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Tumor necrosis factor-α and apoptosis induction in melanoma cells through histone modification by 3-deazaneplanocin A.
Ryo Tanaka et al.
The Journal of investigative dermatology, 134(5), 1470-1473 (2013-11-15)
Guide to Receptors and Channels (GRAC), 4th Edition.
British journal of pharmacology, 158 Suppl 1, S1-254 (2009-11-04)
D Haeusler et al.
European journal of nuclear medicine and molecular imaging, 42(6), 928-939 (2015-03-06)
Since the adenosine A3 receptor (A3R) is considered to be of high clinical importance in the diagnosis and treatment of ischaemic conditions (heart and brain), glaucoma, asthma, arthritis, cancer and inflammation, a suitable and selective A3R PET tracer such as
Xiaolong Du et al.
Experimental biology and medicine (Maywood, N.J.), 240(11), 1472-1479 (2015-05-15)
Angiogenesis is critical to wound repair due to its role in providing oxygen and nutrients that are required to support the growth and function of reparative cells in damaged tissues. Adenosine receptors are claimed to be of paramount importance in
Peng Zhang et al.
Cardiovascular research, 104(1), 138-146 (2014-08-21)
Vascular endothelial cells synthesize and release vasodilators such as nitric oxide (NO) and epoxyeicosatrienoic acids (EETs). NO is known to inhibit EET-induced smooth muscle hyperpolarization and relaxation. This study investigates the underlying mechanism of this inhibition. Through measurements of membrane
Tobias Heer et al.
American heart journal, 166(6), 999-1009 (2013-11-26)
We sought to evaluate the diagnostic performance of 1.5-T non-contrast enhanced whole-heart magnetic resonance coronary angiography (MRCA) alone and in combination with adenosine stress cardiac magnetic resonance imaging (CMR-Perf). MRCA has been proposed to allow for detection of coronary artery
Rafael Perígolo-Vicente et al.
Biochemical and biophysical research communications, 449(4), 477-482 (2014-05-23)
Several diseases are related to retinal ganglion cell death, such as glaucoma, diabetes and other retinopathies. Many studies have attempted to identify factors that could increase neuroprotection after axotomy of these cells. Interleukin-6 has been shown to be able to
Tadashi Yoshida et al.
Journal of vascular research, 50(6), 512-520 (2013-11-13)
High phosphate-induced phenotypic switching of smooth muscle cells (SMCs) into osteogenic cells is critical for the formation of arterial medial calcification in chronic kidney disease. Because vascular calcification is also prevalent in type 2 diabetes, we examined whether glucose concentration
Lauren Howitt et al.
Pflugers Archiv : European journal of physiology, 467(4), 727-735 (2014-06-14)
Cardiovascular disease is characterised by reduced nitric oxide bioavailability resulting from oxidative stress. Our previous studies have shown that nitric oxide deficit per se increases the contribution of T-type calcium channels to vascular tone through increased superoxide from NADPH oxidase
Reply to the editor.
Øyvind Jakobsen et al.
The Journal of thoracic and cardiovascular surgery, 145(6), 1685-1686 (2013-05-18)
N Duewelhenke et al.
Antimicrobial agents and chemotherapy, 51(1), 54-63 (2006-11-08)
Osteomyelitis, osteitis, spondylodiscitis, septic arthritis, and prosthetic joint infections still represent the worst complications of orthopedic surgery and traumatology. Successful treatment requires, besides surgical débridement, long-term systemic and high-concentration local antibiotic therapy, with possible local antibiotic concentrations of 100 microg/ml
Schraga Schwartz et al.
Cell, 155(6), 1409-1421 (2013-11-26)
N(6)-methyladenosine (m(6)A) is the most ubiquitous mRNA base modification, but little is known about its precise location, temporal dynamics, and regulation. Here, we generated genomic maps of m(6)A sites in meiotic yeast transcripts at nearly single-nucleotide resolution, identifying 1,308 putatively
Lisa C Loram et al.
Brain, behavior, and immunity, 46, 50-54 (2015-02-06)
A single intrathecal dose of adenosine 2A receptor (A2AR) agonist was previously reported to produce a multi-week reversal of allodynia in two different models of neuropathic pain in addition to downregulating glial activation markers in the spinal cord. We aimed
Attila Oláh et al.
The Journal of clinical investigation, 124(9), 3713-3724 (2014-07-26)
The endocannabinoid system (ECS) regulates multiple physiological processes, including cutaneous cell growth and differentiation. Here, we explored the effects of the major nonpsychotropic phytocannabinoid of Cannabis sativa, (-)-cannabidiol (CBD), on human sebaceous gland function and determined that CBD behaves as
Hyung Wook Nam et al.
Molecules and cells, 36(3), 195-202 (2013-08-06)
Adenosine signaling has been implicated in the pathophysiology of alcohol use disorders and other psychiatric disorders such as anxiety and depression. Numerous studies have indicated a role for A1 receptors (A1R) in acute ethanol-induced motor incoordination, while A2A receptors (A2AR)
Sarah Y Branch et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(28), 9310-9318 (2014-07-11)
Substantia nigra dopamine neurons are involved in behavioral processes that include cognition, reward learning, and voluntary movement. Selective deterioration of these neurons is responsible for the motor deficits associated with Parkinson's disease (PD). Aging is the leading risk factor for
Angel L Pey et al.
Biochimica et biophysica acta, 1844(9), 1453-1462 (2014-05-02)
Human cystathionine β-synthase (hCBS) is a key enzyme of sulfur amino acid metabolism, controlling the commitment of homocysteine to the transsulfuration pathway and antioxidant defense. Mutations in hCBS cause inherited homocystinuria (HCU), a rare inborn error of metabolism characterized by
Jayasingh Chellammal Hanish Singh et al.
Pharmaceutical biology, 53(5), 630-636 (2014-12-05)
Vanillic acid (VA), a flavoring agent used in food and drug products, obtained naturally from the plant Angelica sinensis (Oliv.) Diels (Apiaceae), used in the traditional Chinese medicine. It is reported to possess strong antioxidant, anti-inflammatory, and neuroprotective effects. However
Anke E Kip et al.
Antimicrobial agents and chemotherapy, 59(1), 1-14 (2014-11-05)
Recently, there has been a renewed interest in the development of new drugs for the treatment of leishmaniasis. This has spurred the need for pharmacodynamic markers to monitor and compare therapies specifically for visceral leishmaniasis, in which the primary recrudescence
Jason M Hinzman et al.
Biosensors & bioelectronics, 74, 512-517 (2015-07-18)
Throughout the central nervous system extracellular adenosine serves important neuroprotective and neuromodulatory functions. However, current understanding of the in vivo regulation and effects of adenosine is limited by the spatial and temporal resolution of available measurement techniques. Here, we describe
Amabel M Orogo et al.
The Journal of biological chemistry, 290(36), 22061-22075 (2015-07-18)
Transfer of cardiac progenitor cells (CPCs) improves cardiac function in heart failure patients. However, CPC function is reduced with age, limiting their regenerative potential. Aging is associated with numerous changes in cells including accumulation of mitochondrial DNA (mtDNA) mutations, but
Massimo Caruso et al.
Expert opinion on therapeutic targets, 17(7), 761-772 (2013-05-07)
Adenosine receptors (ARs) and their differential pattern of expression modulate a series of pleiotropic activities that are known to contribute to the control of inflammation, remodeling, and tissue repair. Consequently, pharmacological manipulation of adenosine signaling pathway is of great interest
En Hyung Kim et al.
Journal of inflammation (London, England), 12, 41-41 (2015-07-03)
Behçet's disease (BD) is a systemic inflammatory disease with manifestations including recurrent oral and genital ulcerations, and vasculitis involving the skin, mucosa, joints, eyes, veins, arteries, nervous and gastrointestinal systems. BD is seen as a disease at the crossroad between
Weiru Zhang et al.
Circulation research, 112(11), 1466-1478 (2013-04-16)
Hypertension is the most prevalent life-threatening disease worldwide and is frequently associated with chronic kidney disease (CKD). However, the molecular basis underlying hypertensive CKD is not fully understood. We sought to identify specific factors and signaling pathways that contribute to
Janet Taylor et al.
Journal of biomedical materials research. Part A, 103(8), 2582-2590 (2014-12-20)
Kafirin, the sorghum prolamin protein, like its maize homologue zein, can be made into microparticles and films and potentially used as a biomaterial. Zein has good bio- and cyto-compatibility. Kafirin could be advantageous as it is more hydrophobic, more crosslinked
Weiqun Yu et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 28(12), 5288-5298 (2014-09-12)
Purinergic signaling comprises one key pathway in modulating bladder smooth muscle (BSM) contractility, disorders of which become highly prevalent with aging. ADP was first observed to modulate BSM contractility >40 yr ago, yet the underlying molecular mechanism still remains unclear.
Tina Manzhu Kang et al.
Journal of bacteriology, 196(11), 1950-1957 (2014-03-19)
We show here that deoxycytidine deaminase (DCD)-deficient mutants of Escherichia coli are hypersensitive to killing by exogenous cytidine, adenosine, or guanosine, whereas wild-type cells are not. This hypersensitivity is reversed by exogenous thymidine. The mechanism likely involves the allosteric regulation
Hana Vlčková et al.
Journal of separation science, 37(11), 1297-1307 (2014-03-22)
The retention behavior of a large group of analytes (35) with varied properties (pKa and logP) was studied on eight hydrophilic interaction LC columns with different surfaces, stationary phase chemistries, and types of particles. The acetonitrile content (5-95%), buffer concentration
Jinquan Liu et al.
Biosensors & bioelectronics, 70, 54-60 (2015-03-22)
A highly sensitive electrochemiluminescence (ECL) strategy was developed for the protein kinase A (PKA) activity and inhibition assay based on double-quenching of graphene quantum dots (GQDs) ECL by G-quadruplex-hemin DNAzyme and gold nanoparticles (AuNPs). In this strategy, the GQDs were
Ana S Soares et al.
Journal of cancer research and clinical oncology, 140(6), 921-935 (2014-03-25)
Metastatic melanoma is the deadliest form of skin cancer. It is highly resistant to conventional therapies,particularly to drugs that cause apoptosis as the main anticancer mechanism. Recently, induction of autophagic cell death is emerging as a novel therapeutic target for
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