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95660

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Separation and determination of benzene, toluene, ethylbenzene and o-xylene compounds in water using directly suspended droplet microextraction coupled with gas chromatography-flame ionization detector.
Sarafraz-Yazdi, et al.
Talanta, 78(3), 936-941 (2009)
Tassanee Lerksuthirat et al.
PloS one, 10(3), e0118547-e0118547 (2015-03-21)
Pythium insidiosum is a unique oomycete that can infect humans and animals. Patients with a P. insidiosum infection (pythiosis) have high rates of morbidity and mortality. The pathogen resists conventional antifungal drugs. Information on the biology and pathogenesis of P....
Nallely López-López et al.
Archives of dermatological research, 306(9), 809-821 (2014-08-30)
Diabetic foot ulcers (DFUs) are chronic wounds with high matrix metalloproteinase (MMP) activity, and are a frequent complication on diabetics. This work studied the expression of selected MMP and tissue inhibitor of metalloproteinases (TIMP) gene family members in DFU and...
Watchara Chongsa et al.
Journal of ethnopharmacology, 155(1), 396-404 (2014-06-08)
Advancing age is associated with an increased accumulation of visceral fat and liver lipid which is then responsible for an age-related risk for cardiovascular disease. Looking after ourselves well with suitable micronutrients could prevent disease or prolong our healthy cardiovascular...
Nai-Wei Yao et al.
Translational oncology, 0 (2014-05-28)
The targeted migration of neural stem/progenitor cells (NSPCs) is a prerequisite for the use of stem cell therapy in the treatment of pathologies. This migration is regulated mainly by C-X-C motif chemokine 12 (CXCL12). Therefore, promotion of the migratory responses...
Carolin Müller et al.
Science translational medicine, 6(247), 247ra101-247ra101 (2014-08-01)
Glioblastoma multiforme (GBM) is the most frequent and aggressive brain tumor in adults. The dogma that GBM spread is restricted to the brain was challenged by reports on extracranial metastases after organ transplantation from GBM donors. We identified circulating tumor...
Tridib K Goswami et al.
Dalton transactions (Cambridge, England : 2003), 43(31), 11988-11999 (2014-06-28)
Ferrocene-conjugated copper(ii) complexes [Cu(Fc-aa)(aip)](ClO4) () and [Cu(Fc-aa)(pyip)](ClO4) () of l-amino acid reduced Schiff bases (Fc-aa), 2-(9-anthryl)-1H-imidazo[4,5-f][1,10]phenanthroline (aip) and 2-(1-pyrenyl)-1H-imidazo[4,5-f][1,10]phenanthroline (pyip), where Fc-aa is ferrocenylmethyl-l-tyrosine (Fc-Tyr in , ), ferrocenylmethyl-l-tryptophan (Fc-Trp in , ) and ferrocenylmethyl-l-methionine (Fc-Met in , ), were...
James P Apland et al.
The Journal of pharmacology and experimental therapeutics, 351(2), 359-372 (2014-08-27)
Exposure to nerve agents induces prolonged status epilepticus (SE), causing brain damage or death. Diazepam (DZP) is the current US Food and Drug Administration-approved drug for the cessation of nerve agent-induced SE. Here, we compared the efficacy of DZP with...
Sharif Sakr et al.
Endocrinology, 155(4), 1489-1497 (2014-02-04)
Endometriosis is a disease defined by the ectopic growth of uterine endometrium. Stem cells contribute to the generation of endometriosis as well as to repair and regeneration of normal endometrium. Here we demonstrate that the selective estrogen receptor modulator bazedoxifene...
María E Fermento et al.
Experimental and molecular pathology, 97(3), 411-424 (2014-09-23)
There is evidence that p300, a transcriptional co-factor and a lysine acetyl-transferase, could play a role both as an oncoprotein and as a tumor suppressor, although little is known regarding its role in breast cancer (BC). First we investigated the...
Jayamanti Pandit et al.
Journal of liposome research, 24(2), 163-169 (2014-02-01)
Miconazole nitrate is a widely used antifungal agent, but its use in topical formulations is not efficacious because deep seated fungal infections are difficult to treat with conventional topical formulation. Miconazole nitrate loaded ultraflexible liposomes have been prepared and their...
Yan Zuo et al.
Molecular endocrinology (Baltimore, Md.), 28(12), 1948-1960 (2014-10-17)
Neuroepithelial transforming gene 1 (Net1) is a RhoA subfamily-specific guanine nucleotide exchange factor that is overexpressed in human breast cancer and is required for breast cancer cell migration and invasion. However, the role of Net1 in normal mammary gland development...
Roza Dianita et al.
Molecules (Basel, Switzerland), 20(3), 4746-4763 (2015-03-19)
The study was designed to evaluate the cardioprotective effects of the standardized aqueous and 80% ethanol extracts of Labisia pumila var. alata (LPva) in isoproterenol (ISO)-induced myocardial infarction (MI) in rats. The extracts were administered to Wistar rats orally for...
Jennifer V Littlejohns et al.
Journal of hazardous materials, 175(1-3), 872-882 (2009-12-05)
A dynamic mathematical model has been developed to predict the performance of a stirred tank, solid-liquid two-phase partitioning bioreactor (SL-TPPB) for the treatment of benzene, toluene, ethylbenzene and o-xylene (BTEX) contaminated gases. The SL-TPPB system consists of an aqueous phase...
Gladys Valverde-Franco et al.
The American journal of pathology, 185(2), 335-346 (2014-12-03)
Osteoarthritis (OA) is characterized by progressive joint destruction, including synovial membrane alteration. EphB4 and its ligand ephrin-B2 were found in vitro to positively affect OA subchondral bone and cartilage. In vivo in an experimental mouse model overexpressing bone-specific Ephb4 (TgEphB4)...
Ion Cristóbal et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 21(2), 347-356 (2014-11-13)
SET is an endogenous PP2A inhibitor that might represent a novel molecular target for antitumor therapy. The aim of this study was to evaluate the molecular effects of SET deregulation and its potential clinical significance in metastatic colorectal cancer (mCRC)....
Kelly J Clemens et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 39(11), 2584-2593 (2014-05-16)
Tobacco addiction involves a transition from occasional, voluntary smoking towards habitual behavior that becomes increasingly resistant to quitting. The development of smoking habits may reflect a loss of behavioral control that can be modeled in rats. This study investigated the...
Paulo A Silva et al.
Biochimica et biophysica acta, 1842(12 Pt A), 2357-2366 (2014-10-07)
This study has investigated the participation of altered signaling linked to angiotensin II (Ang II) that could be associated with increased Na(+) reabsorption in renal proximal tubules during chronic undernutrition. A multideficient chow for rats (basic regional diet, BRD) was...
Anna Ermund et al.
Clinical and experimental pharmacology & physiology, 42(1), 69-75 (2014-10-15)
Hypertonic saline inhalation has become a cornerstone in the treatment of cystic fibrosis (CF), but its effect on CF mucus is still not understood. In CF, mucus stagnates in the airways, causing mucus plugging, and forming a substrate for bacterial...
Jinghong Chen et al.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 33(1), 47-55 (2014-09-30)
Kashin-Beck disease (KBD) is a chronic, deforming endemic osteoarticular disease with altered metabolism of the cartilage matrix. Matrix metalloproteinases (MMPs), aggrecanases (ATAMTSs), and their inhibitors (TIMPs) play important roles in cartilage formation and matrix degradation. This study investigated these proteases...
J M Gámez et al.
Environmental toxicology and pharmacology, 39(1), 9-15 (2014-12-02)
The research work studies the effect of providing a low dose of bisphenol A (BPA), on the reproductive axis of prepubertal female rats. Wistar mated rats were treated with either 0.1% ethanol or BPA in their drinking water until their...
Sousana Amptoulach et al.
Medical oncology (Northwood, London, England), 32(1), 416-416 (2014-12-06)
There is strong evidence that tumor growth is not only a result of uncontrolled cell proliferation but also of decreased apoptosis. Caspase-3 is a member of interleukin-1 beta-converting enzyme which is involved in the induction of apoptosis. Data on the...
Taher R Kermanshahi et al.
Applied immunohistochemistry & molecular morphology : AIMM, 22(10), 728-734 (2014-11-14)
LEF-1 is a DNA-binding protein that interacts with β-catenin and activates Wnt-responsive target genes. We analyzed the immunohistochemical expression of LEF-1 in 602 gastrointestinal and pancreatobiliary neoplasms in an attempt to (1) investigate the utility of LEF-1 immunohistochemistry as an...
Zhi Xu et al.
PloS one, 9(7), e100442-e100442 (2014-07-16)
Gastric cancer is the one of the major causes of cancer-related death, especially in Asia. Gastric adenocarcinoma, the most common type of gastric cancer, is heterogeneous and its incidence and cause varies widely with geographical regions, gender, ethnicity, and diet....
Ming-Da Zhou et al.
Scientific reports, 4, 7392-7392 (2014-12-10)
The analysis of circulating tumour cells (CTCs) in cancer patients could provide important information for therapeutic management. Enrichment of viable CTCs could permit performance of functional analyses on CTCs to broaden understanding of metastatic disease. However, this has not been...
M M Al-Kaabi et al.
British journal of cancer, 112(5), 901-911 (2015-02-18)
Checkpoint kinase1 (CHK1), which is a key component of DNA-damage-activated checkpoint signalling response, may have a role in breast cancer (BC) pathogenesis and influence response to chemotherapy. This study investigated the clinicopathological significance of phosphorylated CHK1 (pCHK1) protein in BC....
Savina Apolloni et al.
Disease models & mechanisms, 7(9), 1101-1109 (2014-07-20)
In recent years there has been an increasing awareness of the role of P2X7, a receptor for extracellular ATP, in modulating physiopathological mechanisms in the central nervous system. In particular, P2X7 has been shown to be implicated in neuropsychiatry, chronic...
Catherine Grasso et al.
The Journal of molecular diagnostics : JMD, 17(1), 53-63 (2014-12-04)
Changes in gene copy number are important in the setting of precision medicine. Recent studies have established that copy number alterations (CNAs) can be detected in sequencing libraries prepared by hybridization-capture, but there has been comparatively little attention given to...
Elizabeth A Oczypok et al.
Ultrastructural pathology, 39(2), 153-158 (2014-10-01)
This is a case of idiopathic epithelial malignant mesothelioma in a 47-year-old mechanic. The advent of a large battery of immunochemical markers has provided new tools for the diagnosis of mesothelioma in recent years; however, immunostaining can often be misleading...
Masayuki Okamoto et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(7), 2942-2958 (2015-02-24)
Cell positioning and neuronal network formation are crucial for proper brain function. Disrupted-in-Schizophrenia 1 (DISC1) is anterogradely transported to the neurite tips, together with Lis1, and functions in neurite extension via suppression of GSK3β activity. Then, transported Lis1 is retrogradely...
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