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94675

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Topics in Current Chemistry, 128, 175-175 (1985)

Autophagy activation and protection from mitochondrial dysfunction in human chondrocytes.

Paloma López de Figueroa et al.

Arthritis & rheumatology (Hoboken, N.J.), 67(4), 966-976 (2015-01-22)

Autophagy is a key pathway of cellular homeostasis for removing damaged macromolecules and organelles, including mitochondria. Recent studies indicate that activation of autophagy is defective in aging and osteoarthritis (OA), contributing to cell death and tissue damage. In addition, there

Selective synthesis of hydroxy analogues of valinomycin using dioxiranes.

Cosimo Annese et al.

Organic letters, 13(19), 5096-5099 (2011-09-13)

A synthesis of representative monohydroxy derivatives of valinomycin (VLM) was achieved under mild conditions by direct hydroxylation at the side chains of the macrocyclic substrate using dioxiranes. Results demonstrate that the powerful methyl(trifluoromethyl)dioxirane 1b should be the reagent of choice

Membrane potential-dependent uptake of 18F-triphenylphosphonium--a new voltage sensor as an imaging agent for detecting burn-induced apoptosis.

Gaofeng Zhao et al.

The Journal of surgical research, 188(2), 473-479 (2014-03-04)

Mitochondrial dysfunction has been closely related to many pathologic processes, such as cellular apoptosis. Alterations in organelle membrane potential are associated with mitochondrial dysfunction. A fluorine-18 labeled phosphonium compound: (18)F-triphenylphosphonium ((18)F-TPP) was prepared to determine its potential use as a

Metabolomic analysis of acid stress response in Saccharomyces cerevisiae.

Riyanto Heru Nugroho et al.

Journal of bioscience and bioengineering, 120(4), 396-404 (2015-03-22)

Acid stress has been reported to inhibit cell growth and decrease productivity during bio-production processes. In this study, a metabolomics approach was conducted to understand the effect of lactic acid induced stress on metabolite pools in Saccharomyces cerevisiae. Cells were

Enhancing biocompatibility of some cation selective electrodes using heparin modified bacterial cellulose.

Ibrahim H A Badr et al.

Carbohydrate polymers, 134, 687-694 (2015-10-03)

Bacterial cellulose (BC) and heparin-modified bacterial cellulose (HBC) were utilized to enhance the biocompatibility of highly thrombogenic PVC-based potassium and calcium membrane electrodes. Three types of membrane electrodes were prepared: (1) conventional PVC electrode (control), (2) PVC-based electrode sandwiched with

Colloidal bismuth subcitrate impedes proton entry into Helicobacter pylori and increases the efficacy of growth-dependent antibiotics.

E A Marcus et al.

Alimentary pharmacology & therapeutics, 42(7), 922-933 (2015-08-05)

Successful eradication of Helicobacter pylori is becoming more difficult, mainly due to emerging antibiotic resistance. Treatment regimens containing bismuth have increased efficacy, but the mechanism is unknown. Helicobacter pylori is a neutralophile adapted to survive the acidic gastric environment via

SET overexpression in HEK293 cells regulates mitochondrial uncoupling proteins levels within a mitochondrial fission/reduced autophagic flux scenario.

Luciana O Almeida et al.

Biochemical and biophysical research communications, 458(2), 300-306 (2015-02-07)

We hypothesized that SET, a protein accumulated in some cancer types and Alzheimer disease, is involved in cell death through mitochondrial mechanisms. We addressed the mRNA and protein levels of the mitochondrial uncoupling proteins UCP1, UCP2 and UCP3 (S and

Valinomycin induced energy-dependent mitochondrial swelling, cytochrome c release, cytosolic NADH/cytochrome c oxidation and apoptosis.

Dario Domenico Lofrumento et al.

Apoptosis : an international journal on programmed cell death, 16(10), 1004-1013 (2011-07-09)

In valinomycin induced stimulation of mitochondrial energy dependent reversible swelling, supported by succinate oxidation, cytochrome c (cyto-c) and sulfite oxidase (Sox) [both present in the mitochondrial intermembrane space (MIS)] are released outside. This effect can be observed at a valinomycin

[Alteration of transport activity of proton pumps in coleoptile cells during early development stages of maize seedlings].

M F Shishova et al.

Ontogenez, 43(6), 413-424 (2013-02-14)

Comparative analysis of the transport activity of proton pumps (plasmalemma H+-ATPase, vacuolar H+-ATPase, and vacuolar H+-pyrophosphatase) in the membrane preparations obtained from coleoptile cells ofetiolated maize seedlings (Zea mays L.) was carried out. The highest level ofvacuolar pyrophosphatase activity was

[Comparative investigation by spectrofluorimetry and flow cytometry of plasma and inner mitochondrial membranes polarisation in smooth muscle cell using potential-sensitive probe DiOC6(3)].

G V Danylovich et al.

Ukrains'kyi biokhimichnyi zhurnal (1999 ), 83(3), 99-105 (2011-09-06)

Possibility of the use of flow cytometry and spectrofluorimetry analysis for investigation mitochondria and plasma membrane polarization in myometrium cell suspension using potential-sensitive probe 3,3'-dihexyloxacarbocyanine [DiOC6(3)] has been demonstrated. The obtained results confirm the use of DiOC6(3) for studying the

Influence of the lipid environment on valinomycin structure and cation complex formation.

Christopher M Halsey et al.

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 96, 200-206 (2012-06-12)

Carrier-type molecular ionophores, such as the cyclic dodecadepsipeptide valinomycin, often must undergo structural changes during the binding and transport of a cation across the lipid membrane. Observing the structural fluctuations that occur during this process experimentally has proven extremely difficult

P-glycoprotein is fully active after multiple tryptophan substitutions.

Douglas J Swartz et al.

Biochimica et biophysica acta, 1828(3), 1159-1168 (2012-12-25)

P-glycoprotein (Pgp) is an important contributor to multidrug resistance of cancer. Pgp contains eleven native tryptophans (Trps) that are highly conserved among orthologs. We replaced each Trp by a conservative substitution to determine which Trps are important for function. Individual

Daptomycin forms cation- and size-selective pores in model membranes.

TianHua Zhang et al.

Biochimica et biophysica acta, 1838(10), 2425-2430 (2014-05-27)

Daptomycin is a lipopeptide antibiotic that is used clinically to treat severe infections caused by Gram-positive bacteria. Its bactericidal action involves the calcium-dependent binding to membranes containing phosphatidylglycerol, followed by the formation of membrane-associated oligomers. Bacterial cells exposed to daptomycin

Functional characterization of the Plasmodium falciparum chloroquine-resistance transporter (PfCRT) in transformed Dictyostelium discoideum vesicles.

Janni Papakrivos et al.

PloS one, 7(6), e39569-e39569 (2012-06-23)

Chloroquine (CQ)-resistant Plasmodium falciparum malaria has been a global health catastrophe, yet much about the CQ resistance (CQR) mechanism remains unclear. Hallmarks of the CQR phenotype include reduced accumulation of protonated CQ as a weak base in the digestive vacuole

An electrogenic nitric oxide reductase.

Sinan Al-Attar et al.

FEBS letters, 589(16), 2050-2057 (2015-07-08)

Nitric oxide reductases (Nors) are members of the heme-copper oxidase superfamily that reduce nitric oxide (NO) to nitrous oxide (N₂O). In contrast to the proton-pumping cytochrome oxidases, Nors studied so far have neither been implicated in proton pumping nor have

Fructose leads to hepatic steatosis in zebrafish that is reversed by mechanistic target of rapamycin (mTOR) inhibition.

Valerie Sapp et al.

Hepatology (Baltimore, Md.), 60(5), 1581-1592 (2014-07-22)

Nonalcoholic fatty liver disease (NAFLD), the accumulation of lipid within hepatocytes, is increasing in prevalence. Increasing fructose consumption correlates with this increased prevalence, and rodent studies directly support fructose leading to NAFLD. The mechanisms of NAFLD and in particular fructose-induced

Mitochondrial uncouplers inhibit hepatic stellate cell activation.

Eduardo L Guimarães et al.

BMC gastroenterology, 12, 68-68 (2012-06-13)

Mitochondrial dysfunction participates in the progression of several pathologies. Although there is increasing evidence for a mitochondrial role in liver disease, little is known about its contribution to hepatic stellate cell (HSC) activation. In this study we investigated the role

Heat shock protein 90 inhibitor mycoepoxydiene modulates kinase signaling in cervical cancer cells and inhibits in-vivo tumor growth.

Peng Lin et al.

Anti-cancer drugs, 26(1), 25-34 (2014-07-12)

Heat shock protein 90 (Hsp90) functions within multiple signaling pathways on the basis of its ability to serve as a chaperone for more than 100 client proteins. Thus, inhibition of Hsp90 alone can trigger numerous pathways. Mycoepoxydiene (MED) can inhibit

Human organic anion transporter 2 is distinct from organic anion transporters 1 and 3 with respect to transport function.

Maja Henjakovic et al.

American journal of physiology. Renal physiology, 309(10), F843-F851 (2015-09-18)

Phylogentically, organic anion transporter (OAT)1 and OAT3 are closely related, whereas OAT2 is more distant. Experiments with human embryonic kidney-293 cells stably transfected with human OAT1, OAT2, or OAT3 were performed to compare selected transport properties. Common to OAT1, OAT2

Lipid multilayer microarrays for in vitro liposomal drug delivery and screening.

Aubrey E Kusi-Appiah et al.

Biomaterials, 33(16), 4187-4194 (2012-03-07)

Screening for effects of small molecules on cells grown in culture is a well-established method for drug discovery and testing, and faster throughput at lower cost is needed. Small-molecule arrays and microfluidics are promising approaches. Here we introduce a simple

Channelrhodopsin-2 is a leaky proton pump.

Katrin Feldbauer et al.

Proceedings of the National Academy of Sciences of the United States of America, 106(30), 12317-12322 (2009-07-11)

Since its discovery, the light-gated cation channel Channelrhodopsin-2 (ChR2) has proven to be a long-sought tool for the noninvasive, light-activated control of neural cells in culture and in living animals. Although ChR2 is widely used in neurobiological applications, little is

Sustained accumulation of prelamin A and depletion of lamin A/C both cause oxidative stress and mitochondrial dysfunction but induce different cell fates.

Tom Sieprath et al.

Nucleus (Austin, Tex.), 6(3), 236-246 (2015-05-23)

The cell nucleus is structurally and functionally organized by lamins, intermediate filament proteins that form the nuclear lamina. Point mutations in genes that encode a specific subset of lamins, the A-type lamins, cause a spectrum of diseases termed laminopathies. Recent

Fungal and bacterial metabolites in commercial poultry feed from Nigeria.

C N Ezekiel et al.

Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment, 29(8), 1288-1299 (2012-06-26)

Metabolites of toxigenic fungi and bacteria occur as natural contaminants (e.g. mycotoxins) in feedstuffs making them unsafe to animals. The multi-toxin profiles in 58 commercial poultry feed samples collected from 19 districts in 17 states of Nigeria were determined by

Probing the Cl--pumping photocycle of pharaonis halorhodopsin: Examinations with bacterioruberin, an intrinsic dye, and membrane potential-induced modulation of the photocycle.

Takashi Kikukawa et al.

Biochimica et biophysica acta, 1847(8), 748-758 (2015-05-12)

Halorhodopsin (HR) functions as a light-driven inward Cl- pump. The Cl- transfer process of HR from Natronomonas pharaonis (NpHR) was examined utilizing a mutant strain, KM-1, which expresses large amount of NpHR in a complex with the carotenoid bacterioruberin (Brub).

Glutamine, glutamate, and arginine-based acid resistance in Lactobacillus reuteri.

Januana S Teixeira et al.

Food microbiology, 42, 172-180 (2014-06-16)

This study aimed to determine whether glutamine deamidation improves acid resistance of Lactobacillus reuteri, and to assess whether arginine, glutamine, and glutamate-mediated acid resistance are redundant or complementary mechanisms of acid resistance. Three putative glutaminase genes, gls1, gls2, and gls3

Perturbation of intracellular K(+) homeostasis with valinomycin promotes cell death by mitochondrial swelling and autophagic processes.

Barbara Klein et al.

Apoptosis : an international journal on programmed cell death, 16(11), 1101-1117 (2011-08-31)

Perturbation of cellular K(+) homeostasis is a common motif in apoptosis but it is unknown whether a decrease in intracellular K(+) alone is sufficient to replicate apoptotic hallmarks. We investigated, which mode of cell death is induced by decreasing the

Thapsigargin-induced endoplasmic reticulum stress is not accompanied by mitochondrial membrane potential dissipation in murine pro-B cells.

Raluca Jipu et al.

Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi, 116(2), 557-562 (2012-10-20)

There are almost no data concerning the involvement of endoplasmic reticulum stress (Ca2+ fluxes) in the apoptosis of the pro-B cell type Ba/F3. Thus, we aimed the characterization of thapsigargin-induced effects on Ba/F3 cells in vitro. For some experiments Ba/F3

Overexpression of heat shock protein 27 (HSP27) increases gemcitabine sensitivity in pancreatic cancer cells through S-phase arrest and apoptosis.

Yang Guo et al.

Journal of cellular and molecular medicine, 19(2), 340-350 (2014-10-22)

We previously established a role for HSP27 as a predictive marker for therapeutic response towards gemcitabine in pancreatic cancer. Here, we investigate the underlying mechanisms of HSP27-mediated gemcitabine sensitivity. Utilizing a pancreatic cancer cell model with stable HSP27 overexpression, cell

A dimer is the minimal proton-conducting unit of the influenza a virus M2 channel.

Kenichi Kawano et al.

Journal of molecular biology, 426(14), 2679-2691 (2014-05-13)

When influenza A virus infects host cells, its integral matrix protein M2 forms a proton-selective channel in the viral envelope. Although X-ray crystallography and NMR studies using fragment peptides have suggested that M2 stably forms a tetrameric channel irrespective of

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