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Topics in Current Chemistry, 128, 175-175 (1985)
Paloma López de Figueroa et al.
Arthritis & rheumatology (Hoboken, N.J.), 67(4), 966-976 (2015-01-22)
Autophagy is a key pathway of cellular homeostasis for removing damaged macromolecules and organelles, including mitochondria. Recent studies indicate that activation of autophagy is defective in aging and osteoarthritis (OA), contributing to cell death and tissue damage. In addition, there
Cosimo Annese et al.
Organic letters, 13(19), 5096-5099 (2011-09-13)
A synthesis of representative monohydroxy derivatives of valinomycin (VLM) was achieved under mild conditions by direct hydroxylation at the side chains of the macrocyclic substrate using dioxiranes. Results demonstrate that the powerful methyl(trifluoromethyl)dioxirane 1b should be the reagent of choice
Gaofeng Zhao et al.
The Journal of surgical research, 188(2), 473-479 (2014-03-04)
Mitochondrial dysfunction has been closely related to many pathologic processes, such as cellular apoptosis. Alterations in organelle membrane potential are associated with mitochondrial dysfunction. A fluorine-18 labeled phosphonium compound: (18)F-triphenylphosphonium ((18)F-TPP) was prepared to determine its potential use as a
Riyanto Heru Nugroho et al.
Journal of bioscience and bioengineering, 120(4), 396-404 (2015-03-22)
Acid stress has been reported to inhibit cell growth and decrease productivity during bio-production processes. In this study, a metabolomics approach was conducted to understand the effect of lactic acid induced stress on metabolite pools in Saccharomyces cerevisiae. Cells were
Ibrahim H A Badr et al.
Carbohydrate polymers, 134, 687-694 (2015-10-03)
Bacterial cellulose (BC) and heparin-modified bacterial cellulose (HBC) were utilized to enhance the biocompatibility of highly thrombogenic PVC-based potassium and calcium membrane electrodes. Three types of membrane electrodes were prepared: (1) conventional PVC electrode (control), (2) PVC-based electrode sandwiched with
E A Marcus et al.
Alimentary pharmacology & therapeutics, 42(7), 922-933 (2015-08-05)
Successful eradication of Helicobacter pylori is becoming more difficult, mainly due to emerging antibiotic resistance. Treatment regimens containing bismuth have increased efficacy, but the mechanism is unknown. Helicobacter pylori is a neutralophile adapted to survive the acidic gastric environment via
Luciana O Almeida et al.
Biochemical and biophysical research communications, 458(2), 300-306 (2015-02-07)
We hypothesized that SET, a protein accumulated in some cancer types and Alzheimer disease, is involved in cell death through mitochondrial mechanisms. We addressed the mRNA and protein levels of the mitochondrial uncoupling proteins UCP1, UCP2 and UCP3 (S and
Dario Domenico Lofrumento et al.
Apoptosis : an international journal on programmed cell death, 16(10), 1004-1013 (2011-07-09)
In valinomycin induced stimulation of mitochondrial energy dependent reversible swelling, supported by succinate oxidation, cytochrome c (cyto-c) and sulfite oxidase (Sox) [both present in the mitochondrial intermembrane space (MIS)] are released outside. This effect can be observed at a valinomycin
M F Shishova et al.
Ontogenez, 43(6), 413-424 (2013-02-14)
Comparative analysis of the transport activity of proton pumps (plasmalemma H+-ATPase, vacuolar H+-ATPase, and vacuolar H+-pyrophosphatase) in the membrane preparations obtained from coleoptile cells ofetiolated maize seedlings (Zea mays L.) was carried out. The highest level ofvacuolar pyrophosphatase activity was
G V Danylovich et al.
Ukrains'kyi biokhimichnyi zhurnal (1999 ), 83(3), 99-105 (2011-09-06)
Possibility of the use of flow cytometry and spectrofluorimetry analysis for investigation mitochondria and plasma membrane polarization in myometrium cell suspension using potential-sensitive probe 3,3'-dihexyloxacarbocyanine [DiOC6(3)] has been demonstrated. The obtained results confirm the use of DiOC6(3) for studying the
Christopher M Halsey et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 96, 200-206 (2012-06-12)
Carrier-type molecular ionophores, such as the cyclic dodecadepsipeptide valinomycin, often must undergo structural changes during the binding and transport of a cation across the lipid membrane. Observing the structural fluctuations that occur during this process experimentally has proven extremely difficult
Douglas J Swartz et al.
Biochimica et biophysica acta, 1828(3), 1159-1168 (2012-12-25)
P-glycoprotein (Pgp) is an important contributor to multidrug resistance of cancer. Pgp contains eleven native tryptophans (Trps) that are highly conserved among orthologs. We replaced each Trp by a conservative substitution to determine which Trps are important for function. Individual
TianHua Zhang et al.
Biochimica et biophysica acta, 1838(10), 2425-2430 (2014-05-27)
Daptomycin is a lipopeptide antibiotic that is used clinically to treat severe infections caused by Gram-positive bacteria. Its bactericidal action involves the calcium-dependent binding to membranes containing phosphatidylglycerol, followed by the formation of membrane-associated oligomers. Bacterial cells exposed to daptomycin
Janni Papakrivos et al.
PloS one, 7(6), e39569-e39569 (2012-06-23)
Chloroquine (CQ)-resistant Plasmodium falciparum malaria has been a global health catastrophe, yet much about the CQ resistance (CQR) mechanism remains unclear. Hallmarks of the CQR phenotype include reduced accumulation of protonated CQ as a weak base in the digestive vacuole
Sinan Al-Attar et al.
FEBS letters, 589(16), 2050-2057 (2015-07-08)
Nitric oxide reductases (Nors) are members of the heme-copper oxidase superfamily that reduce nitric oxide (NO) to nitrous oxide (N₂O). In contrast to the proton-pumping cytochrome oxidases, Nors studied so far have neither been implicated in proton pumping nor have
Valerie Sapp et al.
Hepatology (Baltimore, Md.), 60(5), 1581-1592 (2014-07-22)
Nonalcoholic fatty liver disease (NAFLD), the accumulation of lipid within hepatocytes, is increasing in prevalence. Increasing fructose consumption correlates with this increased prevalence, and rodent studies directly support fructose leading to NAFLD. The mechanisms of NAFLD and in particular fructose-induced
Eduardo L Guimarães et al.
BMC gastroenterology, 12, 68-68 (2012-06-13)
Mitochondrial dysfunction participates in the progression of several pathologies. Although there is increasing evidence for a mitochondrial role in liver disease, little is known about its contribution to hepatic stellate cell (HSC) activation. In this study we investigated the role
Peng Lin et al.
Anti-cancer drugs, 26(1), 25-34 (2014-07-12)
Heat shock protein 90 (Hsp90) functions within multiple signaling pathways on the basis of its ability to serve as a chaperone for more than 100 client proteins. Thus, inhibition of Hsp90 alone can trigger numerous pathways. Mycoepoxydiene (MED) can inhibit
Maja Henjakovic et al.
American journal of physiology. Renal physiology, 309(10), F843-F851 (2015-09-18)
Phylogentically, organic anion transporter (OAT)1 and OAT3 are closely related, whereas OAT2 is more distant. Experiments with human embryonic kidney-293 cells stably transfected with human OAT1, OAT2, or OAT3 were performed to compare selected transport properties. Common to OAT1, OAT2
Aubrey E Kusi-Appiah et al.
Biomaterials, 33(16), 4187-4194 (2012-03-07)
Screening for effects of small molecules on cells grown in culture is a well-established method for drug discovery and testing, and faster throughput at lower cost is needed. Small-molecule arrays and microfluidics are promising approaches. Here we introduce a simple
Katrin Feldbauer et al.
Proceedings of the National Academy of Sciences of the United States of America, 106(30), 12317-12322 (2009-07-11)
Since its discovery, the light-gated cation channel Channelrhodopsin-2 (ChR2) has proven to be a long-sought tool for the noninvasive, light-activated control of neural cells in culture and in living animals. Although ChR2 is widely used in neurobiological applications, little is
Tom Sieprath et al.
Nucleus (Austin, Tex.), 6(3), 236-246 (2015-05-23)
The cell nucleus is structurally and functionally organized by lamins, intermediate filament proteins that form the nuclear lamina. Point mutations in genes that encode a specific subset of lamins, the A-type lamins, cause a spectrum of diseases termed laminopathies. Recent
C N Ezekiel et al.
Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment, 29(8), 1288-1299 (2012-06-26)
Metabolites of toxigenic fungi and bacteria occur as natural contaminants (e.g. mycotoxins) in feedstuffs making them unsafe to animals. The multi-toxin profiles in 58 commercial poultry feed samples collected from 19 districts in 17 states of Nigeria were determined by
Takashi Kikukawa et al.
Biochimica et biophysica acta, 1847(8), 748-758 (2015-05-12)
Halorhodopsin (HR) functions as a light-driven inward Cl- pump. The Cl- transfer process of HR from Natronomonas pharaonis (NpHR) was examined utilizing a mutant strain, KM-1, which expresses large amount of NpHR in a complex with the carotenoid bacterioruberin (Brub).
Januana S Teixeira et al.
Food microbiology, 42, 172-180 (2014-06-16)
This study aimed to determine whether glutamine deamidation improves acid resistance of Lactobacillus reuteri, and to assess whether arginine, glutamine, and glutamate-mediated acid resistance are redundant or complementary mechanisms of acid resistance. Three putative glutaminase genes, gls1, gls2, and gls3
Barbara Klein et al.
Apoptosis : an international journal on programmed cell death, 16(11), 1101-1117 (2011-08-31)
Perturbation of cellular K(+) homeostasis is a common motif in apoptosis but it is unknown whether a decrease in intracellular K(+) alone is sufficient to replicate apoptotic hallmarks. We investigated, which mode of cell death is induced by decreasing the
Raluca Jipu et al.
Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi, 116(2), 557-562 (2012-10-20)
There are almost no data concerning the involvement of endoplasmic reticulum stress (Ca2+ fluxes) in the apoptosis of the pro-B cell type Ba/F3. Thus, we aimed the characterization of thapsigargin-induced effects on Ba/F3 cells in vitro. For some experiments Ba/F3
Yang Guo et al.
Journal of cellular and molecular medicine, 19(2), 340-350 (2014-10-22)
We previously established a role for HSP27 as a predictive marker for therapeutic response towards gemcitabine in pancreatic cancer. Here, we investigate the underlying mechanisms of HSP27-mediated gemcitabine sensitivity. Utilizing a pancreatic cancer cell model with stable HSP27 overexpression, cell
Kenichi Kawano et al.
Journal of molecular biology, 426(14), 2679-2691 (2014-05-13)
When influenza A virus infects host cells, its integral matrix protein M2 forms a proton-selective channel in the viral envelope. Although X-ray crystallography and NMR studies using fragment peptides have suggested that M2 stably forms a tetrameric channel irrespective of
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