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Sunyoung Park et al.
Biochemical and biophysical research communications, 450(1), 13-18 (2014-05-27)
Although many peptides have therapeutic effects against diverse disease, their short half-lives in vivo hurdle their application as drug candidates. To extend the short elimination half-lives of therapeutic peptides, we developed a novel delivery platform for therapeutic peptides using an
Maksymilian Kulza et al.
Przeglad lekarski, 69(10), 837-840 (2013-02-21)
The use of tobacco is a very serious threat to public health. Reducing the proportion of smokers easily leads to improved health of the general population. Smoking is a proven risk factor for respiratory disease, cardiovascular disease and cancer and
Van T Tong et al.
Acta obstetricia et gynecologica Scandinavica, 94(1), 106-111 (2014-10-29)
Evidence of bias of self-reported smoking cessation during pregnancy is reported in high-income countries but not elsewhere. We sought to evaluate self-reported smoking cessation during pregnancy using biochemical verification and to compare characteristics of women with and without biochemically confirmed
Christian Ginzkey et al.
Toxicology letters, 229(1), 303-310 (2014-07-02)
Human nasal miniorgan cultures (MOC) are a useful tool in ecogenotoxicology. Repetitive exposure to nicotine showed reversible DNA damage, and stable CYP2A6 expression was demonstrated in nasal MOC in previous investigations. The aim of the present study was to evaluate
Jakub Marcin Nowak et al.
Postepy higieny i medycyny doswiadczalnej (Online), 66, 996-1005 (2012-01-01)
This review presents the current state of knowledge on cotinine, the major metabolite of nicotine. Special attention is paid to the formation of this compound in the organism, its metabolism, application in diagnostic procedures and evaluation of its in vitro
A P Santos-Silva et al.
The Journal of endocrinology, 218(1), 13-24 (2013-04-23)
Children from pregnant smokers show more susceptibility to develop obesity in adult life. Previously, we failed to demonstrate a program for obesity in rat offspring only when the mothers were exposed to tobacco smoke during lactation. Here, we studied the
Gonca Yilmaz et al.
Journal of tropical pediatrics, 59(5), 365-371 (2013-05-18)
Little research has focused on brief and practical strategies for addressing environmental tobacco smoke exposure through interventions focused explicitly on creating a smoke-free home. We used a two-group (intervention and control groups) repeated-measures randomized controlled trial design. Families were randomized
Cotinine as a biomarker of environmental tobacco smoke exposure.
N L Benowitz
Epidemiologic reviews, 18(2), 188-204 (1996-01-01)
Natalie S Shenker et al.
Epidemiology (Cambridge, Mass.), 24(5), 712-716 (2013-07-23)
Most biomarkers of exposure tend to have short half-lives. This includes cotinine, a metabolite of nicotine widely used to assess smoke exposure. Cotinine is thus unsuitable as a determinant of past exposure to cigarette smoke. We used bisulphite pyrosequencing of
Sungroul Kim et al.
Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 15(9), 1608-1616 (2013-03-20)
Cutoff values for distinguishing smokers from nonsmokers have generally been derived from studies in White populations. Even though recent population-based studies have demonstrated that cutoff values can differ by race and ethnicity, few studies have explored cutoff values among Asian
Sarah Connor Gorber et al.
Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 11(1), 12-24 (2009-02-28)
Smoking is a leading cause of premature mortality and preventable morbidity. Surveillance is most often based on self-reported data, but studies have shown that self-reports tend to underestimate smoking status. This study systematically reviewed the literature to measure the concordance
Marzenna Broszkiewicz et al.
Przeglad lekarski, 69(10), 846-853 (2013-02-21)
Diagnostics in the intensive interventions of tobacco use and dependence should include, among others assessments of nicotine dependence, motivation to quit and readiness to change. Based on the own research findings critical researcher's assessment of the accuracy of some recommended
Observations on the number of saliva cotinine positives over a nine-year period.
S Mortlock et al.
British journal of biomedical science, 70(1), 43-44 (2013-04-27)
Kuan-Yen Tung et al.
Environmental research, 124, 7-12 (2013-04-30)
Environmental tobacco smoke (ETS) is a hazardous component of indoor air, and may increase the risk of respiratory diseases, atherosclerosis and otitis media in children. In this study, we explored the relationship between time inside the house, ETS exposure and
Ines Moreno-Gonzalez et al.
Nature communications, 4, 1495-1495 (2013-02-21)
Several epidemiological studies have shown that cigarette smoking might alter the incidence of Alzheimer's disease. However, inconsistent results have been reported regarding the risk of Alzheimer's disease among smokers. Previous studies in experimental animal models have reported that administration of
Steven L Bramer et al.
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals, 8(3-4), 187-203 (2003-08-29)
Subjects enrolled in studies are not always screened for routine habits such as smoking. Personal history is not always reliable and therefore an objective biomarker is necessary to screen for smokers. The objectives of this article were to review the
Jinny E Sánchez-Rodríguez et al.
Environmental research, 136, 227-233 (2014-12-03)
Anti-smoking legislation has been associated with an improvement in health indicators. Since the cadmium (Cd) body burden in the general population is markedly increased by smoke exposure, we analyzed the impact of the more restrictive legislation that came into force
The detection of biomarkers of tobacco smoke exposure in wound fluid: a pilot study.
Amy Anne D Lassig et al.
Plastic and reconstructive surgery, 132(5), 892e-894e (2013-10-30)
Irene Shu et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 928, 139-145 (2013-05-02)
Concentrations of nicotine and its metabolites in blood are indicative of patients' current tobacco exposure, and their quantifications have been clinically applied to multiple assessments including demonstration of abstinence prior to heart-lung transplantation. For the purpose of transplant evaluation, the
R R Watts et al.
Environmental health perspectives, 84, 173-182 (1990-03-01)
A two-day technical workshop was convened November 10-11, 1986, to discuss analytical approaches for determining trace amounts of cotinine in human body fluids resulting from passive exposure to environmental tobacco smoke (ETS). The workshop, jointly sponsored by the U.S. Environmental
Valentina Echeverria et al.
CNS neuroscience & therapeutics, 18(7), 517-523 (2012-04-26)
Tobacco smoking has been correlated with a lower incidence of Alzheimer's disease (AD). This negative correlation has been attributed to nicotine's properties. However, the undesired side-effects of nicotine and the absence of clear evidence of positive effects of this drug
Radioimmunoassay for nicotine and cotinine.
H Van Vunakis et al.
IARC scientific publications, (81)(81), 317-330 (1987-01-01)
Andrea Rossnerova et al.
Mutation research, 741-742, 18-26 (2013-03-06)
Gene expression levels are significantly regulated by DNA methylation. Differences in gene expression profiles in the populations from various locations with different environmental conditions were repeatedly observed. In this study we compare the methylation profiles in 200 blood samples of
Brian K Kit et al.
Pediatrics, 131(3), 407-414 (2013-02-13)
To examine exposure to tobacco smoke products (TSPs), environmental tobacco smoke (ETS), and in-home smoke among youth with asthma in the United States. Nationally representative, cross-sectional data from 2250 youth aged 4 to 19 years with current asthma in the
T Berman et al.
Environment international, 59, 478-484 (2013-08-22)
The Ministry of Health Biomonitoring Study estimated exposure of individuals in the Israeli population to bisphenol A (BPA), organophosphate (OP) pesticides, phthalates, cotinine, polycyclic aromatic hydrocarbons (PAHs), and the phytoestrogenic compounds genistein and daidzein. In 2011, 250 individuals (ages 20-74)
Sandri Rachelle van Staden et al.
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 103(11), 865-868 (2013-10-24)
Chronic obstructive pulmonary disease and lung cancer are diseases associated with smoking tobacco cigarettes. Smokers find cessation difficult. To determine whether smoking the Twisp electronic cigarette (e-cigarette), containing nicotine in a vegetable-based glycerine substance, would reduce carboxyhaemoglobin (COHb) levels in
Germaine M Buck Louis et al.
American journal of epidemiology, 180(12), 1168-1175 (2014-11-15)
Concern has arisen about benzophenone (BP) ultraviolet (UV) radiation filters, given their use in sunscreen and personal-care products and their reported estrogenic and antiandrogenic activity. We recruited 501 couples who were discontinuing use of contraceptives in order to become pregnant
L Lu et al.
European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery, 48(6), 703-710 (2014-12-03)
Both active smoking and exposure to secondhand smoke (SHS) are associated with cardiovascular disease, but sidestream smoke contains higher levels of small particles and toxic gases than mainstream smoke. The relationship between the concentration of cotinine and a number of
Ramneet Gill et al.
The Journal of asthma : official journal of the Association for the Care of Asthma, 51(4), 355-359 (2014-03-04)
The effects of low-level environmental tobacco smoke (ETS) exposure, on asthma control, lung function and inflammatory biomarkers in children with asthma have not been well studied. The objective of the study was to assess ETS exposure in school-age children with
Yin Zhu et al.
The Journal of pediatrics, 163(4), 1158-1162 (2013-07-03)
To examine the association between passive smoking and snoring in preschool children using parent-reported questionnaires and urine cotinine levels. This was a population-based cross-sectional survey of 2954 children aged 2-6 years in Hong Kong. Parent-reported questionnaires provided information on snoring
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