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Gui-Bo Sun et al.
Toxicology and applied pharmacology, 279(1), 8-22 (2014-05-21)
Aconitine is a major bioactive diterpenoid alkaloid with high content derived from herbal aconitum plants. Emerging evidence indicates that voltage-dependent Na(+) channels have pivotal roles in the cardiotoxicity of aconitine. However, no reports are available on the role of Ca(2+)
Peijian Tong et al.
Journal of ethnopharmacology, 146(2), 562-571 (2013-02-05)
Fuzi (lateral root of Aconitum carmichaeli) is a popular traditional Chinese medicine well known for its both therapeutic and high-toxic activities. Its toxic alkaloid ingredients, mainly aconitine, mesaconitine, and hypaconitine, are responsible for the high toxicity. However, to date, no
Cuiping Yang et al.
Toxicology and applied pharmacology, 273(3), 561-568 (2013-10-15)
Aconitine (AC) is a highly toxic alkaloid from bioactive plants of the genus Aconitum, some of which have been widely used as medicinal herbs for thousands of years. In this study, we systematically evaluated the potential role of P-glycoprotein (P-gp)
Satyendra K Prasad et al.
The Journal of pharmacy and pharmacology, 66(12), 1808-1817 (2014-08-19)
To scientifically validate the traditional substitution of roots of highly expensive Aconitum heterophyllum (AH) with rhizomes of Cryptocoryne spiralis (CS) in the treatment of diarrhoea. Different fractions from root/rhizome extract of both the plant were subjected to faecal excretion rate
A A Kotliarov et al.
Klinicheskaia meditsina, 90(9), 57-59 (2012-12-12)
Antiarrhythmic therapy of patients with disturbed automatism of the sinus node and impaired atrioventricular conductance may be complicated by hemodynamically significant bradycardias and contraindications for implantation of a cardiac electrical stimulator This study aimed at estimating effect of antiarrhythmic therapy
Ling Ye et al.
Toxicology letters, 216(2-3), 86-99 (2012-12-04)
Aconitum alkaloids including aconitine (AC), mesaconitine (MA), hypaconitine (HA), are highly toxic. Their hydrolysates, such as benzoylaconine (BAC), benzoylmesaconine (BMA), benzoylhypaconine (BHA), aconine, and mesaconine, are considerably less toxic. Efflux transporters, including P-glycoprotein (P-gp), breast cancer resistance protein (BCRP), and
A Ameri et al.
Brain research, 842(2), 332-341 (1999-10-20)
Aconitine, lappaconitine and ajacine are structurally related alkaloids occurring in several species of the Aconitum genus. While aconitine is known to activate the voltage-dependent sodium channel, lappaconitine has been reported to block this channel. To investigate a possible antagonism of
A Ameri
Progress in neurobiology, 56(2), 211-235 (1998-10-07)
Preparations of Aconitum roots are employed in Chinese and Japanese medicine for analgesic, antirheumatic and neurological indications. The recent surge in use of phytomedicine derived from traditional Chinese medicine as well as increasing concerns about possible toxic effects of these
R Onur et al.
Neuropharmacology, 34(9), 1139-1145 (1995-09-01)
Aconitine (ACO), A Na+ channel activator, induces depolarization in skeletal muscle and blocks neuromuscular transmission. We investigated the effects of ACO on neurotransmitter release in the rat isolated phrenic nerve-diaphragm preparation at 24 +/- 1 degrees C. ACO inhibited the
K D Welch et al.
Journal of applied toxicology : JAT, 33(9), 1017-1026 (2013-05-25)
The adverse effects of methyllycaconitine (MLA) have been attributed to competitive antagonism of nicotinic acetylcholine receptors (nAChR). Research has indicated a correlation between the LD50 of MLA and the amount of α7 nAChR in various mouse strains, suggesting that mice
Jing Zhang et al.
PloS one, 7(12), e52352-e52352 (2013-01-04)
A rapid and effective method was developed for separation and identification of diester-diterpenoid alkaloids (DDA) in the roots of Aconitum carmichaeli by ultra-high-pressure liquid chromatography coupled with high resolution LTQ-Orbitrap tandem mass spectrometry (UHPLC-LTQ-Orbitrap-MS(n)). According to accurate mass measurement and
Ling Wang et al.
Natural product communications, 7(12), 1583-1586 (2013-02-19)
The first conversional synthesis of heteratisine has been accomplished in 14 steps and 3.2% overall yield from deltaline, mainly including deoxygenation at C-10, removal of the dioxymethylene moiety, O-demethylation, as well as Baeyer-Villiger oxidation.
[Practical analysis of toxic substances useful for clinical toxicology (2). aconitine alkoloids].
Yuji Fujita et al.
Chudoku kenkyu : Chudoku Kenkyukai jun kikanshi = The Japanese journal of toxicology, 26(2), 121-126 (2013-07-17)
Yang Gao et al.
The Chinese journal of physiology, 55(5), 307-313 (2013-01-04)
Many studies have shown that the relationship between alcohol consumption and most cardiovascular diseases is U-shaped, with nondrinkers and heavier drinkers having higher risks than moderate drinkers. However, the association between cardiac arrhythmias and acute alcohol consumption is not well
Marilena Griguoli et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(3), 1044-1049 (2013-01-18)
In the hippocampus, at excitatory synapses between principal cell and oriens/alveus (O/A) interneurons, a particular form of NMDA-independent long-term synaptic plasticity (LTP) has been described (Lamsa et al., 2007). This type of LTP occurs when presynaptic activation coincides with postsynaptic
Lijun Zhu et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 51, 396-403 (2012-10-23)
Aconitum species are widely used to treat rheumatism, cardiovascular diseases, and tumors in China and other Asian countries. The herbs are always used with drugs such as paclitaxel. Aconitine (AC) is one of the main bioactive/high-toxic alkaloids of Aconitum roots.
Rajib K Paul et al.
Anesthesiology, 121(1), 149-159 (2014-06-18)
Subanesthetic doses of (R,S)-ketamine are used in the treatment of neuropathic pain and depression. In the rat, the antidepressant effects of (R,S)-ketamine are associated with increased activity and function of mammalian target of rapamycin (mTOR); however, (R,S)-ketamine is extensively metabolized
Na Li et al.
Planta medica, 78(7), 692-697 (2012-03-14)
Aconitine (AC), mesaconitine (MA), and hypaconitine (HA) are the active alkaloids identified in aconite tuber, an important traditional Chinese medicine. The study is aimed to investigate their intestinal transport profiles and potential interaction during the intestinal absorption using the Caco-2
Mitsuhisa Koga et al.
Biochemical and biophysical research communications, 455(3-4), 194-197 (2014-12-03)
Varenicline is one of the most widely used drugs for smoking cessation. However, whether an adverse effect of varenicline is associated with the risk of serious cardiovascular events remains controversial. In this study, we determined if varenicline increases the risk
Study on the aconitine-type alkaloids of Radix Aconiti Lateralis and its processed products using HPLC-ESI-MS(n).
Liu, Y., et al.
Drug Testing and Analysis, doi: 10-doi: 10 (2012)
H R Xu et al.
Die Pharmazie, 68(3), 170-172 (2013-04-06)
This study was conducted to determine the pharmacokinetic characteristics of bulleyaconitine A (BLA) after oral gavage and intravenous administration of BLA at a single dose of 0.04, 0.12, 0.36 mg/kg (oral) or 0.02 mg/kg (i.v.) in male Sprague-Dawley rats. Plasma
Kai Yang et al.
World journal of microbiology & biotechnology, 29(5), 933-938 (2012-12-28)
The endophytic fungus XJ-AC03, which was isolated from the healthy roots of Aconitum leucostomum, produced aconitine when grown in potato dextrose agar (PDA) medium. The presence of aconitine was confirmed by the chromatographic and spectroscopic analyses. The yield of aconitine
Juan Du et al.
Molecules (Basel, Switzerland), 18(1), 757-767 (2013-01-10)
The anti-tumor effect of aconitine in melanoma cell line B16 has been studied in this paper. We found that B16 cells showed significantly reduced growth rates and increased apoptotic effects in the presence of aconitine. Furthermore, aconitine inhibited the PI3K/AKT
Iu V Vakhitova et al.
Bioorganicheskaia khimiia, 39(1), 105-116 (2013-07-13)
Allapinine (lappaconitine hydrobromide) is a drug for the treatment of cardiac arrhythmias, it shows IC class antiarrhythmics properties. Its action mechanism is associated with blockade of Na(+)-channels with subsequent inhibition of the depolarization rate and, consequently, of the slowing and
T Y Chan et al.
Veterinary and human toxicology, 36(5), 452-455 (1994-10-01)
Both "chuanwu", the main root of Aconitum carmichaeli, and "caowu", the root of A kusnezoffii, are believed to possess anti-inflammatory, analgesic and cardiotonic effects and have been used in Chinese materia medica mainly for the treatment of musculoskeletal disorders. They
G N Zyuz'kov et al.
Bulletin of experimental biology and medicine, 153(6), 846-850 (2012-11-01)
Regeneratory activities of Baikal aconite alkaloids were studied on the excision skin wound model. Manifest wound healing effects of songorine, napelline, and hypaconitine were detected. The therapeutic efficiency was based on activation of residual mesenchymal progenitor elements. The development of
Li Lin et al.
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 38(7), 995-999 (2013-07-16)
To optimize the conditions of purifying the total alkaloids in Aconitum szechenyianum with macroporous adsorption resin, and compare the content of total alkaloids and aconitine in A. szechenyianum from different producing areas, in order to provide basis for further studies.
Lixin Zhou et al.
Journal of chromatographic science, 53(1), 177-182 (2014-06-05)
A simple and rapid liquid chromatography-ion trap mass spectrometric (LC-IT/MS) method has been developed and validated for quantification of wilfordmine in human plasma. After the protein precipitation was carried out by acetonitrile and the solution was cleaned by solid-phase extraction
Kevin D Welch et al.
Toxicology and applied pharmacology, 266(3), 366-374 (2012-12-12)
Nicotinic acetylcholine receptors (nAChRs) are ligand-gated cation channels found throughout the body, and serve to mediate diverse physiological functions. Muscle-type nAChRs located in the motor endplate region of muscle fibers play an integral role in muscle contraction and thus motor
Hongbin Zhu et al.
Analytica chimica acta, 752, 69-77 (2012-10-30)
This study presents a novel and rapid method to identify chemical markers for the quality control of Radix Aconiti Preparata, a world widely used traditional herbal medicine. In the method, the samples with a fast extraction procedure were analyzed using
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