathology, 165(3), 1033-1044 (2004-08-28)
Vinculin and its muscle splice variant metavinculin link focal adhesions and cell-to-cell contact sites to the actin cytoskeleton. We hypothesized that normal expression of vinculin isoforms would be essential for integrity of cardiomyocytes and preservation of normal cardiac function. We
Kouji Fukuyama et al.
Pharmaceuticals (Basel, Switzerland), 13(6) (2020-06-11)
Recent studies using the genetic partial epilepsy model have demonstrated that hyperfunction of astroglial hemichannels contributes to pathomechanism of epileptic seizure. Therefore, to explore the novel anticonvulsive mechanisms, the present study determined the effects of voltage-dependent Na+ channel (VDSC)-inhibiting anticonvulsants
U Ullmann et al.
Molecular human reproduction, 14(3), 169-179 (2008-02-12)
Feeder-free culture induces spontaneous differentiation of human embryonic stem cells (hESCs), identified as an epithelial to mesenchymal transition (EMT). The maintenance of pluripotency of hESCs in feeder-free cultures through the activation of the WNT pathway using a glycogen synthase kinase
Crystal M Ripplinger et al.
Circulation research, 101(10), 1049-1057 (2007-09-22)
Human hypertrophic cardiomyopathy, characterized by cardiac hypertrophy and myocyte disarray, is the most common cause of sudden cardiac death in the young. Hypertrophic cardiomyopathy is often caused by mutations in sarcomeric genes. We sought to determine arrhythmia propensity and underlying
Jae Hyung Park et al.
Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology, 22(1), 58-64 (2012-06-05)
The existence of myofibroblasts (MFBs) and the role of subendocardial smooth muscle (SSM) layer of human atrial tissue in atrial fibrillation (AF) have not yet been elucidated. We hypothesized that the SSM layer and MFB play some roles in atrial
Emily Farrell et al.
Frontiers in physiology, 9, 1442-1442 (2018-11-10)
Rationale: With a prevalence of 1 in 200 individuals, hypertrophic cardiomyopathy (HCM) is thought to be the most common genetic cardiac disease, with potential outcomes that include severe hypertrophy, heart failure, and sudden cardiac death (SCD). Though much research has
High-Content Screening Identifies New Inhibitors of Connexin 43 Gap Junctions.
Picoli, et al.
Assay and Drug Development Technologies, 17, 240-248 (2020)
Nicole H Bowens et al.
Molecular pharmacology, 83(1), 22-32 (2012-09-27)
4-(2-Butyl-6,7-dichloro-2-cyclopentyl-indan-1-on-5-yl) oxobutyric acid (DCPIB) was identified as the selective blocker of volume-regulated anion channels (VRAC). VRAC are permeable to small inorganic and organic anions, including the excitatory neurotransmitter glutamate. In recent years DCPIB has been increasingly used for probing the
Hui Yang et al.
Frontiers in cellular neuroscience, 12, 129-129 (2018-06-06)
Bone cancer pain (BCP) is common in patients with advanced cancers when the tumors are metastasized to bone. The limited understanding of the complex pathogenesis of BCP leads to the poor effectiveness of clinical treatment. Previous studies have shown that
Lisa Prevedel et al.
The American journal of pathology, 187(9), 1960-1970 (2017-07-09)
Chronic HIV infection due to effective antiretroviral treatment has resulted in a broad range of clinical complications, including accelerated heart disease. Individuals with HIV infection have a 1.5 to 2 times higher incidence of cardiovascular diseases than their uninfected counterparts;
Shaohua Xiao et al.
The Journal of clinical investigation, 130(9), 4858-4870 (2020-06-12)
Connexin-43 (Cx43) gap junctions provide intercellular coupling, which ensures rapid action potential propagation and synchronized heart contraction. Alterations in Cx43 localization and reductions in gap junction coupling occur in failing hearts, contributing to ventricular arrhythmias and sudden cardiac death. Recent
Eugenia Butkevich et al.
Current biology : CB, 14(8), 650-658 (2004-04-16)
Connexins form gap junctions that mediate the transfer of ions, metabolites, and second messengers between contacting cells. Many aspects of connexin function, for example cellular transport, plaque assembly and stability, and channel conductivity, are finely tuned and likely involve proteins
Thi Ngoc Co Zeleny et al.
Frontiers in neurology, 8, 308-308 (2017-07-15)
Meningothelial cells (MECs) play a central role in the maintenance of cerebrospinal fluid (CSF) homeostasis and in physiological and pathophysiological processes within the subarachnoid space (SAS) linking them to optic nerve (ON) pathologies. Still, not much is known about their
Gregory W Serrao et al.
Tissue engineering. Part A, 18(13-14), 1322-1333 (2012-04-17)
The therapeutic potential of mesenchymal stem cells (MSCs) for restoring cardiac function after cardiomyocyte loss remains controversial. Engineered cardiac tissues (ECTs) offer a simplified three-dimensional in vitro model system to evaluate stem cell therapies. We hypothesized that contractile properties of
Dan Tong et al.
Biology of reproduction, 80(6), 1099-1106 (2009-01-30)
Expression of GJA1 (commonly known as connexin43 or Cx43), a major myometrial gap junction protein, is upregulated before the onset of delivery, suggesting an essential role for Cx43-mediated gap junctional intercellular communication (GJIC) in normal uterine contraction during parturition. To
Amanda Denuc et al.
Journal of cellular and molecular medicine, 20(5), 794-803 (2016-02-27)
Connexin 43 (Cx43), the gap junction protein involved in cell-to-cell coupling in the heart, is also present in the subsarcolemmal fraction of cardiomyocyte mitochondria. It has been described to regulate mitochondrial potassium influx and respiration and to be important for
David Johansen et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 28(1), 103-114 (2011-08-26)
Gap junction intercellular communication (GJIC) and hemichannel permeability may have important roles during an ischemic insult. Our aim was to evaluate the effect of ischemia on gap junction channels and hemichannels. We used neonatal rat heart myofibroblasts and simulated ischemia
Shih-Chi Su et al.
The Journal of biological chemistry, 285(52), 40624-40634 (2010-10-16)
Sprouting angiogenesis is a multistep process that involves endothelial cell activation, basement membrane degradation, proliferation, lumen formation, and stabilization. In this study, we identified annexin 2 as a regulator of endothelial morphogenesis using a three-dimensional in vitro model where sprouting
Bennett J Waxse et al.
Journal of cell science, 130(5), 827-840 (2017-01-18)
In this study, we demonstrate myosin VI enrichment at Cx43 (also known as GJA1)-containing gap junctions (GJs) in heart tissue, primary cardiomyocytes and cell culture models. In primary cardiac tissue and in fibroblasts from the myosin VI-null mouse as well
Wing Yan Yu et al.
Stem cells and development, 24(5), 624-639 (2014-10-18)
A growing body of evidence has revealed that stem-like cells in the posterior limbus of the eye between the corneal endothelium (CE) and trabecular meshwork (TM) may be able to rejuvenate these tissues in disease. However, these cells have not
Danielle Wu et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(29), 12096-12101 (2013-07-03)
Osteocytes are bone cells that form cellular networks that sense mechanical loads distributed throughout the bone tissue. Interstitial fluid flow in the lacunar canalicular system produces focal strains at localized attachment sites around the osteocyte cell process. These regions of
Rachael P Norris et al.
Journal of cell science, 130(7), 1333-1340 (2017-02-17)
Gap junction turnover occurs through the internalization of both of the plasma membranes of a gap junction plaque, forming a double membrane-enclosed vesicle, or connexosome. Phosphorylation has a key role in regulation, but further progress requires the ability to clearly
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