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Bo Peng et al.
Molecular bioSystems, 11(1), 105-114 (2014-10-18)
The cancerous inhibitor of protein phosphatase 2A (CIP2A) is a recently characterized endogenous inhibitor of the phosphatase activity of protein phosphatase 2A (PP2A), which extends the half-life of oncogenic protein c-myc and promotes in vivo tumor growth. The function of
Juan Li et al.
Virology, 478, 86-98 (2015-03-03)
Porcine reproductive and respiratory syndrome virus (PRRSV) is a positive-sense ssRNA virus whose envelope contains four glycoproteins and three nonglycosylated proteins. Glycans of major envelope glycoprotein 5 (GP5) are proposed as important for virus assembly and entry into permissive cells.
Joachim G Schulz et al.
Scientific reports, 5, 7805-7805 (2015-01-16)
The brain's impotence to utilize long-chain fatty acids as fuel, one of the dogmas in neuroscience, is surprising, since the nervous system is the tissue most energy consuming and most vulnerable to a lack of energy. Challenging this view, we
M K Quinn et al.
Physical chemistry chemical physics : PCCP, 17(46), 31177-31187 (2015-11-07)
A complete understanding of the role of molecular anisotropy in directing the self assembly of colloids and proteins remains a challenge for soft matter science and biophysics. For proteins in particular, the complexity of the surface at a molecular level
Anna Scislowska-Czarnecka et al.
Journal of biomedical materials research. Part A, 103(12), 3965-3977 (2015-05-28)
Here, we report on modification of one of the model biomedical polymers, poly L-lactide-co-glycolide (PLGA; 85:15), by reactive ion etching (RIE) oxygen plasma treatment. PLGA's major disadvantage is high hydrophobicity which restrains binding of cell-adhesive proteins and host cells. In
Guanyu Chen et al.
The Journal of pharmacy and pharmacology, 67(1), 26-34 (2014-10-11)
The sublingual mucosa provides a promising route for the delivery of glutathione (GSH). However, challenges are encountered in developing sublingual mucoadhesive drug delivery formulations such as: prolonging drug retention, uniform drug content, desirable drug release profiles, adequate drug permeation and
Adnan Cavka et al.
Biotechnology for biofuels, 8, 196-196 (2015-12-01)
Pretreatment of lignocellulose for biochemical conversion commonly results in formation of by-products that inhibit microorganisms and cellulolytic enzymes. To make bioconversion processes more efficient, inhibition problems can be alleviated through conditioning. Ozone is currently commercially employed in pulp and paper
Anne Warner et al.
Journal of pharmaceutical and biomedical analysis, 105, 46-54 (2014-12-22)
Stability-indicating reversed phase HPLC methods have been developed and validated for the determination of 13 potential process and degradation impurities in pemetrexed disodium drug substance (DS) and pemetrexed for injection drug product (DP). This paper describes the development of HPLC-UV
Rahul D Sheth et al.
Biotechnology and bioengineering, 111(8), 1595-1603 (2014-03-07)
In this work, a proof of concept elastin-like polypeptide-Z domain fusion (ELP-Z) based affinity precipitation process is developed for monoclonal antibody (mAb) purification from industrial harvest feeds. Greater than 99% mAb recoveries are obtained during the initial binding step of
Marie-Claire Janin-Bussat et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 981-982, 9-13 (2015-01-18)
Antibody-drug conjugates (ADCs) are becoming a major class of oncology therapeutics. Because ADCs combine the monoclonal antibody specificity with the high toxicity of a drug, they can selectively kill tumor cells while minimizing toxicity to normal cells. Most of the
Aashish Soni et al.
Nucleic acids research, 42(10), 6380-6392 (2014-04-22)
In mammalian cells, ionizing radiation (IR)-induced DNA double-strand breaks (DSBs) are repaired in all phases of the cell cycle predominantly by classical, DNA-PK-dependent nonhomologous end joining (D-NHEJ). Homologous recombination repair (HRR) is functional during the S- and G2-phases, when a
Yuan-Hao Lo et al.
Journal of agricultural and food chemistry, 62(22), 5085-5091 (2014-05-17)
Chin-shin oolong tea, a popular tea in Taiwan, was empirically perceived to induce hunger and accelerate gastric emptying in a manner similar to the physiological effects of ghrelin, an endogenous acylated peptide known as the hunger hormone. Two unique acylated
Wei Jia et al.
Journal of chromatography. A, 1362, 110-118 (2014-08-27)
A new analytical method was developed and validated for simultaneous analysis of 27 phthalates in milk and milk products. Response surface methodology was employed to optimize a quick, easy, cheap, effective, rugged, and safe (QuEChERS) sample preparation method. Ultrahigh-performance liquid
Luís M Magalhães et al.
Talanta, 147, 460-467 (2015-11-26)
Spent coffee grounds (SCGs) are a great source of bioactive compounds with interest to pharmaceutical and cosmetic industries. Phenolics and methylxanthines are the main health related compounds present in SCG samples. Content estimation of these compounds in SCGs is of
David S Wishart et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 871(2), 164-173 (2008-05-27)
With continuing improvements in analytical technology and an increased interest in comprehensive metabolic profiling of biofluids and tissues, there is a growing need to develop comprehensive reference resources for certain clinically important biofluids, such as blood, urine and cerebrospinal fluid
Elina Esmaeilzadeh Gharehdaghi et al.
Nucleic acid therapeutics, 24(6), 420-427 (2014-10-02)
Chitosan nanoparticles were prepared using ultrasonication methodology at specific amplitudes and times of sonication. Subsequently, small interfering RNA (siRNA) was added to the solution at predetermined values of nitrogen to phosphorous ratio (N/P), and stirring time. Employing response surfaces generated
Amir Hossein Abdolghaffari et al.
Life sciences, 139, 30-39 (2015-08-05)
Aluminum phosphide (AlP) is a widely used fumigant and rodenticide. While AlP ingestion leads to high mortality, its exact mechanism of action is unclear. There are ample evidences suggesting cardioprotective effects of triiodothyronine (T3). In this study, we aimed to
Coilín Boland et al.
Cellular and molecular life sciences : CMLS, 71(24), 4895-4910 (2014-07-12)
Membrane proteins are key elements in cell physiology and drug targeting, but getting a high-resolution structure by crystallographic means is still enormously challenging. Novel strategies are in big demand to facilitate the structure determination process that will ultimately hasten the
Flávio Cesar Bedatty Fernandes et al.
Food chemistry, 166, 309-315 (2014-07-24)
A new, simple, rapid and sensitive flow injection spectrophotometric method was developed for the screening and determination of sulphonamides in bovine milk samples. The method is based on the condensation of sulphathiazole, sulphamethazine, and sulphadimethoxine with p-dimethylaminobenzaldehyde (p-DAB) in acid
Kaushalya Ghosh et al.
In vitro cellular & developmental biology. Animal, 51(9), 915-921 (2015-05-29)
Recent studies suggested that placentae amniotic membrane is a valuable source of stem cells in human as well as in livestock species. Advantages of amnion over other sources of stem cells included abundant availability, ethically non-objectionable and non-invasive source. The
Joseph L Sottnik et al.
Journal of cellular biochemistry, 115(8), 1420-1429 (2014-04-05)
Osteosarcoma (OSA) is the most common primary bone tumor in humans. However, the cell of origin of OSA is not clearly defined although there is evidence that osteoblasts may serve as OSA progenitors. The role of osteocytes, terminally differentiated osteoblasts
V K Kolli et al.
Human & experimental toxicology, 33(10), 1051-1065 (2013-12-19)
The efficacy of methotrexate (MTX), a widely used chemotherapeutic drug, is limited by its gastrointestinal toxicity and the mechanism of which is not clear. The present study investigates the possible role of mitochondrial damage in MTX-induced enteritis. Small intestinal injury
María J Trujillo-Rodríguez et al.
Analytical and bioanalytical chemistry, 407(29), 8753-8764 (2015-09-26)
The use of mixed hemimicelles of ionic liquid (IL)-based surfactants in a magnetic-based micro-dispersive solid-phase extraction (m-μdSPE) approach is described. Not only is the symmetric monocationic IL-based surfactant 1,3-didodecylimidazolium bromide (C12C12Im-Br) studied for first time in m-μdSPE, but double-salt (DS)
Kieu T N Nguyen et al.
Journal of AOAC International, 97(4), 1092-1096 (2014-08-26)
A new, simple, and sensitive method was developed for extraction of ochratoxin A (OTA) in beer combined with HPLC-fluorescence detector. Samples were extracted by stir bar sorptive extraction (SBSE) followed by liquid desorption using commercially available Twister EG-Silicone. The main
Le Zhang et al.
Carcinogenesis, 35(6), 1330-1340 (2014-01-28)
Interleukin-23 (IL-23) is a conventional proinflammatory IL related to colorectal carcinoma (CRC). The signal transducer and activator of transcription (STAT) and suppressors of cytokine signaling (Socs) molecules, respectively, serve as agonists and antagonists of IL-23-associated inflammation. However, it remains unknown
Karina Lopes Dornelas et al.
Analytica chimica acta, 858, 82-90 (2015-01-20)
This paper presents a simple and low-cost method for patterning poly(dimethylsiloxane) (PDMS) barriers in porous support such as paper for the construction of flexible microfluidic paper-based analytical devices (μPADs). The fabrication method consisted of contact-printing a solution of PDMS and
Lixin Zhou et al.
Journal of chromatographic science, 53(1), 177-182 (2014-06-05)
A simple and rapid liquid chromatography-ion trap mass spectrometric (LC-IT/MS) method has been developed and validated for quantification of wilfordmine in human plasma. After the protein precipitation was carried out by acetonitrile and the solution was cleaned by solid-phase extraction
Yu Huang et al.
Bioresource technology, 181, 224-230 (2015-02-07)
In this study, steam explosion pretreatment was performed in cotton stalks, leading to 5-6 folds enhancements on biomass enzymatic saccharification distinctive in Gossypium barbadense and Gossypium hirsutum species. Sequential 1% H2SO4 pretreatment could further increase biomass digestibility of the steam-exploded
Luis M Laglera et al.
Analytica chimica acta, 836, 24-33 (2014-07-01)
Thiols are compounds of paramount importance in the cellular metabolism due to their double detoxifying role as radical scavengers and trace metal ligands. However, we have scarce information about their extracellular cycling as limited data are available about their concentration
Ting Xu et al.
Oncology reports, 33(5), 2631-2638 (2015-03-31)
Slug is involved in the radioresistance and chemoresistance of several types of cancers. In the present study, we first studied the effect of Slug on the radioresistance of nasopharyngeal carcinoma (NPC). We established radioresistant CNE-2 cells (CNE-2-RES) by exposing CNE-2
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