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Valeria Feinshtein et al.
American journal of obstetrics and gynecology, 209(6), 573-573 (2013-08-13)
Drugs of abuse affect pregnancy outcomes, however, the mechanisms in which cannabis exerts its effects are not well understood. The aim of this study was to examine the influence of short-term (1-2 hours) exposure to cannabidiol, a major phytocannabinoid, on...
Camilla Montesano et al.
Journal of chromatography. A, 1406, 192-200 (2015-06-30)
Hair analysis has become a routine procedure in most forensic laboratories since this alternative matrix presents clear advantages over classical matrices; particularly wider time window, non-invasive sampling and good stability of the analytes over time. There are, however, some major...
Jane L Armstrong et al.
The Journal of investigative dermatology, 135(6), 1629-1637 (2015-02-13)
Although the global incidence of cutaneous melanoma is increasing, survival rates for patients with metastatic disease remain <10%. Novel treatment strategies are therefore urgently required, particularly for patients bearing BRAF/NRAS wild-type tumors. Targeting autophagy is a means to promote cancer...
Dietmar Rudolf Thal et al.
Journal of neural transmission (Vienna, Austria : 1996), 122(7), 1007-1018 (2015-01-06)
Frontotemporal lobar degeneration with τ pathology (FTLD-tau) is one of a group of neurodegenerative diseases that manifests with cognitive decline. Alzheimer (AD) and cerebrovascular lesions are commonly noted in the brains of most elderly individuals, begging the question as to...
Luan C Koay et al.
American journal of physiology. Gastrointestinal and liver physiology, 307(2), G140-G148 (2014-05-17)
Autophagy is a catabolic process involved in homeostatic and regulated cellular protein recycling and degradation via the lysosomal degradation pathway. Emerging data associate impaired autophagy, increased activity in the endocannabinoid system, and upregulation of suppressor of cytokine signaling-3 (SOCS3) protein...
Pot ingredient for epilepsy.
Annie Sneed
Scientific American, 310(5), 29-29 (2014-05-03)
A W Zuardi et al.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 39(4), 421-429 (2006-04-14)
A high dose of delta9-tetrahydrocannabinol, the main Cannabis sativa (cannabis) component, induces anxiety and psychotic-like symptoms in healthy volunteers. These effects of delta9-tetrahydrocannabinol are significantly reduced by cannabidiol (CBD), a cannabis constituent which is devoid of the typical effects of...
Patrik Roser et al.
Current pharmaceutical design, 18(32), 5141-5155 (2012-06-22)
Several lines of experimental and clinical evidence point to a close relationship between cannabis, the endogenous cannabinoid system, and schizophrenia. A variety of animal and human studies found a dysregulation of endocannabinoid signalling in psychosis. Elevated anandamide levels in schizophrenia...
Joe A Lemire et al.
Antimicrobial agents and chemotherapy, 59(7), 4031-4039 (2015-04-29)
Historically it has been accepted, and recent research has established, that silver (Ag) is an efficacious antimicrobial agent. A dwindling pipeline of new antibiotics, combined with an increase in the number of antibiotic-resistant infections, is bringing Ag to the fore...
Stephen D Skaper et al.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 367(1607), 3193-3200 (2012-10-31)
The psychoactive component of the cannabis resin and flowers, delta9-tetrahydrocannabinol (THC), was first isolated in 1964, and at least 70 other structurally related 'phytocannabinoid' compounds have since been identified. The serendipitous identification of a G-protein-coupled cannabinoid receptor at which THC...
Amr A Fouad et al.
Environmental toxicology and pharmacology, 36(2), 347-357 (2013-06-01)
The potential protective effect of cannabidiol, the major non-psychotropic Cannabis constituent, was investigated against doxorubicin cardiotoxicity in rats. Cardiotoxicity was induced by six equal doses of doxorubicin (2.5mgkg(-1) i.p., each) given at 48h intervals over two weeks to achieve a...
Raymond J M Niesink et al.
Addiction (Abingdon, England), 110(12), 1941-1950 (2015-08-04)
Between 2000 and 2005 the average percentage of Δ(9) -tetrahydrocannabinol (THC) in marijuana as sold in Dutch coffeeshops has increased substantially; the potency of domestic products (Nederwiet and Nederhasj) has particularly increased. In contrast with imported marijuana, Nederwiet hardly contained...
Henriette L Røder et al.
Food microbiology, 51, 18-24 (2015-07-19)
Bacterial attachment and biofilm formation can lead to poor hygienic conditions in food processing environments. Furthermore, interactions between different bacteria may induce or promote biofilm formation. In this study, we isolated and identified a total of 687 bacterial strains from...
Amir Englund et al.
Journal of psychopharmacology (Oxford, England), 27(1), 19-27 (2012-10-09)
Community-based studies suggest that cannabis products that are high in Δ⁹-tetrahydrocannabinol (THC) but low in cannabidiol (CBD) are particularly hazardous for mental health. Laboratory-based studies are ideal for clarifying this issue because THC and CBD can be administered in pure...
Katherine Ann Scott et al.
Anticancer research, 33(10), 4373-4380 (2013-10-15)
Cannabinoids are the bioactive components of the Cannabis plant that display a diverse range of therapeutic qualities. We explored the activity of six cannabinoids, used both alone and in combination in leukaemic cells. Cannabinoids were cytostatic and caused a simultaneous...
Dolores Hernán Pérez de la Ossa et al.
PloS one, 8(1), e54795-e54795 (2013-01-26)
Cannabinoids, the active components of marijuana and their derivatives, are currently investigated due to their potential therapeutic application for the management of many different diseases, including cancer. Specifically, Δ(9)-Tetrahydrocannabinol (THC) and Cannabidiol (CBD) - the two major ingredients of marijuana...
Javier Fernández-Ruiz et al.
British journal of clinical pharmacology, 75(2), 323-333 (2012-05-26)
Cannabidiol (CBD) is a phytocannabinoid with therapeutic properties for numerous disorders exerted through molecular mechanisms that are yet to be completely identified. CBD acts in some experimental models as an anti-inflammatory, anticonvulsant, anti-oxidant, anti-emetic, anxiolytic and antipsychotic agent, and is...
Vinay Dhir et al.
Gastrointestinal endoscopy, 81(4), 913-923 (2014-12-09)
A single session of EUS-guided biliary drainage (EUS-BD) may be a viable alternative to ERCP in patients with malignant distal common bile duct (CBD) obstruction. There is no study comparing EUS-BD and ERCP for the relief of distal malignant biliary obstruction....
Harshini Neelakantan et al.
Behavioural pharmacology, 26(3), 304-314 (2014-12-09)
Cannabinoid and opioid agonists can display overlapping behavioral effects and the combination of these agonists is known to produce enhanced antinociception in several rodent models of acute and chronic pain. The present study investigated the antinociceptive effects of the nonpsychoactive...
Robert Ramer et al.
Molecular cancer therapeutics, 12(1), 69-82 (2012-12-12)
The antitumorigenic mechanism of cannabidiol is still controversial. This study investigates the role of COX-2 and PPAR-γ in cannabidiol's proapoptotic and tumor-regressive action. In lung cancer cell lines (A549, H460) and primary cells from a patient with lung cancer, cannabidiol...
Derik Hermann et al.
Current pharmaceutical design, 18(32), 4897-4905 (2012-06-22)
Cannabis use and the development of schizophrenic psychoses share a variety of similarities. Both start during late adolescence; go along with neuropsychological deficits, reduced activity, motivation deficits, and hallucinations suggesting impairment of similar brain structures. In cannabis heavy users diminished...
Nathalie A Desrosiers et al.
Clinical chemistry, 58(10), 1418-1425 (2012-08-23)
Oral fluid (OF) testing offers noninvasive sample collection for on-site drug testing; however, to date, test performance for Δ(9)-tetrahydrocannabinol (THC) detection has had unacceptable diagnostic sensitivity. On-site tests must accurately identify cannabis exposure because this drug accounts for the highest...
Patrícia Schönhofen et al.
Molecular neurobiology, 52(1), 26-37 (2014-08-12)
Cannabidiol (CBD), one of the most abundant Cannabis sativa-derived compounds, has been implicated with neuroprotective effect in several human pathologies. Until now, no undesired side effects have been associated with CBD. In this study, we evaluated CBD's neuroprotective effect in...
Liliana Soroceanu et al.
Cancer research, 73(5), 1559-1569 (2012-12-18)
Glioblastoma is the most common form of primary adult brain tumors. A majority of glioblastomas grow invasively into distant brain tissue, leading to tumor recurrence, which is ultimately incurable. It is, therefore, essential to discover master regulators that control glioblastoma...
Jochen Weigt et al.
Journal of hepato-biliary-pancreatic sciences, 22(1), 74-78 (2014-10-14)
Direct peroral cholangioscopy (POCS) is an emerging technique complementing endoscopic retrograde cholangiopancreatography (ERCP). Only few data about the learning process of this technique exist. The objective of this study is to investigate the learning process of POCS in a tertiary...
Tatiana Barichello et al.
European journal of pharmacology, 697(1-3), 158-164 (2012-10-23)
Pneumococcal meningitis is a life-threatening disease characterized by an acute infection affecting the pia matter, arachnoid and subarachnoid space. The intense inflammatory response is associated with a significant mortality rate and neurologic sequelae, such as, seizures, sensory-motor deficits and impairment...
Nadine Reichhart et al.
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 253(6), 865-874 (2015-01-27)
The retinal pigment epithelium (RPE) interacts closely with the photoreceptors in fulfilling tasks of visual function. Since an understanding of the RPE function is essential for understanding the patho-mechanisms involved in vision loss, we explored the regulation of the vanilloid...
Alline Cristina Campos et al.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 367(1607), 3364-3378 (2012-10-31)
Cannabidiol (CBD) is a major phytocannabinoid present in the Cannabis sativa plant. It lacks the psychotomimetic and other psychotropic effects that the main plant compound Δ(9)-tetrahydrocannabinol (THC) being able, on the contrary, to antagonize these effects. This property, together with...
Albin Jeanne et al.
Oncotarget, 6(20), 17981-18000 (2015-06-06)
The multi-modular glycoprotein thrombospondin-1 (TSP-1) is considered as a key actor within the tumor microenvironment. Besides, TSP-1 binding to CD47 is widely reported to regulate cardiovascular function as it promotes vasoconstriction and angiogenesis limitation. Therefore, many studies focused on targeting...
Tiina J Kauppila et al.
Drug testing and analysis, 5(3), 186-190 (2012-09-15)
Fast analysis of cannabis samples without prior sample preparation or chromatography was performed using desorption atmospheric pressure photoionization-mass spectrometry (DAPPI-MS). The MS(2) spectra of the molecular ions of tetrahydrocannabinol (THC) and cannabidiol (CBD) formed in DAPPI-MS showed distinct product ions...
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