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Sarah Y Branch et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(28), 9310-9318 (2014-07-11)
Substantia nigra dopamine neurons are involved in behavioral processes that include cognition, reward learning, and voluntary movement. Selective deterioration of these neurons is responsible for the motor deficits associated with Parkinson's disease (PD). Aging is the leading risk factor for
Joseph M Santin et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 308(12), R1045-R1061 (2015-04-03)
Locus coeruleus neurons of anuran amphibians contribute to breathing control and have spontaneous firing frequencies that, paradoxically, increase with cooling. We previously showed that cooling inhibits a depolarizing membrane current, the hyperpolarization-activated current (I h) in locus coeruleus neurons from
Philip A Gurnev et al.
Langmuir : the ACS journal of surfaces and colloids, 28(45), 15824-15830 (2012-10-24)
We demonstrate that the cation-selective channel formed by gramicidin A can be used as a reliable sensor for studying the multivalent ion accumulation at the surfaces of charged lipid membranes and the "charge inversion" phenomenon. In asymmetrically charged membranes with
Takafumi Yamamoto et al.
Inorganic chemistry, 50(22), 11787-11794 (2011-10-25)
The rock salt (B1) structure of binary oxides or chalcogenides transforms to the CsCl (B2) structure under high pressure, with critical pressures P(s) depending on the cation to anion size ratio (R(c)/R(a)). We investigated structural changes of A(2)MO(3) (A =
Hai-Chao Zhou et al.
PloS one, 9(10), e107606-e107606 (2014-10-15)
Tannins from the leaves of a medicinal mangrove plant, Ceriops tagal, were purified and fractionated on Sephadex LH-20 columns. 13C nuclear magnetic resonance (13C-NMR), reversed/normal high performance liquid chromatography electrospray ionization mass spectrometry (HPLC-ESI MS) and matrix-assisted laser desorption/ionization time-of-flight
Heather S Davies et al.
PloS one, 9(9), e108372-e108372 (2014-09-30)
The salivary mucins that include MUC5B (gel-forming) and MUC7 (non-gel-forming) are major contributors to the protective mucus barrier in the oral cavity, and it is possible that dietary components may influence barrier properties. We show how one dietary compound, the
Recording of mechanosensitive currents using piezoelectrically driven mechanostimulator
Jizhe H, et al.
Nature Protocols, 6(7), 979-979 (2011)
Kevin O Saunders et al.
Journal of virology, 89(16), 8334-8345 (2015-06-05)
Broadly neutralizing antibodies (bnAbs) can prevent lentiviral infection in nonhuman primates and may slow the spread of human immunodeficiency virus type 1 (HIV-1). Although protection by passive transfer of human bnAbs has been demonstrated in monkeys, durable expression is essential
C Dika et al.
Physical chemistry chemical physics : PCCP, 15(15), 5691-5700 (2013-03-12)
Previous experimental and theoretical studies have established that electrokinetic and aggregation properties of soft MS2 phages are not only governed by the physico-chemical features of their proteinaceous outer surface but are also significantly impacted by those of their inner RNA
Yingying Lin et al.
Immunology and cell biology, 93(2), 213-217 (2014-10-08)
Dendritic cells (DCs) have the tolerogenic potential to regulate adaptive immunity and induce allografts acceptance. Here we investigated whether blockade of the CD40 pathway could enhance the immune tolerance induced by DC2.4 cells modified to express Jagged-1 (JAG1-DC) in heart
Sarah L Caddy et al.
Journal of clinical microbiology, 53(6), 1873-1883 (2015-04-03)
Human noroviruses (HuNoVs) are a major cause of viral gastroenteritis, with an estimated 3 million cases per year in the United Kingdom. HuNoVs have recently been isolated from pet dogs in Europe (M. Summa, C.-H. von Bonsdorff, and L. Maunula
Yong Xia et al.
Journal of molecular modeling, 18(6), 2291-2299 (2011-10-04)
Theoretical studies of a new ion-pair receptor, meso-octamethylcalix[4]pyrrole (OMCP), and its interactions with the halide anions F(-), Cl(-), and Br(-) and the cesium halides CsF, CsCl, and CsBr have been performed. Geometries, binding energies, and binding enthalpies were evaluated with
Na Li et al.
Applied and environmental microbiology, 81(17), 5845-5854 (2015-06-21)
The occurrence of Cryptosporidium oocysts in drinking source water can present a serious public health risk. To rapidly and effectively assess the source and human-infective potential of Cryptosporidium oocysts in water, sensitive detection and correct identification of oocysts to the
Daniel R Swale et al.
PloS one, 9(8), e103713-e103713 (2014-08-08)
Recent studies suggest that N, N-diethyl-meta-toluamide (DEET) is an acetylcholinesterase inhibitor and that this action may result in neurotoxicity and pose a risk to humans from its use as an insect repellent. We investigated the mode of action of DEET
Andrey G Malyutin et al.
ACS applied materials & interfaces, 7(22), 12089-12098 (2015-05-20)
Here we explore the formation of virus-like nanoparticles (VNPs) utilizing 22-24 nm iron oxide nanoparticles (NPs) as cores and proteins derived from viral capsids of brome mosaic virus (BMV) or hepatitis B virus (HBV) as shells. To accomplish that, hydrophobic
Petr Melnikov et al.
Biological trace element research, 135(1-3), 1-9 (2009-08-06)
The knowledge about cesium metabolism and toxicity is sparse. Oral intake of cesium chloride has been widely promoted on the basis of the hypothesis referred to as "high pH cancer therapy", a complimentary alternative medicine method for cancer treatment. However
D V Amakhin et al.
Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova, 98(12), 1490-1506 (2013-03-07)
Whole-cell patch clamp recordings from isolated neurons from rat prefrontal cortex have been made to study the interaction of responses induced by application of GABA and glutamate. Two different pipette solutions were used in this research: the first one was
Fengqin Zhu et al.
PloS one, 10(11), e0142349-e0142349 (2015-11-12)
More than 170 million individuals worldwide are infected with hepatitis C virus (HCV), and up to an estimated 30% of chronically infected individuals will go on to develop progressive liver disease. Despite the recent advances in antiviral treatment of HCV
Aleksander W Ballo et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 32(15), 5106-5119 (2012-04-13)
We studied how conduction delays of action potentials in an unmyelinated axon depended on the history of activity and how this dependence was changed by the neuromodulator dopamine (DA). The pyloric dilator axons of the stomatogastric nervous system in the
Piotr Jurkiewicz et al.
Biochimica et biophysica acta, 1818(3), 609-616 (2011-12-14)
Effects of alkali metal chlorides on the properties of mixed negatively charged lipid bilayers are experimentally measured and numerically simulated. Addition of 20mol% of negatively charged phosphatidylserine to zwitterionic phosphatidylcholine strengthens adsorption of monovalent cations revealing their specificity, in the
Juan Armendáriz-Borunda et al.
Journal of bioscience and bioengineering, 112(5), 415-421 (2011-08-23)
Gene therapy represents a promising approach in the treatment of several diseases. Currently, the ideal vector has yet to be designed; though, adenoviral vectors (Ad-v) have provided the most utilized tool for gene transfer due principally to their simple production
Mitsuo Hashimoto et al.
Journal of immunology (Baltimore, Md. : 1950), 195(3), 1182-1190 (2015-06-26)
Small airway chronic inflammation is a major pathologic feature of chronic obstructive pulmonary disease (COPD) and is refractory to current treatments. Dendritic cells (DCs) accumulate around small airways in COPD. DCs are critical mediators of Ag surveillance and Ag presentation
Therese Abrahamsson et al.
Neuron, 73(6), 1159-1172 (2012-03-27)
Interneurons are critical for neuronal circuit function, but how their dendritic morphologies and membrane properties influence information flow within neuronal circuits is largely unknown. We studied the spatiotemporal profile of synaptic integration and short-term plasticity in dendrites of mature cerebellar
Jie Wu et al.
Oncology reports, 35(1), 243-252 (2015-11-05)
Multigene-based combination therapy may be an effective practice in cancer gene therapy. Substantial studies have demonstrated that tumor suppressor p53 acetylation is indispensable for p53 activation. Inhibitor of growth 4 (ING4), as a novel tumor suppressor, is capable of remarkably
N M Mel'nykova et al.
Ukrains'kyi biokhimichnyi zhurnal (1999 ), 85(2), 105-109 (2013-07-03)
Cesium is lately accumulated actively in the environment, but its influence on human and animal organism is the least studied among heavy metals. It is shown that the action of cesium chloride in rats caused significant changes in blood chemistry
Piyanuch Wonganan et al.
Drug metabolism and disposition: the biological fate of chemicals, 42(7), 1191-1201 (2014-04-26)
HC-04 cells were evaluated as an in vitro model for mechanistic study of changes in the function of hepatic CYP3A during virus infection. Similar to in vivo observations, infection with a first generation recombinant adenovirus significantly inhibited CYP3A4 catalytic activity
Sandra Aedo et al.
Antimicrobial agents and chemotherapy, 56(11), 5458-5464 (2012-08-08)
DNA topoisomerases are important targets in anticancer and antibacterial therapy because drugs can initiate cell death by stabilizing the transient covalent topoisomerase-DNA complex. In this study, we employed a method that uses CsCl density gradient centrifugation to separate unbound from
Shuji Wakatsuki et al.
The Journal of cell biology, 211(4), 881-896 (2015-11-18)
Oxidative stress is a well-known inducer of neuronal apoptosis and axonal degeneration. We previously showed that the E3 ubiquitin ligase ZNRF1 promotes Wallerian degeneration by degrading AKT to induce GSK3B activation. We now demonstrate that oxidative stress serves as an
Ping Guo et al.
Bioengineered, 4(2), 103-106 (2012-09-21)
Adeno-Associated Virus (AAV) has been widely used for in vivo study and preclinical therapy due to its ability to mediate long-term transgene expression, its lack of pathogenicity and low immunogenicity. It has been found that AAV has more than ten
Swathi Balaji et al.
The Journal of surgical research, 190(1), 367-377 (2014-04-15)
Chronic wounds are characterized by a wound healing and neovascularization deficit. Strategies to increase neovascularization can significantly improve chronic wound healing. Insulin-like growth factor (IGF)-1 is reported to be a keratinocyte mitogen and is believed to induce angiogenesis via a
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