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Huaying Wang et al.
The clinical respiratory journal, 9(3), 330-341 (2014-04-12)
Autoimmune responses mediated by cluster of differentiation 4(+) T cells may contribute to the development of chronic obstructive pulmonary disease (COPD). However, little is known about the frequency of peripheral blood Th17 cells and of regulatory T cells (Tregs) in
Börge Arndt et al.
Journal of leukocyte biology, 97(1), 111-120 (2014-11-13)
It is well established that CD4 and CD8 T cells are required for the initiation of autoimmune diabetes in NOD mice. However, different subsets of CD4 or CD8 cells may play different roles in the initiation of insulitis. In this
Jingjing Feng et al.
Journal of medical virology, 87(4), 708-715 (2015-02-05)
Respiratory syncytial virus (RSV) infection induces activation and imbalance of the immune system; however, the role of T helper 17 cells (Th17) in the response to RSV infection remains unclear. Interleukin-23 (IL-23) is a key cytokine in Th17 cell differentiation.
Yoshihiro Okita et al.
Oncology reports, 34(2), 639-647 (2015-06-18)
Studies of tumor-infiltrating immune cells have revealed that immune escape plays an important role in tumor growth. The aim of the present study was to investigate the impact of metastasis affecting CD4+ T cell subsets in human clinical samples. Single-cell
Donatella Amico et al.
Arthritis research & therapy, 17, 68-68 (2015-04-19)
Abnormal oxidative stress has been described in systemic sclerosis (SSc) and previous works from our laboratory demonstrated an increased generation of reactive oxygen species (ROS) by SSc fibroblasts and monocytes. This study investigated the ability of SSc T lymphocytes to
Yassir Hussien et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(48), 15921-15933 (2015-12-04)
Myelinating cells synthesize large amounts of membrane protein through the secretory pathway, which makes these cells particularly sensitive to perturbations of the endoplasmic reticulum (ER). Ig binding protein (BiP), also known as glucose-regulated protein 78 (GRP78), is a critical ER
Si Chen et al.
Toxicology, 322, 78-88 (2014-05-29)
Sertraline is used for the treatment of depression, and is also used for the treatment of panic, obsessive-compulsive, and post-traumatic stress disorders. Previously, we have demonstrated that sertraline caused hepatic cytotoxicity, with mitochondrial dysfunction and apoptosis being underlying mechanisms. In
Maryam Delfan et al.
Prostaglandins, leukotrienes, and essential fatty acids, 99, 35-40 (2015-06-01)
Physical exercise can induce imbalance of different cytokines by leading them towards an inflammatory and immunosuppressive milieu. Fish-oil (FO) supplementation may modulate the mentioned skewed balance following intense exercise. Therefore, we decided to investigate the effect of intense physical exercise
Elena G Kamburova et al.
PloS one, 9(11), e112658-e112658 (2014-11-14)
Prevention of rejection after renal transplantation requires treatment with immunosuppressive drugs. Data on their in vivo effects on T- and B-cell phenotype and function are limited. In a randomized double-blind placebo-controlled study to prevent renal allograft rejection, patients were treated
Lia Vassena et al.
Journal of virology, 89(10), 5687-5700 (2015-03-31)
Leukocyte recirculation between blood and lymphoid tissues is required for the generation and maintenance of immune responses against pathogens and is crucially controlled by the L-selectin (CD62L) leukocyte homing receptor. CD62L has adhesion and signaling functions and initiates the capture
M Rodriguez-Garcia et al.
Mucosal immunology, 7(6), 1375-1385 (2014-04-25)
Prevention of sexual acquisition of HIV in women requires a substantial increase in our knowledge about HIV-target cell availability and regulation in the female reproductive tract (FRT). In this study, we analyzed the phenotype and susceptibility to HIV infection of
Guoqin Jiang et al.
Immunology letters, 162(1 Pt A), 68-73 (2014-07-30)
Both Th17 and Tc17 cells have been found in various tumors and may play important roles in regulating anti-tumor immune responses. However, the prevalence and distribution of Th17 and Tc17 cells in thyroid tumors are still unclear. In the current
Moustapha Mbow et al.
Immunology, 143(4), 569-577 (2014-06-14)
Differences in lifestyle and break with natural environment appear to be associated with changes in the immune system resulting in various adverse health effects. Although genetics can have a major impact on the immune system and disease susceptibility, the contribution
Li Tong et al.
Clinical immunology (Orlando, Fla.), 155(2), 220-230 (2014-10-14)
Rheumatoid arthritis (RA) is a chronic autoimmune disorder affecting the synovial joints. The currently available drugs for RA are effective only in a proportion of patients and their prolonged use is associated with severe adverse effects. Thus, new anti-arthritic agents
Ponpan Matangkasombut et al.
PLoS neglected tropical diseases, 8(6), e2955-e2955 (2014-06-20)
Dengue viral infection is a global health threat without vaccine or specific treatment. The clinical outcome varies from asymptomatic, mild dengue fever (DF) to severe dengue hemorrhagic fever (DHF). While adaptive immune responses were found to be detrimental in the
Gilles Bioley et al.
Biomaterials, 57, 153-160 (2015-04-29)
Vaccination aims at generating memory immune responses able to protect individuals against pathogenic challenges over long periods of time. Subunit vaccine formulations based on safe, but poorly immunogenic, antigenic entities must be combined with adjuvant molecules to make them efficient
David Anz et al.
Cancer research, 75(21), 4483-4493 (2015-10-04)
The chemokine CCL22 is abundantly expressed in many types of cancer and is instrumental for intratumoral recruitment of regulatory T cells (Treg), an important subset of immunosuppressive and tumor-promoting lymphocytes. In this study, we offer evidence for a generalized strategy
C-C Liu et al.
Thrombosis and haemostasis, 112(3), 537-550 (2014-06-06)
We investigated the role of activated B cells in thrombopoiesis through the production of interleukin (IL)-1beta and IL-6 in patients with essential thrombocythaemia. The number of B cells did not differ between essential thrombocythaemia patients, irrespective of the presence of
Dongchun Liang et al.
Journal of immunology (Baltimore, Md. : 1950), 193(11), 5498-5505 (2014-11-05)
Adenosine is a key endogenous signaling molecule that regulates a wide range of physiological functions, including immune system function and inflammation. Studies have shown that adenosine receptor (AR) agonists can be either anti-inflammatory or proinflammatory in immune responses and in
Sarah Rasche et al.
The review of diabetic studies : RDS, 6(1), 43-53 (2009-06-27)
Autoimmunity to islet cell antigens like glutamic acid decarboxylase 65kD (GAD65) is associated with the destruction of insulin-producing beta-cells and progression to type 1 diabetes (T1D) in NOD mice and humans. T cell responses to GAD65 are detectable in the
Charlotte A Williams et al.
Immunology, 124(1), 89-101 (2007-12-11)
Dendritic cells (DC) are sensitive to their local environment and are affected by proximal cell death. This study investigated the modulatory effect of cell death on DC function. Monocyte-derived DC exposed to apoptotic Jurkat or primary T cells failed to
Geraldine Taylor et al.
Science translational medicine, 7(300), 300ra127-300ra127 (2015-08-14)
Human respiratory syncytial virus (HRSV) is a major cause of lower respiratory tract disease in children and the elderly for which there is still no effective vaccine. We have previously shown that PanAd3-RSV, which is a chimpanzee adenovirus-vectored vaccine candidate
Aimée Domínguez-Nieto et al.
Immunobiology, 220(1), 147-153 (2014-08-31)
Prior exposure to lipopolysaccharides (LPS) induces a state of cell resistance to subsequent LPS restimulation, known as endotoxin tolerance, mainly by repressing the expression of pro-inflammatory cytokines. We established an endotoxin tolerance model in human monocytes Endotoxin-tolerant cells showed a
Chi-Lun Chang et al.
The Journal of biological chemistry, 290(23), 14289-14301 (2015-04-19)
Phosphatidylinositol (PI) 4,5-bisphosphate (PIP2) at the plasma membrane (PM) constitutively controls many cellular functions, and its hydrolysis via receptor stimulation governs cell signaling. The PI transfer protein Nir2 is essential for replenishing PM PIP2 following receptor-induced hydrolysis, but key mechanistic
Xiaomei Yuan et al.
Journal of immunology (Baltimore, Md. : 1950), 194(3), 1334-1346 (2014-12-21)
A network of mechanisms operates to maintain tolerance in the gut mucosa. Although CD103 marks many lymphoid cells within the gut, its direct functional role in intestinal tolerance is poorly understood. CD103 may be part of a redundant pathway, as
Yanping Gong et al.
Digestive diseases and sciences, 60(5), 1308-1314 (2014-09-28)
A subset of interleukin (IL)-10-producing regulatory B (Breg) cells that suppress T-cell-mediated immunity was recently identified; however, their role in chronic hepatitis B (CHB) remains elusive. To explore the possible role of Breg in the interaction with Th cells and
Stephanie A Condotta et al.
Journal of immunology (Baltimore, Md. : 1950), 195(1), 116-125 (2015-05-17)
Patients who survive sepsis display suppressed immune functions, often manifested as an increased susceptibility to secondary infections. Recently, using a cecal-ligation and puncture (CLP) model of sepsis, we showed that sepsis induces substantial and long-lasting changes in the available naive
Lisa A Reynolds et al.
Journal of immunology (Baltimore, Md. : 1950), 193(6), 2984-2993 (2014-08-13)
Helminth parasites remain one of the most common causes of infections worldwide, yet little is still known about the immune signaling pathways that control their expulsion. C57BL/6 mice are chronically susceptible to infection with the gastrointestinal helminth parasite Heligmosomoides polygyrus.
Jeannette Cany et al.
Oncoimmunology, 4(7), e1017701-e1017701 (2015-07-04)
Adoptive transfer of allogeneic natural killer (NK) cells represents a promising treatment approach against cancer, including acute myeloid leukemia (AML). Previously, we reported a cytokine-based culture method for the generation of NK cell products with high cell number and purity.
R De Bruyne et al.
Clinical and experimental immunology, 180(3), 542-550 (2015-02-17)
Calcineurin inhibitors (CNI), used frequently in solid organ transplant patients, are known to inhibit T cell proliferation, but their effect on humoral immunity is far less studied. Total and naive B cells from healthy adult donors were cultured in immunoglobulin
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