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Electrochemical immunosensor for detecting typical bladder cancer biomarker based on reduced graphene oxide-tetraethylene pentamine and trimetallic AuPdPt nanoparticles.

Hongmin Ma et al.

Talanta, 143, 77-82 (2015-06-17)

A highly sensitive electrochemical immunosensor for detection of typical bladder cancer biomarker-nuclear matrix protein 22 (NMP22) was developed by using reduced graphene oxide-tetraethylene pentamine (rGO-TEPA) and trimetallic AuPdPt nanoparticles (NPs). rGO-TEPA was used as the ideal material for signal amplification

miR-124 negatively regulates osteogenic differentiation and in vivo bone formation of mesenchymal stem cells.

Abdul S Qadir et al.

Journal of cellular biochemistry, 116(5), 730-742 (2014-11-27)

MicroRNAs are novel key regulators of cellular differentiation. Dlx transcription factors play an important role in osteoblast differentiation, and Dlx5 and Dlx2 are known targets of miR-124. Therefore, in the present study, we investigated the regulatory effects of miR-124 on

Mutation of Spry2 induces proliferation and differentiation of osteoblasts but inhibits proliferation of gingival epithelial cells.

Terukazu Sanui et al.

Journal of cellular biochemistry, 116(4), 628-639 (2014-11-18)

Sprouty was identified as an inhibitor of the fibroblast growth factor (FGF) receptor, and Sprouty2 (Spry2) functions as a negative regulator of receptor tyrosine kinase signaling. In this study, we investigated how inhibition of Spry2 affects osteoblasts and gingival epithelial

Biofunctionalized ceramic with self-assembled networks of nanochannels.

Hae Lin Jang et al.

ACS nano, 9(4), 4447-4457 (2015-04-02)

Nature designs circulatory systems with hierarchically organized networks of gradually tapered channels ranging from micrometer to nanometer in diameter. In most hard tissues in biological systems, fluid, gases, nutrients and wastes are constantly exchanged through such networks. Here, we developed

Culture of mouse embryonic stem cells with serum but without exogenous growth factors is sufficient to generate functional hepatocyte-like cells.

Karen Pauwelyn et al.

PloS one, 6(8), e23096-e23096 (2011-08-11)

Mouse embryonic stem cells (mESC) have been used to study lineage specification in vitro, including towards a hepatocyte-like fate, and such investigations guided lineage differentiation protocols for human (h)ESC. We recently described a four-step protocol to induce hepatocyte-like cells from

Reference region modeling approaches for amphetamine challenge studies with [11C]FLB 457 and PET.

Christine M Sandiego et al.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 35(4), 623-629 (2015-01-08)

Detecting fluctuations in synaptic dopamine levels in extrastriatal brain regions with [(11)C]FLB 457 and positron emission tomography (PET) is a valuable tool for studying dopaminergic dysfunction in psychiatric disorders. The evaluation of reference region modeling approaches would eliminate the need

Efficient and sustained IGF-1 expression in the adipose tissue-derived stem cells mediated via a lentiviral vector.

Ting Chen et al.

Journal of molecular histology, 46(1), 1-11 (2014-12-04)

The adipose tissue-derived stem cells (ADSCs) represent a significant area of the cell therapy. Genetic modification of ADSCs may further improve their therapeutic potential. Here, we aimed to generate a lentiviral vector expressing insulin-like growth factor-I (IGF-1) and investigate the

Pore size and LbL chitosan coating influence mesenchymal stem cell in vitro fibrosis and biomineralization in 3D porous poly(epsilon-caprolactone) scaffolds.

Nima Ghavidel Mehr et al.

Journal of biomedical materials research. Part A, 103(7), 2449-2459 (2014-12-17)

Poly(epsilon-caprolactone) (PCL) is a hydrophobic bioplastic under development for bone tissue engineering applications. Limited information is available on the role of internal geometry and cell-surface attachment on osseous integration potential. We tested the hypothesis that human bone marrow mesenchymal stem

Caveolin-1 accumulation in the tongue cancer tumor microenvironment is significantly associated with poor prognosis: an in-vivo and in-vitro study.

Marilena Vered et al.

BMC cancer, 15, 25-25 (2015-01-31)

Caveolin-1 (CAV1) may be upregulated by hypoxia and acts in a tumor-dependent manner. We investigated CAV1 in tongue squamous cell carcinoma (TSCC) and its association with clinical outcomes, and studied in vitro possible ways for CAV1 accumulation in the tumor

Urchin-like (gold core)@(platinum shell) nanohybrids: A highly efficient peroxidase-mimetic system for in situ amplified colorimetric immunoassay.

Zhuangqiang Gao et al.

Biosensors & bioelectronics, 70, 194-201 (2015-03-31)

The development of signal-amplified colorimetric immunoassay relies on the design of highly efficient signal-transduction tags. One promising route is to exploit a novel enzyme mimetic system as the signal label. Herein, we report that urchin-like (gold core)@(platinum shell) nanohybrids (Au@PtNHs)

Hemoglobin detection using carbon dots as a fluorescence probe.

Ali Barati et al.

Biosensors & bioelectronics, 71, 470-475 (2015-05-20)

Herein, we have described the application of high fluorescent carbon dots (CDs) without any surface modification as a simple and fast responding fluorescence probe for sensitive and selective determination of hemoglobin (Hb) in the presence of H2O2. Although Hb itself

Erythropoietin responsive cardiomyogenic cells contribute to heart repair post myocardial infarction.

Maria Patapia Zafiriou et al.

Stem cells (Dayton, Ohio), 32(9), 2480-2491 (2014-05-09)

The role of erythropoietin (Epo) in myocardial repair after infarction remains inconclusive. We observed high Epo receptor (EPOR) expression in cardiac progenitor cells (CPCs). Therefore, we aimed to characterize these cells and elucidate their contribution to myocardial regeneration on Epo

3D culture broadly regulates tumor cell hypoxia response and angiogenesis via pro-inflammatory pathways.

Peter DelNero et al.

Biomaterials, 55, 110-118 (2015-05-03)

Oxygen status and tissue dimensionality are critical determinants of tumor angiogenesis, a hallmark of cancer and an enduring target for therapeutic intervention. However, it is unclear how these microenvironmental conditions interact to promote neovascularization, due in part to a lack

Palladium nanoparticles decorated on activated fullerene modified screen printed carbon electrode for enhanced electrochemical sensing of dopamine.

Selvakumar Palanisamy et al.

Journal of colloid and interface science, 448, 251-256 (2015-03-07)

In the present work, an enhanced electrochemical sensor for dopamine (DA) was developed based on palladium nanoparticles decorated activated fullerene-C60 (AC60/PdNPs) composite modified screen printed carbon electrode (SPCE). The scanning electron microscopy and elemental analysis confirmed the formation of PdNPs

Oxidative stress in the brain of cigarette smoke-induced noxiousness: neuroprotective role of Sesbania grandiflora.

Thiyagarajan Ramesh et al.

Metabolic brain disease, 30(2), 573-582 (2014-09-14)

Cigarette smoking is concerned as a major risk factor in the development of various neurological disorders. Oxidative stress is suggested as a possible contributing factor in the pathogenesis of cigarette smoking-induced toxicity. Therefore, the present study was intended to evaluate

Proteome-wide analysis of the amino terminal status of Escherichia coli proteins at the steady-state and upon deformylation inhibition.

Willy V Bienvenut et al.

Proteomics, 15(14), 2503-2518 (2015-05-29)

A proteome wide analysis was performed in Escherichia coli to identify the impact on protein N-termini of actinonin, an antibiotic specifically inhibiting peptide deformylase (PDF). A strategy and tool suite (SILProNaQ) was employed to provide large-scale quantitation of N-terminal modifications.

The effect of AMA0428, a novel and potent ROCK inhibitor, in a model of neovascular age-related macular degeneration.

Karolien Hollanders et al.

Investigative ophthalmology & visual science, 56(2), 1335-1348 (2015-01-30)

Rho kinase (ROCK) is associated with VEGF-driven angiogenesis, as well as with inflammation and fibrosis. Therefore, the effect of AMA0428, a novel ROCK inhibitor, was studied in these processes, which highly contribute to the pathogenesis of neovascular AMD. The effect

Knock-down of p300 decreases the proliferation and odontogenic differentiation potentiality of HDPCs.

H J Liu et al.

International endodontic journal, 48(10), 976-985 (2014-10-08)

To investigate the role of p300 in the regulation of proliferation and odontogenic differentiation of human dental pulp cells (HDPCs). The recombinant lentiviral vector pshRNA-copGFP was used to knock-down p300 expression in HDPCs. Protein level of acetylated H3 was detected.

Functions of vitamin C as a mediator of transmembrane electron transport in blood cells and related cell culture models.

H Goldenberg et al.

Antioxidants & redox signaling, 2(2), 189-196 (2001-03-07)

Vitamin C (ascorbic acid) is an important physiological antioxidant. Within cells, it is practically always present in the reduced form. Several enzymatic and nonenzymatic mechanisms have been reported to maintain this status. In the extracellular environment, oxidation of ascorbate leads

MicroRNA-153 suppresses the osteogenic differentiation of human mesenchymal stem cells by targeting bone morphogenetic protein receptor type II.

Yujing Cao et al.

International journal of molecular medicine, 36(3), 760-766 (2015-07-08)

Elucidation of the molecular mechanisms governing the osteogenic differentiation of human mesenchymal stem cells (hMSCs) is of great importance for improving the treatment of bone-related diseases. MicroRNAs (miRNAs or miRs), a class of small non-coding RNAs, are critical in a

Neuropeptide F neurons modulate sugar reward during associative olfactory learning of Drosophila larvae.

Astrid Rohwedder et al.

The Journal of comparative neurology, 523(18), 2637-2664 (2015-08-04)

All organisms continuously have to adapt their behavior according to changes in the environment in order to survive. Experience-driven changes in behavior are usually mediated and maintained by modifications in signaling within defined brain circuits. Given the simplicity of the

Oxidation of catechols during positive ion electrospray mass spectrometric analysis: evidence for in-source oxidative dimerization.

Luis E Sojo et al.

Rapid communications in mass spectrometry : RCM, 28(20), 2181-2190 (2014-09-03)

Catechols are an important class of analytes occurring in many natural and synthetic products. Electrospray ionization in negative mode is the preferred way of ion generation for these compounds; however, studies in positive ion mode can reveal their potential for

Treatment response to antioxidants and zinc based on CFH and ARMS2 genetic risk allele number in the Age-Related Eye Disease Study.

Carl C Awh et al.

Ophthalmology, 122(1), 162-169 (2014-09-10)

To evaluate the impact of complement factor H (CFH) and age-related maculopathy susceptibility 2 (ARMS2) risk alleles on the observed response to components of the Age-Related Eye Disease Study (AREDS) formulation. Genetic and statistical subgroup analysis of a randomized, prospective

Antibacterial, Antifungal and antioxidant activities of some medicinal plants.

Asma Wazir et al.

Pakistan journal of pharmaceutical sciences, 27(6 Spec No.), 2145-2152 (2015-06-06)

The purpose of this study was to evaluate the antibacterial, antifungal and antioxidant activities of medicinal plants. The antibacterial activity of methanolic extracts of three medicinal plants (Swertia chirata, Terminalia bellerica and Zanthoxylum armatum) were tested against Gentamicin (standard drug)

Synthesis, tumor inhibitory and antioxidant activity of new polyfunctionally 2-substituted 5,6,7,8-tetrahydronaphthalene derivatives containing pyridine, thioxopyridine and pyrazolopyridine moieties.

Nehal A Hamdy et al.

Acta poloniae pharmaceutica, 70(6), 987-1001 (2014-01-05)

2-Acetyl-5,6,7,8-tetrahydronaphthalene (1) was allowed to react with different aromatic aldehydes to produce the cyanopyridones 2a and 2b, which were treated with phosphorous pentasulfide to afford the corresponding thioxopyridine derivatives 3a and 3b, respectively. The reaction of 3a and 3b with

Metabolic suppression during mesodermal differentiation of embryonic stem cells identified by single-cell comprehensive gene expression analysis.

Yuanshu Zhou et al.

Molecular bioSystems, 11(9), 2560-2567 (2015-07-28)

Flk-1 (VEGF receptor 2) is a well-defined mesodermal progenitor marker and the Flk-1-positive (Flk-1(+)) cells derived from embryonic stem cells (ESCs) have been known to generate hemangioblasts and cardiovascular progenitor cells, which are formed in the early and late stages

Estrogen enhances activity of Wnt signaling during osteogenesis by inducing Fhl1 expression.

Shao-Min Wu et al.

Journal of cellular biochemistry, 116(7), 1419-1430 (2015-02-14)

Estrogen is a crucial hormone for osteoclast inhibition and for preventing osteoporosis. However, the hormone's role in osteoblast growth and differentiation remains unclear. The complexity of estrogen's role in guiding osteoblast behavior arises partly from crosstalk with other signaling pathways

Induction of cell cycle arrest and apoptosis in caspase-3 deficient MCF-7 cells by Dillenia suffruticosa root extract via multiple signalling pathways.

Jhi Biau Foo et al.

BMC complementary and alternative medicine, 14, 197-197 (2014-06-21)

Dillenia suffruticosa root dichloromethane extract (DCM-DS) has been reported to exhibit strong cytotoxicity towards breast cancer cells. The present study was designed to investigate the cell cycle profile, mode of cell death and signalling pathways of DCM-DS-treated human caspase-3 deficient

Platelet-Derived Growth Factor BB Enhances Osteogenesis of Adipose-Derived But Not Bone Marrow-Derived Mesenchymal Stromal/Stem Cells.

Ben P Hung et al.

Stem cells (Dayton, Ohio), 33(9), 2773-2784 (2015-05-28)

Tissue engineering using mesenchymal stem cells (MSCs) holds great promise for regenerating critically sized bone defects. While the bone marrow-derived MSC is the most widely studied stromal/stem cell type for this application, its rarity within bone marrow and painful isolation

Comparison of phytoncide with sirolimus as a novel drug candidate for drug-eluting stent.

Sung Nam Kang et al.

Biomaterials, 44, 1-10 (2015-01-27)

A drug-eluting stent (DES) is one of the commonly used treatment techniques in percutaneous coronary intervention (PCI). Sirolimus (SRL) has been widely used for DES as a drug for suppressing neointimal hyperplasia causing restenosis. Phytoncides (PTC) are compounds released from

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