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Carlos T M Moura et al.
The Journal of pharmacy and pharmacology, 69(6), 722-732 (2017-02-18)
Justicia pectoralis is a plant useful for the treatment of respiratory diseases. Here, we studied the antiasthmatic properties of a standardized extract of J. pectoralis (Jp). Ovalbumin (OVA)-sensitized rats were actively challenged with saline or OVA to study airway hyper-responsiveness
Yeseul Cha et al.
Toxicology and applied pharmacology, 314, 48-54 (2016-11-23)
This study investigated the effects of a silk peptide fraction obtained by incubating silk proteins with Protease N and Neutrase (SP-NN) on cognitive dysfunction of Alzheimer disease model rats. In order to elucidate underlying mechanisms, the effect of SP-NN on
Jessica J Roland et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(2), 506-514 (2014-01-10)
The septohippocampal pathway contains cholinergic, GABAergic, and glutamatergic projections and has an established role in learning, memory, and hippocampal theta rhythm. Both GABAergic and cholinergic neurons in the medial septum-diagonal band of Broca (MSDB) have been associated with spatial memory
Michiko Hirayama et al.
Neuropharmacology, 95, 395-404 (2015-05-06)
Modulation of the membrane excitability of rat parasympathetic intracardiac ganglion neurons by muscarinic receptors was studied using an amphotericin B-perforated patch-clamp recording configuration. Activation of muscarinic receptors by oxotremorine-M (OxoM) depolarized the membrane, accompanied by repetitive action potentials. OxoM evoked
A C Keller et al.
Oxidative medicine and cellular longevity, 2018, 7363485-7363485 (2018-10-23)
In the vasculature, sedentary behavior leads to endothelial abnormalities, resulting in elevated cardiovascular disease risk. Endothelial nitric oxide synthase (eNOS) aberrations characterize endothelial dysfunction; eNOS also regulates mitochondrial function. We hypothesized that sepiapterin (a precursor to eNOS cofactor tetrahydrobiopterin (BH4))
Janeyuth Chaisakul et al.
Toxicon : official journal of the International Society on Toxinology, 102, 48-54 (2015-05-12)
Brown snake (Pseudonaja spp.)-induced early cardiovascular collapse is a life-threatening medical emergency in Australia. We have previously shown that this effect can be mimicked in animals and is mediated via the release of endogenous mediators. In the present study, we
William M Howe et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(20), 8742-8752 (2013-05-17)
We previously reported involvement of right prefrontal cholinergic activity in veridical signal detection. Here, we first recorded real-time acetylcholine release in prefrontal cortex (PFC) during specific trial sequences in rats performing a task requiring signal detection as well as rejection
Vienna E Brunt et al.
The Journal of physiology, 597(9), 2361-2378 (2019-02-05)
Age-related arterial dysfunction, characterized by oxidative stress- and inflammation-mediated endothelial dysfunction and arterial stiffening, is the primary risk factor for cardiovascular diseases. To investigate whether age-related changes in the gut microbiome may mediate arterial dysfunction, we suppressed gut microbiota in
Hugo R Arias et al.
The international journal of biochemistry & cell biology, 92, 202-209 (2017-10-19)
The inhibitory activity of coronaridine congeners on human (h) α4β2 and α7 nicotinic acetylcholine receptors (AChRs) is determined by Ca
Göksel Gökçe et al.
Experimental and therapeutic medicine, 15(6), 4697-4702 (2018-05-29)
Exposure to mercury has detrimental effects on the cardiovascular system, particularly the vascular endothelium. The present study aimed to investigate the effects of ergothioneine (EGT) on endothelial dysfunction induced by low-dose mercury chloride (HgCl2). Agonist-induced contractions and relaxations were evaluated
Flavio Pereira et al.
Military medicine, 183(11-12), e713-e720 (2018-03-17)
The main aim of the present study is to evaluate the effects of strenuous exercise, related to special military training for riot control, on systemic microvascular endothelial function and skin capillary density. Endothelium-dependent microvascular reactivity was evaluated in the forearm
Christine Baumgartner et al.
Journal of digestive diseases, 18(1), 13-22 (2016-12-23)
Functional gastrointestinal disorders affect females more often. Changes in colonic motility may be etiological co-factors for the clinical symptoms. The aim of the present study was to analyze the influence of gonadal hormones on colonic contractile activity. In vitro measurements
Xiaochun Jin et al.
Molecular pharmacology, 85(1), 11-17 (2013-11-05)
Heteropentameric neuronal nicotinic receptors assemble so that the canonical acetylcholine-binding sites are located at the interfaces between two pairs of subunits, while the fifth subunit does not participate in a canonical transmitter-binding site. Several subunits are considered to be unable
Aditi Verma et al.
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 24(11), 2434-2446 (2015-09-02)
Estrogen deficiency and increase in protein tyrosine phosphatase (PTPase) activity may be a key mechanism in postmenopausal dyslipidemia-induced vascular dysfunction and dementia. Thus, the present study has been designed to investigate the effect of biochanin A (BCA, a phytoestrogen) and
Ramón A Lorca et al.
Hypertension (Dallas, Tex. : 1979), 73(6), 1319-1326 (2019-04-23)
The chronic hypoxia of high-altitude (HA) residence reduces uterine artery blood flow during pregnancy, likely contributing to an increased frequency of preeclampsia and intrauterine growth restriction. We hypothesized that this lesser pregnancy blood flow rise was due, in part, to
Mei Huang et al.
Pharmacology, biochemistry, and behavior, 157, 16-23 (2017-04-30)
Dopamine (DA) D The purpose of this study was to determine the effects of a selective D PD168077 alone, and in combination with sub-effective dose lurasidone, increased DA and acetylcholine (ACh) efflux in mPFC, but only DA efflux in dSTR.
Wei Liu et al.
Journal of ethnopharmacology, 162, 79-86 (2015-01-06)
Aerial parts of Peganum harmala Linn (APP) is used as traditional medical herb in Uighur medicine in China, and it is traditionally used for treatment of cough and asthma.The aim of the present study is to evaluate the antitussive, expectorant
Fredi Cifuentes et al.
Cardiovascular toxicology, 16(1), 79-88 (2015-02-11)
Arsenic trioxide (As2O3) is used clinically in the management of acute promyelocytic leukemia, and the use of electrocardiogram (ECG) in this management is important as arsenic use may cause distortion of the electrical properties with its attendant sequel. We studied
A S Pivovarov et al.
Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova, 63(2), 256-268 (2013-07-23)
Effects of some inhibitors of serine/threonine and tyrosine protein phosphatases on the depression and spontaneous recovery of the acetylcholine-induced inward current (ACh-current) in command Helix neurons of defensive behavior at the cellular correlate of habituation were investigated. The following drugs
Ruijie Qin et al.
International journal of molecular medicine, 44(1), 89-102 (2019-05-23)
Although sirtuin 1 (Sirt1) has been found to be involved in diabetic vasculopathy and high glucose (HG)‑mediated endothelial injury, the underlying mechanisms remain to be fully elucidated. The aim of the present study was to investigate the role of Sirt1
Konstanze Plaschke et al.
Journal of neural transmission (Vienna, Austria : 1996), 125(10), 1487-1494 (2018-07-25)
Delirium is a common complication seen after surgery and anesthesia, in particular in older patients. Although the etiology of postoperative delirium is only incompletely understood, various lines of evidence suggest that proinflammatory signaling from the peripheral site of inflammation to
Jacob C Nordman et al.
Journal of neurochemistry, 129(4), 649-662 (2013-12-20)
Cholinergic signaling plays an important role in regulating the growth and regeneration of axons in the nervous system. The α7 nicotinic receptor (α7) can drive synaptic development and plasticity in the hippocampus. Here, we show that activation of α7 significantly
Dirk A Ridder et al.
The Journal of experimental medicine, 212(10), 1529-1549 (2015-09-09)
Inactivating mutations of the NF-κB essential modulator (NEMO), a key component of NF-κB signaling, cause the genetic disease incontinentia pigmenti (IP). This leads to severe neurological symptoms, but the mechanisms underlying brain involvement were unclear. Here, we show that selectively
Majid Sheykhzade et al.
European journal of pharmacology, 829, 85-92 (2018-04-14)
The main purpose of this study was to compare in vitro pharmacological properties of human αCGRP (CGRP) and a recently discovered metabolically stable CGRP analogue, SAX, in isolated rat and human artery segments. In rat, CGRP and SAX induced similar
Fangzhou Yin et al.
Journal of separation science, 40(20), 4012-4021 (2017-08-18)
The ripened fruit of Schisandrae Chinensis Fructus has unique medical properties in Chinese medicine. It is commonly used after vinegar steaming. Vinegar steaming changes the color of Schisandrae Chinensis Fructus from red to black and enhances its acidic and astringent
Christopher M Hearon et al.
The Journal of physiology, 597(5), 1321-1335 (2018-12-07)
In humans, the vasodilatory response to skeletal muscle contraction is mediated in part by activation of inwardly rectifying potassium (KIR ) channels. Evidence from animal models suggest that KIR channels serve as electrical amplifiers of endothelium-dependent hyperpolarization (EDH). We found
You-Min Lin et al.
Scientific reports, 8(1), 8831-8831 (2018-06-13)
Motility dysfunction is present not only during bowel obstruction (BO), but after obstruction is resolved. Previous studies found that lumen distension associated mechano-transcription of COX-2 and production of PGE2 in gut smooth muscle cells (SMC) account for motility dysfunction during
Jipei Yuan et al.
Journal of chromatography. A, 1154(1-2), 368-372 (2007-05-18)
Capillary electrophoresis with electrochemiluminescene detection was used to characterize procaine hydrolysis as a probe for butyrylcholinesterase by in vitro procaine metabolism in plasma with butyrylcholinesterase acting as bioscavenger. Procaine and its metabolite N,N-diethylethanolamine were separated at 16 kV and then
Qingqing Zhang et al.
Talanta, 183, 258-267 (2018-03-24)
A highly sensitive electrochemical biosensor based on the synthetized L-Cysteine-Ag(I) coordination polymer (L-Cys-Ag(I) CP), which looks like a protein-mimicking nanowire, was constructed to detect acetylcholinesterase (AChE) activity and screen its inhibitors. This sensing strategy involves the reaction of acetylcholine chloride
Ker Woon Choy et al.
PloS one, 12(5), e0178365-e0178365 (2017-06-01)
Endoplasmic reticulum (ER) stress leads to endothelial dysfunction which is commonly associated in the pathogenesis of several cardiovascular diseases. We explored the vascular protective effects of chronic treatment with paeonol (2'-hydroxy-4'-methoxyacetophenone), the major compound from the root bark of Paeonia
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