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T Hiratsuka et al.
Journal of thrombosis and haemostasis : JTH, 15(7), 1487-1499 (2017-04-30)
Essentials Spatiotemporal regulation of protein kinases during thrombus formation remains elusive in vivo. Activities of protein kinases were live imaged in mouse platelets at laser-ablated arterioles. Protein kinase A was activated in the dislodging platelets at the downstream side of
Lei Jiang et al.
British journal of cancer, 117(5), 695-703 (2017-07-12)
Selective platelet release of pro- or anti-angiogenic factors distinctly regulated angiogenesis. We hypothesised that selective release of platelet angiogenic factors could differently regulate tumour growth. Breast cancer cell proliferation, cancer cell-induced endothelial tube formation in vitro, and tumour growth in
Hongyao Xu et al.
The American journal of sports medicine, 48(1), 197-209 (2019-11-26)
Meniscal injury is very common, and injured meniscal tissue has a limited healing ability because of poor vascularity. Platelets contain both pro- and anti-angiogenic factors, which can be released by platelet selective activation. Platelets release a high level of vascular
Frederic Lagarrigue et al.
Blood, 136(10), 1180-1190 (2020-06-11)
Ras-related protein 1 (Rap1) is a major convergence point of the platelet-signaling pathways that result in talin-1 binding to the integrin β cytoplasmic domain and consequent integrin activation, platelet aggregation, and effective hemostasis. The nature of the connection between Rap1
Anti-apoptotic BCL2L2 increases megakaryocyte proplatelet formation in cultures of human cord blood.
Seema Bhatlekar et al.
Haematologica, 104(10), 2075-2083 (2019-02-09)
Apoptosis is a recognized limitation to generating large numbers of megakaryocytes in culture. The genes responsible have been rigorously studied in vivo in mice, but are poorly characterized in human culture systems. As CD34-positive (+) cells isolated from human umbilical
Plant-based Food Cyanidin-3-Glucoside Modulates Human Platelet Glycoprotein VI Signaling and Inhibits Platelet Activation and Thrombus Formation.
Yanling Yao et al.
The Journal of nutrition, 147(10), 1917-1925 (2017-09-01)
Z Huang et al.
Journal of thrombosis and haemostasis : JTH, 13(3), 465-476 (2014-12-17)
Endothelial progenitor cells (EPCs) are important for endothelial regeneration and angiogenesis. Thrombin protease-activated receptor 1 (PAR1) PAR1 and PAR4 stimulation induces selective release of platelet proangiogenic and antiangiogenic regulators. To investigate if PAR1-stimulated platelet releasate (PAR1-PR) and PAR4-PR regulate angiogenic
Vuong Ba Lê et al.
American journal of respiratory and critical care medicine, 191(7), 804-819 (2015-02-11)
The hallmark of severe influenza virus infection is excessive inflammation of the lungs. Platelets are activated during influenza, but their role in influenza virus pathogenesis and inflammatory responses is unknown. To determine the role of platelets during influenza A virus
Rachel A Rigg et al.
Platelets, 30(1), 126-135 (2018-12-19)
Human platelets express two protease-activated receptors (PARs), PAR1 (F2R) and PAR4 (F2RL3), which are activated by a number of serine proteases that are generated during pathological events and cause platelet activation. Recent interest has focused on PAR4 as a therapeutic
Ruth Ann Henriksen et al.
Arteriosclerosis, thrombosis, and vascular biology, 22(5), 861-866 (2002-05-15)
Previous reports have indicated that thrombin-induced thromboxane production by human platelets occurs through two types of interaction between thrombin and the platelet surface. One of these interactions is with protease activated receptor(PAR)-1, the first identified thrombin receptor. These studies were
Matthew T Duvernay et al.
Molecular pharmacology, 91(1), 39-47 (2016-10-28)
Human platelets display a unique dual receptor system for responding to its primary endogenous activator, α-thrombin. Because of the lack of efficacious antagonists, the field has relied on synthetic peptides and pepducins to describe protease-activated receptor PAR1 and PAR4 signaling.
Annachiara Mitrugno et al.
Platelets, 29(4), 383-394 (2017-05-20)
The release of ADP from platelet dense granules and its binding to platelet P2Y12 receptors is key to amplifying the initial hemostatic response and propagating thrombus formation. P2Y12 has thus emerged as a therapeutic target to safely and effectively prevent
Ming Wang et al.
Pathology oncology research : POR, 25(3), 937-943 (2018-03-05)
Exposure to carcinogens of tobacco smoke may result in methylation of protease-activated receptors-4 (PAR4) gene and further induces the loss of PAR4 expression, which is considered to be involved in carcinogenesis of esophageal squamous cell carcinoma (ESCC). Here we employed
Wenfu Wang et al.
American journal of physiology. Renal physiology, 314(6), F1077-F1086 (2018-01-24)
Bladder pain is a prominent symptom of interstitial cystitis/painful bladder syndrome. Hydrogen sulfide (H2S) generated by cystathionine β-synthase (CBS) or cystathionine γ-lyase (CSE) facilitates bladder hypersensitivity. We assessed involvement of the H2S pathway in protease-activated receptor 4 (PAR4)-induced bladder pain.
Dimitrios E Kouzoukas et al.
PloS one, 11(3), e0152055-e0152055 (2016-03-25)
Pain is the significant presenting symptom in Interstitial Cystitis/Painful Bladder Syndrome (IC/PBS). Activation of urothelial protease activated receptor 4 (PAR4) causes pain through release of urothelial macrophage migration inhibitory factor (MIF). High Mobility Group Box-1 (HMGB1), a chromatin-binding protein, mediates
Amie J Moyes et al.
The Journal of clinical investigation, 124(9), 4039-4051 (2014-08-12)
The endothelium plays a fundamental role in maintaining vascular homeostasis by releasing factors that regulate local blood flow, systemic blood pressure, and the reactivity of leukocytes and platelets. Accordingly, endothelial dysfunction underpins many cardiovascular diseases, including hypertension, myocardial infarction, and
Pernille Just Vinholt et al.
Journal of thrombosis and thrombolysis, 44(2), 216-222 (2017-06-06)
Dabigatran is an oral anticoagulant and a reversible inhibitor of thrombin. Further, dabigatran might affect platelet function through a direct effect on platelet thrombin receptors. The aim was to investigate the effect of dabigatran on platelet activation and platelet aggregation.
M Maeno et al.
Journal of dental research, 96(6), 633-639 (2017-01-14)
The aim of this study was to evaluate the barrier function of platelet-induced epithelial sheets on titanium surfaces. The lack of functional peri-implant epithelial sealing with basal lamina (BL) attachment at the interface of the implant and the adjacent epithelium
Mayumi Hirano et al.
Scientific reports, 6, 20989-20989 (2016-02-13)
The phosphorylation of the 20-kD myosin light chain (MLC) and actin filament formation play a key role in endothelial barrier disruption. MLC is either mono- or di-phosphorylated (pMLC and ppMLC) at T18 or S19. The present study investigated whether there
Fei Ma et al.
International journal of urology : official journal of the Japanese Urological Association, 25(10), 887-893 (2018-08-17)
To develop a rodent model of persistent non-inflammatory bladder pain and to test macrophage migration inhibitory factor and high mobility box group 1 as mediators of bladder pain. Female C57BL/6 mice received intravesical instillations of protease activated receptor 4 (100 μmol/L, for 1 h)
Ivelin I Ivanov et al.
Scientific reports, 9(1), 13397-13397 (2019-09-19)
Tissue factor (TF) plays a central role in haemostasis and thrombosis. Following vascular damage, vessel wall TF initiates the extrinsic coagulation cascade. TF can also be exposed by monocytes. Inflammatory or infectious stimuli trigger synthesis of new TF protein by
Absence of Pear1 does not affect murine platelet function in vivo
Criel M, et al.
Thrombosis Research, 146, 76-83 (2016)
Leonard C Edelstein et al.
Blood, 124(23), 3450-3458 (2014-10-09)
Human platelets express 2 thrombin receptors: protease-activated receptor (PAR)-1 and PAR4. Recently, we reported 3.7-fold increased PAR4-mediated aggregation kinetics in platelets from black subjects compared with white subjects. We now show that platelets from blacks (n = 70) express 14%
Xiaohong Ruby Xu et al.
Nature communications, 9(1), 3608-3608 (2018-09-08)
Platelet αIIbβ3 integrin and its ligands are essential for thrombosis and hemostasis, and play key roles in myocardial infarction and stroke. Here we show that apolipoprotein A-IV (apoA-IV) can be isolated from human blood plasma using platelet β3 integrin-coated beads.
B Batman et al.
Vox sanguinis, 112(8), 773-779 (2017-09-30)
Prophylactic platelet transfusions are administered to prevent bleeding in haemato-oncological patients. However, bleeding still occurs, despite these transfusions. This practice is costly and not without risk. Better predictors of bleeding are needed, and flow cytometric evaluation of platelet function might
Ming Wang et al.
Journal of immunology research, 2018, 4735752-4735752 (2018-10-27)
A previous study showed that a downexpression of protease-activated receptor 4 (PAR4) is associated with the development of esophageal squamous cell carcinoma (ESCC). In this study, we explored the relationship between PAR4 activation and the expression of p16, and elucidated
Dorothee Kaudewitz et al.
Circulation research, 118(3), 420-432 (2015-12-10)
Platelets shed microRNAs (miRNAs). Plasma miRNAs change on platelet inhibition. It is unclear whether plasma miRNA levels correlate with platelet function. To link small RNAs to platelet reactivity. Next-generation sequencing of small RNAs in plasma revealed 2 peaks at 22
N Boknäs et al.
Thrombosis and haemostasis, 112(3), 558-565 (2014-07-06)
Thrombin-induced platelet activation via PAR1 and PAR4 is an important event in haemostasis. Although the underlying mechanisms responsible for ensuring efficient PAR1 activation by thrombin have been extensively studied, the potential involvement of recognitions sites outside the active site of
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