Showing 1-30 of 43 results for "

C-046

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Jonathan A Farrimond et al.
Psychopharmacology, 223(1), 117-129 (2012-05-01)
Increased food consumption following ∆(9)-tetrahydrocannabinol-induced cannabinoid type 1 receptor agonism is well documented. However, possible non-∆(9)-tetrahydrocannabinol phytocannabinoid-induced feeding effects have yet to be fully investigated. Therefore, we have assessed the effects of the individual phytocannabinoids, cannabigerol, cannabidiol and cannabinol, upon...
Yukari Tsumura et al.
Forensic science international, 221(1-3), 77-83 (2012-05-05)
In recent years, increased 'cannabis potency', or Δ(9)-tetrahydrocannabinol (THC) content in cannabis products, has been reported in many countries. A survey of Japanese illicit cannabis was conducted from April 2010 to March 2011. In Japan, all cannabis evidence is transferred...
Lucio Minuti et al.
The Journal of organic chemistry, 77(18), 7923-7931 (2012-08-24)
Diels-Alder reactions of a range of 1-(alkoxy/alkyl/halogen-substituted phenyl)buta-1,3-dienes with methyl propiolate carried out in a green ethanolic medium under 9 kbar pressure were investigated. The use of high pressure as activating method of the Diels-Alder reactions allows efficient and regioselective...
C Balducci et al.
Analytica chimica acta, 641(1-2), 89-94 (2009-04-28)
The determination of delta(9)-tetrahydrocannabinol (Delta9-THC), cannabidiol (CND) and cannabinol (CNB), primary active components in cannabis preparation, was carried out on airborne particulates by applying a specific procedure consisting of soot extraction by ultrasonic bath, purification by solvent partitioning, derivatization with...
Karl B Scheidweiler et al.
Clinical chemistry, 59(7), 1108-1117 (2013-03-23)
Blood and plasma cannabinoid stability is important for test interpretation and is best studied in authentic rather than fortified samples. Low and high blood and plasma pools were created for each of 10 participants after they smoked a cannabis cigarette....
Christian Gratzke et al.
The Journal of urology, 185(2), 731-736 (2010-12-21)
We studied the effects of chronic treatment with the novel selective cannabinoid 2 receptor agonist cannabinor (Procter & Gamble Pharmaceuticals, Cincinnati, Ohio) on bladder function in conscious rats with partial urethral obstruction and on the functional properties of isolated detrusor...
Georg Juckel et al.
Schizophrenia research, 97(1-3), 109-117 (2007-09-22)
Reduced amplitudes of auditory evoked mismatch negativity (MMN) have often been found in schizophrenic patients, indicating deficient auditory information processing and working memory. Cannabis-induced psychotic states may resemble schizophrenia. Currently, there are discussions focusing on the close relationship between cannabis...
Christine Moore et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 852(1-2), 459-464 (2007-02-27)
Tetrahydrocannabinol (THC) is an important psychoactive ingredient in marijuana, which is the most widely used illegal recreational drug in the USA. Since it is generally smoked, the constituents of the plant material, as well as THC may be present in...
Alaa Al Saabi et al.
Drug metabolism and disposition: the biological fate of chemicals, 41(3), 568-574 (2012-12-12)
Ethyl glucuronide (EtG) determination is increasingly used in clinical and forensic toxicology to document ethanol consumption. The enzymes involved in EtG production, as well as potential interactions with common drugs of abuse, have not been extensively studied. Activities of human...
Elissandro Soares Emídio et al.
Analytica chimica acta, 670(1-2), 63-71 (2010-08-06)
The development of an analytical method for the determination of Delta(9)-tetrahydrocannabinol (THC), cannabidiol (CBD) and cannabinol (CBN) in samples of human hair is described. Samples were subjected to a procedure based on the combination of headspace solid-phase microextraction (HS-SPME) with...
Dayong Lee et al.
Clinical chemistry, 57(8), 1127-1136 (2011-06-17)
Oral fluid (OF) is an accepted alternative biological matrix for drug treatment, workplace, and DUID (driving under the influence of drugs) investigations, but establishing the cannabinoid OF detection window and concentration cutoff criteria are important. Cannabinoid concentrations were quantified in...
Spyros P Nikas et al.
Journal of medicinal chemistry, 53(19), 6996-7010 (2010-10-12)
In pursuit of a more detailed understanding of the structural requirements for the key side chain cannabinoid pharmacophore, we have extended our SAR to cover a variety of conformationally modified side chains within the 9-keto and 9-hydroxyl tricyclic structures. Of...
Aizhi Zhang et al.
Se pu = Chinese journal of chromatography, 28(11), 1015-1019 (2011-03-09)
A method for the simultaneous determination of delta-9-tetrahydrocannabinol (THC), cannabidiol (CBD) and cannabinol (CBN) in edible oil was developed using ultra performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). The target compounds were extracted with methanol, purified by an LC-Alumina-N solid phase...
Dayong Lee et al.
Clinical chemistry, 58(4), 748-756 (2012-01-26)
We measured Δ(9)-tetrahydrocannabinol (THC), 11-nor-9-carboxy-THC (THCCOOH), cannabidiol (CBD), and cannabinol (CBN) disposition in oral fluid (OF) following controlled cannabis smoking to evaluate whether monitoring multiple cannabinoids in OF improved OF test interpretation. Cannabis smokers provided written informed consent for this...
Dinesh Thapa et al.
European journal of pharmacology, 650(1), 64-71 (2010-10-19)
Both natural and synthetic cannabinoids have been shown to suppress the growth of tumor cells in culture and in animal models by affecting key signaling pathways including angiogenesis, a pivotal step in tumor growth, invasion, and metastasis. In our search...
Krishna Prasad Bastola et al.
Planta medica, 73(3), 273-275 (2007-03-14)
Cannabinoids, the main constituents of the cannabis plant, are being increasingly studied for their medicinal properties. Cannabinolic acid (CBNA; 1) was synthesized from tetrahydrocannabinolic acid (THCA; 2), a major constituent of the cannabis plant, by aromatization using selenium dioxide mixed...
F Van der Kooy et al.
Inhalation toxicology, 21(2), 87-90 (2008-10-16)
Medicinal cannabis has attracted a lot of attention in recent times. Various forms of administration are used, of which smoking is very common but the least desirable. Smoking cannabis generates a large amount of unwanted side products, of which carcinogenic...
Penchal Reddy Nandaluru et al.
Organic letters, 14(1), 310-313 (2011-12-17)
A multicomponent domino reaction that affords 6H-dibenzo[b,d]pyran-6-ones is reported. The overall transformation consists of six reactions: Knoevenagel condensation, transesterification, enamine formation, an inverse electron demand Diels-Alder (IEDDA) reaction, 1,2-elimination, and transfer hydrogenation. Both the diene and dienophile for the key...
Raymond J M Niesink et al.
Addiction (Abingdon, England), 110(12), 1941-1950 (2015-08-04)
Between 2000 and 2005 the average percentage of Δ(9) -tetrahydrocannabinol (THC) in marijuana as sold in Dutch coffeeshops has increased substantially; the potency of domestic products (Nederwiet and Nederhasj) has particularly increased. In contrast with imported marijuana, Nederwiet hardly contained...
M A Huestis
Handbook of experimental pharmacology, (168)(168), 657-690 (2006-04-07)
Increasing interest in the biology, chemistry, pharmacology, and toxicology of cannabinoids and in the development of cannabinoid medications necessitates an understanding of cannabinoid pharmacokinetics and disposition into biological fluids and tissues. A drug's pharmacokinetics determines the onset, magnitude, and duration...
Smoked marijuana as medicine: not much future.
H Kalant
Clinical pharmacology and therapeutics, 83(4), 517-519 (2008-03-20)
Camilla Montesano et al.
Journal of chromatography. A, 1406, 192-200 (2015-06-30)
Hair analysis has become a routine procedure in most forensic laboratories since this alternative matrix presents clear advantages over classical matrices; particularly wider time window, non-invasive sampling and good stability of the analytes over time. There are, however, some major...
Satoshi Yamaori et al.
Biochemical pharmacology, 79(11), 1691-1698 (2010-02-02)
Inhibitory effects of Delta(9)-tetrahydrocannabinol (Delta(9)-THC), cannabidiol (CBD), and cannabinol (CBN), the three major constituents in marijuana, on catalytic activities of human cytochrome P450 (CYP) 1 enzymes were investigated. These cannabinoids inhibited 7-ethoxyresorufin O-deethylase activity of recombinant CYP1A1, CYP1A2, and CYP1B1...
Nathalie A Desrosiers et al.
Clinical chemistry, 58(10), 1418-1425 (2012-08-23)
Oral fluid (OF) testing offers noninvasive sample collection for on-site drug testing; however, to date, test performance for Δ(9)-tetrahydrocannabinol (THC) detection has had unacceptable diagnostic sensitivity. On-site tests must accurately identify cannabis exposure because this drug accounts for the highest...
Satoshi Yamaori et al.
Drug metabolism and pharmacokinetics, 27(3), 294-300 (2011-12-15)
Inhibitory effects of Δ⁹-tetrahydrocannabinol (Δ⁹-THC), cannabidiol (CBD), and cannabinol (CBN), the three major constituents in marijuana, and polycyclic aromatic hydrocarbons (PAHs) contained in marijuana smoke on catalytic activity of human cytochrome P450 (CYP) 2C9 were investigated. These phytocannabinoids concentration-dependently inhibited...
David M Schwope et al.
Clinical chemistry, 57(10), 1406-1414 (2011-08-13)
Δ⁹-Tetrahydrocannabinol (THC) is the most frequently observed illicit drug in investigations of accidents and driving under the influence of drugs. THC-glucuronide has been suggested as a marker of recent cannabis use, but there are no blood data following controlled THC...
Satoshi Yamaori et al.
Life sciences, 88(15-16), 730-736 (2011-03-02)
In this study, we examined the inhibitory effects of Δ(9)-tetrahydrocannabinol (Δ(9)-THC), cannabidiol (CBD), and cannabinol (CBN), the three major cannabinoids, on the activity of human cytochrome P450 (CYP) 3A enzymes. Furthermore, we investigated the kinetics and structural requirement for the...
Michelle L Holland et al.
European journal of pharmacology, 591(1-3), 128-131 (2008-07-16)
The ATP-binding cassette (ABC) transporter ABCC1, or multidrug resistance-related protein 1 (MRP1) is implicated in Phase II metabolism and multidrug resistance as it effluxes substrate anticancer drugs. As cannabinoids inhibit two related ABC transporters, P-glycoprotein and ABCG2, here we examined...
Yan-Mei Mao et al.
Journal of clinical pharmacology, 49(8), 929-936 (2009-06-23)
The purpose of this study was to characterize the functional consequences of the 393T>C polymorphism of the GNAS1 gene in vivo. PCR-RFLP assays were used to identify GNAS1 and beta 1-adrenoceptor genotypes. The heart rate (HR), blood pressure, left ventricular...
Chengbin Wang et al.
The Journal of infectious diseases, 191(7), 1084-1092 (2005-03-05)
Antigen presentation and immune activation are essential to the effective control of infectious diseases. In 485 North American adolescents at high risk for genital Chlamydia trachomatis infection, we found 2 human leukocyte antigen variants (DRB1*03-DQB1*04 and DQB1*06) to be associated...