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Federica Moalli et al.
The Journal of experimental medicine, 211(13), 2507-2517 (2014-12-10)
Interactions between dendritic cells (DCs) and T cells control the decision between activation and tolerance induction. Thromboxane A2 (TXA2) and its receptor TP have been suggested to regulate adaptive immune responses through control of T cell-DC interactions. Here, we show
Mohammad Hossein Boskabady et al.
Experimental biology and medicine (Maywood, N.J.), 238(2), 200-208 (2013-04-12)
The effects of carvacrol on tracheal responsiveness (TR) to methacholine and ovalbumin (OA), serum nitric oxide (NO) concentration, total and differential white blood cells (WBC) in blood of sensitized guinea pigs were examined. Five groups of guinea pigs sensitized to
G H Grit et al.
Parasite immunology, 36(4), 157-169 (2014-01-01)
Giardia duodenalis is an important intestinal parasite in animals and humans. The role of dendritic cells (DC) in the initiation of the immune response against G. duodenalis is poorly documented. The aim of this study was to test the hypothesis that
Kathrin Straubinger et al.
The Journal of allergy and clinical immunology, 134(6), 1271-1279 (2014-07-22)
Schistosomiasis, a chronic helminth infection, elicits distinct immune responses within the host, ranging from an initial TH1 and subsequent TH2 phase to a regulatory state, and is associated with dampened allergic reactions within the host. We sought to evaluate whether
Hasan Yuksel et al.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 110(3), 150-155 (2013-04-04)
Vascular endothelial growth factor (VEGF) is an important mediator of the neoangiogenesis component of remodeling in asthma. To evaluate the influence of VEGF blockage on airway remodeling, specifically epithelium thickness, subepithelial smooth muscle thickness, number of mast and goblet cells
Nanna Fyhrquist et al.
The Journal of allergy and clinical immunology, 134(6), 1301-1309 (2014-09-30)
The human commensal microbiota interacts in a complex manner with the immune system, and the outcome of these interactions might depend on the immune status of the subject. Previous studies have suggested a strong allergy-protective effect for Gammaproteobacteria. Here we
Mehdi Fazlalipour et al.
Jundishapur journal of microbiology, 8(4), e17157-e17157 (2015-06-03)
Gradual development of a useful vaccine can be the main point in the control and eradication of Hepatitis C virus (HCV) infection. Hepatitis C Virus envelope glycoproteins are considered as the main HCV vaccine candidate. In this study, the Pichia
Shelly Leung et al.
Cellular immunology, 282(2), 79-84 (2013-06-19)
OT-II mice were evaluated as a transgenic strain-specific model to assess T-cell help for B-cell responses. OT-II CD4(+) T-cells express transgenic OVA-specific αβ-TCRs. This high frequency of antigen-specific helper T-lymphocytes may augment induction of B-cell responses. Unexpectedly, OT-II mice did
Afonso P Basto et al.
Molecular immunology, 64(1), 36-45 (2014-12-04)
The use of immunogenic formulations targeting pattern recognition receptors towards modulation of immune responses is a promising strategy to develop better vaccines against infectious and malignant diseases. Molecules targeting TLR2 offer interesting properties that are relevant for vaccine development, including
Jason S Weinstein et al.
Journal of immunology (Baltimore, Md. : 1950), 192(7), 3166-3179 (2014-03-13)
B cells are required for follicular Th (Tfh) cell development, as is the ICOS ligand (ICOS-L); however, the separable contributions of Ag and ICOS-L delivery by cognate B cells to Tfh cell development and function are unknown. We find that
Sheng Zeng et al.
The Journal of asthma : official journal of the Association for the Care of Asthma, 51(4), 360-365 (2014-02-26)
It has been reported that adoptive transfer of γδ T cells increases the cellular infiltration, especially eosinophils, in the lungs of allergic mice, suggesting that γδ T cells may play a proinflammatory role in allergic airway inflammation. Respiratory syncytial virus
Zheng-Rong Chen et al.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 111(4), 276-281 (2013-09-24)
B7 molecules play a key role in regulating allergen-induced T cell activation in asthma, which may occur through T cell recruitment and T helper cell differentiation on allergen provocation. Initial studies have shown that B7-H3 (CD276), a recently identified B7
Rylie P Flesher et al.
Clinical science (London, England : 1979), 126(11), 805-814 (2013-12-19)
Endogenous mediators, such as RvE1 (resolvin E1), promote resolution of an inflammatory response and have potential as novel therapeutic agents. In the present study, we investigated the activity of RvE1 in a model of an acute exacerbation of chronic allergic
So Ri Kim et al.
The Journal of allergy and clinical immunology, 132(6), 1397-1408 (2013-10-29)
Despite many studies on endoplasmic reticulum (ER) stress in patients with various inflammatory diseases, there is scarce information on ER stress in patients with bronchial asthma. In this study we aimed to elucidate the role of ER stress in the
Preety Sahdev et al.
Journal of biomedical nanotechnology, 9(1), 132-141 (2013-05-01)
The main objective of this study was to investigate the potential of calcium phosphate (CAP) nanoparticles for transcutaneous vaccine delivery. CAP nanoparticles were prepared by nanoprecipitation method followed by sequential adsorption of sugars and ovalbumin. Nanoparticles were characterized using dynamic
Chakkrit Khanaree et al.
Oncology research, 20(9), 427-435 (2013-08-09)
Maspin, a tumor suppressor (SERPINB5), inhibits cancer migration, invasion, and metastasis in vitro and in vivo. The tumor-suppressing effects of maspin depend in part on its ability to enhance cell adhesion to extracellular matrix. Although the molecular mechanism of maspin's
Shinji Toki et al.
Journal of leukocyte biology, 94(1), 77-88 (2013-04-30)
PGI₂ signaling through IP inhibits allergen-induced inflammatory responses in mice. We reported previously that PGI₂ analogs decreased proinflammatory cytokine and chemokine production by mature BMDCs. However, whether PGI₂ modulates the function of immature DCs has not been investigated. We hypothesized
Hannah E Cummings et al.
Journal of immunology (Baltimore, Md. : 1950), 191(12), 5807-5810 (2013-11-19)
Leukotriene C4 (LTC4) and its extracellular metabolites, LTD4 and LTE4, mediate airway inflammation. They signal through three specific receptors (type 1 cys-LT receptor [CysLT1R], CysLT2R, and GPR99) with overlapping ligand preferences. In this article, we demonstrate that LTC4, but not
Joel R Wilmore et al.
Journal of immunology (Baltimore, Md. : 1950), 191(9), 4731-4739 (2013-10-02)
High rates of coinfection occur in malaria endemic regions, leading to more severe disease outcomes. Understanding how coinfecting pathogens influence the immune system is important in the development of treatment strategies that reduce morbidity and mortality. Using the Plasmodium chabaudi
Kamal Srivastava et al.
American journal of physiology. Lung cellular and molecular physiology, 305(12), L1002-L1010 (2013-10-29)
Our previous studies have shown that the anti-asthma traditional Chinese medicine herbal formula ASHMI (anti-asthma simplified herbal medicine intervention) inhibits acetylcholine-induced contractions of tracheal rings from ovalbumin-sensitized and naive mice in a β-adrenoceptor-independent manner. We sought to determine whether acute
Ruchi Roy et al.
Toxicology letters, 230(3), 421-433 (2014-08-17)
Our previous studies indicated that zinc oxide nanoparticles (ZnO NPs) have adjuvant properties to a known allergen ovalbumin (OVA) in Balb/c mice. Therefore, in this study, we focused on the mechanisms involved in adjuvant responses induced by ZnO NPs. The
Karin M Knudson et al.
Journal of immunology (Baltimore, Md. : 1950), 191(12), 5797-5801 (2013-11-19)
CD8 T cell memory critically contributes to long-term immunity. Both low- and high-affinity TCR signals are able to support the differentiation of memory CD8 T cells. However, it is unclear whether the requirements for memory development change when TCR signal
Cynthia Kanagaratham et al.
American journal of respiratory cell and molecular biology, 51(6), 783-792 (2014-06-03)
Arachidonic acid (AA) and docosahexaenoic acid (DHA) play important roles in inflammation and disease progression, where AA is viewed as proinflammatory and DHA as antiinflammatory. We observe in our model of allergic asthma that the AA/DHA ratio is significantly skewed
M Ritter et al.
Clinical and experimental immunology, 178(2), 212-223 (2014-06-20)
Overall asthmatic symptoms can be controlled with diverse therapeutic agents. However, certain symptomatic individuals remain at risk for serious morbidity and mortality, which prompts the identification of novel therapeutic targets and treatment strategies. Thus, using an adjuvant-free T helper type
Shin Yoshino et al.
Immunology, 141(4), 617-627 (2013-12-07)
Fab fragments (Fabs) maintain the ability to bind to specific antigens but lack effector functions due to the absence of the Fc portion. In the present study, we tested whether Fabs of an allergen-specific monoclonal antibody (mAb) were able to
S B Wang et al.
Scandinavian journal of immunology, 78(6), 507-515 (2013-10-12)
Lactoferrin (LF) can downregulate allergic airway inflammation in asthma. However, the in vivo effect of exogenous LF on allergic rhinitis (AR), a disease attributed to airway inflammation, has yet to be determined. We investigated the effect of intranasal administration recombinant
Chia-Chi Wang et al.
BMC complementary and alternative medicine, 13, 154-154 (2013-07-03)
Arecae semen, the dried slice of areca nuts, is a traditional Chinese medicine used to treat intestinal parasitosis, rectal tenesmus and diarrhea. Areca nuts contain a rich amount of polyphenols that have been shown to modulate the functionality of mast
M Antošová et al.
Advances in experimental medicine and biology, 838, 1-10 (2014-09-26)
Nitric oxide (NO) effects in airways are influenced by the activity of NO-synthase isoforms and NO metabolism. Inducible NO-synthase (iNOS), which produces large amounts of NO, is active during the inflammatory process. NO quickly reacts, producing reactive oxygen species (ROS).
JangEun Lee et al.
Journal of immunology (Baltimore, Md. : 1950), 192(7), 3190-3199 (2014-02-26)
Fatty acids (FAs) are essential constituents of cell membranes, signaling molecules, and bioenergetic substrates. Because CD8(+) T cells undergo both functional and metabolic changes during activation and differentiation, dynamic changes in FA metabolism also occur. However, the contributions of de
Alison J Hodgkinson et al.
The British journal of nutrition, 112(3), 390-397 (2014-05-30)
Epidemiological studies have shown an association between the consumption of raw farm milk and reduced incidence of allergy. In the present study, we fed untreated raw milk, gamma-sterilised milk, heat-treated milk or water to mice and compared their responses to
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