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Feng Xu et al.
Journal of nanoscience and nanotechnology, 13(1), 558-563 (2013-05-08)
In this article, we describe an aptamer-based sandwich-type electrochemical sensor for the detection of human alpha-thrombin. Au nanoneedles were synthesized in the hole of the naked polycarbonate (PC) template using electrodepositing strategy. The thiolated thrombin aptamer I was immobilized as
Bryan M Hooks et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(10), 4418-4426 (2015-03-13)
Cortical cells integrate synaptic input from multiple sources, but how these different inputs are distributed across individual neurons is largely unknown. Differences in input might account for diverse responses in neighboring neurons during behavior. We present a strategy for comparing
A L Althaus et al.
Journal of neurophysiology, 113(4), 1184-1194 (2014-11-28)
Hilar ectopic dentate granule cells (DGCs) are a salient feature of aberrant plasticity in human temporal lobe epilepsy (TLE) and most rodent models of the disease. Recent evidence from rodent TLE models suggests that hilar ectopic DGCs contribute to hyperexcitability
Adam Drewnowski et al.
The American journal of clinical nutrition, 99(5 Suppl), 1223S-1228S (2014-03-22)
Nutrient profiling is the technique of rating or classifying foods on the basis of their nutritional value. Foods that supply relatively more nutrients than calories are defined as nutrient dense. Nutrient profile models calculate the content of key nutrients per
J Bautista-Ortega et al.
Poultry science, 93(4), 979-988 (2014-04-08)
The effects of l-Arg, vitamin C (VC), and vitamin E (VE) on xanthine- (XO) and NAD(P)H-oxidase (NOX) activities, and nitric oxide (NO) availability of hypoxic broilers were evaluated. Chickens were kept in wire cages with free access to feed and
Eugenio Jose Garcia et al.
The European journal of esthetic dentistry : official journal of the European Academy of Esthetic Dentistry, 7(2), 154-162 (2012-05-31)
It is generally not recommended that bonded restoration treatment should be carried out immediately after bleaching treatment. However, the use of antioxidants such as sodium ascorbate can be useful to avoid a waiting period. This article is a brief review
Differential roles of endothelin-1 in angiotensin II-induced atherosclerosis and aortic aneurysms in apolipoprotein E-null mice
Suen RS, et al.
The American Journal of Pathology, 179(3), 1549-1559 (2011)
Christopher M Stephenson et al.
Cancer chemotherapy and pharmacology, 72(1), 139-146 (2013-05-15)
This phase I clinical trial evaluated the safety, tolerability, and pharmacokinetics of high-dose intravenous (i.v.) ascorbic acid as a monotherapy in patients with advanced solid tumors refractory to standard therapy. Five cohorts of three patients received i.v. ascorbic acid administered
[Not too eager prescribing vitamin C for the common cold!].
N Senn
Revue medicale suisse, 9(401), 1854-1855 (2013-11-07)
Tim J Wigle et al.
Journal of biomolecular screening, 20(6), 810-820 (2015-03-11)
Demethylation of histones by lysine demethylases (KDMs) plays a critical role in controlling gene transcription. Aberrant demethylation may play a causal role in diseases such as cancer. Despite the biological significance of these enzymes, there are limited assay technologies for
Yoshiko Hashikawa et al.
Neuron, 106(5), 743-758 (2020-04-10)
The habenula complex is appreciated as a critical regulator of motivated and pathological behavioral states via its output to midbrain nuclei. Despite this, transcriptional definition of cell populations that comprise both the medial habenular (MHb) and lateral habenular (LHb) subregions
Olivier Fain
La Revue du praticien, 63(8), 1091-1096 (2013-12-05)
Vitamin C is a water soluble vitamin which is mainly fresh fruits and vegetables foodborne. Vitamin C deficiency is most often due to a lack of daily amount. Scurvy is characterized by the occurrence of fatigue, myalgia, arthralgia, purpura, bleeding
Suhas S Kharat et al.
Science signaling, 13(645) (2020-08-21)
Synthetic lethality between poly(ADP-ribose) polymerase (PARP) inhibition and BRCA deficiency is exploited to treat breast and ovarian tumors. However, resistance to PARP inhibitors (PARPis) is common. To identify potential resistance mechanisms, we performed a genome-wide RNAi screen in BRCA2-deficient mouse
Sevnur Serim et al.
Organic & biomolecular chemistry, 13(8), 2293-2299 (2015-01-03)
Activity-based probes (ABPs) are powerful tools for the analysis of active enzyme species in whole proteomes, cells or animals. Quenched fluorescent ABPs (qABPs) can be applied for real time imaging, allowing the visualization of dynamic enzyme activation by fluorescent microscopy.
Beata Jabłonowska-Lietz et al.
Roczniki Panstwowego Zakladu Higieny, 64(1), 43-48 (2013-06-26)
The health benefits arising from antioxidant vitamins A, C and E are well recognised and their recommended dietary intake for the general population have been established. However, there is still a need for assessing antioxidant vitamin intake in different population
Allegra Vit et al.
Chembiochem : a European journal of chemical biology, 16(10), 1490-1496 (2015-06-17)
The ubiquitous sulfur metabolite ergothioneine is biosynthesized by oxidative attachment of a sulfur atom to the imidazole ring of Nα-trimethylhistidine. Most actinobacteria, including Mycobacterium tuberculosis, use γ-glutamyl cysteine as a sulfur donor. In subsequent steps the carbon scaffold of γ-glutamyl
D U A Kumara et al.
Journal of wound care, 24(1), 5-10 (2014-12-30)
Antiseptics are widely used in wound management to prevent or treat wound infections due to their proven wound healing properties regardless of their cytotoxicity. The objective of this study was to determine the bactericidal effects of three antiseptics on pathogens
Sławomir Tokarski et al.
Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego, 35(207), 136-140 (2013-11-15)
One of the main after-effects of chemotherapy used in cancer treatment is an augmented production of reactive oxygen species (ROS). In turn ROS become a source of unwanted side effects of chemotherapy, often forcing the discontinuation of the therapy. Ascorbic
A A Akinlolu et al.
African journal of medicine and medical sciences, 41 Suppl, 149-155 (2013-05-18)
This study investigated the neurotoxic effects of the combined intramuscular administration of Artemether (0.5 mg/kg/b.w.), Quinine (5.14 mg/kg/b.w.) and Ascorbic acid (0.21 mg/kg/b.w) on the cerebellum, trapezoid nuclei and behavioural functions in male Wistar rats for a period of seven
Chongshu Jian et al.
Cell metabolism, 31(5), 892-908 (2020-05-07)
Nonalcoholic steatohepatitis (NASH) is becoming one of the leading causes of hepatocellular carcinoma (HCC). Sorafenib is the only first-line therapy for advanced HCC despite its serious adverse effects. Here, we report that at an equivalent of approximately one-tenth the clinical
Aleksander Hinek et al.
Journal of dermatological science, 75(3), 173-182 (2014-07-13)
Vitamin C (L-ascorbic acid), a known enhancer of collagen deposition, has also been identified as an inhibitor of elastogenesis. Present studies explored whether and how the L-ascorbic acid derivative (+) sodium L-ascorbate (SA) would affect production of collagen and elastic
Tran Thi Nhung et al.
Journal of nanoscience and nanotechnology, 13(8), 5346-5350 (2013-07-26)
Flowerlike gold nanostructure was facilely prepared by the seed-mediated growth of gold nanoparticles in chitosan-TPP template films. Firstly, chitosan nanoparticles, spontaneously formed by inter and/or intra cross-linking with TPP, were transformed into gel-type of chitosan-TPP films under strong sonication process.
S Yaich et al.
Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia, 25(1), 113-116 (2014-01-18)
Renal oxalate deposition can be seen with primary hyperoxaluria, malabsorptive states, ethylene glycol toxicity and, rarely, with excessive vitamin C ingestion. We report a case of secondary hyperoxaluria in which the diagnosis was not considered initially because there was no
Usama Ahmed Ali et al.
The Cochrane database of systematic reviews, 8(8), CD008945-CD008945 (2014-08-22)
Reduced intake and absorption of antioxidants due to pain and malabsorption are probable causes of the lower levels of antioxidants observed in patients with chronic pancreatitis (CP). Improving the status of antioxidants might be effective in slowing the disease process
Qi Xing et al.
Journal of biomedical materials research. Part A, 103(12), 3807-3814 (2015-06-16)
During tissue injury and wound healing process, there are dynamic reciprocal interactions among cells, extracellular matrix (ECM), and mediating molecules which are crucial for functional tissue repair. Nitric oxide (NO) is one of the key mediating molecules that can positively
Justin Pennington et al.
Journal of pharmaceutical and biomedical analysis, 114, 488-492 (2015-04-30)
TEMPO (2,2,6,6-tetramethylpiperidine-1-oxyl) is a stable free radical which has been widely used for various research and industrial applications, including the manufacture of many active pharmaceutical ingredients. TEMPO has been identified as a potential genotoxic impurity resulting in the need for
Paul Henry Golding
SpringerPlus, 3, 442-442 (2014-10-22)
The currently accepted theory, that the human liver store of folate is limited to about four months, is based on the findings of Victor Herbert and others of the era before folate fortification of food. A recent model, developed by
Martin F Pera
Nature genetics, 45(12), 1412-1413 (2013-11-26)
The simple addition of vitamin C to cell culture medium can induce extensive remodeling of the cellular epigenome and facilitates reprogramming of somatic cells to pluripotency. A new study shows that the activity of the enzyme TET1 can inhibit or
Shengxian Liang et al.
Ecotoxicology and environmental safety, 174, 353-362 (2019-03-09)
The liver is one of the major targets of hormones, including thyroid hormones (THs), and many industrial chemicals, such as endocrine-disrupting chemicals. Those compounds may permeate the placenta barrier and pose a risk for embryonic development. Therefore, it is necessary
Toshio Inui et al.
Anticancer research, 33(7), 2917-2919 (2013-06-20)
Immunotherapy has become an attractive new strategy in the treatment of cancer. The laboratory and clinical study of cancer immunotherapy is rapidly advancing. However, in the clinical setting, the results of cancer immunotherapy are mixed. We therefore contend that cancer
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