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Srilakshmi Yalavarthi et al.
Arthritis & rheumatology (Hoboken, N.J.), 67(11), 2990-3003 (2015-06-23)
Antiphospholipid antibodies (aPL), especially those targeting β2 -glycoprotein I (β2 GPI), are well known to activate endothelial cells, monocytes, and platelets, with prothrombotic implications. In contrast, the interaction of aPL with neutrophils has not been extensively studied. Neutrophil extracellular traps
Jessica P Otis et al.
Disease models & mechanisms, 8(3), 295-309 (2015-01-31)
Improved understanding of lipoproteins, particles that transport lipids throughout the circulation, is vital to developing new treatments for the dyslipidemias associated with metabolic syndrome. Apolipoproteins are a key component of lipoproteins. Apolipoproteins are proteins that structure lipoproteins and regulate lipid
Tracy C MacDonald et al.
Metallomics : integrated biometal science, 7(8), 1247-1255 (2015-07-17)
The compounds of mercury can be more toxic than those of any other non-radioactive heavy element. Despite this, environmental mercury pollution and human exposure to mercury are widespread, and are increasing. While the unusual ability of selenium to cancel the
Awanish Kumar et al.
Parasitology international, 64(4), 36-42 (2015-01-20)
Visceral leishmaniasis (VL) is a major fatal disease prevalent in North-East India, caused by a protozoan parasite Leishmania donovani. The parasite multiplies and thrives inside mammalian macrophages and is transmitted by the bite of the sandfly. Due to the unsatisfactory
Li Zhou et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 21(7), 2930-2935 (2014-12-17)
Facile growth of CuS nanowires through self-assembly and their application as building blocks for near-infrared light-responsive functional films have been demonstrated. It is found that DNA is a key factor in preparing the CuS material with defined nanostructure. An exclusive
Xilan Jiang et al.
Talanta, 141, 239-246 (2015-05-13)
In the present study, chitosan (CHI) functionalized Fe3O4 magnetic microspheres coated with polyaniline (PANI) were synthesized for the first time. The chitosan-functionalized magnetic microspheres (Fe3O4@CHI) were synthesized by a co-precipitation method, and then aniline was polymerized on the magnetic core.
Weronika E Borek et al.
Nature communications, 6, 7929-7929 (2015-08-06)
Microtubule nucleation is highly regulated during the eukaryotic cell cycle, but the underlying molecular mechanisms are largely unknown. During mitosis in fission yeast Schizosaccharomyces pombe, cytoplasmic microtubule nucleation ceases simultaneously with intranuclear mitotic spindle assembly. Cytoplasmic nucleation depends on the
Marie-Rose Van Calsteren et al.
Carbohydrate research, 413, 115-122 (2015-06-29)
The neutral exopolysaccharide (NPS) of Lactobacillus delbrueckii subsp. bulgaricus strain OLL1073R-1 was purified and characterized. The molecular mass was 5.0×10(6) g/mol. Sugar and absolute configuration analyses gave the following composition: d-Glc, 1; d-Gal, 1.5. The NPS was also submitted to periodate
Arumugam Suriyam Nagappan et al.
Chemico-biological interactions, 221, 77-87 (2014-08-12)
The clinical use of non-steroidal anti-inflammatory drugs (NSAIDs) is often associated with adverse effects in the kidney. Indomethacin, an NSAID that has been shown to induce oxidative stress in the kidney, was used to study the pathogenesis of renal damage
Malgorzata Nocula-Lugowska et al.
Journal of molecular biology, 427(15), 2532-2547 (2015-06-19)
Focal adhesion protein paxillin links integrin and growth factor signaling to actin cytoskeleton. Most of paxillin signaling activity is regulated via leucine-rich LD motifs (LD1-LD5) located at the N-terminus. Here, we demonstrate a method to engineer highly selective synthetic antibodies
Emmanuel Letavernier et al.
Journal of the American Society of Nephrology : JASN, 29(9), 2337-2347 (2018-07-12)
Pseudoxanthoma elasticum (PXE) is a genetic disease caused by mutations in the ABCC6 gene that result in low pyrophosphate levels and subsequent progressive soft tissue calcifications. PXE mainly affects the skin, retina, and arteries. However, many patients with PXE experience
Yan Yan et al.
ACS applied materials & interfaces, 7(42), 23464-23471 (2015-10-07)
A simple photochemical reaction based on confined photocatalytic oxidation (CPO) treatment and hydrolysis was employed to efficiently convert C-H bonds into C-OH groups on polymeric material surfaces, followed by investigation of monolayer self-assembly decoration on polymeric dielectrics via chemical bonding
Yi-Chu Lin et al.
The Laryngoscope, 125(8), E283-E290 (2015-05-27)
Thermal injury to the recurrent laryngeal nerve (RLN) may not be visually apparent and may go unrecognized intraoperatively. This study aimed to investigate the heat thermal tolerance of RLN and evaluate the electrophysiologic correlates of electromyographic (EMG) signal change during
Maria-Andreea Lungan et al.
Carbohydrate polymers, 125, 323-333 (2015-04-11)
Porous crosslinked microparticles based on glycidyl methacrylate and xanthan were prepared by suspension polymerization and used for loading theophylline, a bronhodilatator drug, in order to obtain new drug delivery systems. The surface morphologies observed by means of SEM and AFM
Jun Ouchida et al.
European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 24(12), 2924-2929 (2014-12-30)
Nonunion is a major complication of anterior cervical fusion that causes poor outcomes and occasionally requires additional operative intervention. The purpose of this study is to evaluate the accuracy of functional computed tomography (CT) scanning for determining fusion status after
Al Omar Suliman Y et al.
Environmental toxicology, 30(2), 149-160 (2013-06-28)
Silver nanoparticles are increasingly used in various products, due to their antibacterial properties. Despite its wide spread use, only little information on possible adverse health effects exists. Therefore, the aim of this study was to assess the toxic potential of
Harshad Harde et al.
International journal of pharmaceutics, 487(1-2), 292-304 (2015-04-22)
The present study reports dual tetanus and diphtheria toxoids loaded stable chitosan-glucomannan nanoassemblies (sCh-GM-NAs) formulated using tandem ionic gelation technique for oral mucosal immunization. The stable, lyophilized sCh-GM-NAs exhibited ~152 nm particle size and ~85% EE of both the toxoids.
Ali A Rownaghi et al.
ChemSusChem, 8(20), 3439-3450 (2015-09-12)
We describe a new template-free method for the in situ formation of a monodispersed spherical mesoporous nanosilica-Torlon hollow-fiber composite. A thin layer of Torlon hollow fiber that comprises silica nanoparticles was created by the in situ extrusion of a tetraethyl orthosilicate/N-methyl-2-pyrrolidone solution
Robert Heald et al.
Journal of medicinal chemistry, 58(22), 8877-8895 (2015-10-13)
Because of their increased activity against activating mutants, first-generation epidermal growth factor receptor (EGFR) kinase inhibitors have had remarkable success in treating non-small-cell lung cancer (NSCLC) patients, but acquired resistance, through a secondary mutation of the gatekeeper residue, means that
Chumin Zhao et al.
Medical physics, 42(11), 6294-6308 (2015-11-02)
Large area x-ray imagers based on complementary metal-oxide-semiconductor (CMOS) active pixel sensor (APS) technology have been proposed for various medical imaging applications including digital breast tomosynthesis (DBT). The low electronic noise (50-300 e-) of CMOS APS x-ray imagers provides a
Jong-Hang Chen et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 82, 27-35 (2015-05-12)
This study explores human neuroblastoma (SH-SY5Y) and human glioblastoma (U-1240 MG) cellular differentiation changes under exposure to acrylamide (ACR). Differentiation of SH-SY5Y and U-1240 MG cells were induced by retinoic acid (RA) and butyric acid (BA), respectively. Morphological observations and
Andrew C-H Sue et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(18), 5591-5596 (2015-04-23)
Multiple organic functionalities can now be apportioned into nanoscale domains within a metal-coordinated framework, posing the following question: how do we control the resulting combination of "heterogeneity and order"? Here, we report the creation of a metal-organic framework, MOF-2000, whose
R Schneider et al.
The British journal of surgery, 102(11), 1380-1387 (2015-09-04)
Continuous monitoring of electromyographic (EMG) amplitudes of the vocal muscles detects impending injury of the recurrent laryngeal nerve (RLN) during thyroid operations earlier than intermittent EMG monitoring. This may alert the surgeon to stop a manoeuvre causing stretching or pressure
Mohammad Zarei et al.
Analytica chimica acta, 887, 245-252 (2015-09-01)
Here, we show, for the first time, the use of graphitic carbon nitride (g-C3N4) nanosheets to improve the resolution and efficiency of protein separation in gel electrophoresis. By loading 0.04% (m/v) g-C3N4 nanosheets into the polyacrylamide gel at 25 °C
Sara N Andres et al.
Nature structural & molecular biology, 22(2), 158-166 (2015-01-13)
Ctp1 (also known as CtIP or Sae2) collaborates with Mre11-Rad50-Nbs1 to initiate repair of DNA double-strand breaks (DSBs), but its functions remain enigmatic. We report that tetrameric Schizosaccharomyces pombe Ctp1 contains multivalent DNA-binding and DNA-bridging activities. Through structural and biophysical
Ariela Hoxha et al.
Clinical chemistry and laboratory medicine, 53(8), 1265-1270 (2015-01-07)
Antiphosphatidylserine/prothrombin complex (aPS/PT) antibodies are emerging as an important marker for antiphospholipid syndrome (APS). We aimed to compare their performance with that of conventional antiphospholipid antibodies (aPL) such as lupus anticoagulant (LA), anticardiolipin (aCL), and anti-β2-glycoprotein I (anti-β2GPI) in APS
S H Christiansen et al.
Neuropeptides, 48(6), 335-344 (2014-10-01)
Neuropeptide Y (NPY) causes anxiolytic- and antidepressant-like effects after central administration in rodents. These effects could theoretically be utilized in future gene therapy for anxiety and depression using viral vectors for induction of overexpression of NPY in specific brain regions.
Karin Taylor et al.
mAbs, 7(1), 53-65 (2014-12-20)
There are many design formats for bispecific antibodies (BsAbs), and the best design choice is highly dependent on the final application. Our aim was to engineer BsAbs to target a novel nanocell (EnGeneIC Delivery Vehicle or EDV(TM)nanocell) to the epidermal
Jingjing Zhang et al.
Biomedical materials (Bristol, England), 10(3), 035016-035016 (2015-06-25)
Macroporous hydrogels have shown great promise as scaffolds for cartilage engineering by facilitating nutrition transport and tissue in growth. Cell-matrix adhesion-a fundamental process in tissue engineering-has shown a profound effect on subsequent cell phenotype, extracellular matrix (ECM) accumulation, and tissue
Jonas Van Rie et al.
Journal of materials science. Materials in medicine, 26(3), 123-123 (2015-02-19)
The present work describes the development and the evaluation of cryogel-poly-ε-caprolactone combinatory scaffolds for bone tissue engineering. Gelatin was selected as cell-interactive biopolymer to enable the adhesion and the proliferation of mouse calvaria pre-osteoblasts while poly-ε-caprolactone was applied for its
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