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Astrid M Doerner et al.
Respiratory research, 10, 100-100 (2009-10-28)
Chronic persistent asthma is characterized by ongoing airway inflammation and airway remodeling. The processes leading to airway remodeling are poorly understood, and there is increasing evidence that even aggressive anti-inflammatory therapy does not completely prevent this process. We sought to
Elisa Roztocil et al.
Scientific reports, 10(1), 8477-8477 (2020-05-23)
Thyroid eye disease (TED) affects 25-50% of patients with Graves' Disease. In TED, collagen accumulation leads to an expansion of the extracellular matrix (ECM) which causes destructive tissue remodeling. The purpose of this study was to investigate the therapeutic potential
Kana Unuma et al.
Biochemical and biophysical research communications, 487(3), 748-754 (2017-04-30)
To investigate septic lung injuries and the possible relief from injury by carbon monoxide (CO), rats were intraperitoneally (i.p.) administered water or the water-soluble CO-releasing molecule CORM (30 mg/kg body weight), followed by the successive administration of PBS or lipopolysaccharide (LPS
Yunjie Lu et al.
Frontiers in cell and developmental biology, 7, 243-243 (2019-11-05)
Trans-differentiation of quiescent hepatic stellate cells (HSC) to myofibroblasts is a hallmark event in liver fibrosis. Previous studies have led to the discovery that myocardin-related transcription factor A (MRTF-A) is a key regulator of HSC trans-differentiation or, activation. In the
Xing Fu et al.
The Journal of clinical investigation, 128(5), 2127-2143 (2018-04-18)
Fibroblasts are a dynamic cell type that achieve selective differentiated states to mediate acute wound healing and long-term tissue remodeling with scarring. With myocardial infarction injury, cardiomyocytes are replaced by secreted extracellular matrix proteins produced by proliferating and differentiating fibroblasts.
Jaco H Houtgraaf et al.
Circulation research, 113(2), 153-166 (2013-05-10)
Mesenchymal precursor cells (MPCs) are a specific Stro-3+ subpopulation of mesenchymal stem cells isolated from bone marrow. MPCs exert extensive cardioprotective effects, and are considered to be immune privileged. This study assessed the safety, feasibility, and efficacy of intracoronary delivery
Juho-Antti Mäkelä et al.
PloS one, 9(3), e90088-e90088 (2014-03-13)
Research on spermatogonia is hampered by complex architecture of the seminiferous tubule, poor viability of testicular tissue ex vivo and lack of physiologically relevant long-term culture systems. Therefore there is a need for an in vitro model that would enable
Gastric mucosal smooth muscles may explain oscillations in glandular pressure: role of vasoactive intestinal peptide.
Synnerstad, et al.
Gastroenterology, 114, 284-294 (2019)
Lingyin Ge et al.
JCI insight, 1(20), e90301-e90301 (2016-12-13)
Maladaptive epithelial repair from chronic injury is a common feature in fibrotic diseases, which in turn activates a pathogenic fibroblast response that produces excessive matrix deposition. Dysregulated microRNAs (miRs) can regulate expression of multiple genes and fundamentally alter cellular phenotypes
Carol Lynn Curchoe et al.
PloS one, 5(11), e13890-e13890 (2010-11-19)
Neural crest stem cells (NCSCs) are a transient multipotent embryonic cell population that represents a defining characteristic of vertebrates. The neural crest (NC) gives rise to many derivatives including the neurons and glia of the sensory and autonomic ganglia of
Ju Youn Lee et al.
Nature communications, 11(1), 2358-2358 (2020-05-14)
Sphingosine kinase1 (SphK1) is an acetyl-CoA dependent acetyltransferase which acts on cyclooxygenase2 (COX2) in neurons in a model of Alzheimer's disease (AD). However, the mechanism underlying this activity was unexplored. Here we show that N-acetyl sphingosine (N-AS) is first generated
Winston T Stauffer et al.
International journal of molecular sciences, 21(4) (2020-02-23)
Activating transcription factor-6 α (ATF6) is one of the three main sensors and effectors of the endoplasmic reticulum (ER) stress response and, as such, it is critical for protecting the heart and other tissues from a variety of environmental insults
Photoperiod-induced differences in uterine growth in Phodopus sungorus are evident at an early age when serum estradiol and uterine estrogen receptor levels are not different.
Phalen, A.N., et al.
Comparative Biochemistry and Physiology, 155, 115-121 (2010)
Revertant mosaic fibroblasts in recessive dystrophic epidermolysis bullosa.
Twaroski, et al.
British Journal of Dermatology, 181, 1247-1253 (2021)
Tao Huang et al.
Journal of animal science and biotechnology, 10, 63-63 (2019-07-25)
N6-Methyladenosine (m6A), the most prevalent modification in mammalian mRNA, plays important roles in numerous biological processes. Several m6A associated proteins such as methyltransferase like 3 (METTL3), methyltransferase like 14 (METTL14), α-ketoglutarate-dependent dioxygenase AlkB homolog 5 (ALKBH5) and YTH domain containing
Ping Gao et al.
Cellular signalling, 50, 160-170 (2018-07-15)
Transforming growth factor β (TGFβ) signaling plays crucial roles in maintaining vascular integrity and homeostasis, and is established as a strong activator of vascular smooth muscle cell (VSMC) differentiation. Chronic inflammation is a hallmark of various vascular diseases. Although TGFβ
Dario F Riascos-Bernal et al.
Nature communications, 7, 12389-12389 (2016-08-09)
Increased activity of the tumour suppressor p53 is incompatible with embryogenesis, but how p53 is controlled is not fully understood. Differential requirements for p53 inhibitors Mdm2 and Mdm4 during development suggest that these control mechanisms are context-dependent. Artery formation requires
Zhen Chang et al.
Disease models & mechanisms, 7(1), 83-91 (2013-10-05)
Transforming growth factor (TGF)-β1 and TGF-β3 have been reported to exert differential effects on wound healing, and possibly even account for tissue-specific differences in scar formation. Scarring is particularly detrimental in the vocal fold mucosa (VFM), where destruction of the
Chunhua Cao et al.
American journal of physiology. Renal physiology, 293(4), F1248-F1255 (2007-08-03)
Descending vasa recta (DVR) are capillary-sized microvessels that supply blood flow to the renal medulla. They are composed of contractile pericytes and endothelial cells. In this study, we used the whole cell patch-clamp method to determine whether inward rectifier potassium
Ingrid Paine et al.
PLoS computational biology, 12(4), e1004839-e1004839 (2016-04-27)
Mathematics is often used to model biological systems. In mammary gland development, mathematical modeling has been limited to acinar and branching morphogenesis and breast cancer, without reference to normal duct formation. We present a model of ductal elongation that exploits
Zengfu Xue et al.
Journal of cellular biochemistry, 113(1), 302-312 (2011-09-14)
Cancer stem cells (CSCs), or tumor initiating cells, are a subpopulation of cancer cells with self-renewal and differentiation properties. However, there has been no direct observation of the properties of gastric CSCs in vitro. Here we describe a vincristine (VCR)-preconditioning
Anja Torsvik et al.
Experimental cell research, 318(5), 441-443 (2012-01-10)
There is at present a controversy in the literature whether MSCs are susceptible to spontaneous in vitro transformation or not. Several groups have reported spontaneous transformation of MSCs from various species. However, some of these reports were not true transformations
Luke C Dutton et al.
Cytometry. Part A : the journal of the International Society for Analytical Cytology, 93(1), 115-124 (2017-08-24)
The clinical application of cardiosphere-derived cells (CDCs) to treat cardiac disease has gained increasing interest over the past decade. Recent clinical trials confirm their regenerative capabilities, although much remains to be elucidated about their basic biology. To develop this new
Sébastien Déglise et al.
Journal of vascular surgery, 41(6), 1043-1052 (2005-06-10)
Intimal hyperplasia is a vascular remodelling process that occurs after a vascular injury. The mechanisms involved in intimal hyperplasia are proliferation, dedifferentiation, and migration of medial smooth muscle cells towards the subintimal space. We postulated that gap junctions, which coordinate
M Pilar Valdecantos et al.
Scientific reports, 8(1), 16461-16461 (2018-11-09)
Non-alcoholic fatty liver disease (NAFLD) is associated with post-operative liver failure (PLF) and impaired liver regeneration. We investigated the effects of a glucagon-like peptide-1 (GLP-1) receptor agonist on NAFLD, PLF and liver regeneration in mice fed chow diet or methionine/choline-deficient
Melanie Königshoff et al.
PloS one, 3(5), e2142-e2142 (2008-05-15)
Idiopathic pulmonary fibrosis (IPF) is a fatal lung disease, characterized by distorted lung architecture and loss of respiratory function. Alveolar epithelial cell injury and hyperplasia, enhanced extracellular matrix deposition, and (myo)fibroblast activation are features of IPF. Wnt/beta-catenin signaling has been
Ventzislav Petkov et al.
The Journal of clinical investigation, 111(9), 1339-1346 (2003-05-03)
Primary pulmonary hypertension is a fatal disease causing progressive right heart failure within 3 years after diagnosis. We describe a new concept for treatment of the disease using vasoactive intestinal peptide, a neuropeptide primarily functioning as a neurotransmitter that acts
Nikhlesh K Singh et al.
The Journal of biological chemistry, 287(43), 36291-36304 (2012-08-16)
Toward understanding the mechanisms of vascular wall remodeling, here we have studied the role of NFATc1 in MCP-1-induced human aortic smooth muscle cell (HASMC) growth and migration and injury-induced rat aortic wall remodeling. We have identified PKN1 as a novel
Yanbin Fu et al.
Cell research, 25(9), 1013-1024 (2015-08-22)
The direct conversion, or transdifferentiation, of non-cardiac cells into cardiomyocytes by forced expression of transcription factors and microRNAs provides promising approaches for cardiac regeneration. However, genetic manipulations raise safety concerns and are thus not desirable in most clinical applications. The
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