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Yuan Li et al.
Toxicology and applied pharmacology, 272(3), 726-735 (2013-08-21)
Curcumin, a phytochemical agent in the spice turmeric, has received increasing attention for its anticancer, anti-inflammatory and antioxidant properties. However, application of curcumin has been limited due to its insolubility in water and poor bioavailability both clinically and experimentally. In
Jianfeng Liu et al.
Stem cells international, 2015, 638153-638153 (2015-06-16)
The poor survival rate of transplanted stem cells in ischemic myocardium has limited their therapeutic efficacy. Curcumin has potent antioxidant property. This study investigates whether prior curcumin treatment protects stem cells from oxidative stress injury and improves myocardial recovery following
Andreas Koeberle et al.
Journal of medicinal chemistry, 57(13), 5638-5648 (2014-06-13)
The anticarcinogenic and anti-inflammatory properties of curcumin have been extensively investigated, identifying prostaglandin E2 synthase (mPGES)-1 and 5-lipoxygenase (5-LO), key enzymes linking inflammation with cancer, as high affinity targets. A comparative structure-activity study revealed three modifications dissecting mPGES-1/5-LO inhibition, namely
Pei-Ling Chi et al.
British journal of pharmacology, 171(12), 2993-3009 (2014-03-19)
Infection with Gram-negative bacteria has been recognized as an initiator of rheumatoid arthritis, which is characterized by chronic inflammation and infiltration of immune cells. Carbon monoxide (CO) exhibits anti-inflammatory properties. Here we have investigated the detailed mechanisms of vascular cell
Dietary curcumin supplement influence on growth, immunity, antioxidant status, and resistance to Aeromonas hydrophila in Oreochromis niloticus
Mahmoud HK, et al.
Aquaculture (Amsterdam, Netherlands), 475, 16-23 (2017)
Ji Ho Kang et al.
Experimental biology and medicine (Maywood, N.J.), 240(11), 1416-1425 (2015-02-27)
Although carboplatin is one of the standard chemotherapeutic agents for non-small cell lung cancer (NSCLC), it has limited therapeutic efficacy due to activation of a survival signaling pathway and the induction of multidrug resistance. Curcumin, a natural compound isolated from
Jianping Chen et al.
PloS one, 9(6), e101277-e101277 (2014-06-28)
This study was to investigate the synergistic effect of NB/Cur on growth and apoptosis in A375 human melanoma cell line by MTT assay, flow cytometry and Western blotting. Our results demonstrated that NB effectively synergized with Cur to enhance its
Wen-Cheng Lu et al.
PloS one, 9(9), e108049-e108049 (2014-09-18)
Oral squamous cell carcinoma (OSCC) is one of the most prevalent carcinomas worldwide. MicroRNAs (miRNAs) are short, non-coding RNAs that regulate gene expression and modulate physiological or pathological processes including OSCC carcinogenesis. miR-31 has been found to be up-regulated in
Liqiang Zou et al.
Food & function, 6(8), 2475-2486 (2015-07-15)
The influence of emulsifier type on the ability of excipient emulsions to improve the solubility, stability, and bioaccessibility of powdered curcumin was examined. Oil-in-water emulsions prepared using three different emulsifiers (whey protein isolate, caseinate, or Tween 80) were mixed with
Shi Yin et al.
Cancer biology & therapy, 19(4), 260-270 (2016-11-08)
Glioblastoma multiforme is the most malignant and common brain tumor in adults and is characterized by poor survival and high resistance to chemotherapy and radiotherapy. Among the new chemotherapy drugs, curcumin, a popular dietary supplement, has proven to have a
Wylly Ramsés García-Niño et al.
Biological trace element research, 167(1), 130-145 (2015-03-17)
Hexavalent chromium [Cr(VI)] compounds are extremely toxic and carcinogenic. Despite the vast quantity of reports about Cr(VI) toxicity, the information regarding its effects when it is intraperitoneally (i.p.) administered is still limited. In contrast, it has been shown that curcumin
Jingfei Zhang et al.
The Journal of nutrition, 144(8), 1211-1218 (2014-06-06)
Curcumin, a naturally occurring antioxidant, has various beneficial effects in the treatment of human diseases. However, little information regarding the protection it provides against acute liver injury is available. The present study investigated the protective effects of curcumin against D-galactosamine
Lichuan Wu et al.
Oncology reports, 34(6), 3311-3317 (2015-09-24)
Tumor recurrence and drug resistance are the main obstacles blocking effective treatment of cancer patients. Cancer stem cells (CSCs) have been demonstrated to be highly related to tumor recurrence and drug resistance. Thus, eliminating CSCs may be an alternative for
W Tripanichkul et al.
European review for medical and pharmacological sciences, 17(10), 1360-1368 (2013-06-07)
Inflammation and oxidative stress are believed to contribute to neuronal degeneration of the nigrostriatal dopaminergic (DA) pathway in Parkinson's disease. Curcumin, a component of the yellow curry spice, has been reported possessing anti-inflammatory and anti-oxidative effects. The present study investigated
Johana Tello Velasquez et al.
PloS one, 9(10), e111787-e111787 (2014-11-02)
One of the promising strategies for neural repair therapies is the transplantation of olfactory ensheathing cells (OECs) which are the glial cells of the olfactory system. We evaluated the effects of curcumin on the behaviour of mouse OECs to determine
Curcumin ameliorates autoimmune diabetes. Evidence in accelerated murine models of type 1 diabetes.
Castro CN, Barcala Tabarrozzi AE, Winnewisser J, et al.
Clinical and Experimental Immunology, 177(1), 149-160 (2014)
Lu Fan et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 68(8), 1141-1148 (2014-12-03)
Sarco/endoplasmic reticulum calcium ATPase (SERCA) enzymes play important roles in several signal transduction pathways that control proliferation, differentiation and apoptosis. Here, we reported that SERCA2 expression was positively correlated with tumor node metastasis (TNM) stages (n=75, P=0.0251) and grades (n=63
Letícia Mazzarino et al.
Journal of pharmaceutical sciences, 103(11), 3764-3771 (2014-09-05)
Mucoadhesive films containing curcumin-loaded nanoparticles were developed, aiming to prolong the residence time of the dosage form in the oral cavity and to increase drug absorption through the buccal mucosa. Films were prepared by the casting method after incorporation of
Bingshan Wu et al.
DNA and cell biology, 32(6), 292-297 (2013-04-30)
DNA methylation plays an essential role in carcinogenesis. Promoter hypermethylation can result in transcriptional silencing of specific genes, such as tumor suppressors. Thus far, few reports have investigated the effect of curcumin, an active component of the perennial herb Curcuma
Benjawan Meesarapee et al.
Phytotherapy research : PTR, 28(4), 611-616 (2013-07-17)
6-Hydroxydopamine (6-OHDA) selectively enters dopaminergic neurons and undergoes auto-oxidation resulting in the generation of reactive oxygen species and dopamine quinones, subsequently leading to apoptosis. This mechanism mimics the pathogenesis of Parkinson's disease and has been used to induce experimental Parkinsonism
Ganji Purnachandra Nagaraju et al.
Cancer letters, 341(2), 195-203 (2013-08-13)
DNA methylation is a rational therapeutic target in pancreatic cancer. The activity of novel curcumin analogues EF31 and UBS109 as demethylating agents were investigated. MiaPaCa-2 and PANC-1 cells were treated with vehicle, curcumin, EF31 or UBS109. EF31 and UBS109 resulted
Linsheng Yu et al.
The American journal of the medical sciences, 349(6), 521-525 (2015-04-14)
Curcumin, extracted from South Asian spice turmeric, has been determined to have the promising ability in antioxidation and anti-inflammation. However, the effect of curcumin on treating brain damage has been not reported. In this article, the aim was to evaluate
Misaki Ono et al.
Anticancer research, 33(5), 1861-1866 (2013-05-07)
Curcumin has potent antitumor activity against many types of human cancers. However, the inhibitory effects and possible mechanisms of curcumin on gallbladder cancer remains to be determined. Using HAG-1 human gallbladder adenocarcinoma cells, we investigated the effects of curcumin on
Reham M Milhem et al.
The international journal of biochemistry & cell biology, 60, 119-129 (2015-01-07)
Muscle, skeletal, receptor tyrosine kinase (MuSK) is a key organizer at the postsynaptic membrane and critical for proper development and maintenance of the neuromuscular junction. Mutations in MUSK result in congenital myasthenic syndrome (CMS). We hypothesized that the CMS-causing missense
Jianping Chen et al.
Journal of agricultural and food chemistry, 63(28), 6440-6449 (2015-06-09)
Curcumin (Cur), an active ingredient from the rhizome of the plant Curcuma longa, has wide anticancer activities. However, due to its poor solubility and hence poor absorption, Cur has limited clinical applications. It is therefore important to develop an effective
Filippo Fontani et al.
Experimental cell research, 323(1), 77-86 (2014-03-04)
Matrix metalloproteinases (MMPs) play a critical role in inflammation and ulcerations in gut of Crohn׳s disease (CD) patients. Intestinal subepithelial myofibroblasts (ISEMFs) secrete MMPs in response to inflammatory stimuli. Previous data showed in CD-ISEMFs increased oxidative status. The aim of
Pattamapan Lomarat et al.
Natural product communications, 10(8), 1431-1434 (2015-10-06)
The objective of this study was to evaluate the health benefits of plants used in Thai food, specifically Acacia pennata Willd., in Alzheimer's prevention. A. pennata twigs strongly inhibited β-amyloid aggregation. Bioactivity-guided separation of the active fractions yielded six known
Pietro Dulbecco et al.
World journal of gastroenterology, 19(48), 9256-9270 (2014-01-11)
Curcumin is a low-molecular-weight hydrophobic polyphenol that is extracted from turmeric, which possesses a wide range of biological properties including anti-inflammatory, anti-oxidant, anti-proliferative and anti-microbial activities. Despite its diverse targets and substantial safety, clinical applications of this molecule for digestive
Shanshan Gao et al.
Journal of molecular and cellular cardiology, 85, 131-139 (2015-05-07)
To address the underlying mechanisms by which curcumin facilitates M2 phenotype polarization of macrophages and its roles in the protective effects during experimental autoimmune myocarditis (EAM). The expression of classic M2 markers, including macrophage mannose receptor (MMR), arginase-1 (Arg-1) and
Krassimira Yoncheva et al.
International journal of pharmaceutics, 490(1-2), 298-307 (2015-06-01)
The aim of the present study was to develop curcumin loaded cationic polymeric micelles and to evaluate their loading, preservation of curcumin antioxidant activity and intracellular uptake ability. The micelles were prepared from a triblock copolymer consisting of poly(ϵ-caprolactone) and
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