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Assessment of nicotine for second hand smoke exposure in some public places in Romania by UPLC-MS
Bratan A, et al.
Chemistry Central Journal, 8(1), 29-29 (2014)
Phedias Diamandis et al.
Nature chemical biology, 3(5), 268-273 (2007-04-10)
The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain cancer. However, the complete repertoire of signaling pathways that governs the
Mohammad A Kaisar et al.
BMC neuroscience, 18(1), 71-71 (2017-10-13)
A sensitive, rapid and selective UHPLC-MS/MS method has been developed and validated for the quantification of Nicotine (NT) and Cotinine (CN) using Continine-d A linear response function was established for the range of concentrations 3-200 (r > 0.995) for NT and 3-600 ng/mL
Laura E Korhonen et al.
Journal of medicinal chemistry, 48(11), 3808-3815 (2005-05-27)
The purpose of this study was to determine the cytochrome P450 1A2 (CYP1A2) inhibition potencies of structurally diverse compounds to create a comprehensive three-dimensional quantitative structure-activity relationship (3D-QSAR) model of CYP1A2 inhibitors and to use this model to predict the
A sensitive HPLC-ESI-MS-MS method for the determination of cotinine in urine
Apinan R, et al.
Journal of Chromatographic Science, 48(6), 460-465 (2010)
Jing Yuan et al.
Nature chemical biology, 5(10), 765-771 (2009-09-08)
Studies of gene function and molecular mechanisms in Plasmodium falciparum are hampered by difficulties in characterizing and measuring phenotypic differences between individual parasites. We screened seven parasite lines for differences in responses to 1,279 bioactive chemicals. Hundreds of compounds were
Michael H Abraham et al.
European journal of medicinal chemistry, 43(3), 478-485 (2007-06-05)
Values of in vitro gas to lung partition coefficients, K(lung), of VOCs have been collected from the literature. For 44 VOCs, application of the Abraham solvation equation to log K(lung) yielded a correlation with R(2)=0.968 and S.D.=0.25 log units. Combination
A simple, sensitive, and rapid method for the determination of cotinine in urine by high-performance liquid chromatography with UV detection
Rabbaa-Khabbaz L, et al.
Journal of Chromatographic Science, 44(9), 535-538 (2006)
Manthena V S Varma et al.
Journal of medicinal chemistry, 53(3), 1098-1108 (2010-01-15)
Oral bioavailability (F) is a product of fraction absorbed (Fa), fraction escaping gut-wall elimination (Fg), and fraction escaping hepatic elimination (Fh). In this study, using a database comprised of Fa, Fg, Fh, and F values for 309 drugs in humans
R Scott Obach et al.
Drug metabolism and disposition: the biological fate of chemicals, 36(7), 1385-1405 (2008-04-23)
We present herein a compilation and trend analysis of human i.v. pharmacokinetic data on 670 drugs representing, to our knowledge, the largest publicly available set of human clinical pharmacokinetic data. This data set provides the drug metabolism scientist with a
Minna Rahnasto et al.
Journal of medicinal chemistry, 48(2), 440-449 (2005-01-22)
The purpose of this study was to develop screening and in silico modeling methods to obtain accurate information on the active center of CYP2A6, a nicotine oxidizing enzyme. The inhibitory potencies of 26 naphthalene and 16 non-naphthalene derivatives were determined
Rapid and sensitive high-performance liquid chromatographic determination of nicotine and cotinine in nonsmoker human and rat urines
Oddoze.C, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 708(1-2), 95-101 (1998)
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