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Ahmed Abdeen et al.
American journal of physiology. Renal physiology, 307(11), F1227-F1237 (2014-10-24)
Urinary exosomes are nano-sized vesicles secreted into urine from all types of renal epithelial cells and are known to contain possible biomarker proteins for renal diseases. Gentamicin has been reported to decrease the level of renal aquaporin (AQP)2, which is
Anna Emde et al.
The EMBO journal, 34(21), 2633-2651 (2015-09-04)
Interest in RNA dysfunction in amyotrophic lateral sclerosis (ALS) recently aroused upon discovering causative mutations in RNA-binding protein genes. Here, we show that extensive down-regulation of miRNA levels is a common molecular denominator for multiple forms of human ALS. We
Mark Pimentel et al.
Digestive diseases and sciences, 60(5), 1195-1205 (2014-11-27)
Acute gastroenteritis can precipitate irritable bowel syndrome (IBS) in humans. Cytolethal distending toxin is common to all pathogens causing gastroenteritis. Its active subunit, CdtB, is associated with post-infectious bowel changes in a rat model of Campylobacter jejuni infection, including small
Pinar Erkekoglu et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 72, 98-110 (2014-07-12)
Most common alkylanilines in the environment are 2,6-dimethylaniline (2,6-DMA), 3,5-dimethylaniline (3,5-DMA), and 3-ethylaniline (3-EA). 3,5-Dimethylaminophenol (3,5-DMAP), a metabolite of 3,5-DMA, is of particular interest, as it is potentially genotoxic. Supplementation with organic or inorganic forms of selenium (Se) may reduce
Huan Zhang et al.
Reproduction (Cambridge, England), 148(1), 43-54 (2014-04-02)
In mammals, the primordial follicle pool, providing all oocytes available to a female throughout her reproductive life, is established perinatally. Dysregulation of primordial follicle assembly results in female reproductive diseases, such as premature ovarian insufficiency and infertility. Female mice lacking
Nirupama Ramkumar et al.
American journal of physiology. Renal physiology, 307(8), F931-F938 (2014-08-15)
The physiological and pathophysiological significance of collecting duct (CD)-derived renin, particularly as it relates to blood pressure (BP) regulation, is unknown. To address this question, we generated CD-specific renin knockout (KO) mice and examined BP and renal salt and water
Shi Tian et al.
Biochimica et biophysica acta, 1850(4), 708-721 (2014-12-09)
To study the role of miR-143 during embryo implantation in rat. MiR-143 expression in rat early pregnancy was detected by Northern blot. The relation between miR-143 and Lifr predicted and confirmed by bioinformatics method, dual-luciferase activity assay, Western blot and
K Korgavkar et al.
The British journal of dermatology, 172(3), 606-615 (2014-09-27)
Striae gravidarum (SG), or stretch marks developing during pregnancy, affect up to 90% of women. While not medically dangerous, SG can be disfiguring, causing emotional and psychological distress. However, studies specifically addressing the prevention of SG, especially during pregnancy, are
Mariana Carasatorre et al.
PloS one, 10(8), e0132676-e0132676 (2015-08-06)
Spatial water maze (WM) overtraining induces hippocampal mossy fiber (MF) expansion, and it has been suggested that spatial pattern separation depends on the MF pathway. We hypothesized that WM experience inducing MF expansion in rats would improve spatial pattern separation
Joanna Jung et al.
Biochimica et biophysica acta, 1853(9), 2115-2121 (2014-12-30)
Myelin oligodendrocyte glycoprotein (MOG) is a type I integral membrane protein that is expressed in the central nervous system. MOG has a single N-glycosylation site within its extracellular domain. MOG has been linked with pathogenesis of multiple sclerosis; anti-MOG antibodies
A Basic et al.
Anaerobe, 35(Pt A), 21-27 (2014-10-05)
Periodontitis is a polymicrobial anaerobe infection. Little is known about the dysbiotic microbiota and the role of bacterial metabolites in the disease process. It is suggested that the production of certain waste products in the proteolytic metabolism may work as
Alexis J Carulli et al.
Developmental biology, 402(1), 98-108 (2015-04-04)
The Notch signaling pathway regulates intestinal epithelial cell homeostasis, including stem cell maintenance, progenitor cell proliferation and differentiation. Notch1 and Notch2 receptors are expressed in the epithelium, but individual contributions to these functions are unclear. We used genetic deletion to
C Couteau et al.
International journal of pharmaceutics, 476(1-2), 160-163 (2014-10-01)
Given that previous studies have highlighted the anti-inflammatory nature, which is influenced by UV radiation, of a certain number of ultraviolet filters currently used in Europe, it seemed interesting to evaluate the persistence of this type of effect. The persistence
Luis Federico Casassa et al.
Molecules (Basel, Switzerland), 20(5), 7820-7844 (2015-05-06)
Four regulated deficit irrigation (RDI) regimes were applied to Cabernet Sauvignon grapes, which were analyzed for phenolics and also made into wine over three consecutive growing seasons. Relative to an industry standard regime (IS), yield was reduced over the three
Swati Mishra et al.
Journal of biomedical materials research. Part A, 103(10), 3237-3249 (2015-03-18)
Three-dimensional (3D) patterning and engineering of biomaterials and biointerfaces have helped bioengineers harness the full potential of cell immobilization for different biomedical applications. However, the bioengineering of an efficient cell immobilized tool, having application in cell biology and tissue engineering
Ahmed Mahmoud Abdelhaleem Ali et al.
Acta pharmaceutica (Zagreb, Croatia), 65(2), 133-146 (2015-05-27)
This study addressed the possibility of forming of co-amorphous systems between clozapine (CZ) and various carboxylic acid plasticizers (CAPs). The aim was to improve the solubility and oral bioavailability of clozapine. Co-amorphous dispersions were prepared using modified solvent evaporation methodology
Felisa Cilurzo et al.
Current drug targets, 16(14), 1612-1622 (2015-11-26)
The ability of some surfactants to self-assemble in a water/oil bi-phase environment thus forming supramolecular structure leading to the formation of w/o/w multiple emulsions was investigated. The w/o/w multiple emulsions obtained by self-assembling (one-step preparation method) were compared with those
Robert A Fenton et al.
American journal of physiology. Renal physiology, 308(12), F1409-F1420 (2015-05-01)
Caffeine is one of the most widely consumed behavioral substances. We have previously shown that caffeine- and theophylline-induced inhibition of renal reabsorption causes diuresis and natriuresis, an effect that requires functional adenosine A1 receptors. In this study, we tested the
Wan Zhang et al.
Molecular medicine reports, 12(5), 7374-7388 (2015-10-16)
Chronic lymphocytic leukemia (CLL) is the most common type of adult leukemia, and is currently incurable due to drug resistance. A previous study indicated that the redox interaction between bone marrow stromal cells and leukemia cells profoundly affected CLL cell
Anna A DePaoli-Roach et al.
The Journal of biological chemistry, 290(2), 841-850 (2014-11-25)
Glycogen is a branched polymer of glucose that acts as an energy reserve in many cell types. Glycogen contains trace amounts of covalent phosphate, in the range of 1 phosphate per 500-2000 glucose residues depending on the source. The function
Shinichi Meguro et al.
PloS one, 10(3), e0120142-e0120142 (2015-03-19)
Fat-rich diets not only induce obesity in humans but also make animals obese. Therefore, animals that accumulate body fat in response to a high-fat diet (especially rodents) are commonly used in obesity research. The effect of dietary fat on body
Víctor Sanabria-Ayala et al.
Parasitology research, 114(1), 55-64 (2014-10-03)
Previous studies demonstrated that antibodies against triosephosphate isomerase of Taenia solium (TTPI) can alter its enzymatic catalysis. In the present study, we used antibodies produced against the NH2-terminal region of TTPI (1/3NH2TTPI) and the phage display technology to find target
Shishu Goindi et al.
Journal of liposome research, 24(3), 249-257 (2014-03-22)
Levocetirizine, an active enantiomer of cetirizine is third generation antihistaminic agent used for treating various allergies like atopic dermatitis, chronic idiopathic urticaria and allergic rhinitis. Development of novel topical formulation of levocetirizine based on flexible vesicles (FVs) with an aim
Kanako Maki et al.
PloS one, 10(4), e0122986-e0122986 (2015-04-16)
Asthma is a chronic inflammatory disorder of the airways, involving oxidative stress. Upon oxidative stress, glutathione covalently binds to protein thiols to protect them against irreversible oxidation. This posttranslational modification, known as protein S-glutathionylation, can be reversed by glutaredoxin 1
Sridhar Chinthakindi et al.
Journal of chromatography. A, 1423, 54-62 (2015-11-12)
Present study aimed at graphene surface modification to achieve selective analyte binding in dispersive solid phase extraction. Magnetic graphene - polystyrene sulfonic acid (MG-PSS) cation exchange nano-composite was prepared by non-covalent wrapping method. Composite was characterized by FT-IR and zeta
Thorbjørn H Christensen et al.
Experimental physiology, 100(11), 1362-1378 (2015-09-05)
What is the central question of this study? Glucocorticoids act in the kidney to promote salt and water retention. Renal 11β-hydroxysteroid dehydrogenase type 1 (11βHSD1), by increasing local concentrations of glucocorticoids, may exert an antinatriuretic effect. We hypothesized that global deletion
Alice E McGovern et al.
British journal of pharmacology, 171(15), 3633-3650 (2014-04-26)
Subtypes of the hyperpolarization-activated cyclic nucleotide-gated (HCN) family of cation channels are widely expressed on nerves and smooth muscle cells in many organ systems, where they serve to regulate membrane excitability. Here we have assessed whether HCN channel inhibitors alter
Yanyan Pei et al.
Journal of colloid and interface science, 453, 194-201 (2015-05-20)
In this study, we report a facile and effective route to synthesize core-shell SiO2@MgO with flower like morphology, which the shell is assembled by magnesium oxide nanosheets. The SiO2@MgO composite (SMC) was characterized by X-ray diffraction (XRD), scanning electron microscopy
Maja Segvić Klarić et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 71, 97-105 (2014-06-17)
The aim of this study was to explore the oxidative properties of ochratoxin A (OTA) and citrinin (CTN) as a possible underlying mechanism of their individual and/or combined cytotoxicity. Metabolic activity of PK15 porcine kidney cells was significantly reduced with
Carlos A Toro et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(2), 571-582 (2015-01-16)
The spatial and temporal distribution of receptors constitutes an important mechanism for controlling the magnitude of cellular responses. Several members of the transient receptor potential (TRP) ion channel family can regulate their function by modulating their expression at the plasma
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