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C2920

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Gregory E Miner et al.
Traffic (Copenhagen, Denmark), 20(11), 841-850 (2019-08-02)
The accumulation of copper in organisms can lead to altered functions of various pathways and become cytotoxic through the generation of reactive oxygen species. In yeast, cytotoxic metals such as Hg+ , Cd2+ and Cu2+ are transported into the lumen...
Csilla-Maria Ferencz et al.
Scientific reports, 7, 45309-45309 (2017-03-28)
Rotary enzymes are complex, highly challenging biomolecular machines whose biochemical working mechanism involves intersubunit rotation. The true intrinsic rate of rotation of any rotary enzyme is not known in a native, unmodified state. Here we use the effect of an...
Farzaneh G Tahrir et al.
Journal of cellular physiology, 233(2), 748-758 (2017-05-12)
Cardiovascular disease remains a leading cause of morbidity and mortality in HIV-positive patients, even in those whose viral loads are well controlled with antiretroviral therapy. However, the underlying molecular events responsible for the development of cardiac disease in the setting...
Sofia Barbosa-Gouveia et al.
Journal of clinical medicine, 8(8) (2019-08-23)
Complex I (nicotinamide adenine dinucleotide (NADH): ubiquinone oxidoreductase) is the largest complex of the mitochondrial oxidative phosphorylation system (OXPHOS) system. Forty-four subunits encoded in nuclear and mitochondrial genomes compose this multiprotein complex, its assembly being a highly complex process involving...
Naohide Kanemoto et al.
Nature communications, 10(1), 2172-2172 (2019-05-17)
Inducing mitochondrial uncoupling (mUncoupling) is an attractive therapeutic strategy for treating metabolic diseases because it leads to calorie-wasting by reducing the efficiency of oxidative phosphorylation (OXPHOS) in mitochondria. Here we report a safe mUncoupler, OPC-163493, which has unique pharmacokinetic characteristics....
Martín Alcalá et al.
Scientific reports, 7(1), 16082-16082 (2017-11-24)
Obesity is associated with severe metabolic diseases such as type 2 diabetes, insulin resistance, cardiovascular disease and some forms of cancer. The pathophysiology of obesity-induced metabolic diseases has been strongly related to white adipose tissue (WAT) dysfunction through several mechanisms...
Isabel C O Morais et al.
PloS one, 10(7), e0132569-e0132569 (2015-07-21)
Acute renal failure is a common complication caused by Bothrops viper envenomation. In this study, the nefrotoxicity of a main component of B. leucurus venom called L-aminoacid oxidase (LAAO-Bl) was evaluated by using tubular epithelial cell lines MDCK and HK-2...
Forrest Keck et al.
Virulence, 8(8), 1849-1866 (2017-01-12)
Mitochondria are sentinel organelles that are impacted by various forms of cellular stress, including viral infections. While signaling events associated with mitochondria, including those activated by pathogen associated molecular patterns (PAMPs), are widely studied, alterations in mitochondrial distribution and changes...
Olli Kärkkäinen et al.
Scientific reports, 8(1), 13036-13036 (2018-08-31)
Despite epidemiological evidence showing that diets rich in whole grains reduce the risk of chronic life-style related diseases, biological mechanisms for these positive effects are mostly unknown. Increased 5-aminovaleric acid betaine (5-AVAB) levels in plasma and metabolically active tissues such...
Masaru Koido et al.
Oncotarget, 8(7), 11841-11854 (2017-01-07)
Mitochondria can be involved in regulating cellular stress response to hypoxia and tumor growth, but little is known about that mechanistic relationship. Here, we show that mitochondrial deficiency severely retards tumor xenograft growth with impairing hypoxic induction of HIF-1 transcriptional...
Andreas Prokesch et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 31(2), 732-742 (2016-11-05)
The ability to adapt cellular metabolism to nutrient availability is critical for survival. The liver plays a central role in the adaptation to starvation by switching from glucose-consuming processes and lipid synthesis to providing energy substrates like glucose to the...
Aisling O'Brien et al.
Journal of immunology (Baltimore, Md. : 1950), 202(12), 3404-3411 (2019-05-12)
Obesity underpins the development of numerous chronic diseases, such as type II diabetes mellitus. It is well established that obesity negatively alters immune cell frequencies and functions. Mucosal-associated invariant T (MAIT) cells are a population of innate T cells, which...
Daniela Fluegge et al.
Nature neuroscience, 15(5), 754-762 (2012-03-27)
In olfactory sensory neurons (OSNs), cytosolic Ca(2+) controls the gain and sensitivity of olfactory signaling. Important components of the molecular machinery that orchestrates OSN Ca(2+) dynamics have been described, but key details are still missing. Here, we demonstrate a critical...
Mingming Yang et al.
PloS one, 12(5), e0177951-e0177951 (2017-05-26)
Bioenergetics of artery smooth muscle cells is critical in cardiovascular health and disease. An acute rise in metabolic demand causes vasodilation in systemic circulation while a chronic shift in bioenergetic profile may lead to vascular diseases. A decrease in intracellular...
Johannes Lerchner et al.
Analytical and bioanalytical chemistry, 411(17), 3763-3768 (2019-05-17)
We describe a chip calorimetric technique that allows the investigation of biological material under anoxic conditions in a micro-scale and in real time. Due to the fast oxygen exchange through the sample flow channel wall, the oxygen concentration inside the...
D Panja et al.
Neuropathology and applied neurobiology, 45(2), 141-156 (2018-04-22)
Neurodegeneration is associated with dysfunction of calcium buffering capacity and thereby sustained cellular and mitochondrial calcium overload. Paraneoplastic cerebellar degeneration (PCD), characterized by progressive Purkinje neurone degeneration following paraneoplastic Yo antibody internalization and binding to cerebellar degeneration-related protein CDR2 and...
Eduardo L Guimarães et al.
BMC gastroenterology, 12, 68-68 (2012-06-13)
Mitochondrial dysfunction participates in the progression of several pathologies. Although there is increasing evidence for a mitochondrial role in liver disease, little is known about its contribution to hepatic stellate cell (HSC) activation. In this study we investigated the role...
Sharon Wein et al.
Antimicrobial agents and chemotherapy, 58(9), 5519-5527 (2014-07-09)
Bis-thiazolium salts constitute a new class of antihematozoan drugs that inhibit parasite phosphatidylcholine biosynthesis. They specifically accumulate in Plasmodium- and Babesia-infected red blood cells (IRBC). Here, we provide new insight into the choline analogue albitiazolium, which is currently being clinically...
Araceli Tobío et al.
Journal of cellular biochemistry, 113(12), 3752-3761 (2012-07-19)
Yessotoxin (YTX) is a marine polyether toxin previously described as a phosphodiesterase (PDE) activator in fresh human lymphocytes. This toxin induces a decrease of adenosine 3',5'-cyclic monophosphate (cAMP) levels in fresh human lymphocytes in a medium with calcium (Ca(2+) )...
Yang-Yi Fan et al.
American journal of physiology. Gastrointestinal and liver physiology, 309(1), G1-G9 (2015-05-16)
Evidence suggests that targeting cancer cell energy metabolism might be an effective therapeutic approach for selective ablation of malignancies. Using a Seahorse Extracellular Flux Analyzer, we have demonstrated that select environmental agents can alter colonic mitochondrial function by increasing respiration-induced...
Qing Yao et al.
Developmental cell, 49(5), 748-763 (2019-05-21)
Oxygen (O2) is both an indispensable metabolic substrate and a regulatory signal that controls the activity of Hypoxia-Inducible Factor 1α (Hif1a), a mediator of the cellular adaptation to low O2 tension (hypoxia). Hypoxic cells require Hif1a to survive. Additionally, Hif1a...
Isabelle Arnoux et al.
eLife, 7 (2018-09-05)
Catching primal functional changes in early, 'very far from disease onset' (VFDO) stages of Huntington's disease is likely to be the key to a successful therapy. Focusing on VFDO stages, we assessed neuronal microcircuits in premanifest Hdh150 knock-in mice. Employing...
Andrew Wang et al.
Proceedings of the National Academy of Sciences of the United States of America, 116(6), 2200-2209 (2019-01-25)
Secondary hemophagocytic lymphohistiocytosis (sHLH) is a highly mortal complication associated with sepsis. In adults, it is often seen in the setting of infections, especially viral infections, but the mechanisms that underlie pathogenesis are unknown. sHLH is characterized by a hyperinflammatory...
Nicolas Germain et al.
International journal of medical sciences, 16(7), 931-938 (2019-07-26)
The diagnosis of mitochondrial diseases is a real challenge because of the vast clinical and genetic heterogeneity. Classically, the clinical examination and genetic analysis must be completed by several biochemical assays to confirm the diagnosis of mitochondrial disease. Here, we...
L C S De Vries et al.
Inflammatory bowel diseases, 25(4), 647-660 (2019-01-23)
Janus kinases (JAKs) mediate cytokine signaling involved in inflammatory bowel disease. The pan-JAK inhibitor tofacitinib has shown efficacy in the treatment of ulcerative colitis. However, concerns regarding adverse events due to their wide spectrum inhibition fueled efforts to develop selective...
Shusong Zhang et al.
Journal of immunology (Baltimore, Md. : 1950), 200(3), 1064-1077 (2017-12-31)
Mature naive T cells circulate through the secondary lymphoid organs in an actively enforced quiescent state. Impaired cell survival and cell functions could be found when T cells have defects in quiescence. One of the key features of T cell...
Albert Herms et al.
Nature communications, 6, 7176-7176 (2015-05-28)
Lipid droplets (LDs) are intracellular organelles that provide fatty acids (FAs) to cellular processes including synthesis of membranes and production of metabolic energy. While known to move bidirectionally along microtubules (MTs), the role of LD motion and whether it facilitates...
Xianwei Cui et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 30(12), 4301-4312 (2016-09-23)
Brown adipose tissue (BAT) oxidizes fatty acids for thermogenesis and could therefore be considered as part of a new strategy in combating obesity and associated metabolic diseases. It is well established that aging is accompanied by a decline of brown...
Shota Ozawa et al.
Scientific reports, 5, 18575-18575 (2015-12-19)
Differentiated podocytes, a type of renal glomerular cells, require substantial levels of energy to maintain glomerular physiology. Mitochondria and glycolysis are two major producers of ATP, but the precise roles of each in podocytes remain unknown. This study evaluated the...
Martina Kunkl et al.
Cells, 8(6) (2019-06-20)
The immunopathogenesis of multiple sclerosis (MS) depend on the expansion of specific inflammatory T cell subsets, which are key effectors of tissue damage and demyelination. Emerging studies evidence that a reprogramming of T cell metabolism may occur in MS, thus...
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